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The CN, SVN, IVN and facial nerve (FN) diameters and cross-sectional areas (CSA) were measured on T2-weighted sequences whilst EH was evaluated on delayed post-gadolinium MRI. Absolute nerve calibre (and that relative to the FN) in unilateral definite MD ears (2015 Barany criteria) was compared to that in both asymptomatic contralateral ears and clinical control ears. Nerve calibre in ears with severe cochlear and vestibular EH was compared to ears without EH.\n                      <jats:italic>t<\/jats:italic>\n                      tests or Wilcoxon signed-rank test\/Mann\u2013Whitney\n                      <jats:italic>U<\/jats:italic>\n                      test were applied (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      173 patients (mean age 51.3\u2009\u00b1\u200915.1, 65 men) with 84 MD (62 unilateral) and 62 clinical control ears were studied. Absolute and relative CN dimensions were decreased in both MD ears (CSA and diameter) and the contralateral asymptomatic ears (CSA) when compared to clinical controls (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Absolute nerve dimensions were reduced in both severe vestibular EH (CN, IVN and SVN) and severe cochlear EH (CN) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), however this was not evident when adjusted according to facial nerve calibre.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>There is decreased absolute CN calibre in both symptomatic and asymptomatic MD ears as well as ears with severe cochlear and vestibular EH on MRI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00405-024-08895-4","type":"journal-article","created":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T15:02:14Z","timestamp":1723820534000},"page":"91-101","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Magnetic resonance imaging evaluation of cochlear and vestibular nerve calibre: a case-control study in M\u00e9ni\u00e8re\u2019s disease and endolymphatic hydrops"],"prefix":"10.1007","volume":"282","author":[{"given":"Radwa","family":"Khalifa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Touska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irumee","family":"Pai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Padormo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicky","family":"Goh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph V.","family":"Hajnal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5502-4972","authenticated-orcid":false,"given":"Steve E. 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