{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T03:39:10Z","timestamp":1792640350520,"version":"4.5.0"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T00:00:00Z","timestamp":1721174400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T00:00:00Z","timestamp":1721174400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001537","name":"University of Auckland","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001537","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Arch Otorhinolaryngol"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>There are few options for treatment of dysphonia secondary to vocal pathology related to lamina propria scar, atrophy, sulcus, or inflammatory disorders. Platelet rich plasma (PRP) may provide anti-inflammatory and regenerative properties seen with other tissue engineering therapies without the risks associated with these treatments. We evaluated vocal fold (VF) injection of PRP for feasibility, phonatory effects, patient satisfaction and durability.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Patients with dysphonia secondary to vocal fold scar, atrophy, sulcus and inflammatory lesions were included. PRP injections were administered in office, to bilateral vocal folds. Patients were followed up at 1 week, 1 month, 3 months and 6 months to assess outcomes (GRBAS scale, maximum phonation time, vocal fatigue index (VFI), voice handicap index (VHI-10) and stroboscopy).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>75 intracordal PRP injections were administered to 48 patients. All injections were completed, and no adverse reactions were experienced. Improvements in VHI-10 scores at 1,3,6 months were seen (mean VHI 21.73 at baseline, 15.62 at six months, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). 72.3% rated improvement at 7 or above on Likert scale. 95.7% of patients would consider a future PRP injection. Secondary outcomes VFI, MPT, and GRBAS also demonstrated significant improvements over time. Patients receiving a single PRP injection (<jats:italic>n<\/jats:italic>\u2009=\u200926) still demonstrated significant VHI-10 improvements at 1,3 and 6 months.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>VF office PRP injections are feasible and safe and can provide phonatory benefit and reduce vocal effort in benign VF disorders. A single PRP injection is sufficient to provide sustained benefit in some cases.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Level of evidence<\/jats:title>\n                <jats:p>Level III: prospective cohort study.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00405-024-08824-5","type":"journal-article","created":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T03:31:22Z","timestamp":1721187082000},"page":"5419-5428","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Platelet Rich plasma injection of the vocal folds in benign vocal pathologies"],"prefix":"10.1007","volume":"281","author":[{"given":"Georgia","family":"Mackay","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3302-7045","authenticated-orcid":false,"given":"Jacqui","family":"Allen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,7,17]]},"reference":[{"issue":"1","key":"8824_CR1","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1002\/lio2.993","volume":"8","author":"NJI Hamilton","year":"2022","unstructured":"Hamilton NJI (2022) The life-cycle and restoration of the human vocal fold. Laryngoscope Invest Otolaryngol 8(1):168\u2013176. https:\/\/doi.org\/10.1002\/lio2.993","journal-title":"Laryngoscope Invest Otolaryngol"},{"issue":"12","key":"8824_CR2","doi-asserted-by":"publisher","first-page":"2187","DOI":"10.1097\/00005537-200312000-00027","volume":"113","author":"ECM de Melo","year":"2003","unstructured":"de Melo ECM, Lemos M, Filho JAX, Sennes LU, Saldiva PHN, Tsuji DH (2003) Distribution of collagen in the Lamina Propria of the Human Vocal fold. Laryngoscope 113(12):2187\u20132191. https:\/\/doi.org\/10.1097\/00005537-200312000-00027","journal-title":"Laryngoscope"},{"issue":"6","key":"8824_CR3","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1097\/00005537-199906000-00001","volume":"109","author":"SD Gray","year":"1999","unstructured":"Gray SD, Titze IR, Chan R, Hammond TH (1999) Vocal Fold proteoglycans and their influence on biomechanics. Laryngoscope 109(6):845\u2013854. https:\/\/doi.org\/10.1097\/00005537-199906000-00001","journal-title":"Laryngoscope"},{"issue":"6","key":"8824_CR4","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1177\/019459980112400602","volume":"124","author":"RW Chan","year":"2001","unstructured":"Chan RW, Gray SD, Titze IR (2001) The importance of Hyaluronic Acid in Vocal fold Biomechanics. Otolaryngol Head Neck Surg 124(6):607\u2013614. https:\/\/doi.org\/10.1177\/019459980112400602","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"4","key":"8824_CR5","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/j.jvoice.2007.12.002","volume":"23","author":"S Hirano","year":"2009","unstructured":"Hirano S, Minamiguchi S, Yamashita M, Ohno T, Kanemaru S, ichi, Kitamura M (2009) Histologic characterization of human scarred vocal folds. J Voice 23(4):399\u2013407. https:\/\/doi.org\/10.1016\/j.jvoice.2007.12.002","journal-title":"J Voice"},{"issue":"9","key":"8824_CR6","doi-asserted-by":"publisher","first-page":"2491","DOI":"10.1007\/s00405-013-2498-9","volume":"270","author":"G Friedrich","year":"2013","unstructured":"Friedrich G, Dikkers FG, Arens C, Remacle M, Hess M, Giovanni A et al (2013) Vocal Fold scars: current concepts and future directions. Consensus report of the phonosurgery committee of the European laryngological society. Eur Arch Oto-rhino-l 270(9):2491\u20132507. https:\/\/doi.org\/10.1007\/s00405-013-2498-9","journal-title":"Eur Arch Oto-rhino-l"},{"key":"8824_CR7","doi-asserted-by":"publisher","unstructured":"Peres A, de CS, Pessim ABB, Rodrigues SA, Martins RHG Effect of aging on the vocal muscle. J Voice. Published online 2022. https:\/\/doi.org\/10.1016\/j.jvoice.2022.03.020","DOI":"10.1016\/j.jvoice.2022.03.020"},{"key":"8824_CR8","doi-asserted-by":"publisher","unstructured":"Santos M, Freitas SV, Sousa CA, e, Silva \u00c1M (2023) da. Presbylarynx: validation of a classification based on morphological characteristics. Eur Arch Oto-rhino-l. ;280(2):781\u2013788. https:\/\/doi.org\/10.1007\/s00405-022-07618-x","DOI":"10.1007\/s00405-022-07618-x"},{"key":"8824_CR9","doi-asserted-by":"publisher","unstructured":"Santos M, Freitas SV, Sousa CA, e, Silva \u00c1M (2021) da. Presbylarynx: stratifying endoscopic signs for future researches. Eur Arch Oto-rhino-l. ;278(6):2157\u20132158. https:\/\/doi.org\/10.1007\/s00405-021-06735-3","DOI":"10.1007\/s00405-021-06735-3"},{"issue":"8","key":"8824_CR10","doi-asserted-by":"publisher","first-page":"2289","DOI":"10.1007\/s00405-019-05489-3","volume":"276","author":"A Hantzakos","year":"2019","unstructured":"Hantzakos A, Dikkers FG, Giovanni A, Benninger MS, Remacle M, Sj\u00f6gren EV et al (2019) Vocal Fold scars: a common classification proposal by the American Laryngological Association and European Laryngological Society. Eur Arch Oto-rhino-l 276(8):2289\u20132292. https:\/\/doi.org\/10.1007\/s00405-019-05489-3","journal-title":"Eur Arch Oto-rhino-l"},{"issue":"8","key":"8824_CR11","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1007\/s004050000254","volume":"257","author":"MW Hsiung","year":"2000","unstructured":"Hsiung MW, Woo P, Wang HW, Su WY (2000) A clinical classification and histopathological study of sulcus vocalis. Eur Arch Oto-rhino-l 257(8):466\u2013468. https:\/\/doi.org\/10.1007\/s004050000254","journal-title":"Eur Arch Oto-rhino-l"},{"issue":"4","key":"8824_CR12","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1002\/term.2603","volume":"12","author":"S Hirano","year":"2018","unstructured":"Hirano S, Kawamoto A, Tateya I, Mizuta M, Kishimoto Y, Hiwatashi N et al (2018) A phase I\/II exploratory clinical trial for intracordal injection of recombinant hepatocyte growth factor for vocal Fold scar and sulcus. J Tissue Eng Regen M 12(4):1031\u20131038. https:\/\/doi.org\/10.1002\/term.2603","journal-title":"J Tissue Eng Regen M"},{"issue":"9","key":"8824_CR13","doi-asserted-by":"publisher","first-page":"2059","DOI":"10.1002\/lary.29200","volume":"131","author":"S Hirano","year":"2021","unstructured":"Hirano S, Sugiyama Y, Kaneko M, Mukudai S, Fuse S, Hashimoto K (2021) Intracordal Injection of Basic Fibroblast Growth factor in 100 cases of Vocal fold atrophy and scar. Laryngoscope 131(9):2059\u20132064. https:\/\/doi.org\/10.1002\/lary.29200","journal-title":"Laryngoscope"},{"issue":"3","key":"8824_CR14","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1002\/lio2.1060","volume":"8","author":"YD Heman-Ackah","year":"2023","unstructured":"Heman-Ackah YD, Ivey CM, Alexander R (2023) Options for treatment of a small glottic gap. Laryngoscope Investig Otolaryngol 8(3):720\u2013729. https:\/\/doi.org\/10.1002\/lio2.1060","journal-title":"Laryngoscope Investig Otolaryngol"},{"issue":"4","key":"8824_CR15","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1177\/0883911504045229","volume":"19","author":"A Borzacchiello","year":"2004","unstructured":"Borzacchiello A, Mayol L, Ambrosio L, G\u00e4rskog O, Dahlqvist \u00c5 (2004) Rheological characterization of vocal folds after injection augmentation in a preliminary animal study. J Bioact Compat Polym 19(4):331\u2013341. https:\/\/doi.org\/10.1177\/0883911504045229","journal-title":"J Bioact Compat Polym"},{"issue":"1","key":"8824_CR16","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1186\/s40463-020-00481-y","volume":"49","author":"M Echternach","year":"2020","unstructured":"Echternach M, D\u00f6llinger M, K\u00f6berlein M, Kuranova L, Gellrich D, Kainz MA (2020) Vocal Fold oscillation pattern changes related to loudness in patients with vocal Fold mass lesions. J Otolaryngol - Head Neck Surg 49(1):80. https:\/\/doi.org\/10.1186\/s40463-020-00481-y","journal-title":"J Otolaryngol - Head Neck Surg"},{"issue":"1","key":"8824_CR17","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1186\/s13287-020-01632-8","volume":"11","author":"S Herteg\u00e5rd","year":"2020","unstructured":"Herteg\u00e5rd S, Nagubothu SR, Malmstr\u00f6m E, LeBlanc K (2020) Treatment of vocal Fold scarring with autologous bone marrow-derived human mesenchymal stromal cells\u2014first phase I\/II human clinical study. Stem Cell Res Ther 11(1):128. https:\/\/doi.org\/10.1186\/s13287-020-01632-8","journal-title":"Stem Cell Res Ther"},{"issue":"4","key":"8824_CR18","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1177\/0194599816628501","volume":"154","author":"TL Shiba","year":"2016","unstructured":"Shiba TL, Hardy J, Luegmair G, Zhang Z, Long JL (2016) Tissue-Engineered Vocal fold mucosa implantation in rabbits. Otolaryngol Head Neck Surg 154(4):679\u2013688. https:\/\/doi.org\/10.1177\/0194599816628501","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"4","key":"8824_CR19","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1001\/jamaoto.2019.4328","volume":"146","author":"A Mattei","year":"2020","unstructured":"Mattei A, Bertrand B, Jouve E, Blaise T, Philandrianos C, Grimaud F et al (2020) Feasibility of first injection of autologous adipose tissue\u2013derived stromal vascular fraction in human scarred vocal folds. Jama Otolaryngol Head Neck Surg 146(4):355\u2013363. https:\/\/doi.org\/10.1001\/jamaoto.2019.4328","journal-title":"Jama Otolaryngol Head Neck Surg"},{"issue":"2","key":"8824_CR20","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1177\/0363546516665809","volume":"45","author":"BJ Cole","year":"2017","unstructured":"Cole BJ, Karas V, Hussey K, Merkow DB, Pilz K, Fortier LA (2017) Hyaluronic Acid Versus platelet-rich plasma: a prospective, double-blind randomized controlled trial comparing clinical outcomes and effects on Intra-articular Biology for the treatment of knee osteoarthritis. Am J Sports Med 45(2):339\u2013346. https:\/\/doi.org\/10.1177\/0363546516665809","journal-title":"Am J Sports Med"},{"issue":"3","key":"8824_CR21","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1007\/s00132-018-03659-5","volume":"48","author":"Y Huang","year":"2019","unstructured":"Huang Y, Liu X, Xu X, Liu J (2019) Intra-articular injections of platelet-rich plasma, hyaluronic acid or corticosteroids for knee osteoarthritis. Orthop 48(3):239\u2013247. https:\/\/doi.org\/10.1007\/s00132-018-03659-5","journal-title":"Orthop"},{"issue":"2","key":"8824_CR22","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1177\/0363546518814532","volume":"47","author":"AD Martino","year":"2019","unstructured":"Martino AD, Matteo BD, Papio T, Tentoni F, Selleri F, Cenacchi A et al (2019) Platelet-Rich plasma Versus Hyaluronic Acid injections for the treatment of knee osteoarthritis: results at 5 years of a Double-Blind, randomized controlled trial. Am J Sports Med 47(2):347\u2013354. https:\/\/doi.org\/10.1177\/0363546518814532","journal-title":"Am J Sports Med"},{"key":"8824_CR23","doi-asserted-by":"publisher","first-page":"979834","DOI":"10.3389\/fbioe.2022.979834","volume":"10","author":"X Xue","year":"2022","unstructured":"Xue X, Bian Y, Yang M, Wei W, Meng L, Zhang Q et al (2022) Evaluation of injectable platelet-rich fibrin produced by a simple twice-centrifugation method combined with vacuum sealing drainage technology in the treatment of chronic refractory wounds. Front Bioeng Biotechnol 10:979834. https:\/\/doi.org\/10.3389\/fbioe.2022.979834","journal-title":"Front Bioeng Biotechnol"},{"key":"8824_CR24","doi-asserted-by":"publisher","first-page":"1078527","DOI":"10.3389\/fbioe.2022.1078527","volume":"10","author":"Y Zhang","year":"2023","unstructured":"Zhang Y, Wang Z, Zong C, Gu X, Fan S, Xu L et al (2023) Platelet-rich plasma attenuates the severity of joint capsule fibrosis following post-traumatic joint contracture in rats. Front Bioeng Biotechnol 10:1078527. https:\/\/doi.org\/10.3389\/fbioe.2022.1078527","journal-title":"Front Bioeng Biotechnol"},{"issue":"11","key":"8824_CR25","doi-asserted-by":"publisher","first-page":"920","DOI":"10.2174\/1389201020666190619111118","volume":"20","author":"L Gato-Calvo","year":"2019","unstructured":"Gato-Calvo L, Hermida-G\u00f3mez T, Romero CR, Burguera EF, Blanco FJ (2019) Anti-inflammatory effects of Novel standardized platelet Rich plasma releasates on knee osteoarthritic chondrocytes and cartilage in vitro. Curr Pharm Biotechnol 20(11):920\u2013933. https:\/\/doi.org\/10.2174\/1389201020666190619111118","journal-title":"Curr Pharm Biotechnol"},{"issue":"4","key":"8824_CR26","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1002\/tox.23456","volume":"37","author":"S Yadav","year":"2022","unstructured":"Yadav S, Srivastava S, Singh G (2022) Platelet-rich plasma exhibits anti\u2010inflammatory effect and attenuates cardiomyocyte damage by reducing NF\u2010\u03baB and enhancing VEGF expression in isoproterenol induced cardiotoxicity model. Environ Toxicol 37(4):936\u2013953. https:\/\/doi.org\/10.1002\/tox.23456","journal-title":"Environ Toxicol"},{"issue":"1","key":"8824_CR27","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1186\/ar4493","volume":"16","author":"X Xie","year":"2014","unstructured":"Xie X, Zhang C, Tuan RS (2014) Biology of platelet-rich plasma and its clinical application in cartilage repair. Arthritis Res Ther 16(1):204. https:\/\/doi.org\/10.1186\/ar4493","journal-title":"Arthritis Res Ther"},{"issue":"2","key":"8824_CR28","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1113\/ep090052","volume":"107","author":"C Sassoli","year":"2022","unstructured":"Sassoli C, Garella R, Chellini F, Tani A, Pavan P, Bambi F et al (2022) Platelet-rich plasma affects gap junctional features in myofibroblasts in vitro via vascular endothelial growth factor (VEGF)\u2010A\/VEGF receptor. Exp Physiol 107(2):106\u2013121. https:\/\/doi.org\/10.1113\/ep090052","journal-title":"Exp Physiol"},{"issue":"3","key":"8824_CR29","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1002\/jcp.22274","volume":"225","author":"P Bendinelli","year":"2010","unstructured":"Bendinelli P, Matteucci E, Dogliotti G, Corsi MM, Banfi G, Maroni P et al (2010) Molecular basis of anti-inflammatory action of platelet\u2010rich plasma on human chondrocytes: mechanisms of NF\u2010\u03baB inhibition via HGF. J Cell Physiol 225(3):757\u2013766. https:\/\/doi.org\/10.1002\/jcp.22274","journal-title":"J Cell Physiol"},{"issue":"6","key":"8824_CR30","doi-asserted-by":"publisher","first-page":"e67303","DOI":"10.1371\/journal.pone.0067303","volume":"8","author":"J Zhang","year":"2013","unstructured":"Zhang J, Middleton KK, Fu FH, Im HJ, Wang JHC (2013) HGF mediates the anti-inflammatory effects of PRP on injured tendons. PLoS ONE 8(6):e67303. https:\/\/doi.org\/10.1371\/journal.pone.0067303","journal-title":"PLoS ONE"},{"issue":"1","key":"8824_CR31","doi-asserted-by":"publisher","first-page":"47","DOI":"10.3342\/ceo.2014.7.1.47","volume":"7","author":"SH Woo","year":"2013","unstructured":"Woo SH, Jeong HS, Kim JP, Koh EH, Lee SU, Jin SM et al (2013) Favorable vocal fold Wound Healing Induced by platelet-rich plasma injection. Clin Exp Otorhinolar 7(1):47\u201352. https:\/\/doi.org\/10.3342\/ceo.2014.7.1.47","journal-title":"Clin Exp Otorhinolar"},{"issue":"6","key":"8824_CR32","doi-asserted-by":"publisher","first-page":"587","DOI":"10.5312\/wjo.v13.i6.587","volume":"13","author":"M Dejnek","year":"2022","unstructured":"Dejnek M, Witkowski J, Moreira H, P\u0142aczkowska S, Morasiewicz P, Reichert P et al (2022) Content of blood cell components, inflammatory cytokines and growth factors in autologous platelet-rich plasma obtained by various methods. World J Orthop 13(6):587\u2013602. https:\/\/doi.org\/10.5312\/wjo.v13.i6.587","journal-title":"World J Orthop"},{"key":"8824_CR33","doi-asserted-by":"publisher","unstructured":"Eppley BL, Woodell JE, Higgins J. Platelet Quantification and Growth Factor Analysis from Platelet-Rich Plasma Implications for Wound Healing. Plast Reconstr Surg. 2004;114(6):1502\u20131508. https:\/\/doi.org\/10.1097\/01.prs.0000138251.07040.51","DOI":"10.1097\/01.prs.0000138251.07040.51"},{"issue":"7","key":"8824_CR34","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1016\/j.arthro.2012.04.148","volume":"28","author":"JM DeLong","year":"2012","unstructured":"DeLong JM, Russell RP, Mazzocca AD, Platelet-Rich, Plasma (2012) The PAW classification system. Arthrosc J Arthrosc Relat Surg 28(7):998\u20131009. https:\/\/doi.org\/10.1016\/j.arthro.2012.04.148","journal-title":"Arthrosc J Arthrosc Relat Surg"},{"issue":"3","key":"8824_CR35","doi-asserted-by":"publisher","first-page":"725","DOI":"10.3390\/jcm11030725","volume":"11","author":"YA Tsou","year":"2022","unstructured":"Tsou YA, Tien VHC, Chen SH, Shih LC, Lin TC, Chiu CJ et al (2022) Autologous Fat Plus platelet-rich plasma versus autologous fat alone on Sulcus Vocalis. J Clin Med 11(3):725. https:\/\/doi.org\/10.3390\/jcm11030725","journal-title":"J Clin Med"},{"issue":"6","key":"8824_CR36","doi-asserted-by":"publisher","first-page":"1516","DOI":"10.3349\/ymj.2013.54.6.1516","volume":"54","author":"SH Woo","year":"2013","unstructured":"Woo SH, Kim JP, Park JJ, Chung PS, Lee SH, Jeong HS (2013) Autologous platelet-poor plasma gel for Injection Laryngoplasty. Yonsei Med J 54(6):1516\u20131523. https:\/\/doi.org\/10.3349\/ymj.2013.54.6.1516","journal-title":"Yonsei Med J"},{"key":"8824_CR37","doi-asserted-by":"publisher","unstructured":"Turkiye UUTF, Kulak Burun Bogaz Hastaliklari Anabilim Dali, Ankara, Ozgursoy SK, Tunckasik F, Tunckasik ME, Turkiye HSCDH Kulak Burun Bogaz Bolumu, Ankara, Akincioglu E et al (2018) Histopathologic Evaluation of Hyaluronic Acid and Plasma-Rich Platelet Injection into Rabbit Vocal Cords: An Experimental Study. Turk Otolarengoloji Arsivi Turkish Archives Otolaryngology. ;56(1):30\u201335. https:\/\/doi.org\/10.5152\/tao.2018.2942","DOI":"10.5152\/tao.2018.2942"},{"key":"8824_CR38","doi-asserted-by":"publisher","unstructured":"Woerd B, O\u2019Dell K, Castellanos CX, Bhatt N, Benssousan Y, Reddy NK et al Safety of Platelet-Rich Plasma Subepithelial Infusion for Vocal Fold Scar, Sulcus, and Atrophy. Laryngoscope. Published online 2022. https:\/\/doi.org\/10.1002\/lary.30288","DOI":"10.1002\/lary.30288"},{"key":"8824_CR39","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2021.02.022","author":"P Woo","year":"2021","unstructured":"Woo P, Murry T (2021) Short-term Voice improvement after repeated Office-based platelet-rich plasma PRP injection in patients with vocal fold scar, Sulcus, and atrophy. J Voice Published Online. https:\/\/doi.org\/10.1016\/j.jvoice.2021.02.022","journal-title":"J Voice Published Online"},{"issue":"6","key":"8824_CR40","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1016\/j.jvoice.2015.07.012","volume":"30","author":"SB Cobden","year":"2016","unstructured":"Cobden SB, Ozt\u00fcrk K, Duman S, Esen H, Aktan TM, Avunduk MC et al (2016) Treatment of Acute Vocal fold Injury with platelet-rich plasma. J Voice 30(6):731\u2013735. https:\/\/doi.org\/10.1016\/j.jvoice.2015.07.012","journal-title":"J Voice"},{"issue":"8","key":"8824_CR41","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1017\/s0022215121004564","volume":"136","author":"A Gaafar","year":"2022","unstructured":"Gaafar A, Eldeghiedy A, ElMaghraby R, Nouh I, Donia M (2022) The role of platelet-rich plasma in microlaryngeal surgery: a randomised, controlled trial. J Laryngology Otology 136(8):737\u2013741. https:\/\/doi.org\/10.1017\/s0022215121004564","journal-title":"J Laryngology Otology"},{"key":"8824_CR42","doi-asserted-by":"publisher","DOI":"10.1002\/lio2.1143","author":"P Woo","year":"2023","unstructured":"Woo P (2023) Platelet-rich plasma in treatment of scar, atrophy, and sulcus: short\u2010 and long\u2010term results. Laryngoscope Investig Otolaryngol Published Online. https:\/\/doi.org\/10.1002\/lio2.1143","journal-title":"Laryngoscope Investig Otolaryngol Published Online"},{"issue":"4","key":"8824_CR43","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1002\/lary.29665","volume":"132","author":"N Medeiros","year":"2022","unstructured":"Medeiros N, Castro MEM, Lith-Bijl JT, Desuter GRR (2022) A systematic review on Surgical treatments for Sulcus Vocalis and Vocal fold scar. Laryngoscope 132(4):822\u2013830. https:\/\/doi.org\/10.1002\/lary.29665","journal-title":"Laryngoscope"},{"key":"8824_CR44","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1007\/978-3-540-68107-6_14","volume-title":"Operative techniques in Laryngology","author":"CA Rosen","year":"2008","unstructured":"Rosen CA, Simpson CB (2008) Principles of Vocal fold Augmentation. Operative techniques in Laryngology. Springer-, Berlin Heidelberg, pp 91\u201396. doi:https:\/\/doi.org\/10.1007\/978-3-540-68107-6_14"},{"issue":"3","key":"8824_CR45","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1002\/lary.21122","volume":"121","author":"J Gartner-Schmidt","year":"2011","unstructured":"Gartner-Schmidt J, Rosen C (2011) Treatment success for age\u2010related vocal Fold atrophy. Laryngoscope 121(3):585\u2013589. https:\/\/doi.org\/10.1002\/lary.21122","journal-title":"Laryngoscope"},{"issue":"6","key":"8824_CR46","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.1002\/lary.27001","volume":"128","author":"VN Young","year":"2018","unstructured":"Young VN, Jeong K, Rothenberger SD, Gillespie AI, Smith LJ, Gartner-Schmidt JL et al (2018) Minimal clinically important difference of voice handicap index\u201010 in vocal Fold paralysis. Laryngoscope 128(6):1419\u20131424. https:\/\/doi.org\/10.1002\/lary.27001","journal-title":"Laryngoscope"},{"key":"8824_CR47","doi-asserted-by":"publisher","unstructured":"Henriques DP, Martins RHG, Cataneo AJM Efficacy of Injectable Laryngoplasty with Hyaluronic Acid and\/or calcium hydroxyapatite in the Treatment of Glottic Incompetence. Systematic review and Meta-analysis. J Voice. Published online 2023. https:\/\/doi.org\/10.1016\/j.jvoice.2023.01.020","DOI":"10.1016\/j.jvoice.2023.01.020"},{"issue":"4","key":"8824_CR48","doi-asserted-by":"publisher","first-page":"2351","DOI":"10.1121\/1.2173516","volume":"119","author":"RW Chan","year":"2006","unstructured":"Chan RW, Titze IR (2006) Dependence of phonation threshold pressure on vocal tract acoustics and vocal Fold tissue mechanics. J Acoust Soc Am 119(4):2351\u20132362. https:\/\/doi.org\/10.1121\/1.2173516","journal-title":"J Acoust Soc Am"},{"issue":"2","key":"8824_CR49","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1080\/00016480310001123","volume":"123","author":"K Sato","year":"2003","unstructured":"Sato K, Hirano M, Nakashima T (2003) 3D structure of the Macula Flava in the Human Vocal fold. Acta Oto-laryngol 123(2):269\u2013273. https:\/\/doi.org\/10.1080\/00016480310001123","journal-title":"Acta Oto-laryngol"},{"issue":"2","key":"8824_CR50","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/j.acthis.2018.12.002","volume":"121","author":"F Sato","year":"2019","unstructured":"Sato F, Chitose S, ichi, Sato K, Kurita T, Sato K, Umeno H et al (2019) Differentiation potential of the cells in the macula flava of the human vocal fold mucosa. Acta Histochem 121(2):164\u2013170. https:\/\/doi.org\/10.1016\/j.acthis.2018.12.002","journal-title":"Acta Histochem"},{"issue":"4","key":"8824_CR51","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1159\/000314261","volume":"62","author":"K Sato","year":"2010","unstructured":"Sato K, Umeno H, Nakashima T (2010) Functional histology of the Macula Flava in the Human Vocal fold \u2013 part 1: its role in the Adult Vocal fold. Folia Phoniatr Logo 62(4):178\u2013184. https:\/\/doi.org\/10.1159\/000314261","journal-title":"Folia Phoniatr Logo"},{"issue":"2","key":"8824_CR52","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1007\/s004050000299","volume":"258","author":"PH Dejonckere","year":"2001","unstructured":"Dejonckere PH, Bradley P, Clemente P, Cornut G, Crevier-Buchman L, Friedrich G et al (2001) A basic protocol for functional assessment of voice pathology, especially for investigating the efficacy of (phonosurgical) treatments and evaluating new assessment techniques. Eur Arch Oto-rhino-l 258(2):77\u201382. https:\/\/doi.org\/10.1007\/s004050000299","journal-title":"Eur Arch Oto-rhino-l"}],"container-title":["European Archives of Oto-Rhino-Laryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00405-024-08824-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00405-024-08824-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00405-024-08824-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,21]],"date-time":"2024-09-21T20:17:42Z","timestamp":1726949862000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00405-024-08824-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,17]]},"references-count":52,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["8824"],"URL":"https:\/\/doi.org\/10.1007\/s00405-024-08824-5","relation":{},"ISSN":["0937-4477","1434-4726"],"issn-type":[{"value":"0937-4477","type":"print"},{"value":"1434-4726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,17]]},"assertion":[{"value":"2 June 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 July 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 July 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The Authors have no conflict of interests to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}