{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T02:38:43Z","timestamp":1789699123683,"version":"4.0.1"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2023,4,20]],"date-time":"2023-04-20T00:00:00Z","timestamp":1681948800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,4,20]],"date-time":"2023-04-20T00:00:00Z","timestamp":1681948800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100007653","name":"Universit\u00e4tsklinikum Jena","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007653","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Arch Otorhinolaryngol"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>To determine whether the preoperative inflammatory serum C-reactive protein (CRP) and leukocyte count (LEUK) are associated with postoperative pain and complaints after otolaryngological surgery.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Retrospective evaluation of 680 patients (33% female, median age 50\u00a0years) receiving otolaryngological surgery between November 2008 and March 2017 in a tertiary university hospital. Postoperative pain on the first postoperative day was assessed using the validated questionnaire of the German-wide project Quality Improvement in Postoperative Pain Treatment (QUIPS) including a numeric rating scale for assessment of postoperative pain (NRS, 0\u201310). The influence of preoperative parameters including CRP and LEUK on patients' postoperative pain was estimated.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Mean CRP value was 15.6\u2009\u00b1\u200934.6\u00a0mg\/l and mean LEUK value 7.8\u2009\u00b1\u20093.2 Gpt\/l. Patients with pharyngeal surgery had the highest CRP values (34.6\u2009\u00b1\u200952.9\u00a0mg\/l), highest LEUK values (9.2\u2009\u00b1\u20094.2 Gpt\/l) and the highest pain levels (3.1\u2009\u00b1\u20092.4 NRS) compared to all other surgical procedures (all <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Higher postoperative pain was associated with LEUK values\u2009&gt;\u200911.3 Gpt\/l (<jats:italic>r<\/jats:italic>\u2009=\u20090.093, <jats:italic>p<\/jats:italic>\u2009=\u20090.016) and higher preoperative chronic pain (<jats:italic>r<\/jats:italic>\u2009=\u20090.127, <jats:italic>p<\/jats:italic>\u2009=\u20090.001). Multivariate analysis confirmed younger age, female gender, duration of surgery, preoperative chronic pain, type of surgery, and higher LEUK values\u2009&gt;\u200911.3 as independent factors for postoperative pain. Perioperative antibiotics had no effect on the postoperative pain.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Beyond known factors, preoperative LEUK as inflammation marker is an independent predictor for pain on the first postoperative day.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00405-023-07980-4","type":"journal-article","created":{"date-parts":[[2023,4,20]],"date-time":"2023-04-20T14:28:14Z","timestamp":1682000894000},"page":"3877-3884","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Association between preoperative serum C-reactive protein level and leukocyte count and postoperative pain after otolaryngological surgery"],"prefix":"10.1007","volume":"280","author":[{"given":"Katharina","family":"Gei\u00dfler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"Brock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Winfried","family":"Mei\u00dfner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Kiehntopf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9671-0784","authenticated-orcid":false,"given":"Orlando","family":"Guntinas-Lichius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,4,20]]},"reference":[{"issue":"10","key":"7980_CR1","doi-asserted-by":"publisher","first-page":"1052","DOI":"10.1007\/s001340050715","volume":"24","author":"P P\u00f3voa","year":"1998","unstructured":"P\u00f3voa P, Almeida E, Moreira P, Fernandes A, Mealha R, Arag\u00e3o A, Sabino H (1998) C-reactive protein as an indicator of sepsis. 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All authors have indicated that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in this study involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The study was approved by the local ethics committee.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}