{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:15:20Z","timestamp":1777943720408,"version":"3.51.4"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2021,7,21]],"date-time":"2021-07-21T00:00:00Z","timestamp":1626825600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,7,21]],"date-time":"2021-07-21T00:00:00Z","timestamp":1626825600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"crossref","award":["2020R1I1A1A01051844"],"award-info":[{"award-number":["2020R1I1A1A01051844"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"crossref","award":["2019M3E5D5064110"],"award-info":[{"award-number":["2019M3E5D5064110"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"crossref","award":["2019M3A9H2032424"],"award-info":[{"award-number":["2019M3A9H2032424"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Arch Otorhinolaryngol"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1007\/s00405-021-06996-y","type":"journal-article","created":{"date-parts":[[2021,7,21]],"date-time":"2021-07-21T16:29:30Z","timestamp":1626884970000},"page":"1943-1950","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Long-term efficacy and safety of 3D printed implant in patients with nasal septal deformities"],"prefix":"10.1007","volume":"279","author":[{"given":"Do Hyun","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Il Hwan","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Won-Soo","family":"Yun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-Hyung","family":"Shim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dami","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Se Hwan","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8981-2536","authenticated-orcid":false,"given":"Sung Won","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,7,21]]},"reference":[{"key":"6996_CR1","doi-asserted-by":"publisher","first-page":"122","DOI":"10.3389\/fphar.2020.00122","volume":"11","author":"D Fan","year":"2020","unstructured":"Fan D, Li Y, Wang X, Zhu T, Wang Q, Cai H, Li W, Tian Y, Liu Z (2020) Progressive 3D printing technology and its application in medical materials. Front Pharmacol 11:122. https:\/\/doi.org\/10.3389\/fphar.2020.00122","journal-title":"Front Pharmacol"},{"key":"6996_CR2","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1089\/ten.TEA.2019.0102","volume":"25","author":"SH Teoh","year":"2019","unstructured":"Teoh SH, Goh BT, Lim J (2019) Three-dimensional printed polycaprolactone scaffolds for bone regeneration success and future perspective. Tissue Eng Part A 25:931\u2013935. https:\/\/doi.org\/10.1089\/ten.TEA.2019.0102","journal-title":"Tissue Eng Part A"},{"key":"6996_CR3","doi-asserted-by":"publisher","first-page":"3299","DOI":"10.1073\/pnas.0905439106","volume":"107","author":"WL Grayson","year":"2010","unstructured":"Grayson WL, Fr\u00f6hlich M, Yeager K, Bhumiratana S, Chan ME, Cannizzaro C, Wan LQ, Liu XS, Guo XE, Vunjak-Novakovic G (2010) Engineering anatomically shaped human bone grafts. Proc Natl Acad Sci U S A 107:3299\u20133304. https:\/\/doi.org\/10.1073\/pnas.0905439106","journal-title":"Proc Natl Acad Sci U S A"},{"key":"6996_CR4","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0153056","volume":"11","author":"JS Lee","year":"2016","unstructured":"Lee JS, Lee DC, Ha DH, Kim SW, Cho DW (2016) Redefining the septal L-strut to prevent collapse. PLoS ONE 11:e0153056. https:\/\/doi.org\/10.1371\/journal.pone.0153056","journal-title":"PLoS ONE"},{"key":"6996_CR5","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1016\/j.msec.2014.06.003","volume":"45","author":"Z Li","year":"2014","unstructured":"Li Z, Tan BH (2014) Towards the development of polycaprolactone based amphiphilic block copolymers: molecular design, self-assembly and biomedical applications. Mater Sci Eng C Mater Biol Appl 45:620\u2013634. https:\/\/doi.org\/10.1016\/j.msec.2014.06.003","journal-title":"Mater Sci Eng C Mater Biol Appl"},{"key":"6996_CR6","first-page":"183","volume":"30","author":"DW Hutmacher","year":"2001","unstructured":"Hutmacher DW, Goh JC, Teoh SH (2001) An introduction to biodegradable materials for tissue engineering applications. Ann Acad Med Singapore 30:183\u2013191","journal-title":"Ann Acad Med Singapore"},{"key":"6996_CR7","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.1021\/bm100125b","volume":"11","author":"H Antheunis","year":"2010","unstructured":"Antheunis H, van der Meer JC, de Geus M, Heise A, Koning CE (2010) Autocatalytic equation describing the change in molecular weight during hydrolytic degradation of aliphatic polyesters. Biomacromol 11:1118\u20131124. https:\/\/doi.org\/10.1021\/bm100125b","journal-title":"Biomacromol"},{"key":"6996_CR8","doi-asserted-by":"publisher","first-page":"1735","DOI":"10.1016\/j.biomaterials.2005.09.019","volume":"27","author":"H Sun","year":"2006","unstructured":"Sun H, Mei L, Song C, Cui X, Wang P (2006) The in vivo degradation, absorption and excretion of PCL-based implant. Biomaterials 27:1735\u20131740. https:\/\/doi.org\/10.1016\/j.biomaterials.2005.09.019","journal-title":"Biomaterials"},{"key":"6996_CR9","doi-asserted-by":"publisher","first-page":"1424","DOI":"10.1016\/j.polymdegradstab.2005.10.016","volume":"91","author":"J Pe\u00f1a","year":"2006","unstructured":"Pe\u00f1a J, Corrales T, Izquierdo-Barba I, Doadrio AL, Vallet-Reg\u00ed M (2006) Long term degradation of poly(\u025b-caprolactone) films in biologically related fluids. Polym Degrad Stab 91:1424\u20131432. https:\/\/doi.org\/10.1016\/j.polymdegradstab.2005.10.016","journal-title":"Polym Degrad Stab"},{"key":"6996_CR10","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1001\/jamaoto.2018.2054","volume":"144","author":"DH Kim","year":"2018","unstructured":"Kim DH, Yun WS, Shim JH, Park KH, Choi D, Park MI, Hwang SH, Kim SW (2018) Clinical application of 3-dimensional printing technology for patients with nasal septal deformities: a multicenter study. JAMA Otolaryngol Head Neck Surg 144:1145\u20131152. https:\/\/doi.org\/10.1001\/jamaoto.2018.2054","journal-title":"JAMA Otolaryngol Head Neck Surg"},{"key":"6996_CR11","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.1177\/0194599816630726","volume":"154","author":"H Kim Do","year":"2016","unstructured":"Kim Do H, Hong YK, Jeun SS, Park YJ, Kim SW, Cho JH, Kim BY, Han S, Jung YH, Lee YJ, Kim SW (2016) Anatomic changes caused by endoscopic endonasal transsphenoidal surgery and their effects on nasal functions. Otolaryngol Head Neck Surg 154:1132\u20131137. https:\/\/doi.org\/10.1177\/0194599816630726","journal-title":"Otolaryngol Head Neck Surg"},{"key":"6996_CR12","doi-asserted-by":"publisher","first-page":"1381","DOI":"10.1002\/lary.23841","volume":"123","author":"DC Lee","year":"2013","unstructured":"Lee DC, Shin JH, Kim SW, Kim SW, Kim BG, Kang JM, Cho JH, Park YJ (2013) Anatomical analysis of nasal obstruction: nasal cavity of patients complaining of stuffy nose. Laryngoscope 123:1381\u20131384. https:\/\/doi.org\/10.1002\/lary.23841","journal-title":"Laryngoscope"},{"key":"6996_CR13","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1002\/lary.26264","volume":"127","author":"JA Veit","year":"2017","unstructured":"Veit JA, Nordmann M, Dietz B, Sommer F, Lindemann J, Rotter N, Greve J, von Bomhard A, Hoffmann TK, Riepl R, Scheithauer MO (2017) Three different turbinoplasty techniques combined with septoplasty: prospective randomized trial. Laryngoscope 127:303\u2013308. https:\/\/doi.org\/10.1002\/lary.26264","journal-title":"Laryngoscope"},{"key":"6996_CR14","doi-asserted-by":"publisher","first-page":"279","DOI":"10.4300\/jgme-d-12-00156.1","volume":"4","author":"GM Sullivan","year":"2012","unstructured":"Sullivan GM, Feinn R (2012) Using effect size-or why the P value is not enough. J Grad Med Educ 4:279\u2013282. https:\/\/doi.org\/10.4300\/jgme-d-12-00156.1","journal-title":"J Grad Med Educ"},{"key":"6996_CR15","doi-asserted-by":"publisher","first-page":"3975","DOI":"10.3390\/ma12233975","volume":"12","author":"KO Boker","year":"2019","unstructured":"Boker KO, Richter K, Jackle K, Taheri S, Grunwald I, Borcherding K, von Byern J, Hartwig A, Wildemann B, Schilling AF, Lehmann W (2019) Current state of bone adhesives-necessities and hurdles. Materials (Basel) 12:3975. https:\/\/doi.org\/10.3390\/ma12233975","journal-title":"Materials (Basel)"},{"key":"6996_CR16","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.actbio.2018.08.004","volume":"78","author":"M D'Este","year":"2018","unstructured":"D\u2019Este M, Eglin D, Alini M (2018) Lessons to be learned and future directions for intervertebral disc biomaterials. Acta Biomater 78:13\u201322. https:\/\/doi.org\/10.1016\/j.actbio.2018.08.004","journal-title":"Acta Biomater"},{"key":"6996_CR17","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.biomaterials.2017.03.026","volume":"131","author":"M Costantini","year":"2017","unstructured":"Costantini M, Testa S, Mozetic P, Barbetta A, Fuoco C, Fornetti E, Tamiro F, Bernardini S, Jaroszewicz J, \u015awi\u0119szkowski W, Trombetta M, Castagnoli L, Seliktar D, Garstecki P, Cesareni G, Cannata S, Rainer A, Gargioli C (2017) Microfluidic-enhanced 3D bioprinting of aligned myoblast-laden hydrogels leads to functionally organized myofibers in vitro and in vivo. Biomaterials 131:98\u2013110. https:\/\/doi.org\/10.1016\/j.biomaterials.2017.03.026","journal-title":"Biomaterials"},{"key":"6996_CR18","doi-asserted-by":"publisher","first-page":"14915","DOI":"10.1038\/s41598-019-51560-8","volume":"9","author":"D Kim","year":"2019","unstructured":"Kim D, Eom S, Park SM, Hong H, Kim DS (2019) A collagen gel-coated, aligned nanofiber membrane for enhanced endothelial barrier function. Sci Rep 9:14915. https:\/\/doi.org\/10.1038\/s41598-019-51560-8","journal-title":"Sci Rep"},{"key":"6996_CR19","doi-asserted-by":"publisher","first-page":"3342","DOI":"10.1021\/acsnano.5b06985","volume":"10","author":"JH Kim","year":"2016","unstructured":"Kim JH, Kim HW, Cha KJ, Han J, Jang YJ, Kim DS, Kim JH (2016) Nanotopography promotes pancreatic differentiation of human embryonic stem cells and induced pluripotent stem cells. ACS Nano 10:3342\u20133355. https:\/\/doi.org\/10.1021\/acsnano.5b06985","journal-title":"ACS Nano"},{"key":"6996_CR20","doi-asserted-by":"publisher","first-page":"10","DOI":"10.3390\/bioengineering4010010","volume":"4","author":"HG Yi","year":"2017","unstructured":"Yi HG, Lee H, Cho DW (2017) 3D printing of organs-on-chips. Bioengineering (Basel) 4:10. https:\/\/doi.org\/10.3390\/bioengineering4010010","journal-title":"Bioengineering (Basel)"},{"key":"6996_CR21","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.cps.2015.09.007","volume":"43","author":"A Ghosh","year":"2016","unstructured":"Ghosh A, Friedman O (2016) Surgical treatment of nasal obstruction in rhinoplasty. Clin Plast Surg 43:29\u201340. https:\/\/doi.org\/10.1016\/j.cps.2015.09.007","journal-title":"Clin Plast Surg"},{"key":"6996_CR22","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1016\/j.otc.2009.03.005","volume":"42","author":"J Haack","year":"2009","unstructured":"Haack J, Papel ID (2009) Caudal septal deviation. Otolaryngol Clin North Am 42:427\u2013436. https:\/\/doi.org\/10.1016\/j.otc.2009.03.005","journal-title":"Otolaryngol Clin North Am"},{"key":"6996_CR23","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1007\/s12070-018-1339-y","volume":"70","author":"J Ghorbani","year":"2018","unstructured":"Ghorbani J, Ganjali M, Givehchi G, Zangi M (2018) Transcutaneous columellar strut for correcting caudal nasal septal deviation. Indian J Otolaryngol Head Neck Surg 70:346\u2013350. https:\/\/doi.org\/10.1007\/s12070-018-1339-y","journal-title":"Indian J Otolaryngol Head Neck Surg"},{"key":"6996_CR24","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1002\/alr.22347","volume":"9","author":"YH Joo","year":"2019","unstructured":"Joo YH, Cho HJ, Jeon YJ, Kim SW (2019) Use of a crossing suture to correct caudal septal deviations. Int Forum Allergy Rhinol 9:939\u2013943. https:\/\/doi.org\/10.1002\/alr.22347","journal-title":"Int Forum Allergy Rhinol"},{"key":"6996_CR25","doi-asserted-by":"publisher","DOI":"10.1002\/lary.28516","author":"HS Seo","year":"2020","unstructured":"Seo HS, Na HS, Kim SD, Yi KI, Mun SJ, Cho KS (2020) Septal cartilage traction suture technique for correction of caudal septal deviation. Laryngoscope. https:\/\/doi.org\/10.1002\/lary.28516","journal-title":"Laryngoscope"},{"key":"6996_CR26","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1002\/alr.21863","volume":"7","author":"D Yaniv","year":"2017","unstructured":"Yaniv D, Hadar T, Hod R, Lansberg R, Koren I, Yaniv E (2017) Repair of caudal septal deviation: the fishing line technique. Int Forum Allergy Rhinol 7:211\u2013214. https:\/\/doi.org\/10.1002\/alr.21863","journal-title":"Int Forum Allergy Rhinol"},{"key":"6996_CR27","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1001\/jamafacial.2017.0092","volume":"19","author":"DY Kim","year":"2017","unstructured":"Kim DY, Nam SH, Alharethy SE, Jang YJ (2017) Surgical outcomes of bony batten grafting to correct caudal septal deviation in septoplasty. JAMA Facial Plast Surg 19:470\u2013475. https:\/\/doi.org\/10.1001\/jamafacial.2017.0092","journal-title":"JAMA Facial Plast Surg"},{"key":"6996_CR28","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.1177\/0003489419866214","volume":"128","author":"SA Kim","year":"2019","unstructured":"Kim SA, Jang YJ (2019) Caudal septal division and interposition batten graft: a novel technique to correct caudal septal deviation in septoplasty. Ann Otol Rhinol Laryngol 128:1158\u20131164. https:\/\/doi.org\/10.1177\/0003489419866214","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"6996_CR29","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1001\/2013.jamafacial.73","volume":"15","author":"JW Lee","year":"2013","unstructured":"Lee JW, Baker SR (2013) Correction of caudal septal deviation and deformity using nasal septal bone grafts. JAMA Facial Plast Surg 15:96\u2013100. https:\/\/doi.org\/10.1001\/2013.jamafacial.73","journal-title":"JAMA Facial Plast Surg"}],"container-title":["European Archives of Oto-Rhino-Laryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00405-021-06996-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00405-021-06996-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00405-021-06996-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,17]],"date-time":"2022-03-17T18:40:09Z","timestamp":1647542409000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00405-021-06996-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,21]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["6996"],"URL":"https:\/\/doi.org\/10.1007\/s00405-021-06996-y","relation":{},"ISSN":["0937-4477","1434-4726"],"issn-type":[{"value":"0937-4477","type":"print"},{"value":"1434-4726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,21]]},"assertion":[{"value":"7 June 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 July 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 July 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Delarations"}},{"value":"Won-Soo Yun, Jin-Hyung Shim, Dami Choi are affiliated in T&R Biofab. Co. Ltd., and serve as C.E.O., C.T.O., and Research Engineer, respectively.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This clinical trial was approved by the Institutional Review Board of Seoul St. Mary\u2019s Hospital (KC19DSSV0897). It was conducted according to the Declaration of Helsinki.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The informed consent was obtained from all participants who heard and understood the description of this clinical study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}