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Published international English literature from January 1, 2000 to December 2021 was screened, checking for studies that compared different materials utilization in patients undergoing stapedotomy surgery for otosclerosis or congenital stapes fixation. Data related to the efficacy and safety of each material were extracted. The primary outcome measure was the air\u2013bone gap (ABG) closure after surgical intervention.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Six studies were included in the metanalysis. Because of the heterogeneity of the treatments adopted, we assessed the use of the fat compared to all other treatments, and the use of the gelfoam compared to all other treatments. In the former analysis (fat vs others) we did not identify differences in ABG closure between the groups (<jats:italic>p<\/jats:italic>\u2009=\u20090.74), with a low heterogeneity of the results (<jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u200928.36%; Hedge\u2019s <jats:italic>g<\/jats:italic>\u2009=\u20090.04, 95% CI \u2212\u20090.19 0.27); similarly, we did not identify differences between the use of gelfoam and other treatments (<jats:italic>p<\/jats:italic>\u2009=\u20090.97), with a low heterogeneity of the results (<jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u200928.91%; Hedge\u2019s <jats:italic>g<\/jats:italic>\u2009=\u20090.00, 95% CI \u2212\u20090.20 0.21).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Numerous options are available for oval window sealing during stapedotomy, with acceptable safety and effectiveness profiles. Based on the current data, no definitive recommendation can be made regarding the choice of one material over another, and the convenience of sealing over no sealing at all.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00405-022-07551-z","type":"journal-article","created":{"date-parts":[[2022,7,20]],"date-time":"2022-07-20T09:02:37Z","timestamp":1658307757000},"page":"5521-5533","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Comparison of different oval window sealing materials in stapes surgery: systematic review and meta-analysis"],"prefix":"10.1007","volume":"279","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9219-6175","authenticated-orcid":false,"given":"Alfonso","family":"Scarpa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pasquale","family":"Marra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Ralli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pasquale","family":"Viola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico Maria","family":"Gioacchini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Chiarella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco Antonio","family":"Salzano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pietro","family":"De Luca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filippo","family":"Ricciardiello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Cassandro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grazia Maria","family":"Corbi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,7,20]]},"reference":[{"issue":"7","key":"7551_CR1","first-page":"729","volume":"66","author":"SYMPOSIUM","year":"1956","unstructured":"SYMPOSIUM (1956) the operation for the mobilization of the stapes in otosclerotic deafness. 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