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A systematic search was performed in four databases (PubMed, Embase, Cochrane Library, Web of Science) on December 14, 2022. Articles were included if cholesteatomas were staged according to the Potsic system and follow-up duration was documented. Risk of bias was evaluated using the Quality In Prognosis Studies (QUIPS) tool. In the statistical synthesis a random effects model was used. Between-study heterogeneity was assessed using <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Thirteen articles were found to be eligible for systematic review and seven were included in the meta-analysis section. All records were retrospective cohort studies with high risk of bias. Regarding the proportions of residual disease, analysis using the <jats:italic>\u03c7<\/jats:italic><jats:sup>2<\/jats:sup> test showed no statistically significant difference between Potsic stages after a follow-up of minimum one year (stage I 0.06 (confidence interval (CI) 0.01\u20130.33); stage II 0.20 (CI 0.09\u20130.38); stage III 0.06 (CI 0.00\u20130.61); stage IV: 0.17 (CI 0.01\u20130.81)). Postoperative and preoperative hearing outcomes could not be analyzed due to varied reporting. Results on cholesteatoma location and mean age at staging were consistent with those previously published.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>No statistically significant difference was found in the proportions of residual disease between Potsic stages, thus the staging system\u2019s applicability for outcome prediction could not be proven based on the available data. Targeted studies are needed for a higher level of evidence.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00405-024-08478-3","type":"journal-article","created":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T17:02:19Z","timestamp":1707843739000},"page":"3557-3568","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Predicting residual cholesteatoma with the Potsic staging system still lacks evidence: a systematic review and meta-analysis"],"prefix":"10.1007","volume":"281","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1534-2201","authenticated-orcid":false,"given":"Kl\u00e1ra Borb\u00e1la","family":"K\u00f6rmendy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kinga","family":"Shenker-Horv\u00e1th","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Shulze Wenning","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u00e9ter","family":"Feh\u00e9rv\u00e1ri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Harnos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u00e9ter","family":"Hegyi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zsolt","family":"Moln\u00e1r","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2939-060X","authenticated-orcid":false,"given":"Kata","family":"Ill\u00e9s","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9617-8628","authenticated-orcid":false,"given":"Tam\u00e1s","family":"Horv\u00e1th","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,2,13]]},"reference":[{"key":"8478_CR1","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1001\/archotol.128.9.1009","volume":"128","author":"WP Potsic","year":"2002","unstructured":"Potsic WP, Samadi DS, Marsh RR, Wetmore RF (2002) A staging system for congenital cholesteatoma. 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