{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:37:30Z","timestamp":1792514250572,"version":"4.5.0"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T00:00:00Z","timestamp":1740096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T00:00:00Z","timestamp":1740096000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Alma Mater Studiorum - Universit\u00e0 di Bologna"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Arch Otorhinolaryngol"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Analysis of existing literature on lymph node yield (LNY) in neck dissection (ND) for head and neck squamous cell carcinomas (HNSCC) used as a prognostic factor and an indication of treatment adequacy.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>PubMed, EMBASE and Web of Science databases were systematically searched from January 2010 to June 2023. Inclusion criteria encompassed studies on mucosal HNSCC patients undergoing ND with data on LNY and its association with survival outcomes. The quality assessment followed the REMARK guidelines.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Among 29 included studies, minimum LNY tresholds associated with improved survival outcomes ranged from 10 to 36.5 nodes. The heterogeneity in subsite involvement and cN0\/cN\u2009+\u2009status constituted a challenge in establishing a consensus cutoff. The review highlights the need for standardized surgical techniques and pathological assessments to ensure data comparability.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>LNY is a prognostic indicator and could reflect ND quality in HNSCC.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s00405-025-09250-x","type":"journal-article","created":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T10:22:23Z","timestamp":1740133343000},"page":"3405-3413","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Defining a minimum nodal yield for neck dissection in mucosal head and neck squamous cell carcinoma, a systematic review"],"prefix":"10.1007","volume":"282","author":[{"given":"Sara","family":"Bassani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3347-4347","authenticated-orcid":false,"given":"Paolo","family":"Tesauro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Monzani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Molteni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,21]]},"reference":[{"key":"9250_CR1","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1038\/s41572-020-00224-3","volume":"6","author":"DE Johnson","year":"2020","unstructured":"Johnson DE et al (2020) Head and neck squamous cell carcinoma. Nat Rev Dis Primer 6:92","journal-title":"Nat Rev Dis Primer"},{"key":"9250_CR2","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1001\/jamaoncol.2017.3852","volume":"4","author":"AS Ho","year":"2018","unstructured":"Ho AS et al (2018) Association of quantitative metastatic lymph node burden with survival in hypopharyngeal and laryngeal cancer. JAMA Oncol 4:985\u2013989","journal-title":"JAMA Oncol"},{"key":"9250_CR3","doi-asserted-by":"publisher","first-page":"3601","DOI":"10.1200\/JCO.2016.71.1176","volume":"35","author":"AS Ho","year":"2017","unstructured":"Ho AS et al (2017) Metastatic lymph node burden and survival in oral cavity cancer. J Clin Oncol Off J Am Soc Clin Oncol 35:3601\u20133609","journal-title":"J Clin Oncol Off J Am Soc Clin Oncol"},{"key":"9250_CR4","doi-asserted-by":"publisher","first-page":"1388","DOI":"10.1002\/cncr.29932","volume":"122","author":"TJ Roberts","year":"2016","unstructured":"Roberts TJ et al (2016) Number of positive nodes is superior to the lymph node ratio and American Joint Committee on Cancer N staging for the prognosis of surgically treated head and neck squamous cell carcinomas. Cancer 122:1388\u20131397","journal-title":"Cancer"},{"key":"9250_CR5","doi-asserted-by":"publisher","first-page":"1590","DOI":"10.1002\/cncr.33414","volume":"127","author":"AS Ho","year":"2021","unstructured":"Ho AS et al (2021) Nodal staging convergence for HPV- and HPV+ oropharyngeal carcinoma. Cancer 127:1590\u20131597","journal-title":"Cancer"},{"key":"9250_CR6","doi-asserted-by":"publisher","first-page":"2274","DOI":"10.1002\/hed.27471","volume":"45","author":"G Molteni","year":"2023","unstructured":"Molteni G et al (2023) Impact of lymph node ratio and number of lymph node metastases on survival and recurrence in laryngeal squamous cell carcinoma. Head Neck 45:2274\u20132293","journal-title":"Head Neck"},{"key":"9250_CR7","doi-asserted-by":"publisher","first-page":"3892","DOI":"10.1200\/JCO.2016.67.3863","volume":"34","author":"V Divi","year":"2016","unstructured":"Divi V et al (2016) Lymph node count from neck dissection predicts mortality in head and neck cancer. J Clin Oncol Off J Am Soc Clin Oncol 34:3892\u20133897","journal-title":"J Clin Oncol Off J Am Soc Clin Oncol"},{"key":"9250_CR8","doi-asserted-by":"publisher","first-page":"1823","DOI":"10.1097\/01.ju.0000120289.78049.0e","volume":"171","author":"H Herr","year":"2004","unstructured":"Herr H, Lee C, Chang S, Lerner S, Bladder Cancer Collaborative Group (2004) Standardization of radical cystectomy and pelvic lymph node dissection for bladder cancer: a collaborative group report. J Urol 171:1823\u20131828 (Discussion 1827-1828)","journal-title":"J Urol"},{"key":"9250_CR9","doi-asserted-by":"publisher","first-page":"1793","DOI":"10.1200\/JCO.2002.07.112","volume":"20","author":"L Weir","year":"2002","unstructured":"Weir L, Speers C, D\u2019yachkova Y, Olivotto IA (2002) Prognostic significance of the number of axillary lymph nodes removed in patients with node-negative breast cancer. J. Clin. Oncol. Off. J. Am. Soc. Clin. Oncol. 20:1793\u20131799","journal-title":"J. Clin. Oncol. Off. J. Am. Soc. Clin. Oncol."},{"key":"9250_CR10","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1093\/jnci\/djk092","volume":"99","author":"GJ Chang","year":"2007","unstructured":"Chang GJ, Rodriguez-Bigas MA, Skibber JM, Moyer VA (2007) Lymph node evaluation and survival after curative resection of colon cancer: systematic review. J Natl Cancer Inst 99:433\u2013441","journal-title":"J Natl Cancer Inst"},{"key":"9250_CR11","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.593470","volume":"11","author":"Y-H Chen","year":"2021","unstructured":"Chen Y-H et al (2021) Retrieval of 30 lymph nodes is mandatory for selected stage II gastric cancer patients. Front Oncol 11:593470","journal-title":"Front Oncol"},{"key":"9250_CR12","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.1002\/cncr.23309","volume":"112","author":"AJ Greenstein","year":"2008","unstructured":"Greenstein AJ et al (2008) Effect of the number of lymph nodes sampled on postoperative survival of lymph node-negative esophageal cancer. Cancer 112:1239\u20131246","journal-title":"Cancer"},{"key":"9250_CR13","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.1002\/hed.21600","volume":"33","author":"A Ebrahimi","year":"2011","unstructured":"Ebrahimi A et al (2011) Lymph node ratio as an independent prognostic factor in oral squamous cell carcinoma. Head Neck 33:1245\u20131251","journal-title":"Head Neck"},{"key":"9250_CR14","doi-asserted-by":"publisher","first-page":"3464","DOI":"10.1002\/cncr.30204","volume":"122","author":"V Divi","year":"2016","unstructured":"Divi V et al (2016) Establishing quality indicators for neck dissection: correlating the number of lymph nodes with oncologic outcomes (NRG Oncology RTOG 9501 and RTOG 0234). Cancer 122:3464\u20133471","journal-title":"Cancer"},{"key":"9250_CR15","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71","author":"MJ Page","year":"2021","unstructured":"Page MJ et al (2021) The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. https:\/\/doi.org\/10.1136\/bmj.n71","journal-title":"BMJ"},{"key":"9250_CR16","unstructured":"American Joint Committee on Cancer. AJCC cancer staging manual. (AJCC, American Joint Committee on Cancer, 2017)."},{"key":"9250_CR17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001216","volume":"9","author":"DG Altman","year":"2012","unstructured":"Altman DG, McShane LM, Sauerbrei W, Taube SE (2012) Reporting recommendations for tumor marker prognostic studies (REMARK): explanation and elaboration. PLoS Med 9:e1001216","journal-title":"PLoS Med"},{"key":"9250_CR18","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1007\/s00405-009-1144-z","volume":"267","author":"HF K\u00f6hler","year":"2010","unstructured":"K\u00f6hler HF, Kowalski LP (2010) How many nodes are needed to stage a neck? A critical appraisal. Eur Arch Otorhinolaryngol 267:785\u2013791","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"9250_CR19","doi-asserted-by":"publisher","first-page":"1062","DOI":"10.1016\/j.joms.2016.10.005","volume":"75","author":"Z Feng","year":"2017","unstructured":"Feng Z, Xu QS, Qin LZ, Li H, Han Z (2017) Predicting radiotherapy necessity in tongue cancer using lymph node yield. J Oral Maxillofac Surg 75:1062\u20131070","journal-title":"J Oral Maxillofac Surg"},{"key":"9250_CR20","doi-asserted-by":"publisher","first-page":"5347","DOI":"10.21873\/anticanres.12862","volume":"38","author":"S Merz","year":"2018","unstructured":"Merz S, Timmesfeld N, Stuck BA, Wiegand S (2018) Impact of lymph node yield on outcome of patients with head and neck cancer and pN0 neck. Anticancer Res 38:5347\u20135350","journal-title":"Anticancer Res"},{"key":"9250_CR21","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1007\/s00405-021-06819-0","volume":"279","author":"X Le\u00f3n","year":"2022","unstructured":"Le\u00f3n X et al (2022) Prognostic value of the nodal yield in elective neck dissections in patients with head and neck carcinomas. Eur Arch Otorhinolaryngol 279:883\u2013889","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"9250_CR22","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1007\/s00066-022-02017-x","volume":"199","author":"Y Butt","year":"2023","unstructured":"Butt Y et al (2023) Traditional risk factors and nodal yield\u2014still relevant with high-quality risk-adapted adjuvant treatment for locally advanced head and neck cancer? Strahlenther Onkol 199:284\u2013292","journal-title":"Strahlenther Onkol"},{"key":"9250_CR23","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1002\/hed.21022","volume":"31","author":"JS Cooper","year":"2009","unstructured":"Cooper JS et al (2009) National cancer database report on cancer of the head and neck: 10-year update. Head Neck 31:748\u2013758","journal-title":"Head Neck"},{"key":"9250_CR24","unstructured":"Surveillance, Epidemiology, and End Results (SEER) Program (www.seer.cancer.gov) SEER*Stat Database: Incidence - SEER Research Data, 8 Registries, Nov 2021 Sub (1975\u20132020) Linked To County Attributes\u2014Time Dependent (1990\u20132020) Income\/Rurality, 1969\u20132020 Counties, National Cancer Institute, DCCPS, Surveillance Research Program, released April 2023, based on the November 2022 submission."},{"key":"9250_CR25","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1590\/S1808-86942012000200005","volume":"78","author":"A Amar","year":"2012","unstructured":"Amar A et al (2012) Significado progn\u00f3stico do n\u00famero de linfonodos no esvaziamento cervical eletivo no c\u00e2ncer de l\u00edngua e soalho de boca. Braz J Otorhinolaryngol 78:22\u201326","journal-title":"Braz J Otorhinolaryngol"},{"key":"9250_CR26","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1016\/j.ijrobp.2015.12.083","volume":"94","author":"JL Shah","year":"2016","unstructured":"Shah JL et al (2016) Nodal yield threshold for early-stage clinically node-negative oral cavity cancer. Int J Radiat Oncol 94:890","journal-title":"Int J Radiat Oncol"},{"key":"9250_CR27","doi-asserted-by":"publisher","first-page":"E338","DOI":"10.1016\/j.ijrobp.2016.06.1478","volume":"96","author":"CJ Tsai","year":"2016","unstructured":"Tsai CJ et al (2016) Number of lymph nodes examined is associated with overall survival in clinically node-negative oral cavity cancer patients receiving definitive surgery\u2014a population-based analysis using the national cancer data base. Int J Radiat Oncol 96:E338\u2013E339","journal-title":"Int J Radiat Oncol"},{"key":"9250_CR28","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1016\/j.ijom.2018.03.007","volume":"47","author":"S Lee","year":"2018","unstructured":"Lee S, Kim HJ, Cha I-H, Nam W (2018) Prognostic value of lymph node count from selective neck dissection in oral squamous cell carcinoma. Int J Oral Maxillofac Surg 47:953\u2013958","journal-title":"Int J Oral Maxillofac Surg"},{"key":"9250_CR29","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1002\/lary.28102","volume":"130","author":"J Zenga","year":"2020","unstructured":"Zenga J et al (2020) Lymph node yield from neck dissection in HPV-associated oropharyngeal cancer. Laryngoscope 130:666\u2013671","journal-title":"Laryngoscope"},{"key":"9250_CR30","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1016\/j.jds.2020.06.002","volume":"15","author":"C-Y Cheng","year":"2020","unstructured":"Cheng C-Y, Sun F-J, Liu C-J (2020) The influence of cervical lymph node number of neck dissection on the prognosis of the early oral cancer patients. J Dent Sci 15:519\u2013525","journal-title":"J Dent Sci"},{"key":"9250_CR31","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2023.106368","volume":"140","author":"L Zhuge","year":"2023","unstructured":"Zhuge L, Cai H, Huang Z, Wang S, Li Z (2023) The optimal number of examined lymph nodes for accurate nodal staging and favorable prognosis of oral tongue squamous cell carcinoma. Oral Oncol 140:106368","journal-title":"Oral Oncol"},{"key":"9250_CR32","doi-asserted-by":"publisher","first-page":"3624","DOI":"10.1002\/cncr.30227","volume":"122","author":"P Kuo","year":"2016","unstructured":"Kuo P et al (2016) Proposing prognostic thresholds for lymph node yield in clinically lymph node-negative and lymph node-positive cancers of the oral cavity. Cancer 122:3624\u20133631","journal-title":"Cancer"},{"key":"9250_CR33","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1177\/0194599815622409","volume":"154","author":"A Lemieux","year":"2016","unstructured":"Lemieux A, Kedarisetty S, Raju S, Orosco R, Coffey C (2016) Lymph node yield as a predictor of survival in pathologically node negative oral cavity carcinoma. Otolaryngol Neck Surg 154:465\u2013472","journal-title":"Otolaryngol Neck Surg"},{"key":"9250_CR34","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.oraloncology.2019.09.028","volume":"98","author":"J Zenga","year":"2019","unstructured":"Zenga J et al (2019) Lymph node yield, depth of invasion, and survival in node-negative oral cavity cancer. Oral Oncol 98:125\u2013131","journal-title":"Oral Oncol"},{"key":"9250_CR35","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1177\/0194599820936637","volume":"164","author":"ED Gomez","year":"2021","unstructured":"Gomez ED et al (2021) Impact of lymph node yield on survival in surgically treated oropharyngeal squamous cell carcinoma. Otolaryngol Neck Surg 164:146\u2013156","journal-title":"Otolaryngol Neck Surg"},{"key":"9250_CR36","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1001\/jamaoto.2022.2312","volume":"148","author":"N Farrokhian","year":"2022","unstructured":"Farrokhian N et al (2022) Assessing prognostic value of quantitative neck dissection quality measures in patients with clinically node-negative oral cavity squamous cell carcinoma. JAMA Otolaryngol Neck Surg 148:947","journal-title":"JAMA Otolaryngol Neck Surg"},{"key":"9250_CR37","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1007\/s00432-020-03352-1","volume":"147","author":"A B\u00f6ttcher","year":"2021","unstructured":"B\u00f6ttcher A et al (2021) Rational surgical neck management in total laryngectomy for advanced stage laryngeal squamous cell carcinomas. J Cancer Res Clin Oncol 147:549\u2013559","journal-title":"J Cancer Res Clin Oncol"},{"key":"9250_CR38","doi-asserted-by":"publisher","first-page":"3049","DOI":"10.1245\/s10434-014-3702-x","volume":"21","author":"A Ebrahimi","year":"2014","unstructured":"Ebrahimi A et al (2014) Minimum nodal yield in oral squamous cell carcinoma: defining the standard of care in a multicenter international pooled validation study. Ann Surg Oncol 21:3049\u20133055","journal-title":"Ann Surg Oncol"},{"key":"9250_CR39","doi-asserted-by":"publisher","first-page":"E349","DOI":"10.1016\/j.ijrobp.2016.06.1507","volume":"96","author":"A Hosni","year":"2016","unstructured":"Hosni A et al (2016) Impact of lymph node count in neck dissection on regional and\/or distant failure in pT1-2 pN0-1 oral cavity squamous cell carcinoma. Int J Radiat Oncol 96:E349","journal-title":"Int J Radiat Oncol"},{"key":"9250_CR40","doi-asserted-by":"publisher","first-page":"3321","DOI":"10.1007\/s00405-016-3928-2","volume":"273","author":"A B\u00f6ttcher","year":"2016","unstructured":"B\u00f6ttcher A et al (2016) Nodal yield of neck dissections and influence on outcome in laryngectomized patients. Eur Arch Otorhinolaryngol 273:3321\u20133329","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"9250_CR41","doi-asserted-by":"publisher","first-page":"2811","DOI":"10.1002\/hed.26324","volume":"42","author":"M Nurimba","year":"2020","unstructured":"Nurimba M et al (2020) Evaluation of lymph node ratio and lymph node yield as prognosticators of locoregional recurrence in p16-associated oropharyngeal squamous cell carcinoma. Head Neck 42:2811\u20132820","journal-title":"Head Neck"},{"key":"9250_CR42","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1016\/j.bjorl.2020.07.012","volume":"87","author":"MA Abakay","year":"2021","unstructured":"Abakay MA, G\u00fcne\u015f S, G\u00fcl\u00fcstan F (2021) Prognostic importance of harvested lymph node number, metastatic lymph node number, and lymph node ratio in surgically managed laryngeal squamous cell carcinoma. Braz J Otorhinolaryngol 87:416\u2013421","journal-title":"Braz J Otorhinolaryngol"},{"key":"9250_CR43","doi-asserted-by":"publisher","first-page":"2092","DOI":"10.1016\/j.jcms.2017.08.020","volume":"45","author":"A-F Safi","year":"2017","unstructured":"Safi A-F et al (2017) Clinicopathological parameters affecting nodal yields in patients with oral squamous cell carcinoma receiving selective neck dissection. J Cranio-Maxillofac Surg 45:2092\u20132096","journal-title":"J Cranio-Maxillofac Surg"},{"key":"9250_CR44","doi-asserted-by":"publisher","first-page":"2923","DOI":"10.1007\/s00405-019-05560-z","volume":"276","author":"M Cayonu","year":"2019","unstructured":"Cayonu M et al (2019) Lymph node yield and lymph node density for elective level II\u2013IV neck dissections in laryngeal squamous cell carcinoma patients. Eur Arch Otorhinolaryngol 276:2923\u20132927","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"9250_CR45","doi-asserted-by":"publisher","first-page":"2142","DOI":"10.1007\/s00464-007-9414-6","volume":"21","author":"MA Ostadi","year":"2007","unstructured":"Ostadi MA, Harnish JL, Stegienko S, Urbach DR (2007) Factors affecting the number of lymph nodes retrieved in colorectal cancer specimens. Surg Endosc 21:2142\u20132146","journal-title":"Surg Endosc"},{"issue":"10","key":"9250_CR46","doi-asserted-by":"publisher","first-page":"2872","DOI":"10.1002\/hed.26343","volume":"42","author":"AJ Holcomb","year":"2020","unstructured":"Holcomb AJ, Perryman M, Goodwin S, Penn J, Villwock MR, Bur AM, Shnayder Y, Tsue TT, Woodroof J, Kakarala K (2020Oct) Pathology protocol increases lymph node yield in neck dissection for oral cavity squamous cell carcinoma. Head Neck 42(10):2872\u20132879. https:\/\/doi.org\/10.1002\/hed.26343","journal-title":"Head Neck"},{"key":"9250_CR47","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1177\/0194599812440263","volume":"147","author":"PAS Johnstone","year":"2012","unstructured":"Johnstone PAS, Miller ED, Moore MG (2012) Preoperative radiotherapy decreases lymph node yield of neck dissections for head and neck cancer. Otolaryngol Neck Surg 147:278\u2013280","journal-title":"Otolaryngol Neck Surg"}],"container-title":["European Archives of Oto-Rhino-Laryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00405-025-09250-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00405-025-09250-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00405-025-09250-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T09:37:15Z","timestamp":1757151435000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00405-025-09250-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,21]]},"references-count":47,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["9250"],"URL":"https:\/\/doi.org\/10.1007\/s00405-025-09250-x","relation":{},"ISSN":["0937-4477","1434-4726"],"issn-type":[{"value":"0937-4477","type":"print"},{"value":"1434-4726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,21]]},"assertion":[{"value":"7 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 January 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 February 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"We declare that there are no conflicts of interest to disclose regarding this research. The authors have no financial, professional, or personal relationships that could inappropriately influence the results or interpretation of the data presented in this study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The data used in this study are available upon request from the corresponding author.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Data availability"}}]}}