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Patients were assigned to two groups: group A (control): 25 patients who planned to receive only complementary supplements, oral vitamin D plus calcium, and group B (case): 75 patients who planned to receive oral bisphosphonate plus routine vitamin D and calcium supplements. Group B was subdivided into B<jats:sub>1<\/jats:sub>: 25 patients without any previous intervention, B<jats:sub>2<\/jats:sub>: 25 patients with persistent tinnitus for more than 6\u00a0months after a previous uncomplicated stapedotomy in the same ear, and B<jats:sub>3<\/jats:sub>: 25 patients with persistent tinnitus for more than 6\u00a0months after hearing aid fitting. The outcome was tinnitus assessment both subjectively (tinnitus intensity, frequency, and questionnaire) and objectively (tinnitus intensity and frequency).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>The female-to-male ratio was 1.6:1 with ages ranging from 40 to 61\u00a0years. The baseline revealed no statistically significant differences between the groups. After 6\u00a0months, there were statistically significant differences, both objectively and subjectively. The tinnitus questionnaire median (IQR) for group B was 16 (30), whereas control group A had 52 (24). The tinnitus severity median (IQR) for group B was 20 (30), compared to group A\u2019s 52 (42). After 6\u00a0months, 40% of the cases in group B demonstrated complete improvement, compared to 0% in control group A.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>We demonstrated significant tinnitus improvement in cases treated with bisphosphonate compared to the control group.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s00405-024-08935-z","type":"journal-article","created":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T11:06:59Z","timestamp":1726225619000},"page":"647-658","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effectiveness of bisphosphonate for alleviating tinnitus associated with otosclerosis: a prospective case\u2013control study"],"prefix":"10.1007","volume":"282","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5565-4923","authenticated-orcid":false,"given":"Ayman","family":"Fouad","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmoud","family":"Mandour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed Osama","family":"Tomoum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reham Mamdouh","family":"Lasheen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,9,13]]},"reference":[{"issue":"1","key":"8935_CR1","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/S00405-008-0790-X\/TABLES\/3","volume":"266","author":"K Markou","year":"2009","unstructured":"Markou K, Goudakos J (2009) An overview of the etiology of otosclerosis. 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