{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T13:44:41Z","timestamp":1767707081988,"version":"3.37.3"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2021,7,21]],"date-time":"2021-07-21T00:00:00Z","timestamp":1626825600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,7,21]],"date-time":"2021-07-21T00:00:00Z","timestamp":1626825600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100012241","name":"High level university construction project of Guangzhou Medical University","doi-asserted-by":"publisher","award":["B185004097"],"award-info":[{"award-number":["B185004097"]}],"id":[{"id":"10.13039\/501100012241","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Projects and Transformation Platform Construction Project of Guangdong Provincial","award":["(2018) 1254 \u2043 19"],"award-info":[{"award-number":["(2018) 1254 \u2043 19"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Arch Otorhinolaryngol"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1007\/s00405-021-06999-9","type":"journal-article","created":{"date-parts":[[2021,7,21]],"date-time":"2021-07-21T20:02:31Z","timestamp":1626897751000},"page":"4901-4908","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["An epidemiological survey of gastroesophageal reflux disease at the digestive endoscopy center in Guangzhou"],"prefix":"10.1007","volume":"278","author":[{"given":"Gui","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weixing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjing","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lijuan","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pingchang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5255-8610","authenticated-orcid":false,"given":"Xiaowen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,7,21]]},"reference":[{"issue":"7","key":"6999_CR1","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1097\/MCG.0b013e318259bd04","volume":"46","author":"L Mathus-Vliegen","year":"2012","unstructured":"Mathus-Vliegen L, Toouli J, Fried M, Khan AG, Garisch J, Hunt R et al (2012) World gastroenterology organisation global guidelines on obesity. J Clin Gastroenterol 46(7):555\u2013561. https:\/\/doi.org\/10.1097\/MCG.0b013e318259bd04","journal-title":"J Clin Gastroenterol"},{"issue":"12","key":"6999_CR2","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.1007\/s40265-013-0101-8","volume":"73","author":"C Hom","year":"2013","unstructured":"Hom C, Vaezi MF (2013) Extra-esophageal manifestations of gastroesophageal reflux disease: diagnosis and treatment. Drugs 73(12):1281\u20131295. https:\/\/doi.org\/10.1007\/s40265-013-0101-8","journal-title":"Drugs"},{"issue":"5","key":"6999_CR3","doi-asserted-by":"publisher","first-page":"327","DOI":"10.3949\/ccjm.77a.09121","volume":"77","author":"DW Barry","year":"2010","unstructured":"Barry DW, Vaezi MF (2010) Laryngopharyngeal reflux: more questions than answers. Clevel Clin J Med 77(5):327\u2013334. https:\/\/doi.org\/10.3949\/ccjm.77a.09121","journal-title":"Clevel Clin J Med"},{"issue":"11","key":"6999_CR4","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1055\/s-2007-963633","volume":"45","author":"Vakil N, van Zanten SV, Kahrilas P, Dent J, Jones R Global Consensus Group","year":"2007","unstructured":"Vakil N, van Zanten SV, Kahrilas P, Dent J, Jones R Global Consensus Group (2007) The Montreal definition and classification of gastroesophageal reflux disease: a global, evidence-based consensus paper. Z Gastroenterol 45(11):1125\u20131140. https:\/\/doi.org\/10.1055\/s-2007-963633","journal-title":"Z Gastroenterol"},{"issue":"2","key":"6999_CR5","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1055\/s-0033-1352504","volume":"18","author":"AM Capagnolo","year":"2014","unstructured":"Capagnolo AM, Priston J, Heidrichthoen R, Medeiros T, Assuncao RA (2014) Laryngopharyngeal reflux: diagnosis, treatment, and latest research. Int Arch Otorhinolaryngol 18(2):184\u2013191. https:\/\/doi.org\/10.1055\/s-0033-1352504","journal-title":"Int Arch Otorhinolaryngol"},{"issue":"12","key":"6999_CR6","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.1007\/s40265-013-0101-8","volume":"73","author":"F Sidhwa","year":"2013","unstructured":"Sidhwa F, Moore A, Alligood E, Fisichella PM (2013) Extra-esophageal manifestations of gastroesophageal reflux disease: diagnosis and treatment. Drugs 73(12):1281\u20131295. https:\/\/doi.org\/10.1007\/s40265-013-0101-8","journal-title":"Drugs"},{"key":"6999_CR7","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1136\/gut.2004.051821","volume":"54","author":"J Dent","year":"2005","unstructured":"Dent J, El-Serag HB, Wallander MA, Johansson S (2005) Epidemiology of gastroesophageal reflux disease: a systematic review. Gut 54:710\u2013717. https:\/\/doi.org\/10.1136\/gut.2004.051821","journal-title":"Gut"},{"issue":"2","key":"6999_CR8","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1053\/j.gastro.2017.07.040","volume":"154","author":"F Vaezi Michael","year":"2018","unstructured":"Vaezi Michael F, Daniel S (2018) Assessing old and new diagnostic tests for gastroesophageal reflux disease. Gastroenterol 154(2):289\u2013301. https:\/\/doi.org\/10.1053\/j.gastro.2017.07.040","journal-title":"Gastroenterol"},{"key":"6999_CR9","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1097\/MOO.0000000000000486","volume":"26","author":"R Lechien Jerome","year":"2018","unstructured":"Lechien Jerome R, Sven S, Karkos Petros D (2018) Laryngopharyngeal reflux disease: clinical presentation, diagnosis and therapeutic challenges in 2018. [J]. Curr Opin Otolaryngol Head Neck Surg 26:392\u2013402. https:\/\/doi.org\/10.1097\/MOO.0000000000000486","journal-title":"Curr Opin Otolaryngol Head Neck Surg"},{"issue":"4","key":"6999_CR10","doi-asserted-by":"publisher","first-page":"A540","DOI":"10.1016\/S0016-5085(03)82733-6","volume":"124","author":"WM Wong","year":"2003","unstructured":"Wong WM, Lam SK, Lam KF et al (2003) A validated symptom questionnaire (Chinese-GERDQ) for the diagnosis of gastroesophageal reflux disease in Chinese population [J]. Gastroenterology 124(4):A540\u2013A541. https:\/\/doi.org\/10.1016\/S0016-5085(03)82733-6","journal-title":"Gastroenterology"},{"issue":"1","key":"6999_CR11","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.jvoice.2013.12.006","volume":"30","author":"J Li","year":"2016","unstructured":"Li J, Zhang L, Zhang C (2016) Linguistic adaptation, reliability, validation, and responsivity of the Chinese version of reflux symptom index. J Voice Off J Voice Found 30(1):104\u2013108. https:\/\/doi.org\/10.1016\/j.jvoice.2013.12.006","journal-title":"J Voice Off J Voice Found"},{"issue":"2","key":"6999_CR12","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1136\/gut.45.2.172","volume":"45","author":"LR Lundell","year":"1999","unstructured":"Lundell LR, Dent J, Bennett JR et al (1999) Endoscopic assessment of oesophagitis: clinical and functional correlates and further validation of the Los Angeles classification. Gut 45(2):172\u2013180. https:\/\/doi.org\/10.1136\/gut.45.2.172","journal-title":"Gut"},{"issue":"10","key":"6999_CR13","doi-asserted-by":"publisher","first-page":"1030","DOI":"10.1111\/j.1365-2036.2009.04142.x","volume":"30","author":"R Jones","year":"2009","unstructured":"Jones R, Junghard O, Dent J et al (2009) Development of the GerdQ, a tool for the diagnosis and management of gastro-oesophageal reflux disease in primary care. Aliment Pharmacol Ther 30(10):1030\u20131038. https:\/\/doi.org\/10.1111\/j.1365-2036.2009.04142.x","journal-title":"Aliment Pharmacol Ther"},{"issue":"2","key":"6999_CR14","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/s0892-1997(02)00097-8","volume":"16","author":"PC Belafsky","year":"2002","unstructured":"Belafsky PC, Postma GN, Koufman JA (2002) Validity and reliability of the reflux symptom index (RSI). J Voice Off J Voice Found 16(2):274\u2013277. https:\/\/doi.org\/10.1016\/s0892-1997(02)00097-8","journal-title":"J Voice Off J Voice Found"},{"issue":"8","key":"6999_CR15","doi-asserted-by":"publisher","first-page":"1424","DOI":"10.1097\/MLG.0b013e31806865cf","volume":"117","author":"M Groome","year":"2007","unstructured":"Groome M, Cotton JP, Borland M et al (2007) Prevalence of laryngopharyngeal reflux in a population with gastroesophageal reflux. Laryngoscope 117(8):1424\u20131428. https:\/\/doi.org\/10.1097\/MLG.0b013e31806865cf","journal-title":"Laryngoscope"},{"issue":"52","key":"6999_CR16","first-page":"213","volume":"10","author":"RT Sataloff","year":"2010","unstructured":"Sataloff RT, Hawkshaw MJ, Gupta R (2010) Laryngopharyngeal reflux and voice disorders: an overview on disease mechanisms, treatments, and research advances. Discov Med 10(52):213\u2013224","journal-title":"Discov Med"},{"issue":"6","key":"6999_CR17","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1016\/S2468-1253(19)30408-X","volume":"5","author":"GBD 2017 Gastro-oesophageal Reflux Disease Collaborators","year":"2020","unstructured":"GBD 2017 Gastro-oesophageal Reflux Disease Collaborators (2020) The global, regional, and national burden of gastro-oesophageal reflux disease in 195 countries and territories, 1990\u20132017: a systematic analysis for the Global burden of disease study 2017. Lancet Gastroenterol Hepatol 5(6):561\u2013581. https:\/\/doi.org\/10.1016\/S2468-1253(19)30408-X","journal-title":"Lancet Gastroenterol Hepatol"},{"issue":"2","key":"6999_CR18","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.dld.2008.06.014","volume":"41","author":"R Wang","year":"2009","unstructured":"Wang R, Yan X, Ma XQ et al (2009) Burden of gastroesophageal reflux disease in Shanghai, China. Dig Liver Dis Off J Ital Soc Gastroenterol Ital Assoc Study Liver 41(2):110\u2013115. https:\/\/doi.org\/10.1016\/j.dld.2008.06.014","journal-title":"Dig Liver Dis Off J Ital Soc Gastroenterol Ital Assoc Study Liver"},{"issue":"10","key":"6999_CR19","doi-asserted-by":"publisher","first-page":"2829","DOI":"10.1007\/s00405-020-06045-0","volume":"277","author":"S Xiao","year":"2020","unstructured":"Xiao S, Li J, Zheng H et al (2020) An epidemiological survey of laryngopharyngeal reflux disease at the otorhinolaryngology-head and neck surgery clinics in China. Eur Arch Otorhinolaryngol 277(10):2829\u20132838. https:\/\/doi.org\/10.1007\/s00405-020-06045-0","journal-title":"Eur Arch Otorhinolaryngol"},{"issue":"1","key":"6999_CR20","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1111\/j.1440-1746.2004.03530.x","volume":"20","author":"K Madan","year":"2005","unstructured":"Madan K, Ahuja V, Gupta SD et al (2005) Impact of 24-h esophageal pH monitoring on the diagnosis of gastroesophageal reflux disease: defining the gold standard. J Gastroenterol Hepatol 20(1):30\u201337. https:\/\/doi.org\/10.1111\/j.1440-1746.2004.03530.x","journal-title":"J Gastroenterol Hepatol"},{"issue":"10","key":"6999_CR21","doi-asserted-by":"publisher","first-page":"1720","DOI":"10.1111\/jgh.14651","volume":"34","author":"W Ming-Wun","year":"2019","unstructured":"Ming-Wun W, Ming-Jong B, Wei-Chuan C et al (2019) Clinical and psychological characteristics in gastroesophageal reflux disease patients overlapping with laryngopharyngeal reflux symptoms. J Gastroenterol Hepatol 34(10):1720\u20131726. https:\/\/doi.org\/10.1111\/jgh.14651","journal-title":"J Gastroenterol Hepatol"},{"issue":"3","key":"6999_CR22","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1159\/000502796","volume":"38","author":"B Ryan","year":"2020","unstructured":"Ryan B, Karl-Hermann F, Wolfram B et al (2020) Clinical presentation of gastroesophageal reflux disease: a prospective study on symptom diversity and modification of questionnaire application. Dig Dis (Basel, Switzerland) 38(3):188\u2013195. https:\/\/doi.org\/10.1159\/000502796","journal-title":"Dig Dis (Basel, Switzerland)"},{"key":"6999_CR23","doi-asserted-by":"publisher","DOI":"10.1002\/lary.29604","author":"R Lechien Jerome","year":"2021","unstructured":"Lechien Jerome R, St\u00e9phane H, De Marrez LG et al (2021) Prevalence and features of laryngopharyngeal reflux in patients with primary burning mouth syndrome. Laryngoscope. https:\/\/doi.org\/10.1002\/lary.29604","journal-title":"Laryngoscope"},{"issue":"9","key":"6999_CR24","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1111\/j.1365-2036.2008.03641.x","volume":"27","author":"G Rubin","year":"2008","unstructured":"Rubin G, Uebel P, A. BRIMO-HAYEK, et al (2008) Validation of a brief symptom questionnaire (ReQuest in practice) for patients with gastro-oesophageal reflux disease. Aliment Pharmacol Ther 27(9):846\u2013851. https:\/\/doi.org\/10.1111\/j.1365-2036.2008.03641.x","journal-title":"Aliment Pharmacol Ther"},{"issue":"2","key":"6999_CR25","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1111\/j.1440-1746.2007.05045.x","volume":"23","author":"YM Li","year":"2008","unstructured":"Li YM, Du J, Zhang H et al (2008) Epidemiological investigation in outpatients with symptomatic gastroesophageal reflux from the Department of medicine in Zhejiang Province, east China. J Gastroenterol Hepatol 23(2):283\u2013289. https:\/\/doi.org\/10.1111\/j.1440-1746.2007.05045.x","journal-title":"J Gastroenterol Hepatol"},{"issue":"2","key":"6999_CR26","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1053\/j.gastro.2017.07.045","volume":"154","author":"JE Richter","year":"2018","unstructured":"Richter JE, Rubenstein JH (2018) Presentation and epidemiology of gastroesophageal reflux disease. Gastroenterology 154(2):267\u2013276. https:\/\/doi.org\/10.1053\/j.gastro.2017.07.045","journal-title":"Gastroenterology"},{"issue":"4","key":"6999_CR27","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1016\/j.cgh.2005.10.011","volume":"4","author":"BC Wong","year":"2006","unstructured":"Wong BC, Kinoshita Y (2006) Systematic review on epidemiology of gastroesophageal reflux disease in Asia. Clin Gastroenterol Hepatol Off Clin Prac J Am Gastroenterol Assoc 4(4):398\u2013407. https:\/\/doi.org\/10.1016\/j.cgh.2005.10.011","journal-title":"Clin Gastroenterol Hepatol Off Clin Prac J Am Gastroenterol Assoc"},{"issue":"11","key":"6999_CR28","doi-asserted-by":"publisher","first-page":"3536","DOI":"10.1007\/s11695-019-04020-1","volume":"29","author":"K Ivan","year":"2019","unstructured":"Ivan K, Matthias P, Gerd J et al (2019) Modern esophageal function testing and gastroesophageal reflux disease in morbidly obese patients. Obes Surg 29(11):3536\u20133541. https:\/\/doi.org\/10.1007\/s11695-019-04020-1","journal-title":"Obes Surg"},{"issue":"2","key":"6999_CR29","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.cgh.2015.04.176","volume":"14","author":"E Nessjensen","year":"2016","unstructured":"Nessjensen E, Hveem K, Elserag H et al (2016) Lifestyle intervention in gastroesophageal reflux disease. Clin Gastroenterol Hepatol Off Clin Prac J Am Gastroenterol Assoc 14(2):175\u201382.e823. https:\/\/doi.org\/10.1016\/j.cgh.2015.04.176","journal-title":"Clin Gastroenterol Hepatol Off Clin Prac J Am Gastroenterol Assoc"},{"issue":"3","key":"6999_CR30","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1038\/ajg.2012.466","volume":"108","author":"E Nessjensen","year":"2013","unstructured":"Nessjensen E, Lindam A, Lagergren J et al (2013) Weight loss and reduction in gastroesophageal reflux. A prospective population-based cohort study: the HUNT study. Am J Gastroenterol 108(3):376\u2013382. https:\/\/doi.org\/10.1038\/ajg.2012.466","journal-title":"Am J Gastroenterol"},{"issue":"3","key":"6999_CR31","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1038\/ajg.2015.18","volume":"110","author":"A Hallan","year":"2015","unstructured":"Hallan A, Bomme M, Hveem K, M\u00f8ller-Hansen J, Ness-Jensen E (2015) Risk factors on the development of new-onset gastroesophageal reflux symptoms. A population-based prospective cohort study: the HUNT study. Am J Gastroenterol 110(3):393\u2013401. https:\/\/doi.org\/10.1038\/ajg.2015.18","journal-title":"Am J Gastroenterol"},{"issue":"11","key":"6999_CR32","doi-asserted-by":"publisher","first-page":"1647","DOI":"10.3748\/wjg.v10.i11.1647","volume":"10","author":"JH Wang","year":"2004","unstructured":"Wang JH, Luo JY, Dong L et al (2004) Epidemiology of gastroesophageal reflux disease: a general population-based study in Xi\u2019an of Northwest China. World J Gastroenterol 10(11):1647\u20131651. https:\/\/doi.org\/10.3748\/wjg.v10.i11.1647","journal-title":"World J Gastroenterol"},{"issue":"12","key":"6999_CR33","doi-asserted-by":"publisher","first-page":"3374","DOI":"10.1111\/j.1572-0241.2000.03347.x","volume":"95","author":"L Bujanda","year":"2000","unstructured":"Bujanda L (2000) The effects of alcohol consumption upon the gastrointestinal tract. Am J Gastroenterol 95(12):3374\u20133382. https:\/\/doi.org\/10.1111\/j.1572-0241.2000.03347.x","journal-title":"Am J Gastroenterol"},{"issue":"1","key":"6999_CR34","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1097\/00042737-200501000-00021","volume":"17","author":"WC Orr","year":"2005","unstructured":"Orr WC (2005) Night-time gastro-oesophageal reflux disease: prevalence, hazards, and management. Eur J Gastroenterol Hepatol 17(1):113\u2013120. https:\/\/doi.org\/10.1097\/00042737-200501000-00021","journal-title":"Eur J Gastroenterol Hepatol"},{"issue":"1","key":"6999_CR35","doi-asserted-by":"publisher","first-page":"7","DOI":"10.5009\/gnl16615","volume":"12","author":"DS Sandhu","year":"2018","unstructured":"Sandhu DS, Fass R (2018) Current trends in the management of gastroesophageal reflux disease. Gut Liver 12(1):7\u201316. https:\/\/doi.org\/10.5009\/gnl16615","journal-title":"Gut Liver"}],"container-title":["European Archives of Oto-Rhino-Laryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00405-021-06999-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00405-021-06999-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00405-021-06999-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T03:37:21Z","timestamp":1635478641000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00405-021-06999-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,21]]},"references-count":35,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["6999"],"URL":"https:\/\/doi.org\/10.1007\/s00405-021-06999-9","relation":{},"ISSN":["0937-4477","1434-4726"],"issn-type":[{"type":"print","value":"0937-4477"},{"type":"electronic","value":"1434-4726"}],"subject":[],"published":{"date-parts":[[2021,7,21]]},"assertion":[{"value":"23 May 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 July 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 July 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}