{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T15:57:35Z","timestamp":1780761455943,"version":"3.54.1"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2024,1,14]],"date-time":"2024-01-14T00:00:00Z","timestamp":1705190400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,1,14]],"date-time":"2024-01-14T00:00:00Z","timestamp":1705190400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Zuiko Medical, Inc."}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Arch Otorhinolaryngol"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>Removal of the current calcium alginate packing materials to the middle meatus in endoscopic sinus surgery (ESS) is usually accompanied by discomfort or pain owing to the hard and brittle nature of these materials. Plus moist HS-W<jats:sup>\u00ae<\/jats:sup> is a new calcium alginate packing material released in 2022 developed to overcome this issue by changing the uronic acid component. We aimed to compare the discomfort\/pain during the removal of Plus moist HS-W<jats:sup>\u00ae<\/jats:sup> with Kaltostat<jats:sup>\u00ae<\/jats:sup>, as well as their suitability as packing materials in ESS.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Kaltostat<jats:sup>\u00ae<\/jats:sup> and Plus moist HS-W<jats:sup>\u00ae<\/jats:sup> were used as packing materials in 22 and 21 patients who underwent ESS in 2021 and 2022, respectively. Patients were asked to rate the pain during the packing removal 10\u00a0days after ESS using the Numerical Rating Scale (NRS). The ratio of residual packing materials, number of suctions (insertions\/extractions of the suction cannula), and time required to remove packing materials were measured. Postoperative complications such as hemorrhage, local infection, lateralization of the middle turbinate, and synechia of the middle meatus were also evaluated.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The Plus moist HS-W<jats:sup>\u00ae<\/jats:sup> group exhibited significantly lower NRS pain scores, a lower ratio of residual packing materials, a reduced number of suctions, and a shorter time required to remove the packing. No obvious postoperative complications occurred in both groups except for one suspicious case of a slight infection in the Kaltostat<jats:sup>\u00ae<\/jats:sup> group.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Compared with Kaltostat<jats:sup>\u00ae<\/jats:sup>, Plus moist HS-W<jats:sup>\u00ae<\/jats:sup>, characterized by better gelatinization than Kaltostat<jats:sup>\u00ae<\/jats:sup>, benefits patients by minimizing discomfort\/pain during removal.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Level of evidence<\/jats:title>\n                <jats:p>Level 3.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00405-023-08437-4","type":"journal-article","created":{"date-parts":[[2024,1,14]],"date-time":"2024-01-14T12:01:48Z","timestamp":1705233708000},"page":"2985-2991","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Plus moist HS-W\u00ae: a new nasal packing material for the middle meatus in endoscopic sinus surgery"],"prefix":"10.1007","volume":"281","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-4251-1760","authenticated-orcid":false,"given":"Ryo","family":"Wakasugi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takanobu","family":"Sasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Takano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisashi","family":"Kamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuniaki","family":"Yoshioka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaori","family":"Tochigi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Ikeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nao","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Matsuyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arata","family":"Horii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,1,14]]},"reference":[{"key":"8437_CR1","doi-asserted-by":"publisher","first-page":"302","DOI":"10.2500\/ajr.2008.22.3171","volume":"22","author":"EK Weitzel","year":"2008","unstructured":"Weitzel EK, Wormald PJ (2008) A scientific review of middle meatal packing\/stents. Am J Rhinol 22:302\u2013307. https:\/\/doi.org\/10.2500\/ajr.2008.22.3171","journal-title":"Am J Rhinol"},{"key":"8437_CR2","first-page":"58","volume":"44","author":"C Chevillard","year":"2006","unstructured":"Chevillard C, Rugina M, Bonfils P, Bougara A, Castillo L, Crampette L, Pandraud L, Samardzic M, Peyn\u00e8gre R (2006) Evaluation of calcium alginate nasal packing (Algost\u00e9ril) versus Polyvinyl acetal (merocel) for nasal packing after inferior turbinate resection. Rhinology 44:58\u201361","journal-title":"Rhinology"},{"key":"8437_CR3","first-page":"669","volume":"21","author":"A Romano","year":"2016","unstructured":"Romano A, Salzano G, Dell\u2019AversanaOrabona G, Cama A, Petrocelli M, Piombino P, Schonauer F, Iaconetta G, Salzano FA, Califano L (2016) Comparative study between biodegradable nasopore (BNP) and Merocel hemox 10 cm after septo-turbinoplasty procedure. Eur Rev Med Pharmacol Sci 21:669\u2013673","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"8437_CR4","doi-asserted-by":"publisher","first-page":"340","DOI":"10.4193\/Rhin21.057","volume":"59","author":"CK Titirungruang","year":"2021","unstructured":"Titirungruang CK, Charakorn N, Chaitusaney B, Hirunwiwatkul P (2021) Is postoperative nasal packing after septoplasty safe? A systematic review and meta-analysis of randomized controlled studies. Rhinology 59:340\u2013351. https:\/\/doi.org\/10.4193\/Rhin21.057","journal-title":"Rhinology"},{"key":"8437_CR5","unstructured":"World Health Organization (2018)\u00a0Global guidelines for the prevention of surgical site infection.\u00a0http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK536404"},{"key":"8437_CR6","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1002\/alr.22085","volume":"8","author":"CH Fang","year":"2018","unstructured":"Fang CH, Fastenberg JH, Fried MP, Jerschow E, Akbar NA, Abuzeid WM (2018) Antibiotic use patterns in endoscopic sinus surgery: a survey of the American Rhinologic Society membership. Int Forum Allergy Rhinol 8:522\u2013529","journal-title":"Int Forum Allergy Rhinol"},{"key":"8437_CR7","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1002\/alr.20098","volume":"2","author":"RA Portela","year":"2012","unstructured":"Portela RA, Hootnick J, McGinn J (2012) Perioperative care in functional endoscopic sinus surgery: a survey study. Int Forum Allergy Rhinol 2:27\u201333","journal-title":"Int Forum Allergy Rhinol"},{"key":"8437_CR8","first-page":"57","volume-title":"Endoscopic sinus surgery","author":"M Yoshikawa","year":"2015","unstructured":"Yoshikawa M, Moriyama H, Haruna S, Otori N (2015) Endoscopic sinus surgery. Igakushoin, pp 57\u201362"},{"key":"8437_CR9","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/0304-3959(83)90127-6","volume":"17","author":"SJ Linton","year":"1983","unstructured":"Linton SJ, G\u00f6testam GK (1983) A clinical comparison of two pain scales: correlation, remembering chronic pain, and a measure of compliance. Pain 17:57\u201365. https:\/\/doi.org\/10.1016\/0304-3959(83)90127-6","journal-title":"Pain"},{"key":"8437_CR10","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1038\/bmt.2012.244","volume":"48","author":"Y Kanda","year":"2013","unstructured":"Kanda Y (2013) Investigation of the freely available easy-to-use software \u201cEZR\u201d for medical statistics. Bone Marrow Transpl 48:452\u2013458. https:\/\/doi.org\/10.1038\/bmt.2012.244","journal-title":"Bone Marrow Transpl"},{"key":"8437_CR11","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.anl.2011.02.008","volume":"39","author":"T Okushi","year":"2012","unstructured":"Okushi T, Yoshikawa M, Otori N, Matsuwaki Y, Asaka D, Nakayama T, Morimoto T, Moriyama H (2012) Evaluation of symptoms and QOL with calcium alginate versus chitin-coated gauze for middle meatus packing after endoscopic sinus surgery. Auris Nasus Larynx 39:31\u201337. https:\/\/doi.org\/10.1016\/j.anl.2011.02.008","journal-title":"Auris Nasus Larynx"},{"key":"8437_CR12","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1017\/s0022215100111004","volume":"103","author":"KS Sirimanna","year":"1989","unstructured":"Sirimanna KS (1989) Calcium alginate fibre (kaltostat 2) for nasal packing after trimming of turbinates-a pilot study. J Laryngol Otol 103:1067\u20131068. https:\/\/doi.org\/10.1017\/s0022215100111004","journal-title":"J Laryngol Otol"},{"key":"8437_CR13","doi-asserted-by":"publisher","first-page":"665","DOI":"10.3389\/fbioe.2020.00665","volume":"8","author":"MI Neves","year":"2020","unstructured":"Neves MI, Moroni L, Barrias CC (2020) Modulating alginate hydrogels for improved biological performance as cellular 3D microenvironments. Front Bioeng Biotechnol 8:665. https:\/\/doi.org\/10.3389\/fbioe.2020.00665","journal-title":"Front Bioeng Biotechnol"},{"key":"8437_CR14","doi-asserted-by":"publisher","first-page":"10908","DOI":"10.1021\/acs.chemrev.0c00923","volume":"121","author":"VG Muir","year":"2021","unstructured":"Muir VG, Burdick JA (2021) Chemically modified biopolymers for the formation of biomedical hydrogels. Chem Rev 121:10908\u201310949. https:\/\/doi.org\/10.1021\/acs.chemrev.0c00923","journal-title":"Chem Rev"},{"key":"8437_CR15","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202001472","volume":"9","author":"A Shavandi","year":"2020","unstructured":"Shavandi A, Hosseini S, Okoro OV, Nie L, EghbaliBabadi FE, Melchels F (2020) 3D bioprinting of lignocellulosic biomaterials. Adv Healthc Mater 9:e2001472. https:\/\/doi.org\/10.1002\/adhm.202001472","journal-title":"Adv Healthc Mater"},{"key":"8437_CR16","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1016\/B978-0-12-813932-5.00011-X","volume-title":"Polymeric nanomaterials in Nanotherapeutics","author":"I Neamtu","year":"2019","unstructured":"Neamtu I, Chiriac AP, Nita LE, Diaconu A, Rusu AG (2019) Chapter 11 Nanogels containing polysaccharides for bioapplications. Polymeric nanomaterials in Nanotherapeutics. Springer, pp 387\u2013420"},{"key":"8437_CR17","doi-asserted-by":"publisher","first-page":"2729","DOI":"10.3390\/polym13162729","volume":"13","author":"R Gheorghita","year":"2021","unstructured":"Gheorghita R, Anchidin-Norocel L, Filip R, Dimian M, Covasa M (2021) Applications of biopolymers for drugs and probiotics delivery. Polymers 13:2729. https:\/\/doi.org\/10.3390\/polym13162729","journal-title":"Polymers"},{"key":"8437_CR18","doi-asserted-by":"publisher","first-page":"56","DOI":"10.12968\/jowc.2000.9.2.26338","volume":"9","author":"S Thomas","year":"2000","unstructured":"Thomas S (2000) Alginate dressings in surgery and wound management\u2013Part 1. J Wound Care 9:56\u201360. https:\/\/doi.org\/10.12968\/jowc.2000.9.2.26338","journal-title":"J Wound Care"},{"key":"8437_CR19","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1046\/j.1524-475x.2002.10502.x","volume":"10","author":"AB Lansdown","year":"2002","unstructured":"Lansdown AB (2002) Calcium: a potential central regulator in wound healing in the skin. Wound Repair Regen 10:271\u2013285. https:\/\/doi.org\/10.1046\/j.1524-475x.2002.10502.x","journal-title":"Wound Repair Regen"},{"key":"8437_CR20","first-page":"153","volume":"69","author":"SE Barnett","year":"1987","unstructured":"Barnett SE, Varley SJ (1987) The effects of calcium alginate on wound healing. Ann R Coll Surg Engl 69:153\u2013155","journal-title":"Ann R Coll Surg Engl"},{"key":"8437_CR21","first-page":"34","volume":"39","author":"D Gensheimer","year":"1993","unstructured":"Gensheimer D (1993) A review of calcium alginates. Ostomy Wound Manage 39:34\u201343","journal-title":"Ostomy Wound Manage"},{"key":"8437_CR22","doi-asserted-by":"publisher","first-page":"1797","DOI":"10.1016\/s0142-9612(00)00072-7","volume":"21","author":"A Thomas","year":"2000","unstructured":"Thomas A, Harding KG, Moore K (2000) Alginates from wound dressings activate human macrophages to secrete tumour necrosis factor-alpha. Biomaterials 21:1797\u20131802. https:\/\/doi.org\/10.1016\/s0142-9612(00)00072-7","journal-title":"Biomaterials"}],"container-title":["European Archives of Oto-Rhino-Laryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00405-023-08437-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00405-023-08437-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00405-023-08437-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T11:04:57Z","timestamp":1714647897000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00405-023-08437-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,14]]},"references-count":22,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["8437"],"URL":"https:\/\/doi.org\/10.1007\/s00405-023-08437-4","relation":{},"ISSN":["0937-4477","1434-4726"],"issn-type":[{"value":"0937-4477","type":"print"},{"value":"1434-4726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,14]]},"assertion":[{"value":"14 October 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 December 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 January 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors Ryo Wakasugi and Takanobu Sasaki have a conflict of interest with Zuiko Medical, Inc.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}