{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T12:00:12Z","timestamp":1791979212240,"version":"4.4.0"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T00:00:00Z","timestamp":1719187200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T00:00:00Z","timestamp":1719187200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100007397","name":"Charles University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007397","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Arch Otorhinolaryngol"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Objective<\/jats:title>\n                <jats:p>One of the possible risks of sinonasal malignancy is its possible spread in the orbit. However, there is no clear consensus among the different departments as to whether it is necessary to exenterate the orbit in limited tumorous infiltration of periorbital fat. The purpose of the study was to demonstrate that periorbital infiltration and periorbital fat invasion without involvement of deeper orbital tissues are not the indication of orbital exenteration.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Materials and methods<\/jats:title>\n                <jats:p>Retrospective analysis was performed over a 17-year period of patients undergoing surgical treatment for sinonasal malignancy with histologically verified periorbital infiltration or deeper invasion into the orbit. A total of 32 patients were included in the study. For each group, the following data were analysed: sex, age, preoperative imaging studies, histological findings, site of origin, stage, surgical reconstruction, oncological treatment, survival, cause of death, number of recurrences in the orbit and functional status of preserved eyes.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Based on our criteria for orbital exenteration, orbital preservation was feasible in 18 patients. Orbital exenteration was performed in 14 patients with deeper tumor infiltration. There was a statistically insignificant difference in survival between the two groups. The 5-year overall survival (OS) was 44% for the orbital preservation group (only 2 patients died from local tumor recurrence) and 34% for the orbital exenteration group. The groups did not differ in other observed factors other than the extent of orbital infiltration. In 11 (61.1%) patients, vision was without significant change after radiation therapy. In 2 (11.1%) patients, visual function was impaired due to diplopia. 5 (27.8%) patients had severely impaired vision due to optic nerve atrophy after radiation therapy.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Our results show a relatively high survival rate in the group of patients with orbital preservation with a high chance of vision preservation, which justifies our approach to orbital preservation even in some tumors with periorbital infiltration.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00405-024-08757-z","type":"journal-article","created":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T20:24:40Z","timestamp":1719260680000},"page":"5303-5310","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Preservation of orbit in tumor invasion through the periorbita in sinonasal malignancy"],"prefix":"10.1007","volume":"281","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1174-0878","authenticated-orcid":false,"given":"Stepan","family":"Novak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuzana","family":"Balatkova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alzbeta","family":"Fikova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marek","family":"Grega","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Kalfert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Plzak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,6,24]]},"reference":[{"issue":"2","key":"8757_CR1","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/j.otc.2016.12.010","volume":"50","author":"GS Neel","year":"2017","unstructured":"Neel GS, Nagel TH, Hoxworth JM, Lal D (2017) Management of Orbital involvement in Sinonasal and ventral Skull Base malignancies. Otolaryngol Clin North Am 50(2):347\u2013364. https:\/\/doi.org\/10.1016\/j.otc.2016.12.010","journal-title":"Otolaryngol Clin North Am"},{"issue":"1","key":"8757_CR2","first-page":"39","volume":"55","author":"J Plzak","year":"2006","unstructured":"Plzak J, Jerabkova P, Skrivan J, Betka J (2006) Tumors of nasal cavity and paranasal sinuses-review of New Knowledge. Otorinolaryngol Foniatr 55(1):39\u201349 (In Czech)","journal-title":"Otorinolaryngol Foniatr"},{"issue":"2","key":"8757_CR3","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1002\/hed.10358","volume":"26","author":"C Suarez","year":"2004","unstructured":"Suarez C, Llorente JL, Fernandez De Leon R, Maseda E, Lopez A (2004) Prognostic factors in sinonasal tumors involving the anterior skull base. Head Neck 26(2):136\u2013144. https:\/\/doi.org\/10.1002\/hed.10358","journal-title":"Head Neck"},{"issue":"2","key":"8757_CR4","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1055\/s-0034-1390403","volume":"76","author":"C Reyes","year":"2015","unstructured":"Reyes C, Mason E, Solares CA, Bush C, Carrau R (2015) To preserve or not to preserve the orbit in paranasal sinus neoplasms: a meta-analysis. J Neurol Surg B Skull Base 76(2):122\u2013128. https:\/\/doi.org\/10.1055\/s-0034-1390403","journal-title":"J Neurol Surg B Skull Base"},{"issue":"10","key":"8757_CR5","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1002\/hed.20432","volume":"28","author":"DJ Howard","year":"2006","unstructured":"Howard DJ, Lund VJ, Wei WI (2006) Craniofacial resection for tumors of the nasal cavity and paranasal sinuses: a 25-year experience. Head Neck 28(10):867\u2013873. https:\/\/doi.org\/10.1002\/hed.20432","journal-title":"Head Neck"},{"issue":"1","key":"8757_CR6","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1017\/s0022215100081767","volume":"90","author":"DF Harrison","year":"1976","unstructured":"Harrison DF (1976) Problems in surgical management of neoplasms arising in the paranasal sinuses. J Laryngol Otol 90(1):69\u201374. https:\/\/doi.org\/10.1017\/s0022215100081767","journal-title":"J Laryngol Otol"},{"issue":"4","key":"8757_CR7","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1016\/s0002-9610(73)80032-7","volume":"126","author":"AS Ketcham","year":"1973","unstructured":"Ketcham AS, Chretien PB, Van Buren JM, Hoye RC, Beazley RM, Herdt JR (1973) The ethmoid sinuses: a re-evaluation of surgical resection. Am J Surg 126(4):469\u2013476. https:\/\/doi.org\/10.1016\/s0002-9610(73)80032-7","journal-title":"Am J Surg"},{"issue":"8","key":"8757_CR8","doi-asserted-by":"publisher","first-page":"2777","DOI":"10.1002\/hed.25759","volume":"41","author":"M Turri-Zanoni","year":"2019","unstructured":"Turri-Zanoni M, Lambertoni A, Margherini S, Giovannardi M, Ferrari M, Rampinelli V et al (2019) Multidisciplinary treatment algorithm for the management of sinonasal cancers with orbital invasion: a retrospective study. Head Neck 41(8):2777\u20132788. https:\/\/doi.org\/10.1002\/hed.25759","journal-title":"Head Neck"},{"issue":"2","key":"8757_CR9","first-page":"123","volume":"108","author":"X Wu","year":"1995","unstructured":"Wu X, Tang P, Qi Y (1995) Management of the orbital contents in radical surgery for squamous cell carcinoma of the maxillary sinus. Chin Med J (Engl) 108(2):123\u2013125","journal-title":"Chin Med J (Engl)"},{"issue":"2","key":"8757_CR10","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1002\/(sici)1097-0347(199803)20:2<97::aid-hed1>3.0.co;2-y","volume":"20","author":"VJ Lund","year":"1998","unstructured":"Lund VJ, Howard DJ, Wei WI, Cheesman AD (1998) Craniofacial resection for tumors of the nasal cavity and paranasal sinuses\u2013a 17-year experience. Head Neck 20(2):97\u2013105. https:\/\/doi.org\/10.1002\/(sici)1097-0347(199803)20:2<97::aid-hed1>3.0.co;2-y","journal-title":"Head Neck"},{"issue":"8 Pt 1","key":"8757_CR11","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.1097\/00005537-200208000-00007","volume":"112","author":"MJ Imola","year":"2002","unstructured":"Imola MJ, Schramm VL Jr (2002) Orbital preservation in surgical management of sinonasal malignancy. Laryngoscope 112(8 Pt 1):1357\u20131365. https:\/\/doi.org\/10.1097\/00005537-200208000-00007","journal-title":"Laryngoscope"},{"issue":"6","key":"8757_CR12","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1097\/01.scs.0000164332.81428.ba","volume":"16","author":"G Iannetti","year":"2005","unstructured":"Iannetti G, Valentini V, Rinna C, Ventucci E, Marianetti TM (2005) Ethmoido-orbital tumors: our experience. J Craniofac Surg 16(6):1085\u20131091. https:\/\/doi.org\/10.1097\/01.scs.0000164332.81428.ba","journal-title":"J Craniofac Surg"},{"issue":"11","key":"8757_CR13","doi-asserted-by":"publisher","first-page":"1650","DOI":"10.1002\/hed.24490","volume":"38","author":"Q Lisan","year":"2016","unstructured":"Lisan Q, Kolb F, Temam S, Tao Y, Janot F, Moya-Plana A (2016) Management of orbital invasion in sinonasal malignancies. Head Neck 38(11):1650\u20131656. https:\/\/doi.org\/10.1002\/hed.24490","journal-title":"Head Neck"},{"issue":"Suppl 2","key":"8757_CR14","doi-asserted-by":"publisher","first-page":"e430","DOI":"10.1055\/s-0041-1730353","volume":"83","author":"CH Shin","year":"2022","unstructured":"Shin CH, Lee HJ, Chung YS, Kim JH (2022) Treatment outcomes of Sinonasal malignancies Involving the Orbit. J Neurol Surg B Skull Base 83(Suppl 2):e430\u2013e7. https:\/\/doi.org\/10.1055\/s-0041-1730353","journal-title":"J Neurol Surg B Skull Base"},{"issue":"6","key":"8757_CR15","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1288\/00005537-197006000-00008","volume":"80","author":"Sisson","year":"1970","unstructured":"Sisson GA (1970) Symposium: 3. Treatment of malignancies of paranasal sinuses. Discussion and summary. Laryngoscope 80(6):945\u2013953. https:\/\/doi.org\/10.1288\/00005537-197006000-00008","journal-title":"Laryngoscope"},{"issue":"2","key":"8757_CR16","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1288\/00005537-198902000-00005","volume":"99","author":"GA Sisson","year":"1989","unstructured":"Sisson GA, Sr., Toriumi DM, Atiyah RA (1989) Paranasal sinus malignancy: a comprehensive update. Laryngoscope 99(2):143\u2013150. https:\/\/doi.org\/10.1288\/00005537-198902000-00005","journal-title":"Laryngoscope"},{"key":"8757_CR17","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.ejca.2022.05.010","volume":"171","author":"M Ferrari","year":"2022","unstructured":"Ferrari M, Mattavelli D, Tomasoni M, Raffetti E, Bossi P, Schreiber A et al (2022) The MUSES *: a prognostic study on 1360 patients with sinonasal cancer undergoing endoscopic surgery-based treatment: *MUlti-institutional collaborative study on endoscopically treated sinonasal cancers. Eur J Cancer 171:161\u2013182. https:\/\/doi.org\/10.1016\/j.ejca.2022.05.010","journal-title":"Eur J Cancer"},{"key":"8757_CR18","doi-asserted-by":"publisher","unstructured":"Galloni C, Locatello LG, Bruno C, Cannavicci A, Maggiore G, Gallo O (2021) The role of Elective Neck Treatment in the management of Sinonasal carcinomas: a systematic review of the literature and a Meta-analysis. Cancers (Basel) 13(8). https:\/\/doi.org\/10.3390\/cancers13081842","DOI":"10.3390\/cancers13081842"},{"key":"8757_CR19","unstructured":"Guidelines Version NCCN (1.2024), Head and Neck Cancers, https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/head-and-neck_blocks.pdf"}],"container-title":["European Archives of Oto-Rhino-Laryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00405-024-08757-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00405-024-08757-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00405-024-08757-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,21]],"date-time":"2024-09-21T20:16:38Z","timestamp":1726949798000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00405-024-08757-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,24]]},"references-count":19,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["8757"],"URL":"https:\/\/doi.org\/10.1007\/s00405-024-08757-z","relation":{},"ISSN":["0937-4477","1434-4726"],"issn-type":[{"value":"0937-4477","type":"print"},{"value":"1434-4726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,24]]},"assertion":[{"value":"5 December 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 May 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 June 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no relevant financial or non-financial interests to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This article does not contain any animal studies conducted by the authors. The study was conducted in accordance with the guidelines of the Helsinki Declaration and its subsequent amendments. Retrospective study does not require approval by an ethical committee in our country.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was not needed; it is a retrospective study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}