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This study evaluates the impact of different intratympanic injection techniques on patient outcomes.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>A retrospective analysis was conducted on patients diagnosed with idiopathic SSNHL (January 2008\u2013May 2023). Patients were grouped by application technique: (1) transtympanic injection under local anesthesia (TI), (2) CO<jats:sub>2<\/jats:sub> laser paracentesis under general anesthesia (LP), and (3) VT application under general anesthesia (VT). Primary outcomes included hearing improvement and tympanic membrane perforation closure time.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>The study included 99 patients: 28 with TI, 34 with VT, and 37 with LP. Groups showed no significant differences in sex, affected side, therapy initiation interval, pretreatment type, preoperative BCPTA4, subjective improvement, or treatment-related pain (all <jats:italic>p<\/jats:italic>\u2009&gt;\u20090.1). Hearing thresholds improved significantly in the LP and VT groups with large (d\u2009=\u20090.832, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and medium (d\u2009=\u20090.513, <jats:italic>p<\/jats:italic>\u2009=\u20090.01) effect sizes, respectively, but not in the TI group (d\u2009=\u20090.294, <jats:italic>p<\/jats:italic>\u2009=\u20090.137). Tympanic membrane closure time differed significantly among groups (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>LP and VT significantly improved hearing thresholds in SSNHL patients. LP demonstrated the highest efficacy, consistent results across SSNHL severities, and the fastest tympanic membrane closure, making it the preferred method.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s00405-025-09432-7","type":"journal-article","created":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T15:35:27Z","timestamp":1747755327000},"page":"5101-5111","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Retrospective analysis of different application methods in intratympanic glucocorticoid therapy for treatment of idiopathic SSNHL: A comparative outcome study"],"prefix":"10.1007","volume":"282","author":[{"given":"C.","family":"Schmit","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Keller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1022-6877","authenticated-orcid":false,"given":"T.","family":"Gottfried","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Santer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Tr\u00f6ger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Kloppenburg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Klarer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Stenzl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Schmutzhard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Hofauer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Dejaco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,5,20]]},"reference":[{"issue":"3","key":"9432_CR1","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1177\/1084713811408349","volume":"15","author":"M Kuhn","year":"2011","unstructured":"Kuhn M, Heman-Ackah SE, Shaikh JA, Roehm PC (2011) Sudden sensorineural hearing loss: a review of diagnosis, treatment, and prognosis. 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All patients who can be identified via images or other information within the manuscript have given their written consent.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"C. Schmit, F. Keller, T. Gottfried, M. Santer, A. Tr\u00f6ger, M. Kloppenburg, J. Klarer, A. Stenzl, J. Schmutzhard, B. Hofauer and D. Dejaco declare that there is no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}