{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T22:08:31Z","timestamp":1790287711896,"version":"4.1.0"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T00:00:00Z","timestamp":1723075200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T00:00:00Z","timestamp":1723075200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100004470","name":"Daewoong Pharmaceutical Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004470","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Arch Otorhinolaryngol"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1007\/s00405-024-08877-6","type":"journal-article","created":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T09:02:11Z","timestamp":1723107731000},"page":"5873-5883","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Efficacy and safety of fexuprazan in patients with symptoms and signs of laryngopharyngeal reflux disease: a randomized clinical trial"],"prefix":"10.1007","volume":"281","author":[{"given":"Su Il","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Chan","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wonjae","family":"Cha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ah Ra","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeon Yeob","family":"Jang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong-Seok","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Kun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hwan Ho","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Su","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoon Se","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4081-5207","authenticated-orcid":false,"given":"Young-Gyu","family":"Eun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,8,8]]},"reference":[{"issue":"4","key":"8877_CR1","doi-asserted-by":"publisher","first-page":"236","DOI":"10.4103\/sjg.SJG_518_17","volume":"24","author":"M Mosli","year":"2018","unstructured":"Mosli M, Alkhathlan B, Abumohssin A et al (2018) Prevalence and clinical predictors of LPR among patients diagnosed with GERD according to the reflux symptom index questionnaire. Saudi J Gastroenterol 24(4):236\u2013241","journal-title":"Saudi J Gastroenterol"},{"issue":"5","key":"8877_CR2","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1177\/0194599819827488","volume":"160","author":"JR Lechien","year":"2019","unstructured":"Lechien JR, Akst LM, Hamdan AL et al (2019) Evaluation and management of laryngopharyngeal reflux disease: state of the art review. Otolaryngol Head Neck Surg 160(5):762\u2013782","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"3","key":"8877_CR3","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.amjoto.2016.01.008","volume":"37","author":"N Gupta","year":"2016","unstructured":"Gupta N, Green RW, Megwalu UC (2016) Evaluation of a laryngopharyngeal reflux management protocol. Am J Otolaryngol 37(3):245\u2013250","journal-title":"Am J Otolaryngol"},{"issue":"2","key":"8877_CR4","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/S0892-1997(02)00097-8","volume":"16","author":"PC Belafsky","year":"2002","unstructured":"Belafsky PC, Postma GN, Koufman JA (2002) Validity and reliability of the reflux symptom index (RSI). J Voice 16(2):274\u2013277","journal-title":"J Voice"},{"issue":"8","key":"8877_CR5","doi-asserted-by":"publisher","first-page":"1313","DOI":"10.1097\/00005537-200108000-00001","volume":"111","author":"PC Belafsky","year":"2011","unstructured":"Belafsky PC, Postma GN, Koufman JA (2011) The validity and reliability of the reflux finding score (RFS). Laryngoscope 111(8):1313\u20131317","journal-title":"Laryngoscope"},{"issue":"12","key":"8877_CR6","doi-asserted-by":"publisher","first-page":"1534","DOI":"10.1001\/jama.294.12.1534","volume":"294","author":"CN Ford","year":"2005","unstructured":"Ford CN (2005) Evaluation and management of laryngopharyngeal reflux. JAMA 294(12):1534\u20131540","journal-title":"JAMA"},{"issue":"7","key":"8877_CR7","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1097\/01.MLG.0000165464.75164.E5","volume":"115","author":"KW Altman","year":"2005","unstructured":"Altman KW, Stephens RM, Lyttle CS, Weiss KB (2005) Changing impact of gastroesophageal reflux in medical and otolaryngology practice. Laryngoscope 115(7):1145\u20131153","journal-title":"Laryngoscope"},{"issue":"s2","key":"8877_CR8","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1111\/j.1365-2036.2006.02943.x","volume":"23","author":"G Sachs","year":"2006","unstructured":"Sachs G, Shin JM, Howden CW (2006) Review article: the clinical pharmacology of proton pump inhibitors. Aliment Pharmacol Ther 23(s2):2\u20138","journal-title":"Aliment Pharmacol Ther"},{"issue":"4","key":"8877_CR9","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1002\/lary.20665","volume":"120","author":"DM Bulmer","year":"2010","unstructured":"Bulmer DM, Ali MS, Brownlee IA, Dettmar PW, Pearson JP (2010) Laryngeal mucosa: its susceptibility to damage by acid and pepsin. Laryngoscope 120(4):777\u2013782","journal-title":"Laryngoscope"},{"issue":"2","key":"8877_CR10","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.jvoice.2017.10.015","volume":"33","author":"AR Jung","year":"2019","unstructured":"Jung AR, Kwon OE, Park JM et al (2019) Association between pepsin in the saliva and the subjective symptoms in patients with laryngopharyngeal reflux. J Voice 33(2):150\u2013154","journal-title":"J Voice"},{"issue":"3","key":"8877_CR11","doi-asserted-by":"publisher","first-page":"299","DOI":"10.21053\/ceo.2019.01669","volume":"13","author":"SI Kim","year":"2020","unstructured":"Kim SI, Lechien JR, Ayad T et al (2020) Management of laryngopharyngeal reflux in Asia. Clin Exp Otorhinolaryngol 13(3):299\u2013307","journal-title":"Clin Exp Otorhinolaryngol"},{"issue":"4","key":"8877_CR12","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1111\/coa.13518","volume":"45","author":"JR Lechien","year":"2020","unstructured":"Lechien JR, Bock JM, Carroll TL, Akst LM (2020) Is empirical treatment a reasonable strategy for laryngopharyngeal reflux? A contemporary review. Clin Otolaryngol 45(4):450\u2013458","journal-title":"Clin Otolaryngol"},{"issue":"2","key":"8877_CR13","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1111\/apt.14818","volume":"48","author":"J Sunwoo","year":"2018","unstructured":"Sunwoo J, Oh J, Moon S et al (2018) Safety, tolerability, pharmacodynamics and pharmacokinetics of DWP 14012, a novel potassium-competitive acid blocker, in healthy male subjects. Aliment Pharmacol Ther 48(2):206\u2013218","journal-title":"Aliment Pharmacol Ther"},{"issue":"7","key":"8877_CR14","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1111\/apt.13121","volume":"41","author":"H Jenkins","year":"2015","unstructured":"Jenkins H, Sakurai Y, Nishimura A et al (2015) Randomised clinical trial: safety, tolerability, pharmacokinetics and pharmacodynamics of repeated doses of TAK-438 (vonoprazan), a novel potassium-competitive acid blocker, in healthy male subjects. Aliment Pharmacol Ther 41(7):636\u2013648","journal-title":"Aliment Pharmacol Ther"},{"key":"8877_CR15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11894-020-0753-y","volume":"22","author":"F Shibli","year":"2020","unstructured":"Shibli F, Kitayama Y, Fass R (2020) Novel therapies for gastroesophageal reflux disease: beyond proton pump inhibitors. Curr Gastroenterol Rep 22:1\u201313","journal-title":"Curr Gastroenterol Rep"},{"issue":"44","key":"8877_CR16","doi-asserted-by":"publisher","first-page":"6294","DOI":"10.3748\/wjg.v28.i44.6294","volume":"28","author":"KN Lee","year":"2022","unstructured":"Lee KN, Lee OY, Chun HJ et al (2022) Randomized controlled trial to evaluate the efficacy and safety of fexuprazan compared with esomeprazole in erosive esophagitis. World J Gastroenterol 28(44):6294","journal-title":"World J Gastroenterol"},{"issue":"3","key":"8877_CR17","doi-asserted-by":"publisher","first-page":"200","DOI":"10.7326\/0003-4819-158-3-201302050-00583","volume":"158","author":"A-W Chan","year":"2013","unstructured":"Chan A-W, Tetzlaff JM, Altman DG et al (2013) SPIRIT 2013 statement: defining standard protocol items for clinical trials. Ann Intern Med 158(3):200\u2013207","journal-title":"Ann Intern Med"},{"issue":"5","key":"8877_CR18","doi-asserted-by":"publisher","first-page":"910","DOI":"10.1177\/01945998211026843","volume":"166","author":"SI Kim","year":"2022","unstructured":"Kim SI, Jeong SJ, Kwon OE et al (2022) 24-hour multichannel intraluminal impedance\u2014pH in proton pump inhibitor nonresponders vs responders in patients with laryngopharyngeal reflux. Otolaryngol Head Neck Surg 166(5):910\u2013916","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"1","key":"8877_CR19","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1177\/0194599820941003","volume":"164","author":"JR Lechien","year":"2021","unstructured":"Lechien JR, Bobin F, Rodriguez A et al (2021) Development and validation of the short version of the reflux symptom score: reflux symptom score\u201312. Otolaryngol Head Neck Surg 164(1):166\u2013174","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"4","key":"8877_CR20","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1001\/archotol.131.4.315","volume":"131","author":"RL Carrau","year":"2005","unstructured":"Carrau RL, Khidr A, Gold KF et al (2005) Validation of a quality-of-life instrument for laryngopharyngeal reflux. Arch Otolaryngol Head Neck Surg 131(4):315\u2013320","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"8877_CR21","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1007\/s00405-010-1475-9","volume":"268","author":"YS Lee","year":"2011","unstructured":"Lee YS, Choi S-H, Son YI, Park Y-H, Kim SY, Nam SY (2011) Prospective, observational study using rabeprazole in 455 patients with laryngopharyngeal reflux disease. Eur Arch Otorhinolaryngol 268:863\u2013869","journal-title":"Eur Arch Otorhinolaryngol"},{"issue":"2","key":"8877_CR22","doi-asserted-by":"publisher","first-page":"190","DOI":"10.26574\/maedica.2023.18.2.190","volume":"18","author":"JR Lechien","year":"2023","unstructured":"Lechien JR, Steffens Y, Calvo-Henriquez C, Mayo-Yanez M, Horoi M, Rodriguez A (2023) Impact of COVID-19 lockdown on stress and diet adherence in patients with laryngopharyngeal reflux. Maedica 18(2):190","journal-title":"Maedica"},{"issue":"2","key":"8877_CR23","doi-asserted-by":"publisher","first-page":"45","DOI":"10.5005\/jp-journals-10003-1186","volume":"7","author":"K Doshi","year":"2015","unstructured":"Doshi K, Varghese A, Badyal DK (2015) Evaluation of omeprazole in the treatment of laryngopharyngeal reflux disease: a single center, prospective and randomized study. Int J Otorhinolaryngol Clin 7(2):45\u201350","journal-title":"Int J Otorhinolaryngol Clin"},{"key":"8877_CR24","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.765061","volume":"8","author":"F Rettura","year":"2021","unstructured":"Rettura F, Bronzini F, Campigotto M et al (2021) Refractory gastroesophageal reflux disease: a management update. Front Med 8:765061","journal-title":"Front Med"},{"issue":"5","key":"8877_CR25","first-page":"295","volume":"19","author":"D Armstrong","year":"2023","unstructured":"Armstrong D (2023) Potassium-competitive acid blockers and gastroesophageal reflux disease. Gastroenterol Hepatol 19(5):295","journal-title":"Gastroenterol Hepatol"},{"issue":"4","key":"8877_CR26","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1097\/00005537-200304000-00003","volume":"113","author":"JM DelGaudio","year":"2003","unstructured":"DelGaudio JM, Waring JP (2003) Empiric esomeprazole in the treatment of laryngopharyngeal reflux. Laryngoscope 113(4):598\u2013601","journal-title":"Laryngoscope"},{"issue":"28","key":"8877_CR27","doi-asserted-by":"publisher","first-page":"3608","DOI":"10.3748\/wjg.v28.i28.3608","volume":"28","author":"W Leowattana","year":"2022","unstructured":"Leowattana W, Leowattana T (2022) Potassium-competitive acid blockers and gastroesophageal reflux disease. World J Gastroenterol 28(28):3608","journal-title":"World J Gastroenterol"},{"issue":"3","key":"8877_CR28","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1016\/j.otohns.2008.06.003","volume":"139","author":"O Reichel","year":"2008","unstructured":"Reichel O, Dressel H, Wieder\u00e4nders K, Issing WJ (2008) Double-blind, placebo-controlled trial with esomeprazole for symptoms and signs associated with laryngopharyngeal reflux. Otolaryngol Head Neck Surg 139(3):414\u2013420","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"4","key":"8877_CR29","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1016\/j.otohns.2004.03.037","volume":"131","author":"DL Steward","year":"2004","unstructured":"Steward DL, Wilson KM, Kelly DH et al (2004) Proton pump inhibitor therapy for chronic laryngo-pharyngitis: a randomized placebo-control trial. Otolaryngol Head Neck Surg 131(4):342\u2013350","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"1","key":"8877_CR30","first-page":"225","volume":"4","author":"C Reimer","year":"2008","unstructured":"Reimer C, Bytzer P (2008) Management of laryngopharyngeal reflux with proton pump inhibitors. Ther Clin Risk Manag 4(1):225\u2013233","journal-title":"Ther Clin Risk Manag"},{"issue":"3","key":"8877_CR31","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1097\/MCG.0b013e31827458f9","volume":"47","author":"ES Yuksel","year":"2013","unstructured":"Yuksel ES, Vaezi MF (2013) Therapeutic strategies for laryngeal manifestations of gastroesophageal reflux disease. J Clin Gastroenterol 47(3):195\u2013204","journal-title":"J Clin Gastroenterol"},{"key":"8877_CR32","doi-asserted-by":"publisher","first-page":"2027","DOI":"10.1007\/s10620-007-0108-7","volume":"53","author":"MP Dore","year":"2008","unstructured":"Dore MP, Maragkoudakis E, Fraley K et al (2008) Diet, lifestyle and gender in gastro-esophageal reflux disease. Dig Dis Sci 53:2027\u20132032","journal-title":"Dig Dis Sci"},{"issue":"9","key":"8877_CR33","doi-asserted-by":"publisher","first-page":"3387","DOI":"10.1007\/s00405-021-06865-8","volume":"278","author":"SI Kim","year":"2021","unstructured":"Kim SI, Jeong SJ, Kwon OE et al (2021) Pharyngeal reflux episodes in patients with suspected laryngopharyngeal reflux versus healthy subjects: a prospective cohort study. Eur Arch Otorhinolaryngol 278(9):3387\u20133392","journal-title":"Eur Arch Otorhinolaryngol"},{"issue":"4","key":"8877_CR34","doi-asserted-by":"publisher","first-page":"1614","DOI":"10.1002\/lary.31134","volume":"134","author":"JR Lechien","year":"2024","unstructured":"Lechien JR, Vaezi MF, Chan WW et al (2024) The Dubai definition and diagnostic criteria of laryngopharyngeal reflux: The IFOS consensus. Laryngoscope 134(4):1614\u20131624","journal-title":"Laryngoscope"},{"issue":"2","key":"8877_CR35","doi-asserted-by":"publisher","first-page":"141","DOI":"10.21053\/ceo.2017.00577","volume":"11","author":"JS Lee","year":"2018","unstructured":"Lee JS, Jung AR, Park JM, Park MJ, Lee YC, Eun YG (2018) Comparison of characteristics according to reflux type in patients with laryngopharyngeal reflux. Clin Exp Otorhinolaryngol 11(2):141\u2013145","journal-title":"Clin Exp Otorhinolaryngol"},{"issue":"19","key":"8877_CR36","doi-asserted-by":"publisher","first-page":"2995","DOI":"10.12998\/wjcc.v7.i19.2995","volume":"7","author":"JR Lechien","year":"2019","unstructured":"Lechien JR, Mouawad F, Barillari MR et al (2019) Treatment of laryngopharyngeal reflux disease: a systematic review. World J Clin Cases 7(19):2995","journal-title":"World J Clin Cases"}],"container-title":["European Archives of Oto-Rhino-Laryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00405-024-08877-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00405-024-08877-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00405-024-08877-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T08:50:31Z","timestamp":1730105431000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00405-024-08877-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,8]]},"references-count":36,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["8877"],"URL":"https:\/\/doi.org\/10.1007\/s00405-024-08877-6","relation":{},"ISSN":["0937-4477","1434-4726"],"issn-type":[{"value":"0937-4477","type":"print"},{"value":"1434-4726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,8]]},"assertion":[{"value":"28 May 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 July 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 August 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflicts interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was approved by the Institutional Review Board (IRB) of Kyung Hee University Hospital at Gangdong (approval no. KHNMC 2022-01-020), Seoul National University Bundang Hospital (B-2022-741-002), Nowon Eulji Medical Center (EMCS 2022-01-033), Ajou University Hospital (AJIRB-MED-CT2-21-681), Inha University Hospital (2022-01-005), Dong-A University Hospital (DAUHIRB-22-042), Kosin University Hospital (KUGH 2022-01-037), Kyung Hee University Medical Center (KHUH 2022-02-007), and Asan Medical Center (S2022-0025-0001). All participants were provided with information regarding the study, and written informed consent was obtained from all eligible participants before enrolment.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}