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Inhibition of Glut-1 expression by 2-DG significantly suppressed such hyperplasia compared to mice exposed to artificial gastric juice containing pepsin at 15, 30, and 45\u00a0days. After treatment with pepsin-containing artificial gastric juice, RT-PCR and Western blotting showed that the levels of Glut-1 and H<jats:sup>+<\/jats:sup>\/K<jats:sup>+<\/jats:sup>-ATPase \u03b1, \u03b2 increased significantly.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Pepsin-containing artificial gastric juice promoted mouse laryngeal epithelial hyperplasia associated with abnormal expression of Glut-1 and H<jats:sup>+<\/jats:sup>\/K<jats:sup>+<\/jats:sup>-ATPase \u03b1, \u03b2.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00405-021-07221-6","type":"journal-article","created":{"date-parts":[[2022,1,27]],"date-time":"2022-01-27T00:03:17Z","timestamp":1643241797000},"page":"2981-2987","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The role of Glut-1 and H+\/K+-ATPase expression in hyperplasia of mice laryngeal epithelium induced by pepsin"],"prefix":"10.1007","volume":"279","author":[{"given":"Yin-Jie","family":"Ao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting-Ting","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zai-Zai","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7163-2289","authenticated-orcid":false,"given":"Shui-Hong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang-Yang","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Fang","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,1,27]]},"reference":[{"issue":"4","key":"7221_CR1","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1016\/j.wjorl.2017.12.011","volume":"4","author":"MM Anis","year":"2018","unstructured":"Anis MM, Razavi MM, Xiao X, Soliman AMS (2018) Association of gastroesophageal reflux disease and laryngeal cancer. 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