{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T13:35:40Z","timestamp":1779197740258,"version":"3.51.4"},"reference-count":67,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T00:00:00Z","timestamp":1702425600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T00:00:00Z","timestamp":1702425600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Natural Science Foundation of Zhejiang Provincial","award":["LY20H130001"],"award-info":[{"award-number":["LY20H130001"]}]},{"name":"Natural Science Foundation of Zhejiang Provincial","award":["LQ21H130001"],"award-info":[{"award-number":["LQ21H130001"]}]},{"name":"Ningbo Health Branding Subject Fund","award":["PPXK2018-02"],"award-info":[{"award-number":["PPXK2018-02"]}]},{"DOI":"10.13039\/100007834","name":"Ningbo Natural Science Foundation","doi-asserted-by":"crossref","award":["202003N4239"],"award-info":[{"award-number":["202003N4239"]}],"id":[{"id":"10.13039\/100007834","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100017549","name":"Science and Technology Innovation 2025 Major Project of Ningbo","doi-asserted-by":"publisher","award":["2018B10015"],"award-info":[{"award-number":["2018B10015"]}],"id":[{"id":"10.13039\/501100017549","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017549","name":"Science and Technology Innovation 2025 Major Project of Ningbo","doi-asserted-by":"publisher","award":["2020Z097"],"award-info":[{"award-number":["2020Z097"]}],"id":[{"id":"10.13039\/501100017549","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Public Welfare Fund Research Project of Zhejiang Province","award":["LGJ22H130001"],"award-info":[{"award-number":["LGJ22H130001"]}]},{"name":"Key Project of Teaching and Research of Ningbo University","award":["JYXMXZD2021033"],"award-info":[{"award-number":["JYXMXZD2021033"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Arch Otorhinolaryngol"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>The purpose of this review is to systematically summarize the application of organoids in the field of otolaryngology and head and neck surgery. It aims to shed light on the current advancements and future potential of organoid technology in these areas, particularly in addressing challenges like hearing loss, cancer research, and organ regeneration.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Review of current literature regrading organoids in the field of otolaryngology and head and neck surgery.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The review highlights several advancements in the field. In otology, the development of organoid replacement therapies offers new avenues for treating hearing loss. In nasal science, the creation of specific organoid models aids in studying nasopharyngeal carcinoma and respiratory viruses. In head and neck surgery, innovative approaches for squamous cell carcinoma prediction and thyroid regeneration using organoids have been developed.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Organoid research in otolaryngology\u2014head and neck surgery is still at an early stage. This review underscores the potential of this technology in advancing our understanding and treatment of various conditions, predicting a transformative impact on future medical practices in these fields.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00405-023-08348-4","type":"journal-article","created":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T11:02:04Z","timestamp":1702465324000},"page":"1643-1649","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Application of organoids in otolaryngology: head and neck surgery"],"prefix":"10.1007","volume":"281","author":[{"given":"Hai","family":"Zhu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siyuan","family":"Qu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongqin","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengdan","family":"Gong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yizhen","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaoshu","family":"Teng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2055-0256","authenticated-orcid":false,"given":"Dong","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,12,13]]},"reference":[{"issue":"6","key":"8348_CR1","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.devcel.2016.08.014","volume":"38","author":"K Kretzschmar","year":"2016","unstructured":"Kretzschmar K, Clevers H (2016) Organoids: modeling development and the stem cell niche in a dish. Dev Cell 38(6):590\u2013600","journal-title":"Dev Cell"},{"issue":"7","key":"8348_CR2","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/s41568-018-0007-6","volume":"18","author":"J Drost","year":"2018","unstructured":"Drost J, Clevers H (2018) Organoids in cancer research. Nat Rev Cancer 18(7):407\u2013418","journal-title":"Nat Rev Cancer"},{"issue":"11","key":"8348_CR3","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/s41576-018-0051-9","volume":"19","author":"G Rossi","year":"2018","unstructured":"Rossi G, Manfrin A, Lutolf MP (2018) Progress and potential in organoid research. Nat Rev Genet 19(11):671\u2013687","journal-title":"Nat Rev Genet"},{"issue":"11","key":"8348_CR4","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1038\/s41575-020-00371-8","volume":"17","author":"K Ray","year":"2020","unstructured":"Ray K (2020) Next-generation intestinal organoids. Nat Rev Gastroenterol Hepatol 17(11):649","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"2","key":"8348_CR5","first-page":"68","volume":"14","author":"K Ray","year":"2017","unstructured":"Ray K (2017) Development: modelling human stomach development with gastric organoids. Nat Rev Gastroenterol Hepatol 14(2):68","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"6","key":"8348_CR6","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1016\/j.cell.2018.11.013","volume":"175","author":"H Hu","year":"2018","unstructured":"Hu H et al (2018) Long-term expansion of functional mouse and human hepatocytes as 3D organoids. Cell 175(6):1591-1606 e19","journal-title":"Cell"},{"issue":"10","key":"8348_CR7","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1038\/s41581-019-0176-x","volume":"15","author":"R Nishinakamura","year":"2019","unstructured":"Nishinakamura R (2019) Human kidney organoids: progress and remaining challenges. Nat Rev Nephrol 15(10):613\u2013624","journal-title":"Nat Rev Nephrol"},{"issue":"4","key":"8348_CR8","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.stem.2020.01.019","volume":"26","author":"MH Geurts","year":"2020","unstructured":"Geurts MH et al (2020) CRISPR-based adenine editors correct nonsense mutations in a cystic fibrosis organoid biobank. Cell Stem Cell 26(4):503-510 e7","journal-title":"Cell Stem Cell"},{"issue":"3","key":"8348_CR9","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1038\/s41587-019-0048-8","volume":"37","author":"F Schutgens","year":"2019","unstructured":"Schutgens F et al (2019) Tubuloids derived from human adult kidney and urine for personalized disease modeling. Nat Biotechnol 37(3):303\u2013313","journal-title":"Nat Biotechnol"},{"issue":"5","key":"8348_CR10","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1038\/s41591-019-0422-6","volume":"25","author":"O Kopper","year":"2019","unstructured":"Kopper O et al (2019) An organoid platform for ovarian cancer captures intra- and interpatient heterogeneity. Nat Med 25(5):838\u2013849","journal-title":"Nat Med"},{"issue":"4","key":"8348_CR11","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2018100300","volume":"38","author":"N Sachs","year":"2019","unstructured":"Sachs N et al (2019) Long-term expanding human airway organoids for disease modeling. EMBO J 38(4):e100300","journal-title":"EMBO J"},{"issue":"4","key":"8348_CR12","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/nmeth1015","volume":"4","author":"GY Lee","year":"2007","unstructured":"Lee GY et al (2007) Three-dimensional culture models of normal and malignant breast epithelial cells. Nat Methods 4(4):359\u2013365","journal-title":"Nat Methods"},{"issue":"7244","key":"8348_CR13","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/nature07935","volume":"459","author":"T Sato","year":"2009","unstructured":"Sato T et al (2009) Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche. Nature 459(7244):262\u2013265","journal-title":"Nature"},{"issue":"6","key":"8348_CR14","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/nm.1951","volume":"15","author":"A Ootani","year":"2009","unstructured":"Ootani A et al (2009) Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche. Nat Med 15(6):701\u2013706","journal-title":"Nat Med"},{"issue":"7360","key":"8348_CR15","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/nature10337","volume":"476","author":"W de Lau","year":"2011","unstructured":"de Lau W et al (2011) Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling. Nature 476(7360):293\u2013297","journal-title":"Nature"},{"issue":"5593","key":"8348_CR16","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/265421a0","volume":"265","author":"JG Rheinwald","year":"1977","unstructured":"Rheinwald JG, Green H (1977) Epidermal growth factor and the multiplication of cultured human epidermal keratinocytes. Nature 265(5593):421\u2013424","journal-title":"Nature"},{"issue":"7536","key":"8348_CR17","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/nature14129","volume":"517","author":"Cancer Genome Atlas N.","year":"2015","unstructured":"Cancer Genome Atlas N. (2015) Comprehensive genomic characterization of head and neck squamous cell carcinomas. Nature 517(7536):576\u2013582","journal-title":"Nature"},{"issue":"5664","key":"8348_CR18","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1126\/science.1093587","volume":"303","author":"AP Haramis","year":"2004","unstructured":"Haramis AP et al (2004) De novo crypt formation and juvenile polyposis on BMP inhibition in mouse intestine. Science 303(5664):1684\u20131686","journal-title":"Science"},{"issue":"1","key":"8348_CR19","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1097\/MAO.0000000000002013","volume":"40","author":"R Hulse","year":"2019","unstructured":"Hulse R et al (2019) Peripheral vestibular disorders: an epidemiologic survey in 70 million individuals. Otol Neurotol 40(1):88\u201395","journal-title":"Otol Neurotol"},{"issue":"6","key":"8348_CR20","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/nbt.3840","volume":"35","author":"KR Koehler","year":"2017","unstructured":"Koehler KR et al (2017) Generation of inner ear organoids containing functional hair cells from human pluripotent stem cells. Nat Biotechnol 35(6):583\u2013589","journal-title":"Nat Biotechnol"},{"issue":"17","key":"8348_CR21","doi-asserted-by":"crossref","first-page":"dev177188","DOI":"10.1242\/dev.177188","volume":"146","author":"M Roccio","year":"2019","unstructured":"Roccio M, Edge ASB (2019) Inner ear organoids: new tools to understand neurosensory cell development, degeneration and regeneration. Development 146(17):dev177188","journal-title":"Development"},{"issue":"6","key":"8348_CR22","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1016\/j.neurobiolaging.2015.02.013","volume":"36","author":"RR Taylor","year":"2015","unstructured":"Taylor RR et al (2015) Characterizing human vestibular sensory epithelia for experimental studies: new hair bundles on old tissue and implications for therapeutic interventions in ageing. Neurobiol Aging 36(6):2068\u20132084","journal-title":"Neurobiol Aging"},{"issue":"4","key":"8348_CR23","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1007\/s00018-018-2950-5","volume":"76","author":"A Czajkowski","year":"2019","unstructured":"Czajkowski A et al (2019) Pluripotent stem cell-derived cochlear cells: a challenge in constant progress. Cell Mol Life Sci 76(4):627\u2013635","journal-title":"Cell Mol Life Sci"},{"issue":"6","key":"8348_CR24","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1016\/j.stemcr.2020.04.008","volume":"14","author":"PC Tang","year":"2020","unstructured":"Tang PC, Hashino E, Nelson RF (2020) Progress in modeling and targeting inner ear disorders with pluripotent stem cells. Stem Cell Rep 14(6):996\u20131008","journal-title":"Stem Cell Rep"},{"issue":"1","key":"8348_CR25","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/s41418-020-00678-8","volume":"28","author":"WH van der Valk","year":"2021","unstructured":"van der Valk WH et al (2021) Building inner ears: recent advances and future challenges for in vitro organoid systems. Cell Death Differ 28(1):24\u201334","journal-title":"Cell Death Differ"},{"issue":"1","key":"8348_CR26","doi-asserted-by":"crossref","first-page":"4027","DOI":"10.1038\/s41467-018-06334-7","volume":"9","author":"M Roccio","year":"2018","unstructured":"Roccio M et al (2018) Molecular characterization and prospective isolation of human fetal cochlear hair cell progenitors. Nat Commun 9(1):4027","journal-title":"Nat Commun"},{"issue":"7774","key":"8348_CR27","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/s41586-019-1535-2","volume":"573","author":"Y Zheng","year":"2019","unstructured":"Zheng Y et al (2019) Controlled modelling of human epiblast and amnion development using stem cells. Nature 573(7774):421\u2013425","journal-title":"Nature"},{"issue":"7","key":"8348_CR28","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1038\/s41592-019-0455-2","volume":"16","author":"A Manfrin","year":"2019","unstructured":"Manfrin A et al (2019) Engineered signaling centers for the spatially controlled patterning of human pluripotent stem cells. Nat Methods 16(7):640\u2013648","journal-title":"Nat Methods"},{"issue":"9","key":"8348_CR29","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1038\/s41551-020-0565-2","volume":"4","author":"N Brandenberg","year":"2020","unstructured":"Brandenberg N et al (2020) High-throughput automated organoid culture via stem-cell aggregation in microcavity arrays. Nat Biomed Eng 4(9):863\u2013874","journal-title":"Nat Biomed Eng"},{"issue":"10278","key":"8348_CR30","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1016\/S0140-6736(21)00516-X","volume":"397","author":"Collaborators GBDHL","year":"2021","unstructured":"Collaborators GBDHL (2021) Hearing loss prevalence and years lived with disability, 1990\u20132019: findings from the Global Burden of Disease Study 2019. Lancet 397(10278):996\u20131009","journal-title":"Lancet"},{"issue":"10","key":"8348_CR31","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.2105\/AJPH.2016.303299","volume":"106","author":"AM Goman","year":"2016","unstructured":"Goman AM, Lin FR (2016) Prevalence of hearing loss by severity in the United States. Am J Public Health 106(10):1820\u20131822","journal-title":"Am J Public Health"},{"key":"8348_CR32","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2022.814528","volume":"14","author":"KL Elliott","year":"2022","unstructured":"Elliott KL et al (2022) Age-related hearing loss: sensory and neural etiology and their interdependence. Front Aging Neurosci 14:814528","journal-title":"Front Aging Neurosci"},{"issue":"5","key":"8348_CR33","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1542\/peds.2014-1173","volume":"134","author":"J Goderis","year":"2014","unstructured":"Goderis J et al (2014) Hearing loss and congenital CMV infection: a systematic review. Pediatrics 134(5):972\u2013982","journal-title":"Pediatrics"},{"issue":"5","key":"8348_CR34","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.ijporl.2009.01.012","volume":"73","author":"ED Brown","year":"2009","unstructured":"Brown ED et al (2009) A systematic review of neonatal toxoplasmosis exposure and sensorineural hearing loss. Int J Pediatr Otorhinolaryngol 73(5):707\u2013711","journal-title":"Int J Pediatr Otorhinolaryngol"},{"issue":"3","key":"8348_CR35","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1007\/s00420-015-1083-5","volume":"89","author":"A Lie","year":"2016","unstructured":"Lie A et al (2016) Occupational noise exposure and hearing: a systematic review. Int Arch Occup Environ Health 89(3):351\u2013372","journal-title":"Int Arch Occup Environ Health"},{"issue":"4","key":"8348_CR36","first-page":"521","volume":"30","author":"M Hormozi","year":"2017","unstructured":"Hormozi M et al (2017) The risk of hearing loss associated with occupational exposure to organic solvents mixture with and without concurrent noise exposure: a systematic review and meta-analysis. Int J Occup Med Environ Health 30(4):521\u2013535","journal-title":"Int J Occup Med Environ Health"},{"issue":"1","key":"8348_CR37","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1002\/lary.25409","volume":"126","author":"Z Farzal","year":"2016","unstructured":"Farzal Z et al (2016) The role of routine hearing screening in children with cystic fibrosis on aminoglycosides: a systematic review. Laryngoscope 126(1):228\u2013235","journal-title":"Laryngoscope"},{"issue":"23","key":"8348_CR38","doi-asserted-by":"crossref","first-page":"2712","DOI":"10.1200\/JCO.2016.66.8822","volume":"34","author":"RD Frisina","year":"2016","unstructured":"Frisina RD et al (2016) Comprehensive audiometric analysis of hearing impairment and tinnitus after cisplatin-based chemotherapy in survivors of adult-onset cancer. J Clin Oncol 34(23):2712\u20132720","journal-title":"J Clin Oncol"},{"issue":"4","key":"8348_CR39","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1055\/s-0037-1601885","volume":"10","author":"A Honeybrook","year":"2017","unstructured":"Honeybrook A et al (2017) Hearing and mortality outcomes following temporal bone fractures. Craniomaxillofac Trauma Reconstr 10(4):281\u2013285","journal-title":"Craniomaxillofac Trauma Reconstr"},{"issue":"6121","key":"8348_CR40","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1126\/science.1231143","volume":"339","author":"L Cong","year":"2013","unstructured":"Cong L et al (2013) Multiplex genome engineering using CRISPR\/Cas systems. Science 339(6121):819\u2013823","journal-title":"Science"},{"issue":"6121","key":"8348_CR41","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1126\/science.1232033","volume":"339","author":"P Mali","year":"2013","unstructured":"Mali P et al (2013) RNA-guided human genome engineering via Cas9. Science 339(6121):823\u2013826","journal-title":"Science"},{"issue":"7785","key":"8348_CR42","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/s41586-019-1711-4","volume":"576","author":"AV Anzalone","year":"2019","unstructured":"Anzalone AV et al (2019) Search-and-replace genome editing without double-strand breaks or donor DNA. Nature 576(7785):149\u2013157","journal-title":"Nature"},{"issue":"4","key":"8348_CR43","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.cell.2006.07.024","volume":"126","author":"K Takahashi","year":"2006","unstructured":"Takahashi K, Yamanaka S (2006) Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126(4):663\u2013676","journal-title":"Cell"},{"issue":"5","key":"8348_CR44","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.cell.2007.11.019","volume":"131","author":"K Takahashi","year":"2007","unstructured":"Takahashi K et al (2007) Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131(5):861\u2013872","journal-title":"Cell"},{"issue":"5","key":"8348_CR45","doi-asserted-by":"crossref","first-page":"561","DOI":"10.5966\/sctm.2015-0252","volume":"5","author":"ZH Tang","year":"2016","unstructured":"Tang ZH et al (2016) Genetic correction of induced pluripotent stem cells from a deaf patient with MYO7A mutation results in morphologic and functional recovery of the derived hair cell-like cells. Stem Cells Transl Med 5(5):561\u2013571","journal-title":"Stem Cells Transl Med"},{"issue":"8","key":"8348_CR46","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1038\/cdd.2016.16","volume":"23","author":"JR Chen","year":"2016","unstructured":"Chen JR et al (2016) Effects of genetic correction on the differentiation of hair cell-like cells from iPSCs with MYO15A mutation. Cell Death Differ 23(8):1347\u20131357","journal-title":"Cell Death Differ"},{"issue":"1","key":"8348_CR47","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.stemcr.2019.05.014","volume":"13","author":"PC Tang","year":"2019","unstructured":"Tang PC et al (2019) Defective Tmprss3-associated hair cell degeneration in inner ear organoids. Stem Cell Rep 13(1):147\u2013162","journal-title":"Stem Cell Rep"},{"issue":"3","key":"8348_CR48","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.radonc.2013.10.020","volume":"110","author":"X Sun","year":"2014","unstructured":"Sun X et al (2014) Long-term outcomes of intensity-modulated radiotherapy for 868 patients with nasopharyngeal carcinoma: an analysis of survival and treatment toxicities. Radiother Oncol 110(3):398\u2013403","journal-title":"Radiother Oncol"},{"issue":"11","key":"8348_CR49","doi-asserted-by":"crossref","first-page":"5116","DOI":"10.1002\/cam4.2429","volume":"8","author":"AK Chung","year":"2019","unstructured":"Chung AK et al (2019) Targeted sequencing of cancer-related genes in nasopharyngeal carcinoma identifies mutations in the TGF-beta pathway. Cancer Med 8(11):5116\u20135127","journal-title":"Cancer Med"},{"issue":"6378","key":"8348_CR50","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1126\/science.aao2774","volume":"359","author":"G Vlachogiannis","year":"2018","unstructured":"Vlachogiannis G et al (2018) Patient-derived organoids model treatment response of metastatic gastrointestinal cancers. Science 359(6378):920\u2013926","journal-title":"Science"},{"issue":"6","key":"8348_CR51","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1002\/jcsm.12627","volume":"11","author":"RDW Vaes","year":"2020","unstructured":"Vaes RDW et al (2020) Generation and initial characterization of novel tumour organoid models to study human pancreatic cancer-induced cachexia. J Cachexia Sarcopenia Muscle 11(6):1509\u20131524","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"11","key":"8348_CR52","doi-asserted-by":"crossref","first-page":"648","DOI":"10.3390\/md17110648","volume":"17","author":"A Costales-Carrera","year":"2019","unstructured":"Costales-Carrera A et al (2019) Plocabulin displays strong cytotoxic activity in a personalized colon cancer patient-derived 3D organoid assay. Mar Drugs 17(11):648","journal-title":"Mar Drugs"},{"issue":"9","key":"8348_CR53","doi-asserted-by":"crossref","first-page":"526","DOI":"10.21037\/atm-22-1076","volume":"10","author":"XW Wang","year":"2022","unstructured":"Wang XW et al (2022) Establishment of a patient-derived organoid model and living biobank for nasopharyngeal carcinoma. Ann Transl Med 10(9):526","journal-title":"Ann Transl Med"},{"issue":"1","key":"8348_CR54","doi-asserted-by":"crossref","first-page":"3046","DOI":"10.1038\/s41467-021-23379-3","volume":"12","author":"RB Ding","year":"2021","unstructured":"Ding RB et al (2021) Molecular landscape and subtype-specific therapeutic response of nasopharyngeal carcinoma revealed by integrative pharmacogenomics. Nat Commun 12(1):3046","journal-title":"Nat Commun"},{"issue":"9","key":"8348_CR55","first-page":"1510","volume":"70","author":"T Oka","year":"2012","unstructured":"Oka T, Komuro I (2012) Molecular and cellular mechanisms of organ fibrosis. Nihon Rinsho 70(9):1510\u20131516","journal-title":"Nihon Rinsho"},{"issue":"2","key":"8348_CR56","doi-asserted-by":"crossref","first-page":"H643","DOI":"10.1152\/ajpheart.00073.2005","volume":"289","author":"Q Yu","year":"2005","unstructured":"Yu Q et al (2005) A role for T lymphocytes in mediating cardiac diastolic function. Am J Physiol Heart Circ Physiol 289(2):H643\u2013H651","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"4","key":"8348_CR57","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1046\/j.1365-2168.1998.00734.x","volume":"85","author":"M Schaffer","year":"1998","unstructured":"Schaffer M, Barbul A (1998) Lymphocyte function in wound healing and following injury. Br J Surg 85(4):444\u2013460","journal-title":"Br J Surg"},{"issue":"26","key":"8348_CR58","doi-asserted-by":"crossref","first-page":"6822","DOI":"10.1073\/pnas.1806308115","volume":"115","author":"J Zhou","year":"2018","unstructured":"Zhou J et al (2018) Differentiated human airway organoids to assess infectivity of emerging influenza virus. Proc Natl Acad Sci U S A 115(26):6822\u20136827","journal-title":"Proc Natl Acad Sci U S A"},{"key":"8348_CR59","doi-asserted-by":"crossref","unstructured":"Rajan A et al (2021) The human nose organoid respiratory virus model: an ex-vivo human challenge model to study RSV and SARS-CoV-2 pathogenesis and evaluate therapeutics. bioRxiv","DOI":"10.1101\/2021.07.28.453844"},{"issue":"13","key":"8348_CR60","volume":"131","author":"JH Ahn","year":"2021","unstructured":"Ahn JH et al (2021) Nasal ciliated cells are primary targets for SARS-CoV-2 replication in the early stage of COVID-19. J Clin Invest 131(13):e148517","journal-title":"J Clin Invest"},{"issue":"1","key":"8348_CR61","doi-asserted-by":"crossref","first-page":"4354","DOI":"10.1038\/s41467-021-24521-x","volume":"12","author":"R Robinot","year":"2021","unstructured":"Robinot R et al (2021) SARS-CoV-2 infection induces the dedifferentiation of multiciliated cells and impairs mucociliary clearance. Nat Commun 12(1):4354","journal-title":"Nat Commun"},{"issue":"1","key":"8348_CR62","doi-asserted-by":"crossref","first-page":"3910","DOI":"10.1038\/s41467-020-17796-z","volume":"11","author":"N Zhu","year":"2020","unstructured":"Zhu N et al (2020) Morphogenesis and cytopathic effect of SARS-CoV-2 infection in human airway epithelial cells. Nat Commun 11(1):3910","journal-title":"Nat Commun"},{"issue":"4","key":"8348_CR63","volume":"13","author":"MC Chiu","year":"2022","unstructured":"Chiu MC et al (2022) Human nasal organoids model SARS-CoV-2 upper respiratory infection and recapitulate the differential infectivity of emerging variants. MBio 13(4):e0194422","journal-title":"MBio"},{"issue":"3","key":"8348_CR64","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","volume":"71","author":"H Sung","year":"2021","unstructured":"Sung H et al (2021) Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 71(3):209\u2013249","journal-title":"CA Cancer J Clin"},{"issue":"4","key":"8348_CR65","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/j.stemcr.2021.02.011","volume":"16","author":"VML Ogundipe","year":"2021","unstructured":"Ogundipe VML et al (2021) Generation and differentiation of adult tissue-derived human thyroid organoids. Stem Cell Rep 16(4):913\u2013925","journal-title":"Stem Cell Rep"},{"issue":"5","key":"8348_CR66","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1053\/j.gastro.2011.07.050","volume":"141","author":"T Sato","year":"2011","unstructured":"Sato T et al (2011) Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett\u2019s epithelium. Gastroenterology 141(5):1762\u20131772","journal-title":"Gastroenterology"},{"issue":"1","key":"8348_CR67","doi-asserted-by":"crossref","first-page":"50","DOI":"10.3390\/biomedicines2010050","volume":"2","author":"DT Harris","year":"2014","unstructured":"Harris DT (2014) Stem cell banking for regenerative and personalized medicine. Biomedicines 2(1):50\u201379","journal-title":"Biomedicines"}],"container-title":["European Archives of Oto-Rhino-Laryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00405-023-08348-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00405-023-08348-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00405-023-08348-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,15]],"date-time":"2024-03-15T12:06:22Z","timestamp":1710504382000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00405-023-08348-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,13]]},"references-count":67,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["8348"],"URL":"https:\/\/doi.org\/10.1007\/s00405-023-08348-4","relation":{},"ISSN":["0937-4477","1434-4726"],"issn-type":[{"value":"0937-4477","type":"print"},{"value":"1434-4726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,13]]},"assertion":[{"value":"28 September 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 October 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 December 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}