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Analysis included the demographical data, clinical course, type of surgical and adjuvant treatment, histology type and margin status, perivascular invasion (LVI), perineural invasion (PNI), metastatic lymph nodes (LN). Facial nerve function, recurrence-free and overall survival were evaluated. Adequate statistics were used for data analysis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The final cohort included 63 SGC patients, with adenoid cystic carcinoma the most common pathological type (27%, <jats:italic>n<\/jats:italic>\u2009=\u200917), followed by adenocarcinoma (17.4% <jats:italic>n<\/jats:italic>\u2009=\u200911). T1 and T2 patients accounted for majority cases (<jats:italic>n<\/jats:italic>\u2009=\u200946). The lymph node metastases were confirmed with the histopathology in 31.7% (<jats:italic>n<\/jats:italic>\u2009=\u200920). Distant metastases were observed in 4.8% of cases (<jats:italic>n<\/jats:italic>\u2009=\u20093). 38% (<jats:italic>n<\/jats:italic>\u2009=\u200924) of SGC were treated selectively with surgery, 49.2% (<jats:italic>n<\/jats:italic>\u2009=\u200931) had postoperative radiotherapy and 15.9% (<jats:italic>n<\/jats:italic>\u2009=\u200910)\u2014radio-chemotherapy. The final facial nerve function was impaired in 38% of patients. Mean overall survival (OS) for all patients was 108.7 (\u00b1\u2009132.1) months, and was the most favorable for acinar cell carcinoma (118.9\u2009\u00b1\u200945.4) and the poorest for squamous cell carcinoma (44\u2009\u00b1\u200932). Cox regression analysis of disease-free survival and OS identified significant association only with patients\u2019 age over 65\u00a0years, the hazard ratio of 7.955 and 6.486, respectively.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The efficacy of treatment modalities for SGC should be verified with regard to the histopathological type, but also the patients\u2019 age should be taken into account.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00405-024-08650-9","type":"journal-article","created":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T03:50:51Z","timestamp":1713844251000},"page":"4305-4313","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Oncologic outcomes of the most prevalent major salivary gland cancers: retrospective cohort study from single center"],"prefix":"10.1007","volume":"281","author":[{"given":"Ewa","family":"Kucharska","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4012-8271","authenticated-orcid":false,"given":"Anna","family":"Rzepakowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micha\u0142","family":"\u017burek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Pikul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Daniel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelika","family":"Oleszczak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazimierz","family":"Niemczyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,4,23]]},"reference":[{"key":"8650_CR1","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1002\/dc.23255","volume":"43","author":"R Tyagi","year":"2015","unstructured":"Tyagi R, Dey P (2015) Diagnostic problems of salivary gland tumors. 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