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Children were assessed for auditory development using the LittlEARS Questionnaire (LEAQ) score, and at the same time, measurements were made of matrix metalloproteinase-9 (MMP-9) plasma levels.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>There were significant negative correlations between plasma levels of MMP-9 at 8-month follow-up and LEAQ score at cochlear implantation (<jats:italic>p<\/jats:italic>\u2009=\u20090.04) and LEAQ score at 18-month follow-up (<jats:italic>p<\/jats:italic>\u2009=\u20090.02) and between MMP-9 plasma levels at 18-month follow-up and LEAQ score at cochlear implantation (<jats:italic>p<\/jats:italic>\u2009=\u20090.04). As already reported, we confirmed a significant negative correlation between MMP-9 plasma level at cochlear implantation and LEAQ score at 18-month follow-up (<jats:italic>p<\/jats:italic>\u2009=\u20090.005). Based on this latter correlation, two clusters of good and poor CI performers could be isolated.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The study shows that children born deaf who have an MMP-9 plasma level of less than 150\u00a0ng\/ml at cochlear implantation have a good chance of attaining a high LEAQ score after 18\u00a0months of speech and language rehabilitation. This indicates that MMP-9 plasma level at cochlear implantation is a good prognostic marker for CI outcome.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00405-023-07924-y","type":"journal-article","created":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T05:57:57Z","timestamp":1680501477000},"page":"4361-4369","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["MMP-9 plasma level as biomarker of cochlear implantation outcome in cohort study of deaf children"],"prefix":"10.1007","volume":"280","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1138-3425","authenticated-orcid":false,"given":"Monika","family":"Matusiak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3454-8002","authenticated-orcid":false,"given":"Dominika","family":"Ozi\u0119b\u0142o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4216-9141","authenticated-orcid":false,"given":"Monika","family":"O\u0142dak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0522-5316","authenticated-orcid":false,"given":"Emilia","family":"Rejmak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7207-3490","authenticated-orcid":false,"given":"Leszek","family":"Kaczmarek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominik","family":"Dobek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henryk","family":"Skar\u017cy\u0144ski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,4,1]]},"reference":[{"key":"7924_CR1","doi-asserted-by":"publisher","first-page":"1438","DOI":"10.1056\/NEJMra0911225","volume":"363","author":"A Kral","year":"2010","unstructured":"Kral A, O\u2019Donoghue G (2010) Profound deafness in childhood. 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