{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T20:52:31Z","timestamp":1785876751411,"version":"3.56.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2021,10,18]],"date-time":"2021-10-18T00:00:00Z","timestamp":1634515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,10,18]],"date-time":"2021-10-18T00:00:00Z","timestamp":1634515200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Programme Hospitalier de Recherche Clinique, French Ministry of Health","award":["AOM 08104"],"award-info":[{"award-number":["AOM 08104"]}]},{"name":"Programme Hospitalier de Recherche Clinique, French Ministry of Health","award":["AOM 11 293"],"award-info":[{"award-number":["AOM 11 293"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Arch Otorhinolaryngol"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1007\/s00405-021-07117-5","type":"journal-article","created":{"date-parts":[[2021,10,18]],"date-time":"2021-10-18T21:48:09Z","timestamp":1634593689000},"page":"3071-3078","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["HPV status and therapeutic initial strategy impact on survival and oncologic outcomes: 5-year results from the multicentric prospective cohort of oropharyngeal cancers Papillophar"],"prefix":"10.1007","volume":"279","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7964-8488","authenticated-orcid":false,"given":"Dorian","family":"Culi\u00e9","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Rousseau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Luc","family":"Pretet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Lacau Saint Guily","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,10,18]]},"reference":[{"issue":"4","key":"7117_CR1","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/j.oraloncology.2015.01.002","volume":"51","author":"KS Louie","year":"2015","unstructured":"Louie KS, Mehanna H, Sasieni P (2015) Trends in head and neck cancers in England from 1995 to 2011 and projections up to 2025. Oral Oncol 51(4):341\u2013348. https:\/\/doi.org\/10.1016\/j.oraloncology.2015.01.002","journal-title":"Oral Oncol"},{"issue":"32","key":"7117_CR2","doi-asserted-by":"publisher","first-page":"4294","DOI":"10.1200\/JCO.2011.36.4596","volume":"29","author":"AK Chaturvedi","year":"2011","unstructured":"Chaturvedi AK, Engels EA, Pfeiffer RM et al (2011) Human papillomavirus and rising oropharyngeal cancer incidence in the United States. J Clin Oncol 29(32):4294\u20134301. https:\/\/doi.org\/10.1200\/JCO.2011.36.4596","journal-title":"J Clin Oncol"},{"issue":"8","key":"7117_CR3","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1016\/S1470-2045(10)70017-6","volume":"11","author":"S Marur","year":"2010","unstructured":"Marur S, D\u2019Souza G, Westra WH, Forastiere AA (2010) HPV-associated head and neck cancer: a virus-related cancer epidemic. Lancet Oncol 11(8):781\u2013789. https:\/\/doi.org\/10.1016\/S1470-2045(10)70017-6","journal-title":"Lancet Oncol"},{"issue":"1","key":"7117_CR4","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1056\/NEJMoa0912217","volume":"363","author":"KK Ang","year":"2010","unstructured":"Ang KK, Harris J, Wheeler R et al (2010) Human papillomavirus and survival of patients with oropharyngeal cancer. N Engl J Med 363(1):24\u201335. https:\/\/doi.org\/10.1056\/NEJMoa0912217","journal-title":"N Engl J Med"},{"issue":"6","key":"7117_CR5","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1016\/j.oraloncology.2013.09.008","volume":"50","author":"E Benson","year":"2014","unstructured":"Benson E, Li R, Eisele D, Fakhry C (2014) The clinical impact of HPV tumor status upon head and neck squamous cell carcinomas. Oral Oncol 50(6):565\u2013574. https:\/\/doi.org\/10.1016\/j.oraloncology.2013.09.008","journal-title":"Oral Oncol"},{"issue":"8","key":"7117_CR6","doi-asserted-by":"publisher","first-page":"1542","DOI":"10.1002\/lary.20533","volume":"119","author":"AR Sedaghat","year":"2009","unstructured":"Sedaghat AR, Zhang Z, Begum S et al (2009) Prognostic significance of human papillomavirus in oropharyngeal squamous cell carcinomas. Laryngoscope 119(8):1542\u20131549. https:\/\/doi.org\/10.1002\/lary.20533","journal-title":"Laryngoscope"},{"issue":"36","key":"7117_CR7","doi-asserted-by":"publisher","first-page":"4550","DOI":"10.1200\/JCO.2013.50.3870","volume":"31","author":"AK Chaturvedi","year":"2013","unstructured":"Chaturvedi AK, Anderson WF, Lortet-Tieulent J et al (2013) Worldwide trends in incidence rates for oral cavity and oropharyngeal cancers. J Clin Oncol 31(36):4550\u20134559. https:\/\/doi.org\/10.1200\/JCO.2013.50.3870","journal-title":"J Clin Oncol"},{"issue":"5","key":"7117_CR8","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1016\/j.oraloncology.2014.01.016","volume":"50","author":"EP Simard","year":"2014","unstructured":"Simard EP, Torre LA, Jemal A (2014) International trends in head and neck cancer incidence rates: differences by country, sex and anatomic site. Oral Oncol 50(5):387\u2013403. https:\/\/doi.org\/10.1016\/j.oraloncology.2014.01.016","journal-title":"Oral Oncol"},{"issue":"2","key":"7117_CR9","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.jcv.2011.03.003","volume":"51","author":"JL St Guily","year":"2011","unstructured":"St Guily JL, Jacquard A-C, Pr\u00e9tet J-L et al (2011) Human papillomavirus genotype distribution in oropharynx and oral cavity cancer in France\u2014The EDiTH VI study. J Clin Virol 51(2):100\u2013104. https:\/\/doi.org\/10.1016\/j.jcv.2011.03.003","journal-title":"J Clin Virol"},{"key":"7117_CR10","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.oraloncology.2016.06.006","volume":"60","author":"AK Chaturvedi","year":"2016","unstructured":"Chaturvedi AK, D\u2019Souza G, Gillison ML, Katki HA (2016) Burden of HPV-positive oropharynx cancers among ever and never smokers in the US population. Oral Oncol 60:61\u201367. https:\/\/doi.org\/10.1016\/j.oraloncology.2016.06.006","journal-title":"Oral Oncol"},{"issue":"12","key":"7117_CR11","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)70495-4","volume":"15","author":"TK Burki","year":"2016","unstructured":"Burki TK (2016) France announces tobacco legislation plan US legislation has little eff ect on chemotherapy prescribing. Lancet Oncol 15(12):e532. https:\/\/doi.org\/10.1016\/S1470-2045(14)70495-4","journal-title":"Lancet Oncol"},{"issue":"4","key":"7117_CR12","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1007\/s11864-014-0309-1","volume":"15","author":"NG Chau","year":"2014","unstructured":"Chau NG, Rabinowits G, Haddad RI (2014) Human papillomavirus-associated oropharynx cancer (HPV-OPC): treatment options. Curr Treat Options Oncol 15(4):595\u2013610. https:\/\/doi.org\/10.1007\/s11864-014-0309-1","journal-title":"Curr Treat Options Oncol"},{"issue":"12","key":"7117_CR13","doi-asserted-by":"publisher","first-page":"1908","DOI":"10.1016\/j.ejso.2018.05.022","volume":"44","author":"D Culi\u00e9","year":"2018","unstructured":"Culi\u00e9 D, Garrel R, Viotti J et al (2018) Impact of HPV-associated p16-expression and other clinical factors on therapeutic decision-making in patients with oropharyngeal cancer: a GETTEC multicentric study. Eur J Surg Oncol 44(12):1908\u20131913. https:\/\/doi.org\/10.1016\/j.ejso.2018.05.022","journal-title":"Eur J Surg Oncol"},{"key":"7117_CR14","doi-asserted-by":"publisher","DOI":"10.1002\/lary.26903","author":"SC Kamran","year":"2017","unstructured":"Kamran SC, Qureshi MM, Jalisi S, Salama A, Grillone G, Truong MT (2017) Primary surgery-versus primary radiation-based treatment for locally advanced oropharyngeal cancer. Laryngoscope. https:\/\/doi.org\/10.1002\/lary.26903","journal-title":"Laryngoscope"},{"issue":"17","key":"7117_CR15","doi-asserted-by":"publisher","first-page":"3269","DOI":"10.1002\/cncr.30728","volume":"123","author":"DF Roden","year":"2017","unstructured":"Roden DF, Schreiber D, Givi B (2017) Triple-modality treatment in patients with advanced stage tonsil cancer. Cancer 123(17):3269\u20133276. https:\/\/doi.org\/10.1002\/cncr.30728","journal-title":"Cancer"},{"issue":"10166","key":"7117_CR16","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/S0140-6736(18)32779-X","volume":"393","author":"ML Gillison","year":"2019","unstructured":"Gillison ML, Trotti AM, Harris J et al (2019) Radiotherapy plus cetuximab or cisplatin in human papillomavirus-positive oropharyngeal cancer (NRG Oncology RTOG 1016): a randomised, multicentre, non-inferiority trial. Lancet 393(10166):40\u201350. https:\/\/doi.org\/10.1016\/S0140-6736(18)32779-X","journal-title":"Lancet"},{"key":"7117_CR17","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/S0140-6736(18)32752-1","volume":"393","author":"H Mehanna","year":"2019","unstructured":"Mehanna H, Robinson M, Hartley A et al (2019) Articles Radiotherapy plus cisplatin or cetuximab in low-risk human papillomavirus-positive oropharyngeal cancer (De-ESCALaTE HPV): an open-label randomised controlled phase 3 trial. Lancet 393:51\u201360. https:\/\/doi.org\/10.1016\/S0140-6736(18)32752-1","journal-title":"Lancet"},{"key":"7117_CR18","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.oraloncology.2017.01.012","volume":"67","author":"GJ Lacau","year":"2017","unstructured":"Lacau GJ, Rousseau A, Baujat B et al (2017) Oropharyngeal cancer prognosis by tumour HPV status in France: the multicentric Papillophar study. Oral Oncol 67:29\u201336. https:\/\/doi.org\/10.1016\/j.oraloncology.2017.01.012","journal-title":"Oral Oncol"},{"issue":"5","key":"7117_CR19","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1111\/cyt.12083","volume":"24","author":"HA Cubie","year":"2013","unstructured":"Cubie HA, Cuschieri K (2013) Understanding HPV tests and their appropriate applications. Cytopathology 24(5):289\u2013308. https:\/\/doi.org\/10.1111\/cyt.12083","journal-title":"Cytopathology"},{"issue":"8","key":"7117_CR20","doi-asserted-by":"publisher","first-page":"1882","DOI":"10.1002\/ijc.24911","volume":"126","author":"AC Jung","year":"2009","unstructured":"Jung AC, Rickman D, Briolat J et al (2009) Biological and clinical relevance of transcriptionally active human papillomavirus (HPV) infection in oropharynx squamous cell carcinoma. Int J Cancer 126(8):1882\u20131894. https:\/\/doi.org\/10.1002\/ijc.24911","journal-title":"Int J Cancer"},{"key":"7117_CR21","doi-asserted-by":"publisher","first-page":"4057","DOI":"10.1200\/JCO","volume":"35","author":"C Fakhry","year":"2017","unstructured":"Fakhry C, Zhang Q, Nguyen-T\u00e2n F et al (2017) Development and validation of nomograms predictive of overall and progression-free survival in patients with oropharyngeal cancer. J Clin Oncol 35:4057\u20134065. https:\/\/doi.org\/10.1200\/JCO","journal-title":"J Clin Oncol"},{"issue":"2","key":"7117_CR22","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1002\/ijc.28355","volume":"134","author":"JP Rodrigo","year":"2014","unstructured":"Rodrigo JP, Heideman DAM, Garc\u00eda-Pedrero JM et al (2014) Time trends in the prevalence of HPV in oropharyngeal squamous cell carcinomas in northern Spain (1990\u20132009). Int J Cancer 134(2):487\u2013492. https:\/\/doi.org\/10.1002\/ijc.28355","journal-title":"Int J Cancer"},{"key":"7117_CR23","doi-asserted-by":"publisher","DOI":"10.1097\/CCO.0000000000000531","author":"A Bozec","year":"2019","unstructured":"Bozec A, Culie D, Poissonnet G, Dassonville O (2019) Current role of primary surgical treatment in patients with head and neck squamous cell carcinoma. Curr Opin Oncol. https:\/\/doi.org\/10.1097\/CCO.0000000000000531","journal-title":"Curr Opin Oncol"},{"issue":"79","key":"7117_CR24","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.oraloncology.2018.02.017","volume":"2018","author":"JR Kelly","year":"2017","unstructured":"Kelly JR, Park HS, An Y et al (2017) Upfront surgery versus definitive chemoradiotherapy in patients with human Papillomavirus-associated oropharyngeal squamous cell cancer. Oral Oncol 2018(79):64\u201370. https:\/\/doi.org\/10.1016\/j.oraloncology.2018.02.017","journal-title":"Oral Oncol"},{"key":"7117_CR25","first-page":"571","volume":"1","author":"H Seikaly","year":"2015","unstructured":"Seikaly H, Biron VL, Zhang H et al (2015) Role of primary surgery in the treatment of advanced oropharyngeal cancer. Head Neck 1:571\u2013579","journal-title":"Head Neck"},{"issue":"4","key":"7117_CR26","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1016\/S1470-2045(15)00560-4","volume":"17","author":"B O\u2019Sullivan","year":"2016","unstructured":"O\u2019Sullivan B, Huang SH, Su J et al (2016) Development and validation of a staging system for HPV-related oropharyngeal cancer by the International Collaboration on Oropharyngeal cancer Network for Staging (ICON-S): a multicentre cohort study. Lancet Oncol 17(4):440\u2013451. https:\/\/doi.org\/10.1016\/S1470-2045(15)00560-4","journal-title":"Lancet Oncol"},{"key":"7117_CR27","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2018.02.013","author":"H Mirghani","year":"2018","unstructured":"Mirghani H, Lacroix L, Rossoni C et al (2018) Does smoking alter the mutation profile of human papillomavirusedriven head and neck cancers? Eur J Cancer. https:\/\/doi.org\/10.1016\/j.ejca.2018.02.013","journal-title":"Eur J Cancer"},{"key":"7117_CR28","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2012.07.015","author":"SH Huang","year":"2013","unstructured":"Huang SH, Perez-Ordonez B, Weinreb I et al (2013) Natural course of distant metastases following radiotherapy or chemoradiotherapy in HPV-related oropharyngeal cancer. Oral Oncol. https:\/\/doi.org\/10.1016\/j.oraloncology.2012.07.015","journal-title":"Oral Oncol"},{"key":"7117_CR29","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.55.1937","author":"C Fakhry","year":"2014","unstructured":"Fakhry C, Zhang Q, Nguyen-Tan F et al (2014) Human papillomavirus and overall survival after progression of oropharyngeal squamous cell carcinoma. J Clin Oncol. https:\/\/doi.org\/10.1200\/JCO.2014.55.1937","journal-title":"J Clin Oncol"},{"key":"7117_CR30","doi-asserted-by":"publisher","DOI":"10.1002\/lio2.37","author":"F Faraji","year":"2017","unstructured":"Faraji F, Eisele DW, Fakhry C (2017) Emerging insights into recurrent and metastatic human papillomavirus-related oropharyngeal squamous cell carcinoma. Laryngoscope Investig Otolaryngol. https:\/\/doi.org\/10.1002\/lio2.37","journal-title":"Laryngoscope Investig Otolaryngol"},{"key":"7117_CR31","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.oraloncology.2016.11.011","volume":"64","author":"M Martel","year":"2017","unstructured":"Martel M, Alemany L, Taberna M et al (2017) The role of HPV on the risk of second primary neoplasia in patients with oropharyngeal carcinoma. Oral Oncol 64:37\u201343. https:\/\/doi.org\/10.1016\/j.oraloncology.2016.11.011","journal-title":"Oral Oncol"},{"key":"7117_CR32","unstructured":"IARC France (2007) Tobacco control: reversal of risk after. 11."}],"container-title":["European Archives of Oto-Rhino-Laryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00405-021-07117-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00405-021-07117-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00405-021-07117-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T04:55:43Z","timestamp":1651726543000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00405-021-07117-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,18]]},"references-count":32,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["7117"],"URL":"https:\/\/doi.org\/10.1007\/s00405-021-07117-5","relation":{},"ISSN":["0937-4477","1434-4726"],"issn-type":[{"value":"0937-4477","type":"print"},{"value":"1434-4726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,18]]},"assertion":[{"value":"4 January 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 February 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 October 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors do not have any potential conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study (NCT00918710) was approved by a national ethical committee and the French data protection authority.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical standards"}},{"value":"All participating patients provided written informed consent.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}