{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T01:44:18Z","timestamp":1782870258662,"version":"3.54.5"},"reference-count":7,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:00:00Z","timestamp":1761609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:00:00Z","timestamp":1761609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Arch Otorhinolaryngol"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Transoral laryngeal surgery (TOLS) may lead to glottic insufficiency and scarring which often causes pronounced hoarseness and sometimes swallowing impairment. Injection laryngoplasty with autologous fat is an established method to restore glottic competence and thus improve voice and swallowing function. We hereby aim to demonstrate how laryngeal fat injection can be applied following TOLS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>Autologous fat is harvested via liposuction and then centrifuged for three minutes at 3000\u2009rpm (rpm) to separate fat cells from liquid fat and debris. Fat cells are then transferred to 1\u2009ml Luer-Lock syringes and injected into the altered larynx via a 20 Gauge (0,9\u2009mm) diameter injection needle under microscopic or endoscopic view. The primary objective hereby is approximation of remaining tissue on the glottic plain. The secondary objective is injection into areas of scarified tissue due to the beneficial effect of Adipose-Derived Mesenchymal Stem Cells and possible restoration of physiological laryngeal tissue properties.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Summary<\/jats:title>\n                    <jats:p>Injection laryngoplasty with autologous fat tissue may improve laryngeal function after partial laryngeal resection by laser surgery. Special attention needs to be paid to the specific individual postoperative anatomy of the patient\u2019s larynx as this may differ profoundly from patient to patient.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00405-025-09736-8","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T15:49:17Z","timestamp":1761666557000},"page":"579-581","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Vocal fold augmentation with autologous fat following transoral laryngeal surgery"],"prefix":"10.1007","volume":"283","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9658-1502","authenticated-orcid":false,"given":"Martin Sylvester","family":"Otte","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8223-7954","authenticated-orcid":false,"given":"Jens Peter","family":"Klussmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5028-0600","authenticated-orcid":false,"given":"Kevin Karl","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,10,28]]},"reference":[{"issue":"19","key":"9736_CR1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11195769","volume":"11","author":"S Hans","year":"2022","unstructured":"Hans S, Baudouin R, Circiu MP, Couineau F, Lisan Q, Crevier-Buchman L, Lechien JR (2022) Laryngeal cancer surgery: history and current indications of transoral laser microsurgery and transoral robotic surgery. 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Eur Arch Otorhinolaryngol 258(2):77\u201382","journal-title":"Eur Arch Otorhinolaryngol"},{"issue":"5","key":"9736_CR6","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1002\/lary.29802","volume":"132","author":"AS Luke","year":"2022","unstructured":"Luke AS, Logan AM, Gawlik AE, Dion GR (2022) Autologous lipoaugmentation long-term clinical outcomes: a systematic review. Laryngoscope 132(5):1042\u20131053","journal-title":"Laryngoscope"},{"issue":"12","key":"9736_CR7","doi-asserted-by":"publisher","first-page":"E402","DOI":"10.1002\/lary.27429","volume":"128","author":"S Voss","year":"2018","unstructured":"Voss S, San-Marina S, Oldenburg MS, Ekbom D, Madden BJ, Charlesworth MC, Janus JR (2018) Histone variants as stem cell biomarkers for long-term injection medialization laryngoplasty. 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The protocol was reviewed and approved by the Institutional Ethics Committee of University Hospital of Cologne under approval number 20-1460_1.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent"}},{"value":"Written informed consent was obtained from the patients for both the surgical procedure and the publication of anonymized clinical data, images, and video material.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Patient consent"}},{"value":"None of the authors has any conflict of interest to declare. The study was supported by the Jean Uhrmacher Foundation, Cologne, Germany.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}