{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T11:18:30Z","timestamp":1791976710823,"version":"4.4.0"},"reference-count":72,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T00:00:00Z","timestamp":1760486400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T00:00:00Z","timestamp":1760486400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Arch Otorhinolaryngol"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Unilateral vocal fold paralysis (UVFP), resulting from recurrent laryngeal nerve injury, significantly impairs phonation and reduces quality of life. Laryngeal reinnervation, including ansa-to-recurrent (ansaNSR) and nerve-muscle pedicle reinnervation combined with arytenoid adduction (NMPR\u2009+\u2009AA), has gained attention as a durable treatment option. This systematic review aims to evaluate the outcomes of laryngeal reinnervation, identify predictive factors and highlight knowledge gaps relevant to clinical practice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic search of PubMed, Embase, Web of Science, the Cochrane Library and Emcare identified 42 studies. Outcome measures included perceptual, acoustic, aerodynamic, videostroboscopic and patient-reported outcomes. The risk of bias was assessed using the Methodological Index for Non-Randomized Studies (MINORS) tool. Weighted mean improvements were calculated for clinically relevant parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We included forty-two studies (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u20091 859 patients) in our review. These studies demonstrated high rates of voice improvement, primarily based on data from the ansaNSR (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u20091 369) and NMPR\u2009+\u2009AA (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u2009278) techniques. Age and duration of denervation emerged as the most influential predictive factor. Younger patients (&lt;\u200960 years) and those with shorter denervation periods (&lt;\u20092 years) had better outcomes, although successful results were also observed beyond these thresholds. The predictive value of preoperative laryngeal electromyography (LEMG), etiology of UVFP and clinical presentation remains inconclusive.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Laryngeal reinnervation (ansaNSR and NMPR\u2009+\u2009AA) is effective for UVFP, offering durable voice improvements with minimal complication rates. Future research should focus on standardizing outcome measurements, clarifying predictive factors and refining patient selection to enhance clinical decision-making.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00405-025-09737-7","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T19:33:31Z","timestamp":1760556811000},"page":"5779-5795","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Laryngeal reinnervation for unilateral vocal fold paralysis in adults; a systematic review of the literature for the clinician"],"prefix":"10.1007","volume":"282","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9796-8434","authenticated-orcid":false,"given":"Stephanie D.","family":"Mes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8309-8773","authenticated-orcid":false,"given":"Bas J.","family":"Heijnen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5254-8842","authenticated-orcid":false,"given":"Martine H.","family":"Hendriksma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonius P.M","family":"Langeveld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1238-0613","authenticated-orcid":false,"given":"Emilie A.C.","family":"Dronkers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth V.","family":"Sj\u00f6gren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,10,15]]},"reference":[{"issue":"1","key":"9737_CR1","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/s0892-1997(05)80323-6","volume":"8","author":"RL Crumley","year":"1994","unstructured":"Crumley RL (1994) Unilateral recurrent laryngeal nerve paralysis. 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