{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T08:16:26Z","timestamp":1790151386951,"version":"4.0.1"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T00:00:00Z","timestamp":1738800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T00:00:00Z","timestamp":1738800000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"University of Health Sciences"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Arch Otorhinolaryngol"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>The aim of this study was to investigate the effects of prognostic nutritional index (PNI), systemic immune inflammation index (SII) and hemoglobin, albumin, lymphocyte, platelet (HALP) score on fistula formation, recurrence and mortality in patients with laryngeal cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>The study included 77 patients who underwent total laryngectomy operation between 2018 and 2021. 66 (85.7%) patients underwent primary and 11 (14.3%) patients underwent salvage total laryngectomy. PNI, SII and HALP scores and cutt-off values of all patients were determined and the relationships between pharyngocutaneous fistula (PCF) formation, recurrence and mortality were statistically analysed. The patients with a score less than the cut-off value were divided into two groups as Group 1, and the patients with a score equal to or greater than the cut-off value were divided into two groups as Group 2.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The effect of PNI, SII and HALP on the development of FKF was not significant (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.110,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.135,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.358). The effect of high SII and low HALP score on the development of recurrence was statistically significant (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.001,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.012). Low PNI increased the development of recurrence, but this increase was not statistically significant (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.075). Overall survival rate was 68.8%. The effect of low PNI and HALP on survival was statistically significant (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.011,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.021). The effect of high SII on survival was not significant (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.533).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Low PNI index and HALP score and high SII index are cost-effective simple prognostic biomarkers that are significant in the development of FCF, as well as in the evaluation of recurrence and overall survival in the long-term follow-up of these patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00405-025-09223-0","type":"journal-article","created":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T13:34:49Z","timestamp":1738848889000},"page":"3203-3209","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The effects of prognostic nutritional index, systemic immune inflammation index and HALP score on fistula formation, recurrence and mortality in laryngeal cancer patients"],"prefix":"10.1007","volume":"282","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2304-7963","authenticated-orcid":false,"given":"B. 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According to this ethics committee regulation, informed consent form is not required for archive scans. (\n                      \n                      ). The data used in this study retrospectively included some of the routine blood tests requested preoperatively, routine radiological examinations performed for staging purposes, some of the pathological data routinely stained postoperatively, and cancer follow-up forms recorded in the data processing software programme (FONET) of our hospital during follow-up. Apart from routine laboratory, radiological and pathological staining, no additional tests or staining that may affect diagnosis and treatment were performed. An archive search including these examinations was performed. The requirement for an informed consent form was waived. However, all patients who underwent surgery were informed that their routine data could be used for study purposes prior to surgery and their signatures were obtained from the patient and relatives.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"We confirm that the manuscript has been read and approved by all named authors and that there are no other persons who satisfied the criteria for authorship but are not listed. We further confirm that the order of authors listed in the manuscript has been approved by all of us. We confirm that we have given due consideration to the protection of intellectual property associated with this work and that there are no impediments to publication, including the timing of publication, concerning intellectual property. In so doing we confirm that we have followed the regulations of our institutions concerning intellectual property. We understand that the Corresponding Author is the sole contact for the Editorial process (including the Editorial Manager and direct communications with the office). She is responsible for communicating with the other authors about progress, submissions of revisions, and final approval of proofs. We confirm that we have provided a current, correct email address accessible by the Corresponding Author.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}