{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T02:00:31Z","timestamp":1774576831409,"version":"3.50.1"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2022,6,9]],"date-time":"2022-06-09T00:00:00Z","timestamp":1654732800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,6,9]],"date-time":"2022-06-09T00:00:00Z","timestamp":1654732800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100007065","name":"Universit\u00e0 degli Studi di Salerno","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007065","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Arch Otorhinolaryngol"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Objectives<\/jats:title>\n            <jats:p>To analyze the demographic data, surgical and adjuvant treatment data and the survival outcomes in adult patients affected by acinic cell carcinoma of the parotid gland (AciCC).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>A retrospective multicenter analysis of patients treated for AciCC of the parotid gland from 2000 to 2021 was performed. Exclusion criteria were pediatric (0\u201318\u00a0years) patients, the absence of follow-up and patients with secondary metastatic disease to the parotid gland. Multivariable logistic regression was used to determine factors associated with survival.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>The study included 81 adult patients with AciCC of the parotid gland. The median age was 46.3\u00a0years (SD 15.81, range 19\u201384\u00a0years), with a gender female prevalence (<jats:italic>F<\/jats:italic>\u2009=\u200948, <jats:italic>M<\/jats:italic>\u2009=\u200933). The mean follow-up was 77.7\u00a0months (min 4\u2013max 361, SD 72.46). The 5\u00a0years overall survival (OS) was 97.5%. The 5\u00a0years disease-free survival (DFS) was 60%. No statistical differences have been found in prognosis for age (&lt;\u200965 or\u2009\u2265\u200965\u00a0years), sex, surgery type (superficial vs profound parotid surgery), radicality (R0 vs R1\u2009+\u2009Rclose), neck dissection, early pathologic T and N stages and adjuvant therapy (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>This study did not find prognostic factor for poorest outcome. In contrast with the existing literature, our results showed how also high-grade tumours cannot be considered predictive of recurrence or aggressive behaviour.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s00405-022-07481-w","type":"journal-article","created":{"date-parts":[[2022,6,9]],"date-time":"2022-06-09T09:13:44Z","timestamp":1654766024000},"page":"5821-5829","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Acinic cell carcinoma of the parotid gland: Timeo Danaos et dona ferentes? 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