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There is considerable controversy surrounding the benefits of prophylactic central lymph-node dissection (pCLND) in patients with clinically negative central compartment lymph nodes (cN0). Therefore, it is crucial to accurately predict the likelihood of cervical CLNM before surgery to make informed surgical decisions.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Date from 214 PTC patients (cN0) who underwent partial or total thyroidectomy and pCLND at the Guizhou Provincial People's Hospital were collected and retrospectively analyzed. They were divided into two groups in accordance with cervical CLNM or not. Their information, including clinical characteristics, ultrasound (US) features, pathological results of fine-needle aspirations biopsy (FNAB), and other characteristics of the groups, was analyzed and compared using univariate and multivariate logistic regression analyses.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>A total of 214 patients were eligible in this study. Among them, 43.5% (93\/214) of PTC patients had cervical CLNM, and 56.5% (121\/214) did not. The two groups were compared using a univariate analyses, and there were no significant differences between the two groups in aspect ratio, boundary, morphology, component, and BRAF<jats:sup>V600E<\/jats:sup> (<jats:italic>P\u2009&gt;\u2009<\/jats:italic>0.05), and there were significant differences between gender, age, maximum tumor size, tumor location, capsule contact, microcalcifications, color Doppler flow imaging (CDFI), and Hashimoto's thyroiditis (HT) (<jats:italic>P\u2009&lt;\u2009<\/jats:italic>0.05). A multivariate logistic regression analysis was performed to further clarify the correlation of these indices. However, only age (OR\u2009=\u20092.455, <jats:italic>P\u2009=\u2009<\/jats:italic>0.009), maximum tumor size (OR\u2009=\u20092.586, <jats:italic>P\u2009=\u2009<\/jats:italic>0.010), capsule contact (OR\u2009=\u20093.208, <jats:italic>P\u2009=\u2009<\/jats:italic>0.001), and CDFI (OR\u2009=\u20092.225, <jats:italic>P\u2009=\u2009<\/jats:italic>0.022) were independent predictors of cervical CLNM. Combining these four factors, the area under the receiver-operating characteristic (ROC) curve for the joint diagnosis is 0.8160 (95% 0.7596\u20130.8725). Univariate analysis indicated\u00a0that capsule contact (<jats:italic>P<\/jats:italic>\u2009=\u20090.001) was a possible predictive\u00a0factor\u00a0of BRAF<jats:sup>V600E<\/jats:sup> mutation.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>In conclusion, four independent predictors of cervical CLNM, including age\u2009&lt;\u200945\u00a0years, tumor size\u2009&gt;\u20091.0\u00a0cm, capsule contact, and rich blood flow, were screened out. Therefore, a comprehensive assessment of these risk factors should be conducted when designing individualized treatment regimens for PTC patients.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00405-023-08156-w","type":"journal-article","created":{"date-parts":[[2023,8,4]],"date-time":"2023-08-04T16:00:36Z","timestamp":1691164836000},"page":"5565-5574","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Integrating US-guided FNAB, BRAFV600E mutation, and clinicopathologic characteristics to predict cervical central lymph-node metastasis in preoperative patients with cN0 papillary thyroid carcinoma"],"prefix":"10.1007","volume":"280","author":[{"given":"Ning","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-Ying","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao-Yan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4668-7096","authenticated-orcid":false,"given":"Dai-Wei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,8,4]]},"reference":[{"issue":"1","key":"8156_CR1","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1089\/thy.2017.0570","volume":"29","author":"P Li","year":"2019","unstructured":"Li P, Zhang A, Liu Y et al (2019) Radioactive iodine therapy in patients with differentiated thyroid cancer: study of external dose rate attenuation law and individualized patient management. 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All authors have contributed significantly, and agree with the content of the manuscript. The authors reported no proprietary or commercial interest in any product mentioned or concept discussed in this article.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study has been approved by the Institutional Review Board of Guizhou Provincial People's Hospital ethics committee, and has been performed according to the ethical standards laid down in the 1964 Declaration of Helsinki.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Due to the retrospective nature of this study, the need for informed consent was waived.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}