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This study investigates the effects of heavy smoking on taste perception in patients undergoing glossectomy type IIIa (i.e. non-compartment hemiglossectomy) for SCC of the tongue.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>Gustatory function was assessed in 30 heavy-smoking patients with SCC of the tongue using a validated taste strips test. Psychophysical evaluations were conducted at baseline and at 3, 6, 9, and 12 months post-surgery.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>At baseline, mean taste strip scores (TSS [SD]) were significantly lower in patients compared to controls (8.7 [1.9] vs. 11.6 [2.1], <jats:italic>P<\/jats:italic>\u2009&lt;.001). Post-treatment, TSS in patients declined to 7.2 [1.0] at 3 months, followed by a gradual recovery to 7.6 [2.3] at 6 months, 8.4 [2.8] at nine months, and 8.9 [3.9] at 12 months. Patients who quit smoking achieved significant recovery, with TSS improving from 7.4 [0.9] at three months to 11.8 [1.4] at twelve months, nearing control values. In contrast, smokers experienced a progressive decline, from 6.8 [1.2] at three months to 4.6 [1.6] at twelve months (<jats:italic>P<\/jats:italic>\u2009&lt;.001). Adjuvant radiotherapy exacerbated short-term deficits (TSS of 6.6 [1.0] vs. 7.5 [0.9], <jats:italic>P<\/jats:italic>\u2009=.027 at three months) but showed no significant long-term impact.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>Persistent smoking worsens taste perception and impedes recovery in patients undergoing glossectomy type IIIa for tongue SCC. Smoking cessation significantly enhances sensory restoration, underscoring its importance in post-treatment care.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s00405-025-09590-8","type":"journal-article","created":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T10:29:34Z","timestamp":1753266574000},"page":"5315-5321","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of smoking cessation on taste function in heavy smokers undergoing hemiglossectomy for tongue squamous cell carcinoma"],"prefix":"10.1007","volume":"282","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4635-7959","authenticated-orcid":false,"given":"Paolo","family":"Boscolo-Rizzo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Hummel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto Vito","family":"Marcuzzo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonino","family":"Maniaci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giacomo","family":"Spinato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Raimondo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi Angelo","family":"Vaira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachele","family":"Tulissi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Menini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franco","family":"Trabalzini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enzo","family":"Emanuelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vittorio","family":"Grill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerry","family":"Polesel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabiola","family":"Giudici","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giancarlo","family":"Tirelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,7,23]]},"reference":[{"key":"9590_CR1","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1007\/s00106-010-2145-3","volume":"58","author":"BN Landis","year":"2010","unstructured":"Landis BN, Just T (2010) Schmeckst\u00f6rungen. 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