{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T19:44:11Z","timestamp":1777491851017,"version":"3.51.4"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2022,10,18]],"date-time":"2022-10-18T00:00:00Z","timestamp":1666051200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,10,18]],"date-time":"2022-10-18T00:00:00Z","timestamp":1666051200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Fund of China","doi-asserted-by":"crossref","award":["82160212"],"award-info":[{"award-number":["82160212"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Arch Otorhinolaryngol"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1007\/s00405-022-07696-x","type":"journal-article","created":{"date-parts":[[2022,10,18]],"date-time":"2022-10-18T09:03:15Z","timestamp":1666083795000},"page":"1501-1508","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Identification and validation of ferroptosis-related genes for chronic rhinosinusitis with nasal polyps"],"prefix":"10.1007","volume":"280","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9477-3519","authenticated-orcid":false,"given":"Guan-Jiang","family":"Huang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong-Bing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,10,18]]},"reference":[{"key":"7696_CR1","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1164\/rccm.201402-0234OC","volume":"190","author":"LL Shi","year":"2014","unstructured":"Shi LL, Song J, Xiong P et al (2014) Disease-specific T-helper cell polarizing function of lesional dendritic cells in different types of chronic rhinosinusitis with nasal polyps. Am J Respir Crit Care Med 190:628\u2013638","journal-title":"Am J Respir Crit Care Med"},{"key":"7696_CR2","doi-asserted-by":"publisher","first-page":"1900732","DOI":"10.1183\/13993003.00732-2019","volume":"54","author":"Y Peng","year":"2019","unstructured":"Peng Y, Zi XX, Tian TF et al (2019) Whole-transcriptome sequencing reveals heightened inflammation and defective host defence responses in chronic rhinosinusitis with nasal polyps. Eur Respir J 54:1900732","journal-title":"Eur Respir J"},{"key":"7696_CR3","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1016\/j.jaci.2020.01.020","volume":"145","author":"C Bachert","year":"2020","unstructured":"Bachert C, Zhang N, Cavaliere C et al (2020) Biologics for chronic rhinosinusitis with nasal polyps. J Allergy Clin Immunol 145:725\u2013739","journal-title":"J Allergy Clin Immunol"},{"key":"7696_CR4","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1056\/NEJMcp1800215","volume":"381","author":"C Hopkins","year":"2019","unstructured":"Hopkins C (2019) Chronic rhinosinusitis with nasal polyps. N Engl J Med 381:55\u201363","journal-title":"N Engl J Med"},{"key":"7696_CR5","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1016\/j.iac.2018.06.006","volume":"38","author":"AD Workman","year":"2018","unstructured":"Workman AD, Kohanski MA, Cohen NA (2018) Biomarkers in chronic rhinosinusitis with nasal polyps. Immunol Allergy Clin North Am 38:679\u2013692","journal-title":"Immunol Allergy Clin North Am"},{"key":"7696_CR6","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","volume":"149","author":"SJ Dixon","year":"2012","unstructured":"Dixon SJ, Lemberg KM, Lamprecht MR et al (2012) Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell 149:1060\u20131072","journal-title":"Cell"},{"key":"7696_CR7","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1038\/cdd.2015.158","volume":"23","author":"Y Xie","year":"2016","unstructured":"Xie Y, Hou W, Song X et al (2016) Ferroptosis: process and function. Cell Death Differ 23:369\u2013379","journal-title":"Cell Death Differ"},{"key":"7696_CR8","doi-asserted-by":"publisher","first-page":"1589","DOI":"10.1038\/s41467-021-21841-w","volume":"12","author":"Y Zhang","year":"2021","unstructured":"Zhang Y, Swanda RV, Nie L et al (2021) mTORC1 couples cyst(e)ine availability with GPX4 protein synthesis and ferroptosis regulation. Nat Commun 12:1589","journal-title":"Nat Commun"},{"key":"7696_CR9","doi-asserted-by":"publisher","first-page":"517","DOI":"10.18632\/oncoscience.160","volume":"2","author":"N Eling","year":"2015","unstructured":"Eling N, Reuter L, Hazin J, Hamacher-Brady A, Brady NR (2015) Identification of artesunate as a specific activator of ferroptosis in pancreatic cancer cells. Oncoscience 2:517\u2013532","journal-title":"Oncoscience"},{"key":"7696_CR10","doi-asserted-by":"publisher","first-page":"4089","DOI":"10.1038\/onc.2017.11","volume":"36","author":"D Basuli","year":"2017","unstructured":"Basuli D, Tesfay L, Deng Z et al (2017) Iron addiction: a novel therapeutic target in ovarian cancer. Oncogene 36:4089\u20134099","journal-title":"Oncogene"},{"key":"7696_CR11","doi-asserted-by":"publisher","first-page":"4860","DOI":"10.1038\/s41467-021-24859-2","volume":"12","author":"DM Kremer","year":"2021","unstructured":"Kremer DM, Nelson BS, Lin L et al (2021) GOT1 inhibition promotes pancreatic cancer cell death by ferroptosis. Nat Commun 12:4860","journal-title":"Nat Commun"},{"key":"7696_CR12","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.cell.2013.12.010","volume":"156","author":"WS Yang","year":"2014","unstructured":"Yang WS, SriRamaratnam R, Welsch ME et al (2014) Regulation of ferroptotic cancer cell death by GPX4. Cell 156:317\u2013331","journal-title":"Cell"},{"key":"7696_CR13","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20210518","volume":"218","author":"X Chen","year":"2021","unstructured":"Chen X, Kang R, Kroemer G, Tang D (2021) Ferroptosis in infection, inflammation, and immunity. J Exp Med 218:e20210518","journal-title":"J Exp Med"},{"key":"7696_CR14","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110108","volume":"127","author":"Y Sun","year":"2020","unstructured":"Sun Y, Chen P, Zhai B et al (2020) The emerging role of ferroptosis in inflammation. Biomed Pharmacother 127:110108","journal-title":"Biomed Pharmacother"},{"key":"7696_CR15","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1038\/s41420-021-00579-w","volume":"7","author":"Y Yu","year":"2021","unstructured":"Yu Y, Yan Y, Niu F et al (2021) Ferroptosis: a cell death connecting oxidative stress, inflammation and cardiovascular diseases. Cell Death Discov 7:193","journal-title":"Cell Death Discov"},{"key":"7696_CR16","doi-asserted-by":"publisher","unstructured":"Wang F, He J, Xing R, Sha T, Sun B (2021) Molecular mechanisms of ferroptosis and their role in inflammation. Int Rev Immunol. https:\/\/doi.org\/10.1080\/08830185.2021.2016739 (Epub ahead of print)","DOI":"10.1080\/08830185.2021.2016739"},{"key":"7696_CR17","doi-asserted-by":"crossref","unstructured":"Zhou N, Bao J (2020) FerrDb: a manually curated resource for regulators and markers of ferroptosis and ferroptosis-disease associations. Database (Oxford) 2020:baaa021","DOI":"10.1093\/database\/baaa021"},{"key":"7696_CR18","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/1471-2105-14-7","volume":"14","author":"S Hanzelmann","year":"2013","unstructured":"Hanzelmann S, Castelo R, Guinney J (2013) GSVA: gene set variation analysis for microarray and RNA-seq data. BMC Bioinformatics 14:7","journal-title":"BMC Bioinformatics"},{"key":"7696_CR19","doi-asserted-by":"publisher","first-page":"R3","DOI":"10.1186\/gb-2007-8-1-r3","volume":"8","author":"P Carmona-Saez","year":"2007","unstructured":"Carmona-Saez P, Chagoyen M, Tirado F, Carazo JM, Pascual-Montano A (2007) GENECODIS: a web-based tool for finding significant concurrent annotations in gene lists. Genome Biol 8:R3","journal-title":"Genome Biol"},{"key":"7696_CR20","doi-asserted-by":"publisher","first-page":"W317","DOI":"10.1093\/nar\/gkp416","volume":"37","author":"R Nogales-Cadenas","year":"2009","unstructured":"Nogales-Cadenas R, Carmona-Saez P, Vazquez M et al (2009) GeneCodis: interpreting gene lists through enrichment analysis and integration of diverse biological information. Nucleic Acids Res 37:W317\u2013W322","journal-title":"Nucleic Acids Res"},{"key":"7696_CR21","doi-asserted-by":"publisher","first-page":"15545","DOI":"10.1073\/pnas.0506580102","volume":"102","author":"A Subramanian","year":"2005","unstructured":"Subramanian A, Tamayo P, Mootha VK et al (2005) Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A 102:15545\u201315550","journal-title":"Proc Natl Acad Sci U S A"},{"key":"7696_CR22","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.684259","volume":"9","author":"Q Tian","year":"2021","unstructured":"Tian Q, Zhou Y, Zhu L, Gao H, Yang J (2021) Development and Validation of a Ferroptosis-Related Gene Signature for Overall Survival Prediction in Lung Adenocarcinoma. Front Cell Dev Biol 9:684259","journal-title":"Front Cell Dev Biol"},{"key":"7696_CR23","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2107266119","volume":"119","author":"Z Ren","year":"2022","unstructured":"Ren Z, Liang H, Galbo PJ et al (2022) Redox signaling by glutathione peroxidase 2 links vascular modulation to metabolic plasticity of breast cancer. Proc Natl Acad Sci U S A 119:e2107266119","journal-title":"Proc Natl Acad Sci U S A"},{"key":"7696_CR24","doi-asserted-by":"crossref","unstructured":"Du H, Chen B, Jiao NL, et al. (2020) Elevated glutathione peroxidase 2 expression promotes cisplatin resistance in lung adenocarcinoma. Oxid Med Cell Longev 2020:7370157","DOI":"10.1155\/2020\/7370157"},{"key":"7696_CR25","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.1016\/j.neo.2017.10.005","volume":"19","author":"S Hao","year":"2017","unstructured":"Hao S, Yu J, He W et al (2017) Cysteine dioxygenase 1 mediates erastin-induced ferroptosis in human gastric cancer cells. Neoplasia 19:1022\u20131032","journal-title":"Neoplasia"}],"container-title":["European Archives of Oto-Rhino-Laryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00405-022-07696-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00405-022-07696-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00405-022-07696-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,6]],"date-time":"2023-02-06T03:13:06Z","timestamp":1675653186000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00405-022-07696-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,18]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["7696"],"URL":"https:\/\/doi.org\/10.1007\/s00405-022-07696-x","relation":{},"ISSN":["0937-4477","1434-4726"],"issn-type":[{"value":"0937-4477","type":"print"},{"value":"1434-4726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,18]]},"assertion":[{"value":"12 September 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 October 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 October 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was approved by the ethics committee of The Second Affiliated Hospital of Nanchang University.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}