{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T04:46:48Z","timestamp":1788583608948,"version":"build-2803163510"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T00:00:00Z","timestamp":1719532800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T00:00:00Z","timestamp":1719532800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100016925","name":"Takeda Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Arch Otorhinolaryngol"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>In Japan, two types of tests for diagnosing olfactory disorders, T and T (T&amp;T) olfactometry and intravenous olfactory tests, are covered by insurance and performed on patients with olfactory disorders. This study examined the validity of these olfactory tests and whether psychophysical or morphological tests are more helpful in evaluating olfactory disorders.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We evaluated patients who visited our department and underwent two types of olfaction tests and sinus computed tomography (CT). Data regarding the age, sex, peripheral blood eosinophil percentage, presence of bronchial asthma, diagnoses, olfactory symptom score, results of the two olfactory tests, and CT findings in eligible patients were extracted from medical records and retrospectively reviewed.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>One hundred and sixty-three patients underwent all tests during the study period. The results of the T&amp;T olfactometry and intravenous olfactory tests were significantly correlated. However, only the results of T&amp;T olfactometry and olfactory cleft opacification on CT were statistically significant predictors of the olfactory symptom scores.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>T&amp;T olfactometry and CT evaluations of olfactory cleft opacification helped evaluate olfactory dysfunction. It is important to note that intravenous olfactory tests are best performed with careful control and not blindly to assess olfactory disorders.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00405-024-08803-w","type":"journal-article","created":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T12:02:35Z","timestamp":1719576155000},"page":"5801-5806","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Propriety of various examinations for subjective symptoms of olfactory disorders"],"prefix":"10.1007","volume":"281","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9860-3293","authenticated-orcid":false,"given":"Tomotaka","family":"Hemmi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Nomura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuta","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Numano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryoukichi","family":"Ikeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuru","family":"Sugawara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,6,28]]},"reference":[{"key":"8803_CR1","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1111\/j.1749-6632.1987.tb43476.x","volume":"510","author":"SF Takagi","year":"1987","unstructured":"Takagi SF (1987) A standardized olfactometer in Japan. A review over ten years. Ann N Y Acad Sci 510:113\u2013118. https:\/\/doi.org\/10.1111\/j.1749-6632.1987.tb43476.x","journal-title":"Ann N Y Acad Sci"},{"key":"8803_CR2","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/s0385-8146(88)80006-3","volume":"15","author":"M Furukawa","year":"1988","unstructured":"Furukawa M, Kamide M, Miwa T, Umeda R (1988) Significance of intravenous olfaction test using thiamine propyldisulfide (Alinamin) in olfactometry. Auris Nasus Larynx 15:25\u201331. https:\/\/doi.org\/10.1016\/s0385-8146(88)80006-3","journal-title":"Auris Nasus Larynx"},{"key":"8803_CR3","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1016\/j.anl.2012.12.005","volume":"40","author":"E Mori","year":"2013","unstructured":"Mori E, Matsuwaki Y, Mitsuyama C, Okushi T, Nakajima T, Moriyama H (2013) Risk factors for olfactory dysfunction in chronic rhinosinusitis. Auris Nasus Larynx 40:465\u2013469. https:\/\/doi.org\/10.1016\/j.anl.2012.12.005","journal-title":"Auris Nasus Larynx"},{"key":"8803_CR4","doi-asserted-by":"publisher","first-page":"35361","DOI":"10.1038\/srep35361","volume":"6","author":"S Kikuta","year":"2016","unstructured":"Kikuta S, Matsumoto Y, Kuboki A et al (2016) Longer latency of sensory response to intravenous odor injection predicts olfactory neural disorder. Sci Rep 6:35361. https:\/\/doi.org\/10.1038\/srep35361","journal-title":"Sci Rep"},{"key":"8803_CR5","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1159\/000049081","volume":"64","author":"M Kawamoto","year":"2002","unstructured":"Kawamoto M, Ohno K, Tamura M, Kawasaki Y, Kubo T (2002) Evaluation of the T&T olfactometer by mapping c-fos protein in an olfactory bulb. 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A summary of this study is available online, and refusals to participate were excluded from consideration.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}