{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T05:12:23Z","timestamp":1777525943951,"version":"3.51.4"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T00:00:00Z","timestamp":1713398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T00:00:00Z","timestamp":1713398400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Arch Otorhinolaryngol"],"published-print":{"date-parts":[[2024,7]]},"DOI":"10.1007\/s00405-024-08606-z","type":"journal-article","created":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T05:01:56Z","timestamp":1713416516000},"page":"3853-3858","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Electrochemotherapy as adjuvant treatment in a sinonasal mucosal melanoma in elderly patient: a case report"],"prefix":"10.1007","volume":"281","author":[{"given":"Silvia","family":"Carpen\u00e8","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8959-9465","authenticated-orcid":false,"given":"Barbara","family":"Silvestri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina","family":"Bertinazzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrico","family":"Armato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurizio","family":"Amadori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Spinato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"de Terlizzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Azzarello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,4,18]]},"reference":[{"key":"8606_CR1","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.critrevonc.2017.01.019","volume":"112","author":"PA Ascierto","year":"2017","unstructured":"Ascierto PA, Accorona R, Botti G et al (2017) Mucosal melanoma of the head and neck. Crit Rev Oncol Hematol 112:136\u2013152. https:\/\/doi.org\/10.1016\/j.critrevonc.2017.01.019","journal-title":"Crit Rev Oncol Hematol"},{"key":"8606_CR2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.702287","volume":"11","author":"Y Ma","year":"2021","unstructured":"Ma Y, Xia R, Ma X, Judson-Torres RL, Zeng H (2021) Mucosal melanoma: pathological evolution, pathway dependency and targeted therapy. Front Oncol 11:702287. https:\/\/doi.org\/10.3389\/fonc.2021.702287","journal-title":"Front Oncol"},{"key":"8606_CR3","doi-asserted-by":"publisher","DOI":"10.3892\/mco.2019.1870","author":"H Hahn","year":"2019","unstructured":"Hahn H, Lee K, Choi W, Cheong S, Myung K, Hahn H (2019) An updated review of mucosal melanoma: survival meta-analysis. Mol Clin Onc. https:\/\/doi.org\/10.3892\/mco.2019.1870","journal-title":"Mol Clin Onc."},{"key":"8606_CR4","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1016\/j.cps.2021.05.010","volume":"48","author":"D Olla","year":"2021","unstructured":"Olla D, Neumeister MW (2021) Mucosal melanoma. Clin Plast Surg 48:707\u2013711. https:\/\/doi.org\/10.1016\/j.cps.2021.05.010","journal-title":"Clin Plast Surg"},{"key":"8606_CR5","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1097\/CMR.0000000000000686","volume":"30","author":"LH Mikkelsen","year":"2020","unstructured":"Mikkelsen LH, Maag E, Andersen MK et al (2020) The molecular profile of mucosal melanoma. Melanoma Res 30:533\u2013542. https:\/\/doi.org\/10.1097\/CMR.0000000000000686","journal-title":"Melanoma Res"},{"key":"8606_CR6","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1007\/s00428-007-0524-2","volume":"452","author":"RS Rivera","year":"2008","unstructured":"Rivera RS, Nagatsuka H, Gunduz M et al (2008) C-kit protein expression correlated with activating mutations in KIT gene in oral mucosal melanoma. Virchows Arch 452:27\u201332. https:\/\/doi.org\/10.1007\/s00428-007-0524-2","journal-title":"Virchows Arch"},{"key":"8606_CR7","doi-asserted-by":"publisher","first-page":"3163","DOI":"10.1038\/s41467-019-11107-x","volume":"10","author":"F Newell","year":"2019","unstructured":"Newell F, Kong Y, Wilmott JS et al (2019) Whole-genome landscape of mucosal melanoma reveals diverse drivers and therapeutic targets. Nat Commun 10:3163. https:\/\/doi.org\/10.1038\/s41467-019-11107-x","journal-title":"Nat Commun"},{"key":"8606_CR8","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/j.jaad.2014.03.031","volume":"71","author":"JD Tacastacas","year":"2014","unstructured":"Tacastacas JD, Bray J, Cohen YK et al (2014) Update on primary mucosal melanoma. J Am Acad Dermatol 71:366\u2013375. https:\/\/doi.org\/10.1016\/j.jaad.2014.03.031","journal-title":"J Am Acad Dermatol"},{"key":"8606_CR9","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1080\/21678707.2019.1672534","volume":"7","author":"S Khan","year":"2019","unstructured":"Khan S, Carvajal RD (2019) Mucosal melanoma: current strategies and future directions. Expert Opin Orphan Drugs 7:427\u2013434. https:\/\/doi.org\/10.1080\/21678707.2019.1672534","journal-title":"Expert Opin Orphan Drugs"},{"key":"8606_CR10","doi-asserted-by":"publisher","first-page":"1108","DOI":"10.1016\/j.ijrobp.2014.03.042","volume":"90","author":"S Lazarev","year":"2014","unstructured":"Lazarev S, Gupta V, Hu K, Harrison LB, Bakst R (2014) Mucosal melanoma of the head and neck: a systematic review of the literature. Int J Radiat Oncol*Biol*Phys 90:1108\u20131118. https:\/\/doi.org\/10.1016\/j.ijrobp.2014.03.042","journal-title":"Int J Radiat Oncol*Biol*Phys"},{"key":"8606_CR11","doi-asserted-by":"publisher","first-page":"345","DOI":"10.6004\/jnccn.2012.0034","volume":"10","author":"RD Carvajal","year":"2012","unstructured":"Carvajal RD, Spencer SA, Lydiatt W (2012) Mucosal melanoma: a clinically and biologically unique disease entity. J Natl Compr Canc Netw 10:345\u2013356. https:\/\/doi.org\/10.6004\/jnccn.2012.0034","journal-title":"J Natl Compr Canc Netw"},{"key":"8606_CR12","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1002\/cncr.20775","volume":"103","author":"S Temam","year":"2005","unstructured":"Temam S, Mamelle G, Marandas P et al (2005) Postoperative radiotherapy for primary mucosal melanoma of the head and neck. Cancer 103:313\u2013319. https:\/\/doi.org\/10.1002\/cncr.20775","journal-title":"Cancer"},{"key":"8606_CR13","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1001\/archoto.2010.217","volume":"136","author":"A Benlyazid","year":"2010","unstructured":"Benlyazid A, Thariat J, Temam S et al (2010) Postoperative radiotherapy in head and neck mucosal melanoma: a GETTEC study. Arch Otolaryngol Head Neck Surg 136:1219. https:\/\/doi.org\/10.1001\/archoto.2010.217","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"8606_CR14","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1200\/JCO.2016.67.9258","volume":"35","author":"SP D\u2019Angelo","year":"2017","unstructured":"D\u2019Angelo SP, Larkin J, Sosman JA et al (2017) Efficacy and safety of nivolumab alone or in combination with ipilimumab in patients with mucosal melanoma: a pooled analysis. JCO 35:226\u2013235. https:\/\/doi.org\/10.1200\/JCO.2016.67.9258","journal-title":"JCO"},{"key":"8606_CR15","doi-asserted-by":"publisher","first-page":"621","DOI":"10.3109\/0284186X.2011.573626","volume":"50","author":"LW Matthiessen","year":"2011","unstructured":"Matthiessen LW, Chalmers RL, Sainsbury DCG et al (2011) Management of cutaneous metastases using electrochemotherapy. Acta Oncol 50:621\u2013629. https:\/\/doi.org\/10.3109\/0284186X.2011.573626","journal-title":"Acta Oncol"},{"key":"8606_CR16","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/0277-5379(91)90064-K","volume":"27","author":"LM Mir","year":"1991","unstructured":"Mir LM, Orlowski S, Belehradek J, Paoletti C (1991) Electrochemotherapy potentiation of antitumour effect of bleomycin by local electric pulses. Eur J Cancer Clin Oncol 27:68\u201372. https:\/\/doi.org\/10.1016\/0277-5379(91)90064-K","journal-title":"Eur J Cancer Clin Oncol"},{"key":"8606_CR17","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.ejca.2020.06.020","volume":"138","author":"AJP Clover","year":"2020","unstructured":"Clover AJP, de Terlizzi F, Bertino G et al (2020) Electrochemotherapy in the treatment of cutaneous malignancy: outcomes and subgroup analysis from the cumulative results from the pan-European International Network for Sharing Practice in Electrochemotherapy database for 2482 lesions in 987 patients (2008\u20132019). Eur J Cancer 138:30\u201340. https:\/\/doi.org\/10.1016\/j.ejca.2020.06.020","journal-title":"Eur J Cancer"},{"key":"8606_CR18","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/j.ejca.2017.10.008","volume":"87","author":"CC Plaschke","year":"2017","unstructured":"Plaschke CC, Bertino G, McCaul JA et al (2017) European Research on Electrochemotherapy in Head and Neck Cancer (EURECA) project: results from the treatment of mucosal cancers. Eur J Cancer 87:172\u2013181. https:\/\/doi.org\/10.1016\/j.ejca.2017.10.008","journal-title":"Eur J Cancer"},{"key":"8606_CR19","doi-asserted-by":"publisher","first-page":"90","DOI":"10.3109\/00016489.2014.947655","volume":"135","author":"FJ Landstr\u00f6m","year":"2015","unstructured":"Landstr\u00f6m FJ, Reizenstein JA, Nilsson COS et al (2015) Electrochemotherapy \u2013 possible benefits and limitations to its use in the head and neck region. Acta Otolaryngol 135:90\u201395. https:\/\/doi.org\/10.3109\/00016489.2014.947655","journal-title":"Acta Otolaryngol"},{"key":"8606_CR20","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.3109\/00016489.2015.1049663","volume":"135","author":"FJ Landstr\u00f6m","year":"2015","unstructured":"Landstr\u00f6m FJ, Reizenstein J, Adamsson G-B, von Beckerath M, M\u00f6ller C (2015) Long-term follow-up in patients treated with curative electrochemotherapy for cancer in the oral cavity and oropharynx. Acta Otolaryngol 135:1070\u20131078. https:\/\/doi.org\/10.3109\/00016489.2015.1049663","journal-title":"Acta Otolaryngol"},{"key":"8606_CR21","doi-asserted-by":"publisher","DOI":"10.1002\/hed.25454","author":"CC Plaschke","year":"2018","unstructured":"Plaschke CC, Johannesen HH, Hansen RH et al (2018) The DAHANCA 32 study: electrochemotherapy for recurrent mucosal head and neck cancer. Head Neck. https:\/\/doi.org\/10.1002\/hed.25454","journal-title":"Head Neck"},{"key":"8606_CR22","doi-asserted-by":"publisher","first-page":"874","DOI":"10.1080\/0284186X.2018.1454602","volume":"57","author":"J Gehl","year":"2018","unstructured":"Gehl J, Sersa G, Matthiessen LW et al (2018) Updated standard operating procedures for electrochemotherapy of cutaneous tumours and skin metastases. Acta Oncol 57:874\u2013882. https:\/\/doi.org\/10.1080\/0284186X.2018.1454602","journal-title":"Acta Oncol"},{"key":"8606_CR23","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.ejcsup.2006.08.003","volume":"4","author":"LM Mir","year":"2006","unstructured":"Mir LM, Gehl J, Sersa G et al (2006) Standard operating procedures of the electrochemotherapy: instructions for the use of bleomycin or cisplatin administered either systemically or locally and electric pulses delivered by the CliniporatorTM by means of invasive or non-invasive electrodes. Eur J Cancer Suppl 4:14\u201325. https:\/\/doi.org\/10.1016\/j.ejcsup.2006.08.003","journal-title":"Eur J Cancer Suppl"},{"key":"8606_CR24","doi-asserted-by":"publisher","first-page":"3199","DOI":"10.3390\/cancers13133199","volume":"13","author":"D Rega","year":"2021","unstructured":"Rega D, Granata V, Petrillo A et al (2021) Organ sparing for locally advanced rectal cancer after neoadjuvant treatment followed by electrochemotherapy. Cancers 13:3199. https:\/\/doi.org\/10.3390\/cancers13133199","journal-title":"Cancers"},{"key":"8606_CR25","doi-asserted-by":"publisher","first-page":"285","DOI":"10.2478\/raon-2022-0022","volume":"56","author":"FM Schipilliti","year":"2022","unstructured":"Schipilliti FM, Onorato M, Arrivi G et al (2022) Electrochemotherapy for solid tumors: literature review and presentation of a novel endoscopic approach. Radiol Oncol 56:285\u2013291. https:\/\/doi.org\/10.2478\/raon-2022-0022","journal-title":"Radiol Oncol"},{"key":"8606_CR26","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0059557","volume":"8","author":"B Markelc","year":"2013","unstructured":"Markelc B, Sersa G, Cemazar M (2013) Differential mechanisms associated with vascular disrupting action of electrochemotherapy: intravital microscopy on the level of single normal and tumor blood vessels. PLoS ONE 8:e59557. https:\/\/doi.org\/10.1371\/journal.pone.0059557","journal-title":"PLoS ONE"},{"key":"8606_CR27","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1586\/era.10.43","volume":"10","author":"T Jarm","year":"2010","unstructured":"Jarm T, Cemazar M, Miklavcic D, Sersa G (2010) Antivascular effects of electrochemotherapy: implications in treatment of bleeding metastases. Expert Rev Anticancer Ther 10:729\u2013746. https:\/\/doi.org\/10.1586\/era.10.43","journal-title":"Expert Rev Anticancer Ther"},{"key":"8606_CR28","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1097\/DSS.0000000000002191","volume":"46","author":"SER Horbach","year":"2020","unstructured":"Horbach SER, Wolkerstorfer A, Jolink F, Bloemen PR, Van Der Horst CMAM (2020) Electrosclerotherapy as a novel treatment option for hypertrophic capillary malformations: a randomized controlled pilot trial. Dermatol Surg 46:491\u2013498. https:\/\/doi.org\/10.1097\/DSS.0000000000002191","journal-title":"Dermatol Surg"},{"key":"8606_CR29","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1111\/ijd.14314","volume":"58","author":"CA Goggins","year":"2019","unstructured":"Goggins CA, Khachemoune A (2019) The use of electrochemotherapy in combination with immunotherapy in the treatment of metastatic melanoma: a focused review. Int J Dermatol 58:865\u2013870. https:\/\/doi.org\/10.1111\/ijd.14314","journal-title":"Int J Dermatol"},{"key":"8606_CR30","doi-asserted-by":"publisher","first-page":"4289","DOI":"10.3390\/cancers13174289","volume":"13","author":"LG Campana","year":"2021","unstructured":"Campana LG, Peric B, Mascherini M et al (2021) Combination of pembrolizumab with electrochemotherapy in cutaneous metastases from melanoma: a comparative retrospective study from the InspECT and Slovenian Cancer Registry. Cancers 13:4289. https:\/\/doi.org\/10.3390\/cancers13174289","journal-title":"Cancers"},{"key":"8606_CR31","doi-asserted-by":"publisher","first-page":"2876","DOI":"10.3390\/cancers14122876","volume":"14","author":"TF Justesen","year":"2022","unstructured":"Justesen TF, Orhan A, Raskov H, Nolsoe C, G\u00f6genur I (2022) Electroporation and immunotherapy\u2014unleashing the abscopal effect. Cancers 14:2876. https:\/\/doi.org\/10.3390\/cancers14122876","journal-title":"Cancers"},{"key":"8606_CR32","doi-asserted-by":"publisher","unstructured":"Sersa G, Mascherini M, Di Prata C, Odili J, de Terlizzi F, McKenzie GAG, Clover AJP, Bertino G, Spina R, Groselj A, Cappellesso R, Gehl J, Bisase B, Curatolo P, Kis E, Lico V, Muir T, Orlando A, Quaglino P, Matteucci P, Valpione S, Campana LG. Outcomes of older adults aged 90 and over with cutaneous malignancies after electrochemotherapy with bleomycin: A matched cohort analysis from the InspECT registry. Eur J Surg Oncol. 2021;47(4):902\u2013912. https:\/\/doi.org\/10.1016\/j.ejso.2020.10.037","DOI":"10.1016\/j.ejso.2020.10.037"}],"container-title":["European Archives of Oto-Rhino-Laryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00405-024-08606-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00405-024-08606-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00405-024-08606-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T19:25:11Z","timestamp":1719516311000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00405-024-08606-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,18]]},"references-count":32,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["8606"],"URL":"https:\/\/doi.org\/10.1007\/s00405-024-08606-z","relation":{},"ISSN":["0937-4477","1434-4726"],"issn-type":[{"value":"0937-4477","type":"print"},{"value":"1434-4726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,18]]},"assertion":[{"value":"20 October 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 February 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 April 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors did not receive support from any organization for the submitted work. Francesca de Terlizzi is an IGEA employer.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The only conflict of interest can be ascribed to the fact that the author FdT is an IGEA employer.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The participant has consented to the submission of the case report to the journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical statement"}}]}}