{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T23:57:41Z","timestamp":1789775861112,"version":"4.0.1"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T00:00:00Z","timestamp":1757376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T00:00:00Z","timestamp":1757376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Beijing Natural Science Foundation","award":["7244308"],"award-info":[{"award-number":["7244308"]}]},{"name":"Beijing Hospitals Authority Youth Programme","award":["QML20230206"],"award-info":[{"award-number":["QML20230206"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Arch Otorhinolaryngol"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s00405-025-09680-7","type":"journal-article","created":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T19:55:25Z","timestamp":1757447725000},"page":"6425-6435","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Clinical heterogeneity and prognostic markers in head and neck Kimura disease: A retrospective study"],"prefix":"10.1007","volume":"282","author":[{"given":"Yifan","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongzhi","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lizhen","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shizhi","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ru","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jugao","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6533-4795","authenticated-orcid":false,"given":"Ling","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,9,9]]},"reference":[{"key":"9680_CR1","doi-asserted-by":"publisher","first-page":"650","DOI":"10.5858\/2007-131-650-KD","volume":"131","author":"M Abuel-Haija","year":"2007","unstructured":"Abuel-Haija M, Hurford MT (2007) Kimura disease. Arch Pathol Lab Med 131:650\u2013651","journal-title":"Arch Pathol Lab Med"},{"key":"9680_CR2","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1111\/1346-8138.17021","volume":"51","author":"S Ao","year":"2024","unstructured":"Ao S, Huang G, Tang X, Zhu Z, Han J, Wang F, Zhai W (2024) Anti-immunoglobulin E provides an additional therapy to conventional steroids for Kimura\u2019s disease. J Dermatol 51:602\u2013606","journal-title":"J Dermatol"},{"key":"9680_CR3","first-page":"227","volume":"61","author":"P Boccato","year":"1999","unstructured":"Boccato P, Mannar\u00e0 GM, Rinaldo A, La Rosa F, Ferlito A (1999) Kimura\u2019s disease of the intraparotid lymph nodes: fine needle aspiration biopsy findings. Its Relat Specialties 61:227\u2013231ORL; journal for oto-rhino-laryngology","journal-title":"Its Relat Specialties"},{"key":"9680_CR4","first-page":"1181","volume":"25","author":"V Deshpande","year":"2012","unstructured":"Deshpande V, Zen Y, Chan JK, Yi EE, Sato Y, Yoshino T, Kl\u00f6ppel G, Heathcote JG, Khosroshahi A, Ferry JA, Aalberse RC, Bloch DB, Brugge WR, Bateman AC, Carruthers MN, Chari ST, Cheuk W, Cornell LD, Fernandez-Del Castillo C, Forcione DG, Hamilos DL, Kamisawa T, Kasashima S, Kawa S, Kawano M, Lauwers GY, Masaki Y, Nakanuma Y, Notohara K, Okazaki K, Ryu JK, Saeki T, Sahani DV, Smyrk TC, Stone JR, Takahira M, Webster GJ, Yamamoto M, Zamboni G, Umehara H, Stone JH (2012) Consensus statement on the pathology of igg4-related disease. Modern pathology: an official journal of the united States and Canadian academy of pathology. Inc 25:1181\u20131192","journal-title":"Inc"},{"key":"9680_CR5","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1159\/000335372","volume":"223","author":"Y Hamaguchi","year":"2011","unstructured":"Hamaguchi Y, Fujimoto M, Matsushita Y, Kitamura-Sawada S, Kawano M, Takehara K (2011) Igg4-related skin disease, a mimic of angiolymphoid hyperplasia with eosinophilia. Dermatology 223:301\u2013305","journal-title":"Dermatology"},{"key":"9680_CR6","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1136\/jclinpath-2012-200749","volume":"65","author":"T Hattori","year":"2012","unstructured":"Hattori T, Miyanaga T, Tago O, Udagawa M, Kamiyama Y, Nagai Y, Ishikawa O (2012) Isolated cutaneous manifestation of igG4-related disease. J Clin Pathol 65:815\u2013818","journal-title":"J Clin Pathol"},{"key":"9680_CR7","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1089\/105072503321319422","volume":"13","author":"Y Hidaka","year":"2003","unstructured":"Hidaka Y, Kimura M, Izumi Y, Takano T, Tatsumi KI, Amino N (2003) Increased serum concentration of eosinophil-derived neurotoxin in patients with graves\u2019 disease. Thyroid 13:129\u2013132","journal-title":"Thyroid"},{"key":"9680_CR8","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1016\/j.amjoto.2017.07.007","volume":"38","author":"Y Jiang","year":"2017","unstructured":"Jiang Y, Hua Q, Ren J, Zeng F, Sheng J, Liao H, Zhang Z, Guan H (2017) Eosinophilic hyperplastic lymphogranuloma: clinical diagnosis and treatment experience of 41 cases. Am J Otolaryngol 38:626\u2013629","journal-title":"Am J Otolaryngol"},{"key":"9680_CR9","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1016\/S1079-2104(96)80202-2","volume":"82","author":"TJ Li","year":"1996","unstructured":"Li TJ, Chen XM, Wang SZ, Fan MW, Semba I, Kitano M (1996) Kimura\u2019s disease: a clinicopathologic study of 54 Chinese patients. Oral surgery, oral medicine, oral pathology, oral radiology. Endodontics 82:549\u2013555","journal-title":"Oral surgery, oral medicine, oral pathology, oral radiology. Endodontics"},{"key":"9680_CR10","first-page":"517","volume":"21","author":"C Liu","year":"2008","unstructured":"Liu C, Hu W, Chen H, Tang Z, Zeng C, Liu Z, Li L (2008) Clinical and pathological study of kimura\u2019s disease with renal involvement. J Nephrol 21:517\u2013525","journal-title":"J Nephrol"},{"key":"9680_CR11","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1007\/s10067-013-2462-5","volume":"34","author":"L Liu","year":"2015","unstructured":"Liu L, Chen Y, Fang Z, Kong J, Wu X, Zhang Z (2015) Kimura\u2019s disease or IgG4-related disease? A case-based review. Clin Rheumatol 34:385\u2013389","journal-title":"Clin Rheumatol"},{"key":"9680_CR12","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1007\/s10266-018-0377-y","volume":"107","author":"T Maehara","year":"2019","unstructured":"Maehara T, Moriyama M, Nakamura S (2019) Pathogenesis of IgG4-related disease: a critical review. Odontology 107:127\u2013132","journal-title":"Odontology"},{"key":"9680_CR13","doi-asserted-by":"publisher","first-page":"1850","DOI":"10.1007\/s12070-020-01870-5","volume":"74","author":"S Nagaraj","year":"2022","unstructured":"Nagaraj S, Singh SN, Sharma VK, Soni A, Harshvardhan R, Agarwal S (2022) Kimura disease: a case report and review of literature. Indian J Otolaryngol Head Neck Surgery: Official Publication Association Otolaryngologists India 74:1850\u20131853","journal-title":"Indian J Otolaryngol Head Neck Surgery: Official Publication Association Otolaryngologists India"},{"key":"9680_CR14","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1067\/j.cpradiol.2020.10.003","volume":"51","author":"A Sangwan","year":"2022","unstructured":"Sangwan A, Goyal A, Bhalla AS, Kumar A, Sharma R, Arava S, Dawar R (2022) Kimura disease: a case series and systematic review of clinico-radiological features. Curr Probl Diagn Radiol 51:130\u2013142","journal-title":"Curr Probl Diagn Radiol"},{"key":"9680_CR15","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1111\/j.1445-5994.2008.01711.x","volume":"38","author":"QF Sun","year":"2008","unstructured":"Sun QF, Xu DZ, Pan SH, Ding JG, Xue ZQ, Miao CS, Cao GJ, Jin DJ (2008) Kimura disease: review of the literature. Intern Med J 38:668\u2013672","journal-title":"Intern Med J"},{"key":"9680_CR16","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1093\/ajcp\/88.2.236","volume":"88","author":"S Suster","year":"1987","unstructured":"Suster S (1987) Nodal angiolymphoid hyperplasia with eosinophilia. Am J Clin Pathol 88:236\u2013239","journal-title":"Am J Clin Pathol"},{"key":"9680_CR17","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1016\/j.humimm.2013.06.001","volume":"74","author":"K Yamazaki","year":"2013","unstructured":"Yamazaki K, Kawashima H, Sato S, Tsunoda H, Yoshimura Y, Higuchi M, Hokibara S, Yamazaki T, Agematsu K (2013) Increased cd45ro\u2009+\u2009cd62l\u2009+\u2009cd4\u2009+\u2009t-cell subpopulation responsible for th2 response in Kimura\u2019s disease. Hum Immunol 74:1097\u20131102","journal-title":"Hum Immunol"},{"key":"9680_CR18","doi-asserted-by":"publisher","DOI":"10.1186\/s12886-022-02378-y","volume":"22","author":"B Yang","year":"2022","unstructured":"Yang B, Liao H, Wang M, Long Q, Zhong H, Luo L, Liu Z, Cheng X (2022) Kimura\u2019s disease successively affecting multiple body parts: a case-based literature review. BMC Ophthalmol 22:154","journal-title":"BMC Ophthalmol"},{"key":"9680_CR19","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1084879","volume":"13","author":"B Yang","year":"2022","unstructured":"Yang B, Yu H, Jia M, Yao W, Diao R, Li B, Wang Y, Li T, Ge L, Wang H (2022) Successful treatment of dupilumab in Kimura disease independent of IgE: a case report with literature review. Front Immunol 13:1084879","journal-title":"Front Immunol"},{"key":"9680_CR20","doi-asserted-by":"publisher","DOI":"10.1186\/s12893-019-0673-7","volume":"20","author":"G Zhang","year":"2020","unstructured":"Zhang G, Li X, Sun G, Cao Y, Gao N, Qi W (2020) Clinical analysis of Kimura\u2019s disease in 24 cases from China. BMC Surg 20:1","journal-title":"BMC Surg"},{"key":"9680_CR21","doi-asserted-by":"publisher","first-page":"532","DOI":"10.55563\/clinexprheumatol\/lahgfo","volume":"40","author":"Y Zhang","year":"2022","unstructured":"Zhang Y, Bao H, Zhang X, Yang F, Liu Y, Li H, Lu J, Liu Y (2022) Kimura\u2019s disease: clinical characteristics, management and outcome of 20 cases from China. Clin Exp Rheumatol 40:532\u2013538","journal-title":"Clin Exp Rheumatol"},{"key":"9680_CR22","doi-asserted-by":"publisher","first-page":"3371","DOI":"10.2147\/JIR.S462098","volume":"17","author":"F Zhao","year":"2024","unstructured":"Zhao F, Zhou M, Mao A, Zhang Y, Chen Y (2024) Kimura disease: a detailed analysis of clinical and radiological manifestations in a retrospective case series. J Inflamm Res 17:3371\u20133381","journal-title":"J Inflamm Res"}],"container-title":["European Archives of Oto-Rhino-Laryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00405-025-09680-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00405-025-09680-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00405-025-09680-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T18:58:12Z","timestamp":1764961092000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00405-025-09680-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,9]]},"references-count":22,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["9680"],"URL":"https:\/\/doi.org\/10.1007\/s00405-025-09680-7","relation":{},"ISSN":["0937-4477","1434-4726"],"issn-type":[{"value":"0937-4477","type":"print"},{"value":"1434-4726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,9]]},"assertion":[{"value":"5 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 August 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 September 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was conducted in accordance with the Declaration of Helsinki and approved by the ethics committee of Beijing Tongren Hospital, Capital Medical University, which waived the requirement for individual informed consent for this retrospective analysis of anonymized data.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"All of the authors had no any personal, financial, commercial, or academic conflicts of interest separately.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}