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Radiological and pathological DOI and TDFM were correlated. The main outcomes were overall (OS) and loco-regional recurrence free survival (LRRFS). The linear relationship between DOI and TDFM with 2-year OS and LRRFS was tested. Survival estimates were obtained by the Kaplan-Meier method. Univariate analysis was performed for variables of interest, and results expressed in terms of hazard ratios and 95% confidence intervals.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>A total of 64 patients underwent CTS and neck dissection. No significant difference was found between pathological (pDOI) and radiological DOI (rDOI) (<jats:italic>p<\/jats:italic>\u2009=\u20090.321) or between pathological (pTDFM) and radiological TDFM (<jats:italic>p<\/jats:italic>\u2009=\u20090.435). Two- and 5-year OS and LRRFS were 85.7% and 70.4%, 84.3% and 76.1%, respectively. A linear and significant relationship with OS (<jats:italic>p<\/jats:italic>\u2009=\u20090.020) and LRRFS (<jats:italic>p<\/jats:italic>\u2009=\u20090.013) was found for pDOI; although linear, the relationship between pTDFM was not statistically significant for either survival outcomes. Once categorized, the ideal cut-off for pDOI according to OS was set at 10\u00a0mm (<jats:italic>p<\/jats:italic>\u2009=\u20090.023).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>In patients undergoing CTS for primary OTSCC, magnetic resonance-derived rDOI represents an accurate estimate of pDOI, In contrast, TDFM was not associated with OS suggesting that the median raphe is a safe deep margin for CTS.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>protocol n.<\/jats:title>\n            <jats:p> BS\/231,009 retrospectively registered.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s00405-024-08929-x","type":"journal-article","created":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T03:35:12Z","timestamp":1725420912000},"page":"417-425","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Role of midline raphe in compartmental surgery for squamous cell carcinoma of the tongue"],"prefix":"10.1007","volume":"282","author":[{"given":"Grammatica","family":"Alberto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ravanelli","family":"Marco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomasoni","family":"Michele","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5933-2936","authenticated-orcid":false,"given":"Conti","family":"Carlo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pinacoli","family":"Aurora","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bozzola","family":"Anna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farina","family":"Davide","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mattavelli","family":"Davide","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piazza","family":"Cesare","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,9,4]]},"reference":[{"key":"8929_CR1","doi-asserted-by":"publisher","unstructured":"Kowalski LP, Bagietto R, Lara JR, Santos RL, Tagawa EK, Santos IR (1999) Factors influencing contralateral lymph node metastasis from oral carcinoma. 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