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In addition, a comparison of FEES results and clinical scores was carried out.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>A prospective pilot study was conducted including ten symptomatic children with SMA type 1 (two <jats:italic>SMN2<\/jats:italic> copies). They started treatment with one of the three currently approved therapies for SMA at a median age of 3.8\u00a0months (range 0.7\u20138.9). FEES was performed according to a standard protocol using Penetration\u2013Aspiration Scale (PAS) and Murray Secretion Scale as a primary outcome. The Children's Hospital of Philadelphia Infant Test of Neuromuscular Disorders (CHOP-INTEND) for motor function, Neuromuscular Disease Swallowing Status Scale (NdSSS), Oral and Swallowing Abilities Tool (OrSAT), and single clinical swallowing-related parameters were also assessed.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Distinct swallowing disorders were already evident in eight children at inclusion. The most common findings from FEES were pharyngeal secretion pooling, penetration, and aspiration of saliva and food as well as delayed initiation of swallowing. Despite an average increase in motor function, no comparable improvement was found in swallowing function. None of the surveyed clinical scores showed a significant dependence on PAS in a mixed linear model.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Valuable information regarding the status of dysphagia can be gathered endoscopically, particularly concerning secretion management and when oral intake is limited. Currently available clinical tools for children with type 1 may represent a change in nutritional status but are not yet mature enough to conclude swallowing ability. Further development is still required.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00405-022-07685-0","type":"journal-article","created":{"date-parts":[[2022,10,8]],"date-time":"2022-10-08T19:04:46Z","timestamp":1665255886000},"page":"1329-1338","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Flexible endoscopic evaluation of swallowing in children with type 1 spinal muscular atrophy"],"prefix":"10.1007","volume":"280","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4979-4716","authenticated-orcid":false,"given":"Jana","family":"Zang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessika","family":"Johannsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Denecke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deike","family":"Weiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana-Christiane","family":"Koseki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Almut","family":"Nie\u00dfen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie Cl\u00e4re","family":"Nienstedt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Till","family":"Fl\u00fcgel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Pflug","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,10,8]]},"reference":[{"issue":"3","key":"7685_CR1","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.1044\/2021_AJSLP-20-00217","volume":"30","author":"KE McGrattan","year":"2021","unstructured":"McGrattan KE, Graham RJ, DiDonato CJ, Darras BT (2021) Dysphagia phenotypes in spinal muscular atrophy: the past, present, and promise for the future. 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Jana Zang, Jana-Christiane Koseki, Deike Weiss, Almut Nie\u00dfen and Frank M\u00fcller have nothing to disclose. Jessika Johannsen received advisory board and speaker honoraria and financial support for conference attendances from Avexis\/Novartis, Biogen, Roche, PTC, and Sarepta. Jonas Denecke received speaker honoraria from Biogen and Roche. Julie Cl\u00e4re Nienstedt received speaker honoraria from Merz and Olympus. Till Fl\u00fcgel received consulting fees from JCR Pharmaceuticals. Christina Pflug received speaker honoraria from Olympus, Abbvie, and Merz.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The local ethics committee gave ethical approval (2020-10329-BO-ff). All parents gave written informed consent.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}