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The purpose of the present study is to analyze the auditory and vestibular function with audiometric and vestibular-evoked myogenic potentials (VEMP) responses, respectively, in both the affected and unaffected ears of patients with unilateral MD using MRI as diagnostic support for the degree of EH.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We retrospectively reviewed the medical records of 76 consecutive patients with unilateral definite MD (age 55 (28\u201375); 39 women, 37 men). MRI was used through intravenous gadolinium administration, audiometry, and VEMPs. Functional tests were performed up to a week after the MRI. All were followed up one year after imaging utilizing clinical, auditory, and vestibular testing to rule out bilateral involvement.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>In the unaffected ear, the mean pure-tone average is normal even in cases with hydrops and, for a similar severity of hydrops is significantly lower than in the affected ear. Significant differences for the amplitude of the response at 0.5\u00a0kHz, at 1\u00a0kHz between the affected and unaffected ears were found to be lower in the affected ears. The relative amplitude ratio (1\u00a0Kz\u20130.5\u00a0kHz) was significantly lower in the affected ear and in the case of the oVEMP response depends on the degree of EH. The response in the unaffected ear was not modified by the presence or the degree of hydrops.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>In the unaffected ear, hydrops is not associated with hearing deterioration. For a similar degree of hydrops, hearing loss is significantly greater in the affected ear. The endolymphatic hydrops in the vestibule induces a frequency bias in the VEMP response only in the affected ear and not in the unaffected ear. Because of these findings we consider that hydrops does not represent an active disorder in the unaffected ear.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00405-022-07412-9","type":"journal-article","created":{"date-parts":[[2022,5,16]],"date-time":"2022-05-16T18:04:57Z","timestamp":1652724297000},"page":"5591-5600","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Endolymphatic hydrops in the unaffected ear of patients with unilateral M\u00e9ni\u00e8re\u2019s disease"],"prefix":"10.1007","volume":"279","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0343-6964","authenticated-orcid":false,"given":"Carlos","family":"Guajardo-Vergara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Su\u00e1rez-Vega","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Dominguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Manrique-Huarte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorea","family":"Arbizu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1192-5901","authenticated-orcid":false,"given":"Nicol\u00e1s","family":"P\u00e9rez-Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,5,16]]},"reference":[{"key":"7412_CR1","doi-asserted-by":"publisher","first-page":"415","DOI":"10.3389\/fneur.2017.00415","volume":"8","author":"M Maheu","year":"2017","unstructured":"Maheu M, Alvarado-Umanzor JM, Delcenserie A, Champoux F (2017) The clinical utility of vestibular-evoked myogenic potentials in the diagnosis of M\u00e9ni\u00e8re\u2019s disease. 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