{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T19:57:55Z","timestamp":1792180675268,"version":"4.4.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2023,6,6]],"date-time":"2023-06-06T00:00:00Z","timestamp":1686009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,6,6]],"date-time":"2023-06-06T00:00:00Z","timestamp":1686009600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100006692","name":"Universit\u00e0 degli Studi di Torino","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100006692","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Arch Otorhinolaryngol"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The submandibular gland (SMG) is routinely excised during neck dissection. Given the importance of the SMG in saliva production, it is important to understand its involvement rate by cancer tissue and the feasibility of its preservation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective data were collected from five academic centers in Europe. The study involved adult patients\u00a0affected by primary oral cavity carcinoma (OCC) undergoing tumor excision and neck dissection. The main outcome analyzed was the SMG involvement rate. A systematic review and a meta-analysis were also conducted to provide an updated synthesis of the topic.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 642 patients were enrolled. The SMG involvement rate was 12\/642 (1.9%; 95% CI 1.0\u20133.2) when considered per patient, and 12\/852 (1.4%; 95% CI 0.6\u20132.1) when considered per gland. All the glands involved were ipsilateral to the tumor. Statistical analysis showed that predictive factors for gland invasion were: advanced pT status, advanced nodal involvement, presence of extracapsular spread and perivascular invasion. The involvement of level I lymph nodes was associated with gland invasion in 9 out of 12 cases. pN0 cases were correlated with a reduced risk of SMG involvement. The review of the literature and the meta-analysis confirmed the rare involvement of\u00a0the SMG: on the 4458 patients and 5037 glands analyzed, the involvement rate was 1.8% (99% CI 1.1\u20132.7) and 1.6% (99% CI 1.0\u20132.4), respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The incidence of SMG involvement in primary OCC is rare. Therefore, exploring gland preservation as an option in selected cases would be reasonable. Future prospective studies are needed to investigate the oncological safety and the real impact on quality of life of SMG preservation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00405-023-08007-8","type":"journal-article","created":{"date-parts":[[2023,6,6]],"date-time":"2023-06-06T15:21:16Z","timestamp":1686064876000},"page":"4205-4214","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Submandibular gland involvement in oral cavity squamous cell carcinoma: a retrospective multicenter study"],"prefix":"10.1007","volume":"280","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4444-248X","authenticated-orcid":false,"given":"Oreste","family":"Iocca","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Copelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Garzino-Demo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guglielmo","family":"Ramieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Rubattino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Sedran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Volpe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"Manfuso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Longo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregorio","family":"Sanchez-Aniceto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1lvaro","family":"Rivero-Calle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aitor","family":"Garc\u00eda-S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raul","family":"Pellini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerardo","family":"Petruzzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Moretto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laith","family":"Al-Qamachi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiba","family":"Aga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Ridley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasquale","family":"Di Maio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,6,6]]},"reference":[{"key":"8007_CR1","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1002\/(SICI)1097-0347(200005)22:3<207::AID-HED1>3.0.CO;2-9","volume":"22","author":"LP Kowalski","year":"2000","unstructured":"Kowalski LP, Bagietto R, Lara JRL, Santos RL, Silva JF Jr, Magrin J (2000) Prognostic significance of the distribution of neck node metastasis from oral carcinoma. Head Neck 22:207\u2013214","journal-title":"Head Neck"},{"key":"8007_CR2","doi-asserted-by":"publisher","first-page":"1780","DOI":"10.1001\/jama.1906.25210220006001a","volume":"47","author":"G Crile","year":"1906","unstructured":"Crile G (1906) Excision of cancer of the head and neck with special reference to the plan of dissection base of one hundred and thirty-two operations. JAMA 47:1780\u20131786","journal-title":"JAMA"},{"issue":"1","key":"8007_CR3","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/j.joms.2018.08.007","volume":"77","author":"Z Ding","year":"2019","unstructured":"Ding Z, Xiao T, Huang J, Yuan Y, Ye Q, Xuan M, Xie H, Wang X (2019) Elective neck dissection versus observation in squamous cell carcinoma of oral cavity with clinically N0 neck: a systematic review and meta-analysis of prospective studies. J Oral Maxillofac Surg 77(1):184\u2013194. https:\/\/doi.org\/10.1016\/j.joms.2018.08.007. (Epub 2018 Aug 22 PMID: 30218654)","journal-title":"J Oral Maxillofac Surg"},{"issue":"1","key":"8007_CR4","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1002\/1097-0142(19900701)66:1<109::AID-CNCR2820660120>3.0.CO;2-A","volume":"66","author":"JP Shah","year":"1990","unstructured":"Shah JP, Candela FC, Poddar AK (1990) The patterns of cervical lymph node metastases from squamous carcinoma of the oral cavity. Cancer 66(1):109\u2013113","journal-title":"Cancer"},{"key":"8007_CR5","doi-asserted-by":"publisher","first-page":"104740","DOI":"10.1016\/j.oraloncology.2020.104740","volume":"107","author":"O Iocca","year":"2020","unstructured":"Iocca O, Di Maio P, De Virgilio A, et al (2020) Lymph node yield and lymph node ratio in oral cavity and oropharyngeal carcinoma: Preliminary results from a prospective, multicenter, international cohort. Oral Oncol\u00a0107:104740. https:\/\/doi.org\/10.1016\/j.oraloncology.2020.104740. (Epub 2020 May 4. PMID: 32380357)","journal-title":"Oral Oncol"},{"key":"8007_CR6","doi-asserted-by":"publisher","first-page":"105591","DOI":"10.1016\/j.oraloncology.2021.105591","volume":"123","author":"A George","year":"2021","unstructured":"George A, Saseendran A, Joseph ST, Gopal KR (2021) Submandibular gland\u2014the victim of neck dissection. Oral Oncol 123:105591. https:\/\/doi.org\/10.1016\/j.oraloncology.2021.105591. (Epub 2021 Oct 30. PMID: 34744022)","journal-title":"Oral Oncol"},{"issue":"6","key":"8007_CR7","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1097\/00005537-199806000-00007","volume":"108","author":"DM Cunning","year":"1998","unstructured":"Cunning DM, Lipke N, Wax MK (1998) Significance of unilateral submandibular gland excision on salivary flow in noncancer patients. Laryngoscope 108(6):812\u2013815. https:\/\/doi.org\/10.1097\/00005537-199806000-00007. (PMID: 9628494)","journal-title":"Laryngoscope"},{"key":"8007_CR8","doi-asserted-by":"publisher","first-page":"n71","DOI":"10.1136\/bmj.n71","volume":"372","author":"MJ Page","year":"2021","unstructured":"Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD et al (2021) The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ 372:n71. https:\/\/doi.org\/10.1136\/bmj.n71","journal-title":"BMJ"},{"issue":"3","key":"8007_CR9","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1007\/s12070-016-0966-4","volume":"68","author":"G Agarwal","year":"2016","unstructured":"Agarwal G, Nagpure PS, Chavan SS (2016) Questionable necessity for removing submandibular gland in neck dissection in squamous cell carcinoma of oral cavity. Indian J Otolaryngol Head Neck Surg. 68(3):314\u2013316. https:\/\/doi.org\/10.1007\/s12070-016-0966-4. (Epub 2016 Feb 13. PMID: 27508132; PMCID: PMC4961650)","journal-title":"Indian J Otolaryngol Head Neck Surg."},{"issue":"8","key":"8007_CR10","first-page":"565","volume":"24","author":"K Ashfaq","year":"2014","unstructured":"Ashfaq K, Ashfaq M, Ahmed A, Khan M, Azhar M (2014) Submandibular gland involvement in early stage oral cavity carcinomas: can the gland be left behind? J Coll Physicians Surg Pak 24(8):565\u2013568 (PMID: 25149835)","journal-title":"J Coll Physicians Surg Pak"},{"issue":"2","key":"8007_CR11","first-page":"88","volume":"33","author":"B Basaran","year":"2013","unstructured":"Basaran B, Ulusan M, Orhan KS, Gunes S, Suoglu Y (2013) Is it necessary to remove submandibular glands in squamous cell carcinomas of the oral cavity? Acta Otorhinolaryngol Ital 33(2):88\u201392 (PMID: 23853397; PMCID: PMC3665381)","journal-title":"Acta Otorhinolaryngol Ital"},{"issue":"1","key":"8007_CR12","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1080\/00016480802032801","volume":"129","author":"HK Byeon","year":"2009","unstructured":"Byeon HK, Lim YC, Koo BS, Choi EC (2009) Metastasis to the submandibular gland in oral cavity squamous cell carcinomas: pathologic analysis. Acta Otolaryngol 129(1):96\u2013100. https:\/\/doi.org\/10.1080\/00016480802032801. (PMID: 18607927)","journal-title":"Acta Otolaryngol"},{"issue":"5","key":"8007_CR13","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1017\/S0022215118000592","volume":"132","author":"A Cakir Cetin","year":"2018","unstructured":"Cakir Cetin A, Dogan E, Ozay H, Kumus O, Erdag TK, Karabay N, Sarioglu S, Ikiz AO (2018) Submandibular gland invasion and feasibility of gland-sparing neck dissection in oral cavity carcinoma. J Laryngol Otol 132(5):446\u2013451. https:\/\/doi.org\/10.1017\/S0022215118000592. (Epub 2018 May 3 PMID: 29720283)","journal-title":"J Laryngol Otol"},{"issue":"7","key":"8007_CR14","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1002\/hed.21039","volume":"31","author":"TC Chen","year":"2009","unstructured":"Chen TC, Lo WC, Ko JY, Lou PJ, Yang TL, Wang CP (2009) Rare involvement of submandibular gland by oral squamous cell carcinoma. Head Neck 31(7):877\u2013881. https:\/\/doi.org\/10.1002\/hed.21039. (PMID: 19360744)","journal-title":"Head Neck"},{"issue":"5","key":"8007_CR15","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1002\/hed.21499","volume":"33","author":"M Dhiwakar","year":"2011","unstructured":"Dhiwakar M, Ronen O, Malone J, Rao K, Bell S, Phillips R, Shevlin B, Robbins KT (2011) Feasibility of submandibular gland preservation in neck dissection: a prospective anatomic-pathologic study. Head Neck 33(5):603\u2013609. https:\/\/doi.org\/10.1002\/hed.21499. (Epub 2010 Aug 24 PMID: 20737484)","journal-title":"Head Neck"},{"issue":"8","key":"8007_CR16","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1017\/S0022215111001095","volume":"125","author":"AK Ebrahim","year":"2011","unstructured":"Ebrahim AK, Loock JW, Afrogheh A, Hille J (2011) Is it oncologically safe to leave the ipsilateral submandibular gland during neck dissection for head and neck squamous cell carcinoma? J Laryngol Otol 125(8):837\u2013840. https:\/\/doi.org\/10.1017\/S0022215111001095. (Epub 2011 Jun 2 PMID: 21729447)","journal-title":"J Laryngol Otol"},{"issue":"1","key":"8007_CR17","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1007\/s00405-016-4205-0","volume":"274","author":"C Fives","year":"2017","unstructured":"Fives C, Feeley L, Sadadcharam M, O\u2019Leary G, Sheahan P (2017) Incidence of intraglandular lymph nodes within submandibular gland, and involvement by floor of mouth cancer. Eur Arch Otorhinolaryngol 274(1):461\u2013466. https:\/\/doi.org\/10.1007\/s00405-016-4205-0. (Epub 2016 Jul 23 PMID: 27450469)","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"8007_CR18","doi-asserted-by":"publisher","first-page":"105316","DOI":"10.1016\/j.oraloncology.2021.105316","volume":"118","author":"A Jakhetiya","year":"2021","unstructured":"Jakhetiya A, Kaul P, Pandey A, Patel T, Kumar Meena J, Pal Singh M, Kumar GP (2021) Distribution and determinants of submandibular gland involvement in oral cavity squamous cell carcinoma. Oral Oncol 118:105316. https:\/\/doi.org\/10.1016\/j.oraloncology.2021.105316. (105316. Epub 2021 Apr 30. PMID: 33940532)","journal-title":"Oral Oncol"},{"issue":"114","key":"8007_CR19","doi-asserted-by":"publisher","first-page":"23","DOI":"10.22038\/ijorl.2020.44283.2463","volume":"33","author":"S Javadi","year":"2021","unstructured":"Javadi S, Khademi B, Mohamadianpanah M, Shishegar M, Babaei A (2021) Elective submandibular gland resection in patients with squamous cell carcinomas of the tongue. Iran J Otorhinolaryngol 33(114):23\u201329. https:\/\/doi.org\/10.22038\/ijorl.2020.44283.2463. (PMID:33654687; PMCID:PMC7897437)","journal-title":"Iran J Otorhinolaryngol"},{"issue":"6","key":"8007_CR20","doi-asserted-by":"publisher","first-page":"2024","DOI":"10.1097\/SCS.0b013e3181be87a3","volume":"20","author":"A Kruse","year":"2009","unstructured":"Kruse A, Gr\u00e4tz KW (2009) Evaluation of metastases in the submandibular gland in head and neck malignancy. J Craniofac Surg 20(6):2024\u20132027. https:\/\/doi.org\/10.1097\/SCS.0b013e3181be87a3. (PMID: 19881371)","journal-title":"J Craniofac Surg"},{"issue":"Suppl 1","key":"8007_CR21","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1007\/s12070-014-0803-6","volume":"67","author":"MS Malgonde","year":"2015","unstructured":"Malgonde MS, Kumar M (2015) Practicability of submandibular gland in squamous cell carcinomas of oral cavity. Indian J Otolaryngol Head Neck Surg. 67(Suppl 1):138\u2013140. https:\/\/doi.org\/10.1007\/s12070-014-0803-6. (Epub 2014 Nov 22. PMID: 25621270; PMCID: PMC4298607)","journal-title":"Indian J Otolaryngol Head Neck Surg."},{"issue":"11","key":"8007_CR22","doi-asserted-by":"publisher","first-page":"1703","DOI":"10.1002\/hed.24508","volume":"38","author":"A Malik","year":"2016","unstructured":"Malik A, Joshi P, Mishra A, Garg A, Mair M, Chakrabarti S, Nair S, Nair D, Chaturvedi P (2016) Prospective study of the pattern of lymphatic metastasis in relation to the submandibular gland in patients with carcinoma of the oral cavity. Head Neck 38(11):1703\u20131707. https:\/\/doi.org\/10.1002\/hed.24508. (Epub 2016 May 27 PMID: 27232643)","journal-title":"Head Neck"},{"issue":"2","key":"8007_CR23","doi-asserted-by":"publisher","first-page":"103329","DOI":"10.1016\/j.amjoto.2021.103329","volume":"43","author":"A Mazarei","year":"2021","unstructured":"Mazarei A, Khamushian P, Sadeghi Ivraghi M, Heidari F, Saeedi N, Golparvaran S, Yazdani N, Aghazadeh K (2021) Prevalence of submandibular gland involvement in neck dissection specimens of patients with oral cavity carcinoma. Am J Otolaryngol 43(2):103329. https:\/\/doi.org\/10.1016\/j.amjoto.2021.103329. (Epub ahead of print. PMID: 34972007)","journal-title":"Am J Otolaryngol"},{"issue":"3","key":"8007_CR24","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1017\/S0022215111002660","volume":"126","author":"TK Naidu","year":"2012","unstructured":"Naidu TK, Naidoo SK, Ramdial PK (2012) Oral cavity squamous cell carcinoma metastasis to the submandibular gland. J Laryngol Otol 126(3):279\u2013284. https:\/\/doi.org\/10.1017\/S0022215111002660. (Epub 2011 Oct 13 PMID: 22017858)","journal-title":"J Laryngol Otol"},{"issue":"11","key":"8007_CR25","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1016\/j.ijom.2012.07.016","volume":"41","author":"EM Okoturo","year":"2012","unstructured":"Okoturo EM, Trivedi NP, Kekatpure V, Gangoli A, Shetkar GS, Mohan M, Kuriakose MA (2012) A retrospective evaluation of submandibular gland involvement in oral cavity cancers: a case for gland preservation. Int J Oral Maxillofac Surg 41(11):1383\u20131386. https:\/\/doi.org\/10.1016\/j.ijom.2012.07.016. (Epub 2012 Sep 1 PMID: 22944141)","journal-title":"Int J Oral Maxillofac Surg"},{"issue":"4","key":"8007_CR26","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1016\/j.anl.2015.02.006","volume":"42","author":"NK Panda","year":"2015","unstructured":"Panda NK, Patro SK, Bakshi J, Verma RK, Das A, Chatterjee D (2015) Metastasis to submandibular glands in oral cavity cancers: Can we preserve the gland safely? Auris Nasus Larynx 42(4):322\u2013325. https:\/\/doi.org\/10.1016\/j.anl.2015.02.006. (Epub 2015 Feb 25 PMID: 25724734)","journal-title":"Auris Nasus Larynx"},{"issue":"2","key":"8007_CR27","doi-asserted-by":"publisher","first-page":"e279","DOI":"10.1055\/s-0040-1709117","volume":"25","author":"HA Pasha","year":"2021","unstructured":"Pasha HA, Dhanani R, Ghaloo SK, Ghias K, Khan MJ (2021) Level I nodal positivity as a factor for involvement of the submandibular gland in oral cavity carcinoma: a case series report. Int Arch Otorhinolaryngol. 25(2):e279\u2013e283. https:\/\/doi.org\/10.1055\/s-0040-1709117. (PMID: 33968233; PMCID: PMC8096506)","journal-title":"Int Arch Otorhinolaryngol."},{"issue":"12","key":"8007_CR28","doi-asserted-by":"publisher","first-page":"1619","DOI":"10.1002\/hed.21129","volume":"31","author":"A Razfar","year":"2009","unstructured":"Razfar A, Walvekar RR, Melkane A, Johnson JT, Myers EN (2009) Incidence and patterns of regional metastasis in early oral squamous cell cancers: feasibility of submandibular gland preservation. Head Neck 31(12):1619\u20131623. https:\/\/doi.org\/10.1002\/hed.21129. (PMID: 19475546)","journal-title":"Head Neck"},{"issue":"12","key":"8007_CR29","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.1002\/hed.20109","volume":"26","author":"JH Spiegel","year":"2004","unstructured":"Spiegel JH, Brys AK, Bhakti A, Singer MI (2004) Metastasis to the submandibular gland in head and neck carcinomas. Head Neck 26(12):1064\u20131068. https:\/\/doi.org\/10.1002\/hed.20109. (PMID: 15459920)","journal-title":"Head Neck"},{"issue":"2","key":"8007_CR30","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/j.bjoms.2019.11.016","volume":"58","author":"S Yang","year":"2020","unstructured":"Yang S, Su JZ, Gao Y, Yu GY (2020) Clinicopathological study of involvement of the submandibular gland in oral squamous cell carcinoma. Br J Oral Maxillofac Surg 58(2):203\u2013207. https:\/\/doi.org\/10.1016\/j.bjoms.2019.11.016. (Epub 2019 Dec 19 PMID: 31864860)","journal-title":"Br J Oral Maxillofac Surg"},{"issue":"4","key":"8007_CR31","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/j.jormas.2019.12.004","volume":"121","author":"S Yang","year":"2020","unstructured":"Yang S, Su JZ, Gao Y, Yu GY (2020) Involvement of the submandibular gland in oral squamous cell carcinoma patients with positive lymph nodes. J Stomatol Oral Maxillofac Surg 121(4):373\u2013376. https:\/\/doi.org\/10.1016\/j.jormas.2019.12.004. (Epub 2019 Dec 19 PMID: 31866411)","journal-title":"J Stomatol Oral Maxillofac Surg"},{"issue":"15","key":"8007_CR32","doi-asserted-by":"publisher","first-page":"2391","DOI":"10.1016\/j.ejca.2012.04.005","volume":"48","author":"WK So","year":"2012","unstructured":"So WK, Chan RJ, Chan DN, Hughes BG, Chair SY, Choi KC, Chan CW (2012) Quality-of-life among head and neck cancer survivors at one year after treatment\u2013a systematic review. Eur J Cancer 48(15):2391\u20132408. https:\/\/doi.org\/10.1016\/j.ejca.2012.04.005. (Epub 2012 May 12 PMID: 22579456)","journal-title":"Eur J Cancer"},{"issue":"1","key":"8007_CR33","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1186\/s12885-020-07534-5.PMID:33109130;PMCID:PMC7592590","volume":"20","author":"B Gu","year":"2020","unstructured":"Gu B, Fang Q, Wu Y, Du W, Zhang X, Chen D (2020) Impact of submandibular gland preservation in neck management of early-stage buccal squamous cell carcinoma on locoregional control and disease-specific survival. BMC Cancer 20(1):1034. https:\/\/doi.org\/10.1186\/s12885-020-07534-5.PMID:33109130;PMCID:PMC7592590","journal-title":"BMC Cancer"},{"issue":"8","key":"8007_CR34","doi-asserted-by":"publisher","first-page":"2756","DOI":"10.1002\/hed.25761","volume":"41","author":"M Tagliabue","year":"2019","unstructured":"Tagliabue M, Gandini S, Maffini F, Navach V, Bruschini R, Giugliano G, Lombardi F, Chiocca S, Rebecchi E, Sica E, Tommasino M, Calabrese L, Ansarin M (2019) The role of the T-N tract in advanced stage tongue cancer. Head Neck 41(8):2756\u20132767. https:\/\/doi.org\/10.1002\/hed.25761. (PMID: 30942940)","journal-title":"Head Neck"},{"key":"8007_CR35","doi-asserted-by":"publisher","DOI":"10.1111\/odi.13885","author":"D Alterio","year":"2021","unstructured":"Alterio D, Augugliaro M, Tagliabue M, Bruschini R, Gandini S, Calabrese L, Belloni P, Preda L, Maffini FA, Marvaso G, Ferrari A, Volpe S, Zerella MA, Oneta O, Turturici I, Ombretta A, Francesca R, Mohssen A, Orecchia R, Jereczek-Fossa BA (2021) The T-N tract involvement as a new prognostic factor for PORT in locally advanced oral cavity tumors. Oral Dis. https:\/\/doi.org\/10.1111\/odi.13885. (PMID: 33893695)","journal-title":"Oral Dis"},{"issue":"5","key":"8007_CR36","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1016\/j.jcms.2020.02.010","volume":"48","author":"A Ferri","year":"2020","unstructured":"Ferri A, Perlangeli G, Montalto N, Carrillo Lizarazo JL, Bianchi B, Ferrari S, Nicolai P, Sesenna E, Grammatica A (2020) Transoral resection with buccinator flap reconstruction vs. pull-through resection and free flap reconstruction for the management of T1\/T2 cancer of the tongue and floor of the mouth. J Craniomaxillofac Surg 48(5):514\u2013520. https:\/\/doi.org\/10.1016\/j.jcms.2020.02.010. (PMID: 32171649)","journal-title":"J Craniomaxillofac Surg"},{"issue":"5","key":"8007_CR37","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1097\/COC.0b013e318261054e","volume":"37","author":"WM Mendenhall","year":"2014","unstructured":"Mendenhall WM, Mendenhall CM, Mendenhall NP (2014) Submandibular gland-sparing intensity-modulated radiotherapy. Am J Clin Oncol 37(5):514\u2013516. https:\/\/doi.org\/10.1097\/COC.0b013e318261054e. (PMID: 22892434)","journal-title":"Am J Clin Oncol"},{"issue":"4","key":"8007_CR38","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1097\/COC.0000000000000064","volume":"38","author":"M Tam","year":"2015","unstructured":"Tam M, Riaz N, Kannarunimit D, Pe\u00f1a AP, Schupak KD, Gelblum DY, Wolden SL, Rao S, Lee NY (2015) Sparing bilateral neck level IB in oropharyngeal carcinoma and xerostomia outcomes. Am J Clin Oncol 38(4):343\u2013347. https:\/\/doi.org\/10.1097\/COC.0000000000000064. (PMID:26208401;PMCID:PMC5508539)","journal-title":"Am J Clin Oncol"},{"issue":"3","key":"8007_CR39","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1002\/lary.24907","volume":"125","author":"Y Yu","year":"2015","unstructured":"Yu Y, Daly ME, Farwell DG, Luu Q, Gandour-Edwards R, Donald PJ, Chen AM (2015) Level IB nodal involvement in oropharyngeal carcinoma: implications for submandibular gland-sparing intensity-modulated radiotherapy. Laryngoscope 125(3):608\u2013614. https:\/\/doi.org\/10.1002\/lary.24907. (Epub 2014 Sep 12 PMID: 25215891)","journal-title":"Laryngoscope"},{"key":"8007_CR40","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.oraloncology.2018.12.021","volume":"89","author":"V Varra","year":"2019","unstructured":"Varra V, Ross RB, Juloori A, Campbell S, Tom MC, Joshi NP, Woody NM, Ward MC, Xia P, Koyfman SA, Greskovich JF Jr (2019) Selectively sparing the submandibular gland when level Ib lymph nodes are included in the radiation target volume: an initial safety analysis of a novel planning objective. Oral Oncol 89:79\u201383. https:\/\/doi.org\/10.1016\/j.oraloncology.2018.12.021. (Epub 2018 Dec 26 PMID: 30732963)","journal-title":"Oral Oncol"}],"container-title":["European Archives of Oto-Rhino-Laryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00405-023-08007-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00405-023-08007-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00405-023-08007-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,28]],"date-time":"2023-07-28T08:13:23Z","timestamp":1690532003000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00405-023-08007-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,6]]},"references-count":40,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["8007"],"URL":"https:\/\/doi.org\/10.1007\/s00405-023-08007-8","relation":{},"ISSN":["0937-4477","1434-4726"],"issn-type":[{"value":"0937-4477","type":"print"},{"value":"1434-4726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,6]]},"assertion":[{"value":"29 May 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 May 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 June 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"No conflict of interest to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}