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The aim of this study is to systematically review the literature to determine the prevalence and most typical sites of SPCs after NPC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We searched the databases of PubMed, Web of Science, and Scopus for articles on SPCs after NPC. The Preferred Reporting Items for Systematic Review and Meta-Analyses guidelines were followed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>This review includes data on 89 168 patients with NPC from 21 articles. The mean occurrence for SPCs was 6.6% and varied from 4.9% in endemic areas to 8.7% in non-endemic areas. The most frequent locations of SPCs were oral cavity, pharynx, nose and paranasal sinuses, esophagus and lung.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>There is an increased risk for a SPC after NPC management, especially in non-endemic areas. However, their mean rate is lower than after other head and neck carcinomas.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00405-023-08144-0","type":"journal-article","created":{"date-parts":[[2023,7,26]],"date-time":"2023-07-26T13:36:36Z","timestamp":1690378596000},"page":"4775-4781","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The risk of second primary cancer after nasopharyngeal cancer: a systematic review"],"prefix":"10.1007","volume":"280","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5681-1847","authenticated-orcid":false,"given":"Fanni","family":"Sv\u00e4rd","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7655-5924","authenticated-orcid":false,"given":"Rasheed Omobolaji","family":"Alabi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9609-1597","authenticated-orcid":false,"given":"Ilmo","family":"Leivo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0451-2404","authenticated-orcid":false,"given":"Antti A.","family":"M\u00e4kitie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4106-314X","authenticated-orcid":false,"given":"Alhadi","family":"Almangush","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,7,26]]},"reference":[{"issue":"6","key":"8144_CR1","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1158\/1055-9965.EPI-20-1702","volume":"30","author":"ET Chang","year":"2021","unstructured":"Chang ET, Ye W, Zeng YX, Adami H-O (2021) The evolving epidemiology of nasopharyngeal carcinoma. 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