{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T03:07:12Z","timestamp":1740107232077,"version":"3.37.3"},"reference-count":10,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T00:00:00Z","timestamp":1720396800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T00:00:00Z","timestamp":1720396800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Arch Otorhinolaryngol"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Suppurative perichondritis of the auricle is a common disease that can easily cause malformations if it develops into an uncontrolled infection. In nearly half of the cases, otolaryngologists cannot identify the pathogens involved.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>In the present work, we described two cases of pyogenic perichondritis, with negative on conventional culture. However, using metagenomic next-generation sequencing (mNGS), we detected fungal infections in the patients and after the patients were given anti-fungal treatment, the patients achieved a good prognosis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>These cases highlighted the possibility that fungi might be the involved pathogens in patients who have had multiple negative bacterial cultures, and mNGS should be applied in these cases. mNGS could be used as a supplement to traditional culture methods.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00405-024-08792-w","type":"journal-article","created":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T20:21:54Z","timestamp":1720470114000},"page":"5559-5562","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Perichondritis of the auricle: bacterial or fungal? (A case series)"],"prefix":"10.1007","volume":"281","author":[{"given":"Ming","family":"Hu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8275-7689","authenticated-orcid":false,"given":"Yan","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,7,8]]},"reference":[{"issue":"8","key":"8792_CR1","doi-asserted-by":"publisher","first-page":"1827","DOI":"10.1002\/lary.25238","volume":"125","author":"M Sosin","year":"2015","unstructured":"Sosin M, Weissler JM, Pulcrano M, Rodriguez ED (2015) Transcartilaginous ear piercing and infectious complications: a systematic review and critical analysis of outcomes. Laryngoscope 125(8):1827\u20131834. https:\/\/doi.org\/10.1002\/lary.25238Epub 2015 Mar 30","journal-title":"Laryngoscope"},{"issue":"8","key":"8792_CR2","doi-asserted-by":"publisher","first-page":"2199","DOI":"10.1007\/s00405-019-05463-z","volume":"276","author":"TE Klug","year":"2019","unstructured":"Klug TE, Holm N, Greve T, Ovesen T (2019) Perichondritis of the auricle: bacterial findings and clinical evaluation of different antibiotic regimens. Eur Arch Otorhinolaryngol 276(8):2199\u20132203. https:\/\/doi.org\/10.1007\/s00405-019-05463-zEpub 2019 May 11","journal-title":"Eur Arch Otorhinolaryngol"},{"doi-asserted-by":"publisher","unstructured":"Forozidou E, Poutoglidis A, Tsetsos N, Kilmpasanis A, Fyrmpas G (2021) Surgery as a last resort for persistent auricular perichondritis. Ear Nose Throat J 1455613211038343. https:\/\/doi.org\/10.1177\/01455613211038343. Online ahead of print.","key":"8792_CR3","DOI":"10.1177\/01455613211038343"},{"doi-asserted-by":"publisher","unstructured":"Fang L, Xu J, Wang W, Huang Y (2020) Auricular suppurative perichondritis secondary to exclusive endoscopic ear surgery for tympanoplasty: a case report and literature review. Am J Otolaryngol 41(6):102571. https:\/\/doi.org\/10.1016\/j.amjoto.2020.102571Epub 2020 Jun 1","key":"8792_CR4","DOI":"10.1016\/j.amjoto.2020.102571"},{"issue":"6","key":"8792_CR5","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1017\/S0022215107005877","volume":"121","author":"HK Prasad","year":"2007","unstructured":"Prasad HK, Sreedharan S, Prasad HS, Meyyappan MH, Harsha KS (2007) Perichondritis of the auricle and its management. J Laryngol Otol 121(6):530\u2013534. https:\/\/doi.org\/10.1017\/S0022215107005877Epub 2007 Feb 26","journal-title":"J Laryngol Otol"},{"issue":"1","key":"8792_CR6","first-page":"21","volume":"13","author":"E Davidi","year":"2011","unstructured":"Davidi E, Paz A, Duchman H, Luntz M, Potasman I (2011) Perichondritis of the auricle: analysis of 114 cases. Isr Med Assoc J 13(1):21\u201324","journal-title":"Isr Med Assoc J"},{"issue":"6","key":"8792_CR7","doi-asserted-by":"publisher","first-page":"e01888","DOI":"10.1128\/mBio.01888-15","volume":"6","author":"B Goldberg","year":"2015","unstructured":"Goldberg B, Sichtig H, Geyer C, Ledeboer N, Weinstock GM (2015) Making the leap from research laboratory to clinic: challenges and opportunities for next-generation sequencing in infectious disease diagnostics. mBio 6(6):e01888\u2013e01815. https:\/\/doi.org\/10.1128\/mBio.01888-15","journal-title":"mBio"},{"key":"8792_CR8","doi-asserted-by":"publisher","first-page":"1236414","DOI":"10.3389\/fcimb.2023.1236414","volume":"13","author":"Q Wang","year":"2023","unstructured":"Wang Q, Hu R, Zhu Y, Zhu W, Jiang H (2023) Case report: the application of metagenomic next generation sequencing in diagnosing fungal malignant external otitis: a report of two cases. Front Cell Infect Microbiol 13:1236414","journal-title":"Front Cell Infect Microbiol"},{"issue":"12","key":"8792_CR9","doi-asserted-by":"publisher","first-page":"e12476","DOI":"10.1016\/j.heliyon.2022.e12476","volume":"8","author":"Y Liang","year":"2022","unstructured":"Liang Y, Xiong X, Zhang C, Wang W, Zhang G (2022) Scedosporium apiospermum invasive rhinosinusitis in an elderly patient: diagnosis and treatment. Heliyon 8(12):e12476","journal-title":"Heliyon"},{"issue":"3","key":"8792_CR10","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1097\/QCO.0b013e32835fb920","volume":"26","author":"C Garcia-Vidal","year":"2013","unstructured":"Garcia-Vidal C, Viasus D, Carratal\u00e0 J (2013) Pathogenesis of invasive fungal infections. Curr Opin Infect Dis 26(3):270\u2013276. https:\/\/doi.org\/10.1097\/QCO.0b013e32835fb920","journal-title":"Curr Opin Infect Dis"}],"container-title":["European Archives of Oto-Rhino-Laryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00405-024-08792-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00405-024-08792-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00405-024-08792-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,21]],"date-time":"2024-09-21T20:17:30Z","timestamp":1726949850000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00405-024-08792-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,8]]},"references-count":10,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["8792"],"URL":"https:\/\/doi.org\/10.1007\/s00405-024-08792-w","relation":{},"ISSN":["0937-4477","1434-4726"],"issn-type":[{"type":"print","value":"0937-4477"},{"type":"electronic","value":"1434-4726"}],"subject":[],"published":{"date-parts":[[2024,7,8]]},"assertion":[{"value":"26 March 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 June 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 July 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was performed in accordance with the relevant guidelines and regulations. Written informed consent was obtained from all participants.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to participate"}},{"value":"All authors have approved this manuscript for publication. Consent for publication was obtained from the patient.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}