{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T21:04:26Z","timestamp":1783631066227,"version":"3.55.0"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T00:00:00Z","timestamp":1685404800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T00:00:00Z","timestamp":1685404800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100006447","name":"University of Zurich","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100006447","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Arch Otorhinolaryngol"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Studies investigating the impact of sinus surgery for cystic fibrosis (CF) patients performed early after lung transplantation (Ltx) are scarce. Recent studies evaluating frequency of respiratory infections and graft outcomes are not available.\n<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Objectives\/hypothesis<\/jats:title>\n                <jats:p>To determine whether there is a difference in allograft infection, allograft function and overall survival among CF lung transplant recipients with and without concomitant sinus surgery.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Study design<\/jats:title>\n                <jats:p>Retrospective single-center study.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We examined 71 CF patients who underwent Ltx between 2009 and 2019 at our center. Fifty-nine patients had sinus surgery before or\/and after transplantation and twelve did not undergo sinus surgery. We assessed the survival, the diagnosis of chronic allograft dysfunction (CLAD) and all elevated (&gt;\u20095\u00a0mg\/l) c-reactive protein episodes during the observed period. The infectious events of the upper and lower airways were categorized in mild infections (5\u201315\u00a0mg\/l CRP) and severe infections (&gt;\u200915\u00a0mg\/l CRP).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>There was no difference in the long-time overall survival (<jats:italic>p<\/jats:italic>\u2009=\u20090.87) and no benefit in the short-term survival at 4 year post-transplant (<jats:italic>p<\/jats:italic>\u2009=\u20090.29) in both groups. There was no difference in both groups concerning CLAD diagnosis (<jats:italic>p<\/jats:italic>\u2009=\u20090.92). The incidence of severe upper and lower airway infections (CRP\u2009&gt;\u200915\u00a0mg\/l) was significantly decreased in the sinus surgery group (<jats:italic>p<\/jats:italic>\u2009=\u20090.015), whereas in mild infections there was a trend to decreased infections in the sinus surgery group (<jats:italic>p<\/jats:italic>\u2009=\u20090.056).\n<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>CF patients undergoing Ltx benefit from extended endoscopic\u00a0sinus surgery (eESS) in terms of frequency of severe infectious events of the upper and lower airways. There was no difference in overall survival and frequency of CLAD in the two groups.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00405-023-08028-3","type":"journal-article","created":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T08:02:31Z","timestamp":1685433751000},"page":"4501-4507","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Impact of extended sinus surgery on allograft infection, allograft function and overall survival in cystic fibrosis lung transplant recipients"],"prefix":"10.1007","volume":"280","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2012-4847","authenticated-orcid":false,"given":"Manuel","family":"Meier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mac\u00e9 M.","family":"Schuurmans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenic","family":"Vital","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilhan","family":"Inci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Holzman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael B.","family":"Soyka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,5,30]]},"reference":[{"issue":"9678","key":"8028_CR1","doi-asserted-by":"publisher","first-page":"1891","DOI":"10.1016\/S0140-6736(09)60327-5","volume":"373","author":"BP O'Sullivan","year":"2009","unstructured":"O\u2019Sullivan BP, Freedman SD (2009) Cystic fibrosis. Lancet 373(9678):1891\u20131904. https:\/\/doi.org\/10.1016\/S0140-6736(09)60327-5","journal-title":"Lancet"},{"issue":"9358","key":"8028_CR2","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1016\/S0140-6736(03)12567-6","volume":"361","author":"F Ratjen","year":"2003","unstructured":"Ratjen F, D\u00f6ring G (2003) Cystic fibrosis. Lancet 361(9358):681\u2013689. https:\/\/doi.org\/10.1016\/S0140-6736(03)12567-6","journal-title":"Lancet"},{"issue":"4","key":"8028_CR3","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1016\/j.healun.2008.12.025","volume":"28","author":"M Hofer","year":"2009","unstructured":"Hofer M, Benden C, Inci I et al (2009) True survival benefit of lung transplantation for cystic fibrosis patients: the Zurich experience. J Heart Lung Transplant 28(4):334\u2013339. https:\/\/doi.org\/10.1016\/j.healun.2008.12.025","journal-title":"J Heart Lung Transplant"},{"issue":"1","key":"8028_CR4","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1007\/s00405-012-2002-y","volume":"270","author":"D Vital","year":"2013","unstructured":"Vital D, Hofer M, Boehler A, Holzmann D (2013) Posttransplant sinus surgery in lung transplant recipients with cystic fibrosis: a single institutional experience. Eur Arch Otorhinolaryngol 270(1):135\u2013139. https:\/\/doi.org\/10.1007\/s00405-012-2002-y","journal-title":"Eur Arch Otorhinolaryngol"},{"issue":"6","key":"8028_CR5","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1002\/alr.22935","volume":"12","author":"JR Johnson","year":"2022","unstructured":"Johnson JR, Hwang PH, Nayak JV, Patel ZM (2022) Comparison of endoscopic sinus surgery timing in lung transplant patients with cystic fibrosis. Int Forum Allergy Rhinol 12(6):821\u2013827. https:\/\/doi.org\/10.1002\/alr.22935","journal-title":"Int Forum Allergy Rhinol"},{"issue":"6","key":"8028_CR6","doi-asserted-by":"publisher","first-page":"1451","DOI":"10.1007\/s00330-003-1825-8","volume":"13","author":"HB Eggesb\u00f8","year":"2003","unstructured":"Eggesb\u00f8 HB, S\u00f8vik S, D\u00f8lvik S, Eiklid K, Kolmannskog F (2003) Proposal of a CT scoring system of the paranasal sinuses in diagnosing cystic fibrosis. Eur Radiol 13(6):1451\u20131460. https:\/\/doi.org\/10.1007\/s00330-003-1825-8","journal-title":"Eur Radiol"},{"issue":"1","key":"8028_CR7","doi-asserted-by":"publisher","first-page":"3918","DOI":"10.1038\/s41598-020-60936-0","volume":"10","author":"W Figiel","year":"2020","unstructured":"Figiel W, Gr\u0105t M, Niewi\u0144ski G, Patkowski W, Zieniewicz K (2020) Applicability of common inflammatory markers in diagnosing infections in early period after liver transplantation in intensive care setting. Sci Rep 10(1):3918. https:\/\/doi.org\/10.1038\/s41598-020-60936-0","journal-title":"Sci Rep"},{"issue":"2","key":"8028_CR8","doi-asserted-by":"publisher","first-page":"192","DOI":"10.2500\/ajr.2008.22.3146","volume":"22","author":"M-K Leung","year":"2008","unstructured":"Leung M-K, Rachakonda L, Weill D, Hwang PH (2008) Effects of sinus surgery on lung transplantation outcomes in cystic fibrosis. Am J Rhinol 22(2):192\u2013196. https:\/\/doi.org\/10.2500\/ajr.2008.22.3146","journal-title":"Am J Rhinol"},{"issue":"1","key":"8028_CR9","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1097\/01.TP.0000100467.74330.49","volume":"77","author":"D Holzmann","year":"2004","unstructured":"Holzmann D, Speich R, Kaufmann T et al (2004) Effects of sinus surgery in patients with cystic fibrosis after lung transplantation: a 10-year experience. Transplantation 77(1):134\u2013136. https:\/\/doi.org\/10.1097\/01.TP.0000100467.74330.49","journal-title":"Transplantation"},{"issue":"1","key":"8028_CR10","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1159\/000339627","volume":"86","author":"D Vital","year":"2013","unstructured":"Vital D, Hofer M, Benden C, Holzmann D, Boehler A (2013) Impact of sinus surgery on pseudomonal airway colonization, bronchiolitis obliterans syndrome and survival in cystic fibrosis lung transplant recipients. Respiration 86(1):25\u201331. https:\/\/doi.org\/10.1159\/000339627","journal-title":"Respiration"},{"key":"8028_CR11","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/S8756-3452(08)79140-0","volume":"2009","author":"J Maurer","year":"2009","unstructured":"Maurer J (2009) Pseudomonas aeruginosa colonization of the allograft after lung transplantation and the risk of Bronchiolitis Obliterans syndrome. Yearbook Pulmonary Dis 2009:255\u2013256. https:\/\/doi.org\/10.1016\/S8756-3452(08)79140-0","journal-title":"Yearbook Pulmonary Dis"},{"issue":"5","key":"8028_CR12","doi-asserted-by":"publisher","first-page":"387","DOI":"10.2500\/ajra.2013.27.3919","volume":"27","author":"MR Chaaban","year":"2013","unstructured":"Chaaban MR, Kejner A, Rowe SM, Woodworth BA (2013) Cystic fibrosis chronic rhinosinusitis: a comprehensive review. Am J Rhinol Allergy 27(5):387\u2013395. https:\/\/doi.org\/10.2500\/ajra.2013.27.3919","journal-title":"Am J Rhinol Allergy"},{"key":"8028_CR13","doi-asserted-by":"publisher","unstructured":"Taylor CJ, McGaw J, Howden R, Duerden BI, Baxter PS. Bacterial reservoirs in cystic fibrosis. Arch Dis Child. 1990;65(2):175-177. https:\/\/doi.org\/10.1136\/adc.65.2.175","DOI":"10.1136\/adc.65.2.175"},{"issue":"6","key":"8028_CR14","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1136\/thx.47.6.426","volume":"47","author":"RF Taylor","year":"1992","unstructured":"Taylor RF, Morgan DW, Nicholson PS, Mackay IS, Hodson ME, Pitt TL (1992) Extrapulmonary sites of Pseudomonas aeruginosa in adults with cystic fibrosis. Thorax 47(6):426\u2013428. https:\/\/doi.org\/10.1136\/thx.47.6.426","journal-title":"Thorax"},{"issue":"6","key":"8028_CR15","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1136\/thx.2008.104711","volume":"64","author":"JG Mainz","year":"2009","unstructured":"Mainz JG, Naehrlich L, Schien M et al (2009) Concordant genotype of upper and lower airways P. aeruginosa and S. aureus isolates in cystic fibrosis. Thorax 64(6):535\u2013540. https:\/\/doi.org\/10.1136\/thx.2008.104711","journal-title":"Thorax"},{"issue":"2","key":"8028_CR16","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.jcf.2011.10.009","volume":"11","author":"JG Mainz","year":"2012","unstructured":"Mainz JG, Hentschel J, Schien C et al (2012) Sinonasal persistence of Pseudomonas aeruginosa after lung transplantation. J Cyst Fibros 11(2):158\u2013161. https:\/\/doi.org\/10.1016\/j.jcf.2011.10.009","journal-title":"J Cyst Fibros"},{"issue":"5","key":"8028_CR17","doi-asserted-by":"publisher","first-page":"e12924","DOI":"10.1111\/tid.12924","volume":"20","author":"LC Morlacchi","year":"2018","unstructured":"Morlacchi LC, Greer M, Tudorache I et al (2018) The burden of sinus disease in cystic fibrosis lung transplant recipients. Transpl Infect Dis 20(5):e12924. https:\/\/doi.org\/10.1111\/tid.12924","journal-title":"Transpl Infect Dis"},{"issue":"3","key":"8028_CR18","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1002\/alr.22067","volume":"8","author":"KJ Choi","year":"2018","unstructured":"Choi KJ, Cheng TZ, Honeybrook AL et al (2018) Correlation between sinus and lung cultures in lung transplant patients with cystic fibrosis. Int Forum Allergy Rhinol 8(3):389\u2013393. https:\/\/doi.org\/10.1002\/alr.22067","journal-title":"Int Forum Allergy Rhinol"},{"issue":"3","key":"8028_CR19","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1002\/lary.27454","volume":"129","author":"SD Pletcher","year":"2019","unstructured":"Pletcher SD, Goldberg AN, Cope EK (2019) Loss of microbial niche specificity between the upper and lower airways in patients with cystic fibrosis. Laryngoscope 129(3):544\u2013550. https:\/\/doi.org\/10.1002\/lary.27454","journal-title":"Laryngoscope"},{"issue":"2","key":"8028_CR20","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/j.otohns.2006.01.027","volume":"135","author":"A Shatz","year":"2006","unstructured":"Shatz A (2006) Management of recurrent sinus disease in children with cystic fibrosis: a combined approach. Otolaryngol Head Neck Surg 135(2):248\u2013252. https:\/\/doi.org\/10.1016\/j.otohns.2006.01.027","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"1","key":"8028_CR21","doi-asserted-by":"publisher","first-page":"70","DOI":"10.2500\/ajra.2012.26.3705","volume":"26","author":"FW Virgin","year":"2012","unstructured":"Virgin FW, Rowe SM, Wade MB et al (2012) Extensive surgical and comprehensive postoperative medical management for cystic fibrosis chronic rhinosinusitis. Am J Rhinol Allergy 26(1):70\u201375. https:\/\/doi.org\/10.2500\/ajra.2012.26.3705","journal-title":"Am J Rhinol Allergy"},{"issue":"5","key":"8028_CR22","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.1007\/s00405-019-05308-9","volume":"276","author":"P Luparello","year":"2019","unstructured":"Luparello P, Lazio MS, Voltolini L, Borchi B, Taccetti G, Maggiore G (2019) Outcomes of endoscopic sinus surgery in adult lung transplant patients with cystic fibrosis. Eur Arch Otorhinolaryngol 276(5):1341\u20131347. https:\/\/doi.org\/10.1007\/s00405-019-05308-9","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"8028_CR23","doi-asserted-by":"publisher","unstructured":"Tracy Z. Cheng, MHS, Kevin J. Choi, et al. Decreased antibiotic utilization after sinus surgery in cystic fibrosis patients with lung transplantation. Am J Rhinol Allergy. 2019;33(4):354-358. https:\/\/doi.org\/10.1177\/1945892419830624","DOI":"10.1177\/1945892419830624"},{"key":"8028_CR24","doi-asserted-by":"publisher","DOI":"10.1002\/lary.30642","author":"S Uyttebroek","year":"2023","unstructured":"Uyttebroek S, Dupont L, Jorissen M, van Gerven L (2023) Upper airway disease in adults with cystic fibrosis in the era of CFTR modulators. Laryngoscope. https:\/\/doi.org\/10.1002\/lary.30642","journal-title":"Laryngoscope"}],"container-title":["European Archives of Oto-Rhino-Laryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00405-023-08028-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00405-023-08028-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00405-023-08028-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T06:04:00Z","timestamp":1693807440000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00405-023-08028-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,30]]},"references-count":24,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["8028"],"URL":"https:\/\/doi.org\/10.1007\/s00405-023-08028-3","relation":{},"ISSN":["0937-4477","1434-4726"],"issn-type":[{"value":"0937-4477","type":"print"},{"value":"1434-4726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,30]]},"assertion":[{"value":"8 March 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 May 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 May 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}