{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T21:14:19Z","timestamp":1782422059764,"version":"3.54.5"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T00:00:00Z","timestamp":1620000000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T00:00:00Z","timestamp":1620000000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI19\/01661"],"award-info":[{"award-number":["PI19\/01661"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Arch Otorhinolaryngol"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1007\/s00405-021-06819-0","type":"journal-article","created":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T20:25:49Z","timestamp":1620073549000},"page":"883-889","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Prognostic value of the nodal yield in elective neck dissections in patients with head and neck carcinomas"],"prefix":"10.1007","volume":"279","author":[{"given":"Xavier","family":"Le\u00f3n","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda del Prado","family":"Venegas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4183-5832","authenticated-orcid":false,"given":"Maria","family":"Casasayas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilo","family":"Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduard D.","family":"Neumann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Holgado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miquel","family":"Quer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,5,3]]},"reference":[{"issue":"11","key":"6819_CR1","doi-asserted-by":"publisher","first-page":"2401","DOI":"10.1002\/cncr.23474","volume":"112","author":"JL Wright","year":"2008","unstructured":"Wright JL, Lin DW, Porter MP (2008) The association between extent of lymphadenectomy and survival among patients with lymph node metastases undergoing radical cystectomy. Cancer 112(11):2401\u20132408","journal-title":"Cancer"},{"issue":"7","key":"6819_CR2","doi-asserted-by":"publisher","first-page":"1793","DOI":"10.1200\/JCO.2002.07.112","volume":"20","author":"L Weir","year":"2002","unstructured":"Weir L, Speers C, D\u2019yachkova Y, Olivotto IA (2002) Prognostic significance of the number of axillary lymph nodes examined in breast cancer. J Clin Oncol 20(7):1793\u20131799","journal-title":"J Clin Oncol"},{"issue":"6","key":"6819_CR3","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1093\/jnci\/djk092","volume":"99","author":"GJ Chang","year":"2007","unstructured":"Chang GJ, Rodriguez-Bigas MA, Skibber JM, Moyer VA (2007) Lymph node evaluation and survival after curative resection of colon cancer: systematic review. J Natl Cancer Inst 99(6):433\u2013441","journal-title":"J Natl Cancer Inst"},{"issue":"2","key":"6819_CR4","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1007\/s10434-000-0139-1","volume":"7","author":"CM Volpe","year":"2000","unstructured":"Volpe CM, Driscoll DL, Douglass HO (2000) Outcome of patients with proximal gastric cancer depends on extent of resection and number of resected lymph nodes. Ann Surg Oncol 7(2):139\u2013144","journal-title":"Ann Surg Oncol"},{"issue":"6","key":"6819_CR5","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.1002\/cncr.23309","volume":"112","author":"AJ Greenstein","year":"2008","unstructured":"Greenstein AJ, Litle VR, Swanson SJ, Divino CM, Packer S, Wisnivesky JP (2008) Effect of the number of lymph nodes sampled on postoperative survival of lymph node-negative esophageal cancer. Cancer 112(6):1239\u20131246","journal-title":"Cancer"},{"issue":"7","key":"6819_CR6","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1001\/archotol.1994.01880310005001","volume":"120","author":"MH Weiss","year":"1994","unstructured":"Weiss MH, Harrison LB, Isaacs RS (1994) Use of decision analysis in planning a management strategy for the stage N0 neck. Arch Otolaryngol Head Neck Surg 120(7):699\u2013702","journal-title":"Arch Otolaryngol Head Neck Surg"},{"issue":"3","key":"6819_CR7","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1002\/hed.2890100304","volume":"10","author":"RM Byers","year":"1988","unstructured":"Byers RM, Wolf PFBA (1988) Rationale for elective modified neck dissection. Head Neck Surg 10(3):160\u2013167","journal-title":"Head Neck Surg"},{"issue":"9","key":"6819_CR8","doi-asserted-by":"publisher","first-page":"2070","DOI":"10.1002\/lary.26545","volume":"127","author":"JD Pou","year":"2017","unstructured":"Pou JD, Barton BM, Lawlor CM, Frederick CH, Moore BA, Hasney CP (2017) Minimum lymph node yield in elective level I-III neck dissection. Laryngoscope 127(9):2070\u20132073","journal-title":"Laryngoscope"},{"issue":"23","key":"6819_CR9","doi-asserted-by":"publisher","first-page":"3624","DOI":"10.1002\/cncr.30227","volume":"122","author":"P Kuo","year":"2016","unstructured":"Kuo P, Mehra S, Sosa JA, Roman SA, Husain ZA, Burtness BA et al (2016) Proposing prognostic thresholds for lymph node yield in clinically lymph node-negative and lymph node-positive cancers of the oral cavity. Cancer 122(23):3624\u20133631","journal-title":"Cancer"},{"issue":"10","key":"6819_CR10","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1002\/hed.23475","volume":"36","author":"J Jaber","year":"2014","unstructured":"Jaber J, Zender CA, Mehta V, Davis K, Ferris RL, Lavertu P, Rezaee R, Feustel PJ (2014) Multi-institutional investigation of the prognostic value of lymph nodel yield in advancedstage oral cavity squamous cell carcinoma. Head Neck 36(10):1446\u20131452","journal-title":"Head Neck"},{"issue":"9","key":"6819_CR11","doi-asserted-by":"publisher","first-page":"3049","DOI":"10.1245\/s10434-014-3702-x","volume":"21","author":"A Ebrahimi","year":"2014","unstructured":"Ebrahimi A, Clark JR, Amit M, Yen TC, Liao CT, Kowalski LP et al (2014) Minimum nodal yield in oral squamous cell carcinoma: defining the standard of care in a multicenter international pooled validation study. Ann Surg Oncol 21(9):3049\u20133055","journal-title":"Ann Surg Oncol"},{"issue":"3","key":"6819_CR12","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1177\/0194599815622409","volume":"154","author":"A Lemieux","year":"2016","unstructured":"Lemieux A, Kedarisetty S, Raju S, Orosco R, Coffey C (2016) Lymph node yield as a predictor of survival in pathologically node negative oral cavity carcinoma. Otolaryngol\u2014Head Neck Surg (United States) 154(3):465\u2013472","journal-title":"Otolaryngol\u2014Head Neck Surg (United States)"},{"issue":"32","key":"6819_CR13","doi-asserted-by":"publisher","first-page":"3892","DOI":"10.1200\/JCO.2016.67.3863","volume":"34","author":"V Divi","year":"2016","unstructured":"Divi V, Chen MM, Nussenbaum B, Rhoads KF, Sirjani DB, Holsinger FC et al (2016) Lymph node count from neck dissection predicts mortality in head and neck cancer. J Clin Oncol 34(32):3892\u20133897","journal-title":"J Clin Oncol"},{"issue":"10","key":"6819_CR14","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1001\/jamaoto.2017.0947","volume":"143","author":"CJ Tsai","year":"2017","unstructured":"Tsai CJ, Zheng J, Zhang Z, Riaz N, Baxi SS, Wong RJ et al (2017) Association of number of dissected lymph nodes with survival in clinically node-negative oral cavity squamous cell carcinoma patients undergoing primary surgery: a population-based analysis. JAMA Otolaryngol\u2014Head Neck Surg 143(10):1049\u20131052","journal-title":"JAMA Otolaryngol\u2014Head Neck Surg"},{"issue":"12","key":"6819_CR15","doi-asserted-by":"publisher","first-page":"2092","DOI":"10.1016\/j.jcms.2017.08.020","volume":"45","author":"AF Safi","year":"2017","unstructured":"Safi AF, Kauke M, Grandoch A, Nickenig HJ, Drebber U, Z\u00f6ller J et al (2017) Clinicopathological parameters affecting nodal yields in patients with oral squamous cell carcinoma receiving selective neck dissection. J Cranio-Maxillofacial Surg 45(12):2092\u20132096","journal-title":"J Cranio-Maxillofacial Surg"},{"issue":"8","key":"6819_CR16","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1016\/j.ijom.2018.03.007","volume":"47","author":"S Lee","year":"2018","unstructured":"Lee S, Kim HJ, Cha IH, Nam W (2018) Prognostic value of lymph node count from selective neck dissection in oral squamous cell carcinoma. Int J Oral Maxillofac Surg 47(8):953\u2013958. https:\/\/doi.org\/10.1016\/j.ijom.2018.03.007","journal-title":"Int J Oral Maxillofac Surg"},{"issue":"9","key":"6819_CR17","doi-asserted-by":"publisher","first-page":"5347","DOI":"10.21873\/anticanres.12862","volume":"38","author":"S Merz","year":"2018","unstructured":"Merz S, Timmesfeld N, Stuck BA, Wiegand S (2018) Impact of lymph node yield on outcome of patients with head and neck cancer and pN0 neck. Anticancer Res 38(9):5347\u20135350","journal-title":"Anticancer Res"},{"issue":"July","key":"6819_CR18","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.oraloncology.2019.09.028","volume":"98","author":"J Zenga","year":"2019","unstructured":"Zenga J, Divi V, Stadler M, Massey B, Campbell B, Shukla M et al (2019) Lymph node yield, depth of invasion, and survival in node-negative oral cavity cancer. Oral Oncol 98(July):125\u2013131","journal-title":"Oral Oncol"},{"issue":"11","key":"6819_CR19","doi-asserted-by":"publisher","first-page":"2473","DOI":"10.1016\/j.joms.2009.04.126","volume":"67","author":"FL Ampil","year":"2009","unstructured":"Ampil FL, Caldito G, Ghali GE, Baluna RG (2009) Does the negative node count affect disease-free survival in early-stage oral cavity cancer? J Oral Maxillofac Surg 67(11):2473\u20132475. https:\/\/doi.org\/10.1016\/j.joms.2009.04.126","journal-title":"J Oral Maxillofac Surg"},{"issue":"10","key":"6819_CR20","doi-asserted-by":"publisher","first-page":"3321","DOI":"10.1007\/s00405-016-3928-2","volume":"273","author":"A B\u00f6ttcher","year":"2016","unstructured":"B\u00f6ttcher A, Dommerich S, Sander S, Olze H, Stromberger C, Coordes A et al (2016) Nodal yield of neck dissections and influence on outcome in laryngectomized patients. Eur Arch Oto-Rhino-Laryngology 273(10):3321\u20133329","journal-title":"Eur Arch Oto-Rhino-Laryngology"},{"issue":"3","key":"6819_CR21","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/S0001-6519(02)78299-X","volume":"53","author":"X Le\u00f3n","year":"2002","unstructured":"Le\u00f3n X, Or\u00fas C, Quer M (2002) Dise\u00f1o, mantenimiento y explotaci\u00f3n de una base de datos oncol\u00f3gica para pacientes con tumores malignos de cabeza y cuello. Acta Otorrinolaringol Esp 53(3):185\u2013190","journal-title":"Acta Otorrinolaringol Esp"},{"issue":"3","key":"6819_CR22","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.otorri.2017.07.002","volume":"69","author":"J Lop","year":"2018","unstructured":"Lop J, Rig\u00f3 A, Codina A, de Juan J, Quer M, Le\u00f3n X (2018) Prognostic significance of extranodal extension in head and neck squamous cell carcinoma cN0 patients with occult metastatic neck nodes. Acta Otorrinolaringol Esp 69(3):156\u2013164. https:\/\/doi.org\/10.1016\/j.otorri.2017.07.002","journal-title":"Acta Otorrinolaringol Esp"},{"issue":"4","key":"6819_CR23","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1001\/archotol.124.4.412","volume":"124","author":"N Bhattacharyya","year":"1998","unstructured":"Bhattacharyya N (1998) The effects of more conservative neck dissections and radiotherapy on nodal yields from the neck. Arch Otolaryngol\u2014Head Neck Surg 124(4):412\u2013416","journal-title":"Arch Otolaryngol\u2014Head Neck Surg"},{"issue":"6","key":"6819_CR24","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.1177\/0194599818756830","volume":"158","author":"S Cheraghlou","year":"2018","unstructured":"Cheraghlou S, Otremba M, Kuo YuP, Agogo GO, Hersey D, Judson BL (2018) Prognostic value of lymph node yield and density in head and neck malignancies. Otolaryngol\u2014Head Neck Surg (United States) 158(6):1016\u20131023","journal-title":"Otolaryngol\u2014Head Neck Surg (United States)"},{"issue":"8","key":"6819_CR25","doi-asserted-by":"publisher","first-page":"2801","DOI":"10.1002\/hed.25764","volume":"41","author":"WWB de Kort","year":"2019","unstructured":"de Kort WWB, Maas SLN, Van Es RJJ, Willems SM (2019) Prognostic value of the nodal yield in head and neck squamous cell carcinoma: a systematic review. Head Neck 41(8):2801\u20132810","journal-title":"Head Neck"}],"container-title":["European Archives of Oto-Rhino-Laryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00405-021-06819-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00405-021-06819-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00405-021-06819-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,3]],"date-time":"2023-11-03T06:12:32Z","timestamp":1698991952000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00405-021-06819-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,3]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["6819"],"URL":"https:\/\/doi.org\/10.1007\/s00405-021-06819-0","relation":{},"ISSN":["0937-4477","1434-4726"],"issn-type":[{"value":"0937-4477","type":"print"},{"value":"1434-4726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,3]]},"assertion":[{"value":"19 January 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 April 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 May 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in this study involving human participants were in accordance with the ethical standards of the institutional, regional and national research committee and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"For this type of study, formal consent was not required.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent to participate"}},{"value":"For this type of study, formal consent was not required.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent for publication"}}]}}