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In 60 obese MS elderly with CSTC, studying the response of CSTC-related discomfort, MS components, and CSTC severity to lifestyle-modification approach was the aim of this study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this randomized\/controlled lifestyle-modification trial, the recruitment of 60 obese MS elderly with CSTC from a local general hospital was randomly executed. The recruited elderly with MS and CSTC were randomly assigned to a study group (performed lifestyle-modification approach and the components of this 12-week approach were on-electrical treadmill walking plus diet restriction) or waitlist\/control group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200930). Besides MS components\/variables such as elderly\u2019s waist circumference (WC), elderly\u2019s fasting glucose in serum (FGIS), elderly\u2019s triglycerides (TriGly), elderly\u2019s blood pressure, and elderly\u2019s high-density lipoprotein (HDLipo), lifestyle-modification approach\u2019s outcomes of this trial were elderly\u2019s body mass index, visual analogue scale (VAS) of CSTC-related discomfort, tinnitus handicap inventory (THI), and VAS of CSTC severity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Tracking all outcomes of this lifestyle-modification approach in the study group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200930 MS elderly with CSTC) showed significant improvements while the control group\u2019s outcome did not improve.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>BMI, VAS of CSTC severity, components of MS (WC, FGIS, blood pressure, TriGly, and HDLipo), THI, and VAS of CSTC-related discomfort could be improved after involving obese MS elderly with CSTS in a 12-week lifestyle-modification approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration number<\/jats:title>\n                    <jats:p>NCT06702085.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00405-025-09494-7","type":"journal-article","created":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T16:01:48Z","timestamp":1749657708000},"page":"4307-4315","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Effectiveness of lifestyle-modification approach (a randomized-controlled program of diet restriction and treadmill walking exercise) on elderly\u2019s metabolic syndrome-associated subjective tinnitus"],"prefix":"10.1007","volume":"282","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1447-8817","authenticated-orcid":false,"given":"Ali Mohamed Ali","family":"Ismail","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed Mahmoud Nasr","family":"Tolba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,6,11]]},"reference":[{"key":"9494_CR1","doi-asserted-by":"publisher","first-page":"101611","DOI":"10.1016\/j.ctcp.2022.101611","volume":"48","author":"AMA Ismail","year":"2022","unstructured":"Ismail AMA, Ali SM, Ghuiba K, Elfahl AMA, Tolba AMN, Ghaleb HAM (2022) Autonomic functions, tinnitus annoyance and loudness, and quality of life: Randomized-controlled responses to bee-humming (vibrational) respiratory training in tinnitus elderly. 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To apply the lifestyle-modification approach in patients with MS and CSTC, Cairo University\u2019s local institutional clearance (P.T.REC\/012\/004623) was obtained.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"All CSTC older patients were consented.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"To apply the lifestyle-modification approach in patients with MS and CSTC, Consenting - as a part of local institutional clearance (P.T.REC\/012\/004623) - was obtained.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"The authors of this lifestyle-modification approach executed on MS elderly with CSTC declare no competing interests.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}