{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:57:23Z","timestamp":1790888243018,"version":"4.1.0"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,8,9]],"date-time":"2025-08-09T00:00:00Z","timestamp":1754697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,8,9]],"date-time":"2025-08-09T00:00:00Z","timestamp":1754697600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Arch Otorhinolaryngol"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1007\/s00405-025-09585-5","type":"journal-article","created":{"date-parts":[[2025,8,9]],"date-time":"2025-08-09T12:01:08Z","timestamp":1754740868000},"page":"19-32","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Comparative analysis of serum SCC antigen levels in inverted sinonasal papilloma and nasal polyps: a diagnostic meta-analysis"],"prefix":"10.1007","volume":"283","author":[{"given":"Islam","family":"Soltan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saad","family":"Elzayat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2717-6631","authenticated-orcid":false,"given":"Hussein A.","family":"El-Shirbeny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim","family":"Gehad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Aouf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hesham","family":"Gomaa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Abdel-Maboud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Elgendy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,9]]},"reference":[{"key":"9585_CR1","unstructured":"Fokkens WJ, Lund VJ, Hopkins C, Hellings PW, Kern R, Reitsma S, et al (2020) European position paper on rhinosinusitis and nasal polyps 2020. Rhinol J 1\u2013464. Available from: https:\/\/www.rhinologyjournal.com\/Documents\/Supplements\/supplement_29.pdf"},{"key":"9585_CR2","doi-asserted-by":"crossref","unstructured":"DeMarcantonio MA, Han JK (2011) Nasal polyps: Pathogenesis and treatment implications. Otolaryngol Clin North Am 44(3):685\u201395. Available from: https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0030666511000491","DOI":"10.1016\/j.otc.2011.03.005"},{"key":"9585_CR3","doi-asserted-by":"crossref","unstructured":"Lisan Q, Laccourreye O, Bonfils P (2016) Sinonasal inverted papilloma: From diagnosis to treatment. Eur Ann Otorhinolaryngol Head Neck Dis 133(5):337\u201341. Available from: https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1879729616300540","DOI":"10.1016\/j.anorl.2016.03.006"},{"key":"9585_CR4","doi-asserted-by":"crossref","unstructured":"Mirza S, Bradley PJ, Acharya A, Stacey M, Jones NS (2007) Sinonasal inverted papillomas: recurrence, and synchronous and metachronous malignancy. J Laryngol Otol 121(9):857\u201364. Available from: https:\/\/www.cambridge.org\/core\/product\/identifier\/S002221510700624X\/type\/journal_article","DOI":"10.1017\/S002221510700624X"},{"key":"9585_CR5","doi-asserted-by":"crossref","unstructured":"Attlmayr B, Derbyshire SG, Kasbekar A V, Swift AC (2017) Management of inverted papilloma: review. J Laryngol Otol 131(4):284\u20139. Available from: https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215117000172\/type\/journal_article","DOI":"10.1017\/S0022215117000172"},{"key":"9585_CR6","doi-asserted-by":"crossref","unstructured":"Miyazaki T, Haku Y, Yoshizawa A, Iwanaga K, Fujiwara T, Mizuta M, et al (2018) Clinical features of nasal and sinonasal inverted papilloma associated with malignancy. Auris Nasus Larynx 45(5):1014\u20139. Available from: https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S038581461730809X","DOI":"10.1016\/j.anl.2018.02.009"},{"key":"9585_CR7","doi-asserted-by":"crossref","unstructured":"Duffy MJ (2006) Serum tumor markers in breast cancer: are they of clinical value? Clin Chem 52(3):345\u201351. Available from: https:\/\/academic.oup.com\/clinchem\/article\/52\/3\/345\/5626680","DOI":"10.1373\/clinchem.2005.059832"},{"issue":"5","key":"9585_CR8","doi-asserted-by":"publisher","first-page":"365","DOI":"10.2500\/ajra.2012.26.3797","volume":"26","author":"M Suzuki","year":"2012","unstructured":"Suzuki M, Deng Z, Hasegawa M, Uehara T, Kiyuna A, Maeda H (2012) Squamous cell carcinoma antigen production in nasal inverted papilloma. Am J Rhinol Allergy 26(5):365\u2013370","journal-title":"Am J Rhinol Allergy"},{"issue":"1","key":"9585_CR9","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.wjorl.2020.02.002","volume":"7","author":"C Promsopa","year":"2021","unstructured":"Promsopa C, Suwansri S, Khuntikij P (2021) The serum squamous cell carcinoma antigen level in inverted sinonasal papilloma and nasal polyps patients. World J Otorhinolaryngol - Head Neck Surg 7(1):23\u201327","journal-title":"World J Otorhinolaryngol - Head Neck Surg"},{"issue":"3","key":"9585_CR10","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1007\/s00405-013-2604-z","volume":"271","author":"P Matou\u0161ek","year":"2014","unstructured":"Matou\u0161ek P, Zelen\u00edk K, \u0160afar\u010d\u00edk K, \u010c\u00e1balov\u00e1 L, Kom\u00ednek P (2014) Squamous cell carcinoma antigen as a marker of sinonasal inverted papilloma. Eur Arch Oto-Rhino-Laryngology 271(3):535\u2013538","journal-title":"Eur Arch Oto-Rhino-Laryngology"},{"issue":"2","key":"9585_CR11","doi-asserted-by":"publisher","first-page":"122","DOI":"10.2500\/ajra.2016.30.4287","volume":"30","author":"Y Yamashita","year":"2016","unstructured":"Yamashita Y, Uehara T, Hasegawa M, Deng Z, Matayoshi S, Kiyuna A et al (2016) Squamous cell carcinoma antigen as a diagnostic marker of nasal inverted papilloma. Am J Rhinol Allergy 30(2):122\u2013127","journal-title":"Am J Rhinol Allergy"},{"key":"9585_CR12","doi-asserted-by":"crossref","unstructured":"Kitamura Y, Kamimura S, Fujii T, Kanamura R, Fukuda J, Kondo E, et al (2022) Long-term changes in serum squamous cell carcinoma antigen levels after surgery in patients with sinonasal inverted papilloma. Auris Nasus Larynx 49(4):697\u2013702. Available from: https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0385814621002820","DOI":"10.1016\/j.anl.2021.12.004"},{"key":"9585_CR13","doi-asserted-by":"crossref","unstructured":"Hirakawa H, Ikegami T, Toyama M, Ooshiro Y, Higa T, Kinjyo H, et al (2024) Prospective analysis of squamous cell carcinoma antigen-1 and -2 for diagnosing sinonasal inverted papilloma. J Clin Med 13(9):2721. Available from: https:\/\/www.mdpi.com\/2077-0383\/13\/9\/2721","DOI":"10.3390\/jcm13092721"},{"issue":"3","key":"9585_CR14","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1111\/coa.12757","volume":"42","author":"FVWJ van Zijl","year":"2017","unstructured":"van Zijl FVWJ, Monserez DA, Korevaar TIM, Bugter O, Wieringa MH, de Jong Baatenburg RJ et al (2017) Postoperative value of serum squamous cell carcinoma antigen as a predictor of recurrence in sinonasal inverted papilloma. Clin Otolaryngol. 42(3):528\u201335","journal-title":"Clin Otolaryngol."},{"issue":"1","key":"9585_CR15","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1002\/hed.20115","volume":"27","author":"R Yasumatsu","year":"2005","unstructured":"Yasumatsu R, Nakashima T, Masuda M, Kuratomi Y, Shiratsuchi H, Hirakawa N et al (2005) Clinical value of serum squamous cell carcinoma antigen in the management of sinonasal inverted papilloma. Head Neck 27(1):44\u201348","journal-title":"Head Neck"},{"key":"9585_CR16","doi-asserted-by":"crossref","unstructured":"Liu Z, Shi H (2019) Prognostic role of squamous cell carcinoma antigen in cervical cancer: a meta-analysis. Dis Markers 2019:1\u201310. Available from: https:\/\/www.hindawi.com\/journals\/dm\/2019\/6710352\/","DOI":"10.1155\/2019\/6710352"},{"key":"9585_CR17","doi-asserted-by":"publisher","unstructured":"Yoo JG, Lee SJ, Nam EJ, No JH, Park JY, Song JY, et al (2024) Clinical practice guidelines for cervical cancer: the Korean Society of Gynecologic Oncology guidelines. J Gynecol Oncol 35(2). Available from: https:\/\/doi.org\/10.3802\/jgo.2024.35.e44","DOI":"10.3802\/jgo.2024.35.e44"},{"key":"9585_CR18","doi-asserted-by":"publisher","unstructured":"Jeon YJ, Joo Y, Cho H, Kim S, Park B, Choi HG (2023) Associations between chronic rhinosinusitis and cancers: a nationwide population\u2010based cohort study. Laryngoscope 133(5):1044\u201351. Available from: https:\/\/doi.org\/10.1002\/lary.30162","DOI":"10.1002\/lary.30162"},{"key":"9585_CR19","doi-asserted-by":"crossref","unstructured":"Charakorn C, Thadanipon K, Chaijindaratana S, Rattanasiri S, Numthavaj P, Thakkinstian A (2018) The association between serum squamous cell carcinoma antigen and recurrence and survival of patients with cervical squamous cell carcinoma: A systematic review and meta-analysis. Gynecol Oncol 150(1):190\u2013200. Available from: https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0090825818302361","DOI":"10.1016\/j.ygyno.2018.03.056"},{"key":"9585_CR20","doi-asserted-by":"crossref","unstructured":"Xu B, Zhang Z, Wang L, Zhang J, Yan X, Du X, et al (2025) Role of SCCA and CYFRA 21\u20131 in the differential diagnosis of sinonasal benign and malignant diseases. J Craniomaxillofac Surg 53(6):667\u201373. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/39971650","DOI":"10.1016\/j.jcms.2025.01.028"},{"key":"9585_CR21","doi-asserted-by":"crossref","unstructured":"Zhu H (2024) Squamous cell carcinoma antigen: clinical application and research status. Diagnostics 12(5):1065. Available from: https:\/\/www.mdpi.com\/2075-4418\/12\/5\/1065","DOI":"10.3390\/diagnostics12051065"}],"container-title":["European Archives of Oto-Rhino-Laryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00405-025-09585-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00405-025-09585-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00405-025-09585-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T07:15:57Z","timestamp":1770966957000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00405-025-09585-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,9]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["9585"],"URL":"https:\/\/doi.org\/10.1007\/s00405-025-09585-5","relation":{},"ISSN":["0937-4477","1434-4726"],"issn-type":[{"value":"0937-4477","type":"print"},{"value":"1434-4726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,9]]},"assertion":[{"value":"27 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 August 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"There is no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}