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Kaplan\u2013Meier analyses and multivariate Cox regression were performed to investigate OS.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Mean times to treatment initiation (TTI) of 2003, 2008 and 2013 were 17.11\u2009\u00b1\u200918.00, 30.26\u2009\u00b1\u200930.08 and 17.30\u2009\u00b1\u200937.04\u00a0days, respectively. TTI for patients with T3\/T4 tumors was higher than for T1\/T2 (<jats:italic>p\u2009=\u2009<\/jats:italic>0.010). In univariable analysis on OS, TTI\u2009&gt;\u20095\u00a0days showed lower OS (<jats:italic>p\u2009=\u2009<\/jats:italic>0.047). In multivariate analysis, longer TTI had no influence on lower OS [hazard ratio (HR) 1.236; 95% CI 0.852\u20131.791; <jats:italic>p\u2009=\u2009<\/jats:italic>0.264], but male gender [HR 2.342; 95% CI 1.229\u20134.466; <jats:italic>p\u2009=\u2009<\/jats:italic>0.010], increased age [HR 1.026; 95% CI 1.008\u20131.045; <jats:italic>p\u2009=\u2009<\/jats:italic>0.005], M1 [HR 5.823; 95% CI 2.252\u201315.058; <jats:italic>p\u2009=\u2009<\/jats:italic>0.003], hypopharynx tumor [HR 2.508; 95% CI 1.571\u20134.003; <jats:italic>p\u2009&lt;\u2009\u2009<\/jats:italic>0.001] and oral cavity tumor [HR 1.712; CI 1.101\u20132.661; <jats:italic>p\u2009=\u2009<\/jats:italic>0.017]. The year of treatment showed no significant effect on OS.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Median TTI seemed to be very short compared to other studies. There was no clear trend in the impact of TTI on OS from 2003 to 2013.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00405-022-07392-w","type":"journal-article","created":{"date-parts":[[2022,4,30]],"date-time":"2022-04-30T10:07:43Z","timestamp":1651313263000},"page":"4549-4560","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["No impact of time to treatment initiation for head and neck cancer in a tertiary university center in 2003, 2008 and 2013"],"prefix":"10.1007","volume":"279","author":[{"given":"Mussab","family":"Kouka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Max","family":"Engelhardt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Wittig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Schultze-Mosgau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Ernst","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9671-0784","authenticated-orcid":false,"given":"Orlando","family":"Guntinas-Lichius","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,4,30]]},"reference":[{"key":"7392_CR1","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1001\/jamaoto.2020.0222","volume":"146","author":"DA Levy","year":"2020","unstructured":"Levy DA, Li H, Sterba KR, Hughes-Halbert C, Warren GW, Nussenbaum B et al (2020) Development and validation of nomograms for predicting delayed postoperative radiotherapy initiation in head and neck squamous cell carcinoma. 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