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The aim of the present study was to optimize a sensitive technique generating strong contrast enhancement from minimum gadolinium\u2013diethylenetriamine pentaacetic acid (Gd\u2013DTPA) while reliably detecting EH in the inner ear, including the apex.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>All imaging was performed using a\u00a03.0\u00a0T MR system 24\u00a0h after intratympanic injection of low-dose Gd\u2013DTPA. Heavily T2-weighted 3-dimensional fluid-attenuated inversion recovery reconstructed with magnitude and zero-filled interpolation (hT<jats:sub>2<\/jats:sub>W\u2013FLAIR\u2013ZFI) was optimized and validated in phantom studies and compared with medium inversion time inversion recovery imaging with magnitude reconstruction (MIIRMR). The following parameters were used in hT<jats:sub>2<\/jats:sub>W\u2013FLAIR\u2013ZFI: repetition time 14,000\u00a0ms, echo time 663\u00a0ms, inversion time 2900\u00a0ms, flip angle 120\u00b0, echo train length 271, and field of view 166\u2009\u00d7\u2009196\u00a0mm<jats:sup>2<\/jats:sup>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>MRI obtained using hT<jats:sub>2<\/jats:sub>W\u2013FLAIR\u2013MZFI yielded high-quality images with sharper and smoother borders between the endolymph and perilymph and a higher signal intensity ratio and more homogenous perilymph enhancement than those generated with MIIRMR (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). There were predominantly grade II EHs in the cochleae and grade III EHs in the vestibule in definite MD. EH was detected in the apex of 11\/16 ipsilateral ears, 3\/16 contralateral ears in unilateral definite MD and 3\/6 ears in bilateral MD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The novel hT<jats:sub>2<\/jats:sub>W\u2013FLAIR\u2013MZFI technique is sensitive and demonstrates strong and homogenous enhancement by minimum Gd\u2013DTPA in the inner ear, including the apex, and yields high-quality images with sharp borders between the endolymph and perilymph.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00405-021-06912-4","type":"journal-article","created":{"date-parts":[[2021,6,18]],"date-time":"2021-06-18T18:02:40Z","timestamp":1624039360000},"page":"2279-2290","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["High-quality imaging of endolymphatic hydrops acquired in 7 minutes using sensitive hT2W\u20133D\u2013FLAIR reconstructed with magnitude and zero-filled interpolation"],"prefix":"10.1007","volume":"279","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0315-7092","authenticated-orcid":false,"given":"Jing","family":"Zou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luguang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongbin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilmari","family":"Pyykk\u00f6","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianping","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,6,18]]},"reference":[{"key":"6912_CR1","unstructured":"Zou J, Pyykko I, Bjelke B, Bretlau P, and Tayamaga T (2000) Endolympahtic hydrops is caused by increased porosity of stria vascularis? 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