{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T22:53:42Z","timestamp":1768344822644,"version":"3.49.0"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T00:00:00Z","timestamp":1662940800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T00:00:00Z","timestamp":1662940800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"The state research funding of the Helsinki University Hospital"},{"name":"University of Helsinki including Helsinki University Central Hospital"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Arch Otorhinolaryngol"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>Hypopharyngeal carcinoma (HPC) is typically diagnosed at late stages, the patients tend to have serious co-morbidities, distant relapses are frequent, and the related mortality remains high. The treatment paradigm of HPC has remarkably changed from primary surgical approach toward definitive, platinum-based concomitant chemoradiotherapy (CRT). Our aim was to analyze the HPC treatment approaches and outcome in a nationwide series and to make a comparison with a previously published corresponding nationwide patient cohort from the period 1990\u20131999.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We retrospectively reviewed all patients diagnosed with HPC at the five university hospitals in Finland between 2005 and 2014.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The cohort comprised 231 patients. Treatment with curative intent was offered for 175 (76%) patients and consisted of definitive radiotherapy (RT) or CRT in 156 (89%) patients, while 20 (11%) patients had primary surgery with or without adjuvant RT or CRT. The 5-year estimates for overall survival (OS) and disease specific survival (DSS) for the whole study group were 22.7% and 36.5%, respectively. For patients treated with curative intent, the 5-year estimates for OS and DSS were 29.4% and 44.3%, respectively.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The treatment approach of HPC in Finland has changed thoroughly, as in the 1990s, 63% of HPC patients with curative treatment intent underwent primary surgery with or without RT, while in the current study, the primary treatment approach was non-surgical in 89% of the patients. However, the survival figures have not changed and remain dismal, but most of the few surviving patients now can retain their larynx.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00405-022-07648-5","type":"journal-article","created":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T05:03:31Z","timestamp":1662959011000},"page":"1361-1367","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Hypopharyngeal carcinoma in Finland from 2005 to 2014: outcome remains poor after major changes in treatment"],"prefix":"10.1007","volume":"280","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5390-472X","authenticated-orcid":false,"given":"Harri","family":"Keski-S\u00e4ntti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marjaana","family":"Luukkaa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timo","family":"Carp\u00e9n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Jouppila-M\u00e4tt\u00f6","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaisa","family":"Lehti\u00f6","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanna","family":"M\u00e4enp\u00e4\u00e4","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristiina","family":"Vuolukka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tero","family":"Vahlberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antti","family":"M\u00e4kitie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,9,12]]},"reference":[{"key":"7648_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2021.105470","volume":"121","author":"CG Hochfelder","year":"2021","unstructured":"Hochfelder CG, Mehta V, Kabarriti R, McGinn AP, Castellucci E, Ow TJ (2021) Survival analysis of patients with advanced hypopharyngeal cancer comparing patients who received primary surgery to those who received chemoradiation: an analysis of the NCDB. Oral Oncol 121:105470","journal-title":"Oral Oncol"},{"key":"7648_CR2","doi-asserted-by":"publisher","first-page":"1570","DOI":"10.1080\/0284186X.2019.1657585","volume":"58","author":"KK Jakobsen","year":"2019","unstructured":"Jakobsen KK, Wingstrand VL, Jensen JS, Gronhoj C, Jensen DH, Karnov K, Agander TK, Specht L, von Buchwald C (2019) Incidence and survival of hypopharyngeal cancer: a Danish Nation-Wide Study from 1980 to 2014. Acta Oncol 58:1570\u20131576. https:\/\/doi.org\/10.1080\/0284186X.2019.1657585","journal-title":"Acta Oncol"},{"key":"7648_CR3","doi-asserted-by":"publisher","DOI":"10.1186\/s12957-020-01866-z","author":"YT Tsai","year":"2020","unstructured":"Tsai YT, Chen WC, Chien CY, Hsu CM, Lee YC, Tsai MS, Lin MH, Lai CH, Chang KP (2020) Treatment patterns and survival outcomes of advanced hypopharyngeal squamous cell carcinoma. World J Surg Oncol. https:\/\/doi.org\/10.1186\/s12957-020-01866-z","journal-title":"World J Surg Oncol"},{"key":"7648_CR4","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1007\/s00405-017-4766-6","volume":"275","author":"JF Petersen","year":"2018","unstructured":"Petersen JF, Timmermans AJ, van Dijk BAC, Overbeek LIH, Smit LA, Hilgers FJM, Stuiver MM, van den Brekel MWM (2018) Trends in treatment, incidence and survival of hypopharynx cancer: a 20-year population-based study in the Netherlands. Eur Arch Otorhinolaryngol 275:181\u2013189. https:\/\/doi.org\/10.1007\/s00405-017-4766-6","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"7648_CR5","doi-asserted-by":"publisher","first-page":"3042","DOI":"10.1002\/hed.26793","volume":"43","author":"N Burbure","year":"2021","unstructured":"Burbure N, Handorf E, Ridge JA, Bauman J, Liu JC, Giri A, Galloway TJ (2021) Prognostic significance of human papillomavirus status and treatment modality in hypopharyngeal cancer. Head Neck 43:3042\u20133052. https:\/\/doi.org\/10.1002\/hed.26793","journal-title":"Head Neck"},{"key":"7648_CR6","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1007\/s00405-004-0847-4","volume":"262","author":"J Laranne","year":"2005","unstructured":"Laranne J, B\u00e4ck L, Koivunen P, Pukkila M, Pulkkinen J, Gr\u00e9nman R (2005) Hypopharyngeal carcinoma in Finland from 1990\u20131999. Eur Arch Otorhinolaryngol 262:374\u2013378. https:\/\/doi.org\/10.1007\/s00405-004-0847-4","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"7648_CR7","doi-asserted-by":"publisher","first-page":"1685","DOI":"10.1056\/NEJM199106133242402","volume":"324","author":"GT Wolf","year":"1991","unstructured":"Department of Veterans Affairs Laryngeal Cancer Study Group, Wolf GT, Fisher SG, Hong WK, Hillman R, Spaulding M, Laramore GE, Endicott JW, McClatchey K, Henderson WG (1991) Induction chemotherapy plus radiation compared with surgery plus radiation in patients with advanced laryngeal cancer. N Engl J Med 324:1685\u20131690. https:\/\/doi.org\/10.1056\/NEJM199106133242402","journal-title":"N Engl J Med"},{"key":"7648_CR8","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1093\/jnci\/88.13.890","volume":"88","author":"JL Lefebvre","year":"1996","unstructured":"Lefebvre JL, Chevalier D, Luboinski B, Kirkpatrick A, Collette L, Sahmoud T (1996) Larynx preservation in pyriform sinus cancer: preliminary results of a European Organization for Research and Treatment of Cancer phase III trial. EORTC Head and Neck Cancer Cooperative Group. J Natl Cancer Inst 88:890\u2013899","journal-title":"J Natl Cancer Inst"},{"issue":"Supplement 5","key":"7648_CR9","doi-asserted-by":"publisher","first-page":"v184","DOI":"10.1093\/annonc\/mdq185","volume":"21","author":"V Gr\u00e9goire","year":"2010","unstructured":"Gr\u00e9goire V, Lefebvre J-L, Licitra L, Felip E (2010) Squamous cell carcinoma of the head and neck: EHNS-ESMO-ESTRO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 21(Supplement 5):v184\u2013v186. https:\/\/doi.org\/10.1093\/annonc\/mdq185","journal-title":"Ann Oncol"},{"issue":"4","key":"7648_CR10","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1080\/02841860310004364","volume":"42","author":"L Marcu","year":"2003","unstructured":"Marcu L, van Doorn T, Olver I (2003) Cisplatin and radiotherapy in the treatment of locally advanced head and neck cancer\u2014a review of their cooperation. Acta Oncol 42(4):315\u2013325. https:\/\/doi.org\/10.1080\/02841860310004364","journal-title":"Acta Oncol"},{"issue":"1","key":"7648_CR11","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.radonc.2010.10.015","volume":"98","author":"V Loimu","year":"2011","unstructured":"Loimu V, Collan J, Vaalavirta L, B\u00e4ck L, Kapanen M, M\u00e4kitie AA, Tenhunen M, Saarilahti K (2011) Patterns of relapse following definitive treatment of head and neck squamous cell cancer by intensity modulated radiotherapy and weekly cisplatin. Radiother Oncol 98(1):34\u201337. https:\/\/doi.org\/10.1016\/j.radonc.2010.10.015","journal-title":"Radiother Oncol"},{"key":"7648_CR12","doi-asserted-by":"publisher","first-page":"2509","DOI":"10.1007\/s00405-015-3857-5","volume":"273","author":"R Niemensivu","year":"2016","unstructured":"Niemensivu R, Saarilahti K, Ylikoski J, Aarnisalo A, M\u00e4kitie AA (2016) Hearing and tinnitus in head and neck cancer patients after chemoradiotherapy. Eur Arch Otorhinolaryngol 273:2509\u20132514. https:\/\/doi.org\/10.1007\/s00405-015-3857-5","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"7648_CR13","doi-asserted-by":"publisher","first-page":"903","DOI":"10.3109\/02841869009096387","volume":"29","author":"M Kajanti","year":"1990","unstructured":"Kajanti M, M\u00e4ntyla M (1990) Carcinoma of the hypopharynx. A retrospective analysis of the treatment results over a 25-year period. Acta Oncol 29:903\u2013907","journal-title":"Acta Oncol"},{"issue":"1","key":"7648_CR14","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1186\/s12885-022-09337-2","volume":"22","author":"A Koskinen","year":"2022","unstructured":"Koskinen A, Hemminki O, F\u00f6rsti A, Hemminki K (2022) Incidence and survival in oral and pharyngeal cancers in Finland and Sweden through half century. BMC Cancer 22(1):227. https:\/\/doi.org\/10.1186\/s12885-022-09337-2","journal-title":"BMC Cancer"},{"key":"7648_CR15","doi-asserted-by":"publisher","first-page":"2489","DOI":"10.1007\/s00405-014-3221-1","volume":"272","author":"H Keski-S\u00e4ntti","year":"2015","unstructured":"Keski-S\u00e4ntti H, M\u00e4kitie AA, Saarilahti K (2015) Intensity-modulated radiotherapy in definitive oncological treatment of hypopharyngeal squamous cell carcinoma. Eur Arch Otorhinolaryngol 272:2489\u20132495. https:\/\/doi.org\/10.1007\/s00405-014-3221-1","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"7648_CR16","doi-asserted-by":"publisher","first-page":"6","DOI":"10.14639\/0392-100X-N0879","volume":"41","author":"CM Chiesa-Estomba","year":"2021","unstructured":"Chiesa-Estomba CM, Lechien JR, Ayad T, Calvo-Henriquez C, Gonzalez-Garcia JA, Sistiaga-Suarez JA, Dequanter D, Fakhry N, Melesse G, Piazza C (2021) Clinical and histopathological risk factors for distant metastasis in head and neck cancer patients. Acta Otorhinolaryngol Ital 41:6\u201317. https:\/\/doi.org\/10.14639\/0392-100X-N0879","journal-title":"Acta Otorhinolaryngol Ital"},{"key":"7648_CR17","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1002\/lio2.443","volume":"5","author":"DC Marshall","year":"2020","unstructured":"Marshall DC, Kao DD, Bakst R, Sharma S, Ferrandino R, Rosenzweig K, Wisnivesky J, Sigel K (2020) Prognostic role of human papilloma virus status in hypopharyngeal squamous cell carcinoma. Laryngoscope Investig Otolaryngol 5:860\u2013867. https:\/\/doi.org\/10.1002\/lio2.443","journal-title":"Laryngoscope Investig Otolaryngol"},{"key":"7648_CR18","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8020256","author":"A De Virgilio","year":"2019","unstructured":"De Virgilio A, Iocca O, Malvezzi L, Di Maio P, Pellini R, Ferreli F, Cugini G, Colombo G, Spriano G (2019) The emerging role of robotic surgery among minimally invasive surgical approaches in the treatment of hypopharyngeal carcinoma: systematic review and meta-analysis. J Clin Med. https:\/\/doi.org\/10.3390\/jcm8020256","journal-title":"J Clin Med"}],"container-title":["European Archives of Oto-Rhino-Laryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00405-022-07648-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00405-022-07648-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00405-022-07648-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,6]],"date-time":"2023-02-06T03:10:05Z","timestamp":1675653005000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00405-022-07648-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,12]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["7648"],"URL":"https:\/\/doi.org\/10.1007\/s00405-022-07648-5","relation":{},"ISSN":["0937-4477","1434-4726"],"issn-type":[{"value":"0937-4477","type":"print"},{"value":"1434-4726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,12]]},"assertion":[{"value":"18 May 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 September 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 September 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. This research involved only patient charts.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"As this study was a retrospective chart review, no informed consent was needed according to the Finnish legislation.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}