{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:09:32Z","timestamp":1787504972052,"version":"build-2736575974"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2023,3,9]],"date-time":"2023-03-09T00:00:00Z","timestamp":1678320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,3,9]],"date-time":"2023-03-09T00:00:00Z","timestamp":1678320000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Arch Otorhinolaryngol"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1007\/s00405-023-07885-2","type":"journal-article","created":{"date-parts":[[2023,3,9]],"date-time":"2023-03-09T06:03:23Z","timestamp":1678341803000},"page":"2945-2952","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Association between tooth extraction during radiotherapy and the risk of osteoradionecrosis in patients with head and neck cancers"],"prefix":"10.1007","volume":"280","author":[{"given":"Pei-Hsun","family":"Liao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Che","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Yang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsin-Mei","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8599-7430","authenticated-orcid":false,"given":"Tsu-Jen","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,3,9]]},"reference":[{"key":"7885_CR1","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","volume":"71","author":"H Sung","year":"2021","unstructured":"Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A et al (2021) Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin 71:209\u2013249","journal-title":"CA Cancer J Clin"},{"key":"7885_CR2","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.ctrv.2017.07.003","volume":"59","author":"P Strojan","year":"2017","unstructured":"Strojan P, Hutcheson KA, Eisbruch A, Beitler JJ, Langendijk JA, Lee AWM et al (2017) Treatment of late sequelae after radiotherapy for head and neck cancer. Cancer Treat Rev 59:79\u201392","journal-title":"Cancer Treat Rev"},{"key":"7885_CR3","unstructured":"Lalla RV, Brennan MT, Gordon SM, Sonis ST, Rosenthal DI, Keefe DM (2019) Oral mucositis due to high-dose chemotherapy and\/or head and neck radiation therapy. J Natl Cancer Inst Monogr 2019(53):lgz011"},{"key":"7885_CR4","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.tripleo.2011.07.042","volume":"113","author":"S Nabil","year":"2012","unstructured":"Nabil S, Samman N (2012) Risk factors for osteoradionecrosis after head and neck radiation: a systematic review. Oral Surg Oral Med Oral Pathol Oral Radiol 113:54\u201369","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"7885_CR5","doi-asserted-by":"publisher","first-page":"2918","DOI":"10.1002\/cam4.1221","volume":"6","author":"HY Sroussi","year":"2017","unstructured":"Sroussi HY, Epstein JB, Bensadoun RJ, Saunders DP, Lalla RV, Migliorati CA et al (2017) Common oral complications of head and neck cancer radiation therapy: mucositis, infections, saliva change, fibrosis, sensory dysfunctions, dental caries, periodontal disease, and osteoradionecrosis. Cancer Med 6:2918\u20132931","journal-title":"Cancer Med"},{"key":"7885_CR6","doi-asserted-by":"publisher","first-page":"3425","DOI":"10.1007\/s00405-020-06529-z","volume":"278","author":"PH Liao","year":"2021","unstructured":"Liao PH, Chu CH, Hung YM, Tang PL, Kuo TJ (2021) Tumor subsites and risk of osteoradionecrosis of the jaw in patients with oral cavity cancer: a national-based cohort study. Eur Arch Otorhinolaryngol 278:3425\u20133433","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"7885_CR7","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.oraloncology.2016.03.005","volume":"56","author":"TJ Kuo","year":"2016","unstructured":"Kuo TJ, Leung CM, Chang HS, Wu CN, Chen WL, Chen GJ et al (2016) Jaw osteoradionecrosis and dental extraction after head and neck radiotherapy: a nationwide population-based retrospective study in Taiwan. Oral Oncol 56:71\u201377","journal-title":"Oral Oncol"},{"key":"7885_CR8","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1038\/sj.bdj.2018.442","volume":"225","author":"S Clough","year":"2018","unstructured":"Clough S, Burke M, Daly B, Scambler S (2018) The impact of pre-radiotherapy dental extractions on head and neck cancer patients: a qualitative study. Br Dent J 225:28\u201332","journal-title":"Br Dent J"},{"issue":"4","key":"7885_CR9","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1111\/odi.13826","volume":"28","author":"I Saito","year":"2021","unstructured":"Saito I, Hasegawa T, Kawashita Y, Kato S, Yamada SI, Kojima Y et al (2021) Association between dental extraction after radiotherapy and osteoradionecrosis: a multi-centre retrospective study. Oral Dis 28(4):1181\u20131187","journal-title":"Oral Dis"},{"key":"7885_CR10","doi-asserted-by":"publisher","DOI":"10.4178\/epih.e2018062","volume":"40","author":"LY Lin","year":"2018","unstructured":"Lin LY, Warren-Gash C, Smeeth L, Chen PC (2018) Data resource profile: the National Health Insurance Research Database (NHIRD). Epidemiol Health 40:e2018062","journal-title":"Epidemiol Health"},{"key":"7885_CR11","doi-asserted-by":"publisher","first-page":"1741","DOI":"10.1111\/odi.14029","volume":"28","author":"C Lin","year":"2022","unstructured":"Lin C, Shih YJ, Kuo TJ, Liao PH (2022) Letter to the editor - Reply to the \u201cAssociation between dental extraction after radiotherapy and osteoradionecrosis.\u201d Oral Dis 28:1741\u20131742","journal-title":"Oral Dis"},{"key":"7885_CR12","doi-asserted-by":"publisher","first-page":"2171","DOI":"10.1002\/1097-0142(19921015)70:8<2171::AID-CNCR2820700827>3.0.CO;2-S","volume":"70","author":"J Jansma","year":"1992","unstructured":"Jansma J, Vissink A, Spijkervet FK, Roodenburg JL, Panders AK, Vermey A et al (1992) Protocol for the prevention and treatment of oral sequelae resulting from head and neck radiation therapy. Cancer 70:2171\u20132180","journal-title":"Cancer"},{"key":"7885_CR13","doi-asserted-by":"crossref","unstructured":"Eliyas S, Al-Khayatt A, Porter RW, Briggs P (2013) Dental extractions prior to radiotherapy to the jaws for reducing post-radiotherapy dental complications. Cochrane Database Syst Rev 2013(2):CD008857","DOI":"10.1002\/14651858.CD008857.pub2"},{"key":"7885_CR14","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.oooo.2017.04.012","volume":"124","author":"Y Kojima","year":"2017","unstructured":"Kojima Y, Yanamoto S, Umeda M, Kawashita Y, Saito I, Hasegawa T et al (2017) Relationship between dental status and development of osteoradionecrosis of the jaw: a multicenter retrospective study. Oral Surg Oral Med Oral Pathol Oral Radiol 124:139\u2013145","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"7885_CR15","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1007\/s00520-017-3934-y","volume":"26","author":"JM Schuurhuis","year":"2018","unstructured":"Schuurhuis JM, Stokman MA, Witjes MJH, Reintsema H, Langendijk JA, Vissink A et al (2018) Patients with advanced periodontal disease before intensity-modulated radiation therapy are prone to develop bone healing problems: a 2-year prospective follow-up study. Support Care Cancer 26:1133\u20131142","journal-title":"Support Care Cancer"},{"key":"7885_CR16","first-page":"e524","volume":"23","author":"MS Irie","year":"2018","unstructured":"Irie MS, Mendes EM, Borges JS, Osuna LG, Rabelo GD, Soares PB (2018) Periodontal therapy for patients before and after radiotherapy: A review of the literature and topics of interest for clinicians. Medicina oral, patologia oral y cirugia bucal 23:e524\u2013e530","journal-title":"Medicina oral, patologia oral y cirugia bucal"},{"key":"7885_CR17","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1016\/j.tripleo.2007.10.011","volume":"105","author":"K Katsura","year":"2008","unstructured":"Katsura K, Sasai K, Sato K, Saito M, Hoshina H, Hayashi T (2008) Relationship between oral health status and development of osteoradionecrosis of the mandible: a retrospective longitudinal study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 105:731\u2013738","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"7885_CR18","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/j.radonc.2011.09.018","volume":"101","author":"JM Schuurhuis","year":"2011","unstructured":"Schuurhuis JM, Stokman MA, Roodenburg JL, Reintsema H, Langendijk JA, Vissink A et al (2011) Efficacy of routine pre-radiation dental screening and dental follow-up in head and neck oncology patients on intermediate and late radiation effects. A retrospective evaluation. Radiother Oncol 101:403\u2013409","journal-title":"Radiother Oncol"},{"key":"7885_CR19","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1002\/hed.20538","volume":"29","author":"DT Chang","year":"2007","unstructured":"Chang DT, Sandow PR, Morris CG, Hollander R, Scarborough L, Amdur RJ et al (2007) Do pre-irradiation dental extractions reduce the risk of osteoradionecrosis of the mandible? Head Neck 29:528\u2013536","journal-title":"Head Neck"},{"key":"7885_CR20","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1016\/j.ijrobp.2012.05.032","volume":"85","author":"CJ Tsai","year":"2013","unstructured":"Tsai CJ, Hofstede TM, Sturgis EM, Garden AS, Lindberg ME, Wei Q et al (2013) Osteoradionecrosis and radiation dose to the mandible in patients with oropharyngeal cancer. Int J Radiat Oncol Biol Phys 85:415\u2013420","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"7885_CR21","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1002\/hed.23949","volume":"38","author":"JA Chen","year":"2016","unstructured":"Chen JA, Wang CC, Wong YK, Wang CP, Jiang RS, Lin JC et al (2016) Osteoradionecrosis of mandible bone in patients with oral cancer\u2013associated factors and treatment outcomes. Head Neck 38:762\u2013768","journal-title":"Head Neck"},{"key":"7885_CR22","doi-asserted-by":"publisher","first-page":"1313","DOI":"10.1002\/hed.24761","volume":"39","author":"TH Wang","year":"2017","unstructured":"Wang TH, Liu CJ, Chao TF, Chen TJ, Hu YW (2017) Risk factors for and the role of dental extractions in osteoradionecrosis of the jaws: a national-based cohort study. Head Neck 39:1313\u20131321","journal-title":"Head Neck"},{"key":"7885_CR23","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/j.ajoms.2014.03.010","volume":"26","author":"Y-m Jiang","year":"2014","unstructured":"Jiang Y-m, Zhu X-d, Qu S (2014) Incidence of osteoradionecrosis in patients who have undergone dental extraction prior to radiotherapy: a systematic review and meta-analysis. J Oral Maxillofac Surg Med Pathol 26:269\u2013275","journal-title":"J Oral Maxillofac Surg Med Pathol"},{"key":"7885_CR24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13014-020-01701-5","volume":"16","author":"H Kubota","year":"2021","unstructured":"Kubota H, Miyawaki D, Mukumoto N, Ishihara T, Matsumura M, Hasegawa T et al (2021) Risk factors for osteoradionecrosis of the jaw in patients with head and neck squamous cell carcinoma. Radiat Oncol 16:1","journal-title":"Radiat Oncol"},{"key":"7885_CR25","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1007\/s00066-006-1477-0","volume":"182","author":"G Studer","year":"2006","unstructured":"Studer G, Studer SP, Zwahlen RA, Huguenin P, Gr\u00e4tz KW, L\u00fctolf UM et al (2006) Osteoradionecrosis of the mandible: minimized risk profile following intensity-modulated radiation therapy (IMRT). Strahlentherapie und Onkologie Organ der Deutschen Rontgengesellschaft [et al] 182:283\u2013288","journal-title":"Strahlentherapie und Onkologie Organ der Deutschen Rontgengesellschaft [et al]"},{"key":"7885_CR26","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1002\/lary.27870","volume":"130","author":"L Renda","year":"2020","unstructured":"Renda L, Tsai TY, Huang JJ, Ito R, Hsieh WC, Kao HK et al (2020) A nomogram to predict osteoradionecrosis in oral cancer after marginal mandibulectomy and radiotherapy. Laryngoscope 130:101\u2013107","journal-title":"Laryngoscope"},{"key":"7885_CR27","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1038\/s41405-020-00044-3","volume":"6","author":"Z Iqbal","year":"2020","unstructured":"Iqbal Z, Kyzas P (2020) Analysis of the critical dose of radiation therapy in the incidence of Osteoradionecrosis in head and neck cancer patients: a case series. BDJ Open 6:18","journal-title":"BDJ Open"},{"key":"7885_CR28","doi-asserted-by":"publisher","first-page":"359","DOI":"10.2165\/00002018-200831050-00001","volume":"31","author":"K Shim","year":"2008","unstructured":"Shim K, MacKenzie MJ, Winquist E (2008) Chemotherapy-associated osteonecrosis in cancer patients with solid tumours: a systematic review. Drug Saf 31:359\u2013371","journal-title":"Drug Saf"},{"key":"7885_CR29","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.ijom.2010.10.005","volume":"40","author":"S Nabil","year":"2011","unstructured":"Nabil S, Samman N (2011) Incidence and prevention of osteoradionecrosis after dental extraction in irradiated patients: a systematic review. Int J Oral Maxillofac Surg 40:229\u2013243","journal-title":"Int J Oral Maxillofac Surg"}],"container-title":["European Archives of Oto-Rhino-Laryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00405-023-07885-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00405-023-07885-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00405-023-07885-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,11]],"date-time":"2023-05-11T07:12:09Z","timestamp":1683789129000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00405-023-07885-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,9]]},"references-count":29,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["7885"],"URL":"https:\/\/doi.org\/10.1007\/s00405-023-07885-2","relation":{},"ISSN":["0937-4477","1434-4726"],"issn-type":[{"value":"0937-4477","type":"print"},{"value":"1434-4726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,9]]},"assertion":[{"value":"1 October 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 February 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 March 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}