{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T03:07:12Z","timestamp":1740107232551,"version":"3.37.3"},"reference-count":5,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2024,7,13]],"date-time":"2024-07-13T00:00:00Z","timestamp":1720828800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,7,13]],"date-time":"2024-07-13T00:00:00Z","timestamp":1720828800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Arch Otorhinolaryngol"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Introduction<\/jats:title>\n                <jats:p>Primary squamous cell carcinoma of the parotid gland typically presents as a palpable, often painless mass. Peripheral facial palsy as the only sign of malignant neoplasia is rare. In these cases, the diagnosis is regularly confirmed by radiological imaging followed by surgical exploration and biopsy. However, if there is no detection of malignant lesions and no evidence of a tumor, the reluctance to take a biopsy of an unremarkable nerve can lead to misdiagnoses.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case report<\/jats:title>\n                <jats:p>A 40-year-old female patient without medical history presented to our clinic with a complete right-sided peripheral facial palsy that had slowly progressed for 2.5 years. All other otorhinolaryngological examination findings were within normal limits. Magnetic resonance imaging examination of the head and neck and 18-fluorodeoxyglucose positron emission tomography showed unremarkable results. We proceeded with surgical exploration, which revealed no evidence of a tumor and an externally completely unremarkable facial nerve. A biopsy from the main trunk area of the nerve revealed an infiltration by a squamous cell carcinoma. Total parotidectomy with resection and reconstruction of the facial nerve and neck dissection was performed. Considering the absence of a primary tumor and other tumor formations the diagnosis of a completely regressive primary squamous cell carcinoma of the parotid gland was confirmed.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>In conclusion, in the case of slow-onset peripheral facial palsy that persists without signs of recovery, a gadolinium-enhanced MRI should be performed. If imaging is unremarkable and there is no primary tumor detection along the course of the facial nerve, a surgical exploration with biopsy of the facial nerve is necessary.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00405-024-08826-3","type":"journal-article","created":{"date-parts":[[2024,7,13]],"date-time":"2024-07-13T06:02:21Z","timestamp":1720850541000},"page":"6035-6039","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Biopsy of the facial nerve in slow-onset facial palsy"],"prefix":"10.1007","volume":"281","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-7712-0156","authenticated-orcid":false,"given":"Gianluca","family":"Sistori","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"G\u00f6tting","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cornelia","family":"Radke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Jungeh\u00fclsing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,7,13]]},"reference":[{"issue":"2","key":"8826_CR1","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.ijom.2020.06.010","volume":"50","author":"M Xiao","year":"2021","unstructured":"Xiao M, Liu J, You Y, Yang X, Wang Y (2021) Primary squamous cell carcinoma of the parotid gland: clinicopathological characteristics, treatment, and prognosis. Int J Oral Maxillofac Surg 50(2):151\u2013157. https:\/\/doi.org\/10.1016\/j.ijom.2020.06.010","journal-title":"Int J Oral Maxillofac Surg"},{"issue":"5","key":"8826_CR2","doi-asserted-by":"publisher","first-page":"E40","DOI":"10.1002\/mus.25727","volume":"56","author":"A Taga","year":"2017","unstructured":"Taga A, Di Lella F, Corcione L, Pavesi G (2017) Isolated facial palsy from perineural spread of cutaneous squamous cell carcinoma. Muscle Nerve 56(5):E40\u2013E41. https:\/\/doi.org\/10.1002\/mus.25727","journal-title":"Muscle Nerve"},{"issue":"4","key":"8826_CR3","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1001\/archotol.126.4.506","volume":"126","author":"M Jungehuelsing","year":"2000","unstructured":"Jungehuelsing M, Sittel C, Fischbach R, Wagner M, Stennert E (2000) Limitations of magnetic resonance imaging in the evaluation of perineural tumor spread causing facial nerve paralysis. Arch Otolaryngol Head Neck Surg 126(4):506\u2013510. https:\/\/doi.org\/10.1001\/archotol.126.4.506","journal-title":"Arch Otolaryngol Head Neck Surg"},{"issue":"4","key":"8826_CR4","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1016\/j.otohns.2003.12.013","volume":"130","author":"DO Boahene","year":"2004","unstructured":"Boahene DO, Olsen KD, Driscoll C, Lewis JE, McDonald TJ (2004) Facial nerve paralysis secondary to occult malignant neoplasms. Otolaryngol Head Neck Surg 130(4):459\u2013465. https:\/\/doi.org\/10.1016\/j.otohns.2003.12.013","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"1","key":"8826_CR5","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.amjoto.2018.10.004","volume":"40","author":"M Eggerstedt","year":"2019","unstructured":"Eggerstedt M, Kuhar HN, Revenaugh PC, Ghai R, Mark Wiet R (2019) Slowly progressive facial paralysis: intraneural squamous cell carcinoma of unknown primary. Am J Otolaryngol 40(1):129\u2013131. https:\/\/doi.org\/10.1016\/j.amjoto.2018.10.004","journal-title":"Am J Otolaryngol"}],"container-title":["European Archives of Oto-Rhino-Laryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00405-024-08826-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00405-024-08826-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00405-024-08826-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,26]],"date-time":"2024-10-26T22:03:15Z","timestamp":1729980195000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00405-024-08826-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,13]]},"references-count":5,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["8826"],"URL":"https:\/\/doi.org\/10.1007\/s00405-024-08826-3","relation":{},"ISSN":["0937-4477","1434-4726"],"issn-type":[{"type":"print","value":"0937-4477"},{"type":"electronic","value":"1434-4726"}],"subject":[],"published":{"date-parts":[[2024,7,13]]},"assertion":[{"value":"21 April 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 July 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 July 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The Authors have no conflict of interest to declare. No funding was received for conducting this study. All co-authors have seen and agree with the content of manuscript and there are no financial or non-financial interests that are directly or indirectly related to the work submitted for publication to report. We certify that the submission is original work and is not under review at any other publication.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Patients signed informed consent regarding publishing their data and photographs.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}}]}}