{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T06:38:38Z","timestamp":1784011118445,"version":"3.55.0"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2024,9,26]],"date-time":"2024-09-26T00:00:00Z","timestamp":1727308800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,9,26]],"date-time":"2024-09-26T00:00:00Z","timestamp":1727308800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100007052","name":"Universit\u00e0 degli Studi di Verona","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007052","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Arch Otorhinolaryngol"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>The purpose of this study is to determine the recurrence rate of cholesteatoma in patients who have undergone exclusive endoscopic tympanoplasty at our tertiary referral institution. A secondary objective is to analyze different clinical aspects that could be considered risk factors for recurrence to establish if it is possible to determine when a second-look procedure is indicated instead of a clinical follow-up.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>A retrospective study was performed on patients who had undergone exclusive endoscopic tympanoplasty for cholesteatoma in the last eight years and who were followed up for at least one year. The efficacy of the treatment performed only with the exclusive endoscopic technique was analyzed. Then, the anamnestic and intraoperative data were studied to identify possible factors that could increase the risk of recurrence.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The recurrence rate (14.5%) in patients (164) who underwent primary surgery with the exclusive endoscopic technique between January 2014 and January 2022 was similar to that in patients who underwent the microscopic technique with mastoidectomy in literature. In addition, we analyzed several clinical factors such as age, ossicular chain erosion, extension and localization of the cholesteatoma finding that only the last one could potentially be a risk factor for recurrence in this selected population.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Exclusive endoscopic tympanoplasty has been shown to be effective in removing cholesteatoma in patients without evidence of mastoid involvement, with recurrence rates comparable to traditional microscopic technique and a minimally invasive approach, even considering the patient\u2019s age, ossicular chain erosion and extension of the disease.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00405-024-08778-8","type":"journal-article","created":{"date-parts":[[2024,9,26]],"date-time":"2024-09-26T19:02:04Z","timestamp":1727377324000},"page":"5669-5675","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Exclusive endoscopic tympanoplasty efficacy in the treatment of cholesteatoma without mastoid involvement"],"prefix":"10.1007","volume":"281","author":[{"given":"Luca","family":"Bianconi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9103-3332","authenticated-orcid":false,"given":"Stefano","family":"Meneghesso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerio","family":"Arietti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomo","family":"Leonardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Monzani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Sacchetto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,9,26]]},"reference":[{"key":"8778_CR1","doi-asserted-by":"publisher","unstructured":"Robinson JM (1997) Cholesteatoma: Skin in the Wrong Place. J R Soc Med 1997; 90:93\u201396. https:\/\/doi.org\/10.1177\/014107689709000212","DOI":"10.1177\/014107689709000212"},{"key":"8778_CR2","doi-asserted-by":"publisher","unstructured":"Kuo C-L, Shiao A-S, Yung M, Sakagami M, Sudhoff H, Wang C-H, Hsu CH, Lien C-F (2015) Updates and Knowledge Gaps in Cholesteatoma Research. BioMed Res Int; 2015:1\u201317. https:\/\/doi.org\/10.1155\/2015\/854024","DOI":"10.1155\/2015\/854024"},{"key":"8778_CR3","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/S0165-5876(99)00029-4","volume":"49","author":"CAJ Prescott","year":"1999","unstructured":"Prescott CAJ (1999) Cholesteatoma in children\u2014the experience at the Red Cross War Memorial Children\u2019s hospital in South Africa 1988\u20131996. Int J Pediatr Otorhinolaryngol 49:15\u201319. https:\/\/doi.org\/10.1016\/S0165-5876(99)00029-4","journal-title":"Int J Pediatr Otorhinolaryngol"},{"key":"8778_CR4","doi-asserted-by":"publisher","first-page":"1998","DOI":"10.1016\/j.ijporl.2013.09.021","volume":"77","author":"ES Diom","year":"2013","unstructured":"Diom ES, Cisse Z, Tall A, Ndiaye M, Pegbessou E, Ndiaye IC, Diallo BK, Diouf R, Diop EM (2013) Management of acquired cholesteatoma in children: a 15 year review in ENT service of CHNU De FANN Dakar. Int J Pediatr Otorhinolaryngol 77:1998\u20132003. https:\/\/doi.org\/10.1016\/j.ijporl.2013.09.021","journal-title":"Int J Pediatr Otorhinolaryngol"},{"key":"8778_CR5","doi-asserted-by":"publisher","first-page":"3601","DOI":"10.1007\/s00405-014-3291-0","volume":"272","author":"C-L Kuo","year":"2015","unstructured":"Kuo C-L, Liao W-H, Shiao A-S (2015) A review of current progress in acquired cholesteatoma management. Eur Arch Otorhinolaryngol 272:3601\u20133609. https:\/\/doi.org\/10.1007\/s00405-014-3291-0","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"8778_CR6","doi-asserted-by":"publisher","first-page":"102451","DOI":"10.1016\/j.amjoto.2020.102451","volume":"42","author":"B Li","year":"2021","unstructured":"Li B, Zhou L, Wang M, Wang Y, Zou J (2021) Endoscopic versus microscopic surgery for treatment of middle ear cholesteatoma: a systematic review and meta-analysis. Am J Otolaryngol 42:102451. https:\/\/doi.org\/10.1016\/j.amjoto.2020.102451","journal-title":"Am J Otolaryngol"},{"key":"8778_CR7","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1016\/j.joto.2020.06.004","volume":"15","author":"B Verma","year":"2020","unstructured":"Verma B, Dabholkar YG (2020) Role of endoscopy in surgical management of cholesteatoma: a systematic review. J Otol 15:166\u2013170. https:\/\/doi.org\/10.1016\/j.joto.2020.06.004","journal-title":"J Otol"},{"issue":"1","key":"8778_CR8","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.otc.2020.09.003","volume":"54","author":"D Marchioni","year":"2021","unstructured":"Marchioni D, Rubini A, Soloperto D, Endoscopic Ear S (2021) Redefining middle ear anatomy and physiology. Otolaryngol Clin North Am Feb 54(1):25\u201343. https:\/\/doi.org\/10.1016\/j.otc.2020.09.003","journal-title":"Otolaryngol Clin North Am Feb"},{"key":"8778_CR9","doi-asserted-by":"publisher","unstructured":"Alicandri-Ciufelli M, Marchioni D, Kakehata S, Presutti L, Villari D Endoscopic management of attic cholesteatoma: long-term results (2016). Otolaryngol Clin North Am. 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