{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T10:47:36Z","timestamp":1778064456080,"version":"3.51.4"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2022,2,7]],"date-time":"2022-02-07T00:00:00Z","timestamp":1644192000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,2,7]],"date-time":"2022-02-07T00:00:00Z","timestamp":1644192000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Arch Otorhinolaryngol"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>To determine the long-term outcomes of patients with vestibular schwannomas (VS) after stereotactic radiosurgery (SRS) who experience delayed tumour regrowth.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We carried out a retrospective case series in tertiary university settings. We included patients with VS with initial response to SRS and delayed regrowth, assessing a database of 735 patients with VS and 159 patients who had SRS as sole treatment. Following SRS, all patients had clinical follow-up and serial magnetic resonance imaging (MRI). We documented the post-SRS clinical assessment, pre- and post-SRS VS size as per MRI in predetermined time periods, response to treatment and rate of (re-) growth and the final outcome in each case.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>We identified six patients with good initial response but delayed VS regrowth at a faster rate than pre-SRS. The mean growth rate for these VS was 0.347\u00a0mm\/month (range 0.04\u20130.78\u00a0mm\/month) prior to treatment; the mean growth rate at the time of delayed re-growth was 0.48\u00a0mm\/month (range 0.17\u20130.75\u00a0mm\/month); this did not reach the level of statistical significance (<jats:italic>p<\/jats:italic>\u2009=\u20090.08). This regrowth occurred at a mean time of 42\u00a0months (range 36\u201366\u00a0months) post-SRS and stopped 22\u00a0months (mean, range 12\u201336\u00a0months) post regrowth detection in all cases.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Given that delayed post-SRS VS regrowth can occur in approximately 4% of the treated cases, it is important to continue close clinical and radiological follow-up. Despite this abnormal behaviour, VS do stop growing again; still, patients should be made aware of the possibility of this uncommon VS behaviour following SRS.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00405-022-07281-2","type":"journal-article","created":{"date-parts":[[2022,2,7]],"date-time":"2022-02-07T16:19:04Z","timestamp":1644250744000},"page":"4825-4830","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Long-term growth patterns of vestibular schwannomas after stereotactic radiotherapy: delayed re-growth"],"prefix":"10.1007","volume":"279","author":[{"given":"Owen","family":"Conlan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1637-1661","authenticated-orcid":false,"given":"Georgios","family":"Kontorinis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,2,7]]},"reference":[{"key":"7281_CR1","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1001\/archotol.131.3.241","volume":"131","author":"D Lin","year":"2005","unstructured":"Lin D, Hegarty JL, Fischbein NJ (2005) The prevalence of \u201cincidental\u201d acoustic neuroma. 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