{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T13:21:22Z","timestamp":1770038482839,"version":"3.49.0"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2023,7,19]],"date-time":"2023-07-19T00:00:00Z","timestamp":1689724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,7,19]],"date-time":"2023-07-19T00:00:00Z","timestamp":1689724800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Arch Otorhinolaryngol"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1007\/s00405-023-08129-z","type":"journal-article","created":{"date-parts":[[2023,7,19]],"date-time":"2023-07-19T15:04:30Z","timestamp":1689779070000},"page":"4285-4290","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The causal association between peripheral blood eosinophils and nasal polyps: a Mendelian randomization study"],"prefix":"10.1007","volume":"280","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9477-3519","authenticated-orcid":false,"given":"Guan-Jiang","family":"Huang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zi-Qing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi-Jun","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shao-Hua","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,7,19]]},"reference":[{"key":"8129_CR1","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1056\/NEJMcp1800215","volume":"381","author":"C Hopkins","year":"2019","unstructured":"Hopkins C (2019) Chronic rhinosinusitis with nasal polyps. N Engl J Med 381:55\u201363","journal-title":"N Engl J Med"},{"key":"8129_CR2","doi-asserted-by":"publisher","first-page":"1638","DOI":"10.1016\/S0140-6736(19)31881-1","volume":"394","author":"C Bachert","year":"2019","unstructured":"Bachert C, Han JK, Desrosiers M et al (2019) Efficacy and safety of dupilumab in patients with severe chronic rhinosinusitis with nasal polyps (LIBERTY NP SINUS-24 and LIBERTY NP SINUS-52): results from two multicentre, randomised, double-blind, placebo-controlled, parallel-group phase 3 trials. Lancet 394:1638\u20131650","journal-title":"Lancet"},{"key":"8129_CR3","doi-asserted-by":"publisher","first-page":"2337","DOI":"10.1111\/all.14809","volume":"76","author":"I Agache","year":"2021","unstructured":"Agache I, Song Y, Alonso-Coello P et al (2021) Efficacy and safety of treatment with biologicals for severe chronic rhinosinusitis with nasal polyps: a systematic review for the EAACI guidelines. Allergy 76:2337\u20132353","journal-title":"Allergy"},{"key":"8129_CR4","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1186\/s13223-022-00739-2","volume":"18","author":"T Pongdee","year":"2022","unstructured":"Pongdee T, Bielinski SJ, Decker PA, Kita H, Larson NB (2022) White blood cells and chronic rhinosinusitis: a Mendelian randomization study. Allergy Asthma Clin Immunol 18:98","journal-title":"Allergy Asthma Clin Immunol"},{"key":"8129_CR5","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1111\/coa.13990","volume":"48","author":"Q Luo","year":"2023","unstructured":"Luo Q, Zhou S, Yuan B et al (2023) Blood eosinophil count in the diagnosis of allergic-like rhinitis with chronic rhinosinusitis. Clin Otolaryngol 48:339\u2013346","journal-title":"Clin Otolaryngol"},{"key":"8129_CR6","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.jaci.2020.04.040","volume":"146","author":"T Delemarre","year":"2020","unstructured":"Delemarre T, Holtappels G, De Ruyck N et al (2020) Type 2 inflammation in chronic rhinosinusitis without nasal polyps: Another\u00a0 relevant endotype. J Allergy Clin Immunol 146:337\u2013343","journal-title":"J Allergy Clin Immunol"},{"key":"8129_CR7","doi-asserted-by":"publisher","first-page":"1054201","DOI":"10.3389\/fimmu.2022.1054201","volume":"13","author":"Z Wang","year":"2022","unstructured":"Wang Z, Wang Q, Duan S et al (2022) A diagnostic model for predicting type 2 nasal polyps using biomarkers in nasal secretion. Front Immunol 13:1054201","journal-title":"Front Immunol"},{"key":"8129_CR8","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1016\/j.jaci.2006.05.031","volume":"118","author":"P Gevaert","year":"2006","unstructured":"Gevaert P, Lang-Loidolt D, Lackner A et al (2006) Nasal IL-5 levels determine the response to anti-IL-5 treatment in patients with nasal polyps. J Allergy Clin Immunol 118:1133\u20131141","journal-title":"J Allergy Clin Immunol"},{"key":"8129_CR9","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.k601","volume":"362","author":"NM Davies","year":"2018","unstructured":"Davies NM, Holmes MV, Davey SG (2018) Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians. BMJ 362:k601","journal-title":"BMJ"},{"key":"8129_CR10","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1002\/sim.3034","volume":"27","author":"DA Lawlor","year":"2008","unstructured":"Lawlor DA, Harbord RM, Sterne JA, Timpson N, Davey SG (2008) Mendelian randomization: using genes as instruments for making causal inferences in epidemiology. Stat Med 27:1133\u20131163","journal-title":"Stat Med"},{"key":"8129_CR11","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a040501","volume":"12","author":"RC Richmond","year":"2022","unstructured":"Richmond RC, Davey SG (2022) Mendelian randomization: concepts and scope. Cold Spring Harb Perspect Med 12:a040501","journal-title":"Cold Spring Harb Perspect Med"},{"key":"8129_CR12","doi-asserted-by":"publisher","first-page":"1614","DOI":"10.1001\/jama.2021.18236","volume":"326","author":"VW Skrivankova","year":"2021","unstructured":"Skrivankova VW, Richmond RC, Woolf B et al (2021) Strengthening the reporting of observational studies in epidemiology using Mendelian randomization: the STROBE-MR statement. JAMA 326:1614\u20131621","journal-title":"JAMA"},{"key":"8129_CR13","doi-asserted-by":"publisher","first-page":"2785","DOI":"10.1007\/s00405-022-07798-6","volume":"280","author":"Z Zhang","year":"2022","unstructured":"Zhang Z, Li G, Yu L et al (2022) Causal relationships between potential risk factors and chronic rhinosinusitis: a bidirectional two-sample Mendelian randomization study. Eur Arch Otorhinolaryngol 280:2785\u20132793","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"8129_CR14","doi-asserted-by":"publisher","first-page":"2816","DOI":"10.1093\/eurheartj\/ehab291","volume":"42","author":"S Park","year":"2021","unstructured":"Park S, Lee S, Kim Y et al (2021) Atrial fibrillation and kidney function: a bidirectional Mendelian randomization study. Eur Heart J 42:2816\u20132823","journal-title":"Eur Heart J"},{"issue":"Suppl 1","key":"8129_CR15","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1016\/S2214-109X(23)00086-4","volume":"11","author":"Y Wei","year":"2023","unstructured":"Wei Y, Zhan Y, Carlsson S (2023) Childhood adiposity and novel subtypes of diabetes in adults: a Mendelian randomisation and genome-wide genetic correlation study. Lancet Glob Health 11(Suppl 1):S1","journal-title":"Lancet Glob Health"},{"key":"8129_CR16","doi-asserted-by":"publisher","first-page":"1925","DOI":"10.1001\/jama.2017.17219","volume":"318","author":"CA Emdin","year":"2017","unstructured":"Emdin CA, Khera AV, Kathiresan S (2017) Mendelian randomization. JAMA 318:1925\u20131926","journal-title":"JAMA"},{"key":"8129_CR17","doi-asserted-by":"publisher","first-page":"715","DOI":"10.3390\/diagnostics13040715","volume":"13","author":"JJ Seah","year":"2023","unstructured":"Seah JJ, Thong M, Wang Y (2023) The diagnostic and prognostic role of biomarkers in chronic rhinosinusitis. Diagnostics (Basel) 13:715","journal-title":"Diagnostics (Basel)"},{"key":"8129_CR18","doi-asserted-by":"publisher","DOI":"10.4193\/Rhin22.328","author":"J Deng","year":"2023","unstructured":"Deng J, Wang Z, Xu Z et al (2023) Blood eosinophils to direct oral corticosteroid treatment for patients with nasal  polyps - an open label, non-inferiority, randomized control trial. Rhinology.\u00a0https:\/\/doi.org\/10.4193\/Rhin22.328","journal-title":"Rhinology"},{"key":"8129_CR19","doi-asserted-by":"publisher","DOI":"10.1111\/coa.14070","author":"VS Benson","year":"2023","unstructured":"Benson VS, Fu Q, Yang S et al (2023) Real-world characterisation of patients with chronic rhinosinusitis with nasal polyps with and without surgery in England. Clin Otolaryngol. https:\/\/doi.org\/10.1111\/coa.14070","journal-title":"Clin Otolaryngol"},{"key":"8129_CR20","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.1016\/j.jaci.2021.08.030","volume":"149","author":"C Bachert","year":"2022","unstructured":"Bachert C, Han JK, Desrosiers MY et al (2022) Efficacy and safety of benralizumab in chronic rhinosinusitis with nasal polyps: a randomized, placebo-controlled trial. J Allergy Clin Immunol 149:1309\u20131317","journal-title":"J Allergy Clin Immunol"}],"container-title":["European Archives of Oto-Rhino-Laryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00405-023-08129-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00405-023-08129-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00405-023-08129-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,28]],"date-time":"2023-07-28T12:16:53Z","timestamp":1690546613000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00405-023-08129-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,19]]},"references-count":20,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["8129"],"URL":"https:\/\/doi.org\/10.1007\/s00405-023-08129-z","relation":{},"ISSN":["0937-4477","1434-4726"],"issn-type":[{"value":"0937-4477","type":"print"},{"value":"1434-4726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,19]]},"assertion":[{"value":"3 May 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 July 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 July 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflicts of interest in the work.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Ethics approval or patient written informed consent were not required because the data were extracted from the public databases.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}