{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T13:43:47Z","timestamp":1775483027307,"version":"3.50.1"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T00:00:00Z","timestamp":1767657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T00:00:00Z","timestamp":1767657600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100002871","name":"Chubu University","doi-asserted-by":"publisher","award":["26IM01B"],"award-info":[{"award-number":["26IM01B"]}],"id":[{"id":"10.13039\/501100002871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002871","name":"Chubu University","doi-asserted-by":"publisher","award":["27IM01B"],"award-info":[{"award-number":["27IM01B"]}],"id":[{"id":"10.13039\/501100002871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["15K10763"],"award-info":[{"award-number":["15K10763"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["18K09356"],"award-info":[{"award-number":["18K09356"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21K09589"],"award-info":[{"award-number":["21K09589"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Arch Otorhinolaryngol"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1007\/s00405-025-09933-5","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T20:21:57Z","timestamp":1767730917000},"page":"2237-2242","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of the rs17822931 (538G\u2009>\u2009A, G180R) in the ABCC11 gene with risk of middle ear cholesteatoma in older adults: a hospital-based case\u2013control study at Heidelberg University Hospital, Germany"],"prefix":"10.1007","volume":"283","author":[{"given":"Hiroshi","family":"Nakagawa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ritsuko","family":"Imai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Gestewitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Praetorius","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megumi","family":"Tsukamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias","family":"Albrecht","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Kusunoki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuhisa","family":"Ikeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serkan","family":"Sertel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,1,6]]},"reference":[{"issue":"6","key":"9933_CR1","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.1016\/j.otc.2006.08.003","volume":"39","author":"MT Semaan","year":"2006","unstructured":"Semaan MT, Megerian CA (2006) The pathophysiology of cholesteatoma. Otolaryngol Clin North Am 39(6):1143\u20131159. https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17097438","journal-title":"Otolaryngol Clin North Am"},{"issue":"1","key":"9933_CR2","doi-asserted-by":"publisher","first-page":"e18","DOI":"10.1055\/s-0039-1697989","volume":"24","author":"PR Moller","year":"2020","unstructured":"Moller PR, Pedersen CN, Grosfjeld LR, Faber CE, Djurhuus BD (2020) Recurrence of Cholesteatoma - A retrospective study including 1,006 patients for more than 33 years. Int Arch Otorhinolaryngol 24(1):e18\u2013e23. https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31915464","journal-title":"Int Arch Otorhinolaryngol"},{"key":"9933_CR3","volume-title":"Cholesteatoma","author":"WBJ Moran","year":"1980","unstructured":"Moran WBJ (1980) Cholesteatoma. Harper & Row, New York"},{"issue":"1","key":"9933_CR4","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/S0030-6665(20)32576-7","volume":"11","author":"MM Paparella","year":"1978","unstructured":"Paparella MM, Rybak L (1978) Congenital cholesteatoma. Otolaryngol Clin North Am 11(1):113\u2013120","journal-title":"Otolaryngol Clin North Am"},{"issue":"9","key":"9933_CR5","doi-asserted-by":"publisher","first-page":"1140","DOI":"10.1288\/00005537-198309000-00005","volume":"93","author":"K Aimi","year":"1983","unstructured":"Aimi K (1983) Role of the tympanic ring in the pathogenesis of congenital cholesteatoma. Laryngoscope 93(9):1140\u20131146","journal-title":"Laryngoscope"},{"issue":"6","key":"9933_CR6","doi-asserted-by":"publisher","first-page":"910","DOI":"10.1016\/S0022-3476(89)80741-3","volume":"115","author":"J Piza","year":"1989","unstructured":"Piza J, Gonzalez M, Northrop CC, Eavey RD (1989) Meconium contamination of the neonatal middle ear. J Pediatr 115(6):910\u2013914","journal-title":"J Pediatr"},{"key":"9933_CR7","doi-asserted-by":"publisher","first-page":"854024","DOI":"10.1155\/2015\/854024","volume":"2015","author":"CL Kuo","year":"2015","unstructured":"Kuo CL, Shiao AS, Yung M, Sakagami M, Sudhoff H, Wang CH, Hsu CH, Lien CF (2015) Updates and knowledge gaps in cholesteatoma research. Biomed Res Int 2015:854024. https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25866816","journal-title":"Biomed Res Int"},{"key":"9933_CR8","first-page":"250","volume":"11","author":"W Lange","year":"1925","unstructured":"Lange W (1925) \u00dcber die entstehung der Mittelohrcholesteatoma. Z Hals Nas Ohrenheilk 11:250\u2013271","journal-title":"Z Hals Nas Ohrenheilk"},{"key":"9933_CR9","first-page":"1","volume":"361","author":"L Ruedi","year":"1979","unstructured":"Ruedi L (1979) Pathogenesis and surgical treatment of the middle ear cholesteatoma. Acta Otolaryngol Suppl 361:1\u201345","journal-title":"Acta Otolaryngol Suppl"},{"key":"9933_CR10","unstructured":"von Tr\u00f6ltsch A (1864) The diseases of the ear, their diagnosis and treatment. New York"},{"key":"9933_CR11","first-page":"428","volume":"14","author":"H Wendt","year":"1873","unstructured":"Wendt H (1873) Desquamative Entz\u00fcndung des Mittelohres (Cholesteatoma des Felsenbeins). Arch Ohr Nasen Kehlkopf Heilk 14:428\u2013446","journal-title":"Arch Ohr Nasen Kehlkopf Heilk"},{"key":"9933_CR12","unstructured":"W.C. C (1999) Otolaryngology - Head and Neck Surgery 3rd edition. Mosby"},{"key":"9933_CR13","first-page":"110","volume":"40","author":"M Tos","year":"1988","unstructured":"Tos M (1988) Incidence, etiology and pathogenesis of cholesteatoma in children. Adv Otorhinolaryngol 40:110\u2013117. https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/3389223","journal-title":"Adv Otorhinolaryngol"},{"issue":"11","key":"9933_CR14","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1017\/S0022215100110898","volume":"103","author":"N Padgham","year":"1989","unstructured":"Padgham N, Mills R, Christmas H (1989) Has the increasing use of grommets influenced the frequency of surgery for cholesteatoma? J Laryngol Otol 103(11):1034\u20131035","journal-title":"J Laryngol Otol"},{"issue":"5","key":"9933_CR15","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1080\/00016489950180801","volume":"119","author":"HO Kemppainen","year":"1999","unstructured":"Kemppainen HO, Puhakka HJ, Laippala PJ, Sipila MM, Manninen MP, Karma PH (1999) Epidemiology and aetiology of middle ear cholesteatoma. Acta Otolaryngol 119(5):568\u2013572. https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/10478597","journal-title":"Acta Otolaryngol"},{"key":"9933_CR16","doi-asserted-by":"crossref","unstructured":"Shibata S, Murakami K, Umeno Y, Komune S (2015) Epidemiological study of cholesteatoma in Fukuoka City. J Laryngol Otol 129 Suppl 2(S6-11). https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25706164","DOI":"10.1017\/S002221511400231X"},{"issue":"4","key":"9933_CR17","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1017\/S0022215117000299","volume":"131","author":"A Britze","year":"2017","unstructured":"Britze A, Moller ML, Ovesen T (2017) Incidence, 10-year recidivism rate and prognostic factors for cholesteatoma. J Laryngol Otol 131(4):319\u2013328","journal-title":"J Laryngol Otol"},{"key":"9933_CR18","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.mehy.2018.02.030","volume":"114","author":"H Nakagawa","year":"2018","unstructured":"Nakagawa H, Toyoda Y, Albrecht T, Tsukamoto M, Praetorius M, Ishikawa T, Kamiya K, Kusunoki T, Ikeda K, Sertel S (2018) Are human ATP-binding cassette transporter C11 and earwax associated with the incidence of cholesteatoma? Med Hypotheses 114:19\u201322. https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29602456","journal-title":"Med Hypotheses"},{"issue":"1","key":"9933_CR19","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1177\/01945998211000374","volume":"166","author":"S Hara","year":"2022","unstructured":"Hara S, Kusunoki T, Nakagawa H, Toyoda Y, Nojiri S, Kamiya K, Furukawa M, Takata Y, Okada H, Anzai T, Matsumoto F, Ikeda K (2022) Association between earwax-Determinant genotypes and acquired middle ear cholesteatoma in a Japanese population. Otolaryngol Head Neck Surg 166(1):139\u2013145. https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/33722103","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"7","key":"9933_CR20","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1001\/archotol.128.7.810","volume":"128","author":"M Nelson","year":"2002","unstructured":"Nelson M, Roger G, Koltai PJ, Garabedian EN, Triglia JM, Roman S, Castellon RJ, Hammel JP (2002) Congenital cholesteatoma: classification, management, and outcome. Arch Otolaryngol Head Neck Surg 128(7):810\u2013814. https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12117341","journal-title":"Arch Otolaryngol Head Neck Surg"},{"issue":"5","key":"9933_CR21","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1001\/jamaoto.2023.0048","volume":"149","author":"A Bonnard","year":"2023","unstructured":"Bonnard A, Engmer Berglin C, Wincent J, Eriksson PO, Westman E, Feychting M, Mogensen H (2023) The risk of cholesteatoma in individuals with First-degree relatives surgically treated for the disease. JAMA Otolaryngol Head Neck Surg 149(5):390\u2013396. https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/36929420","journal-title":"JAMA Otolaryngol Head Neck Surg"},{"issue":"3","key":"9933_CR22","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1038\/ng1733","volume":"38","author":"K Yoshiura","year":"2006","unstructured":"Yoshiura K, Kinoshita A, Ishida T, Ninokata A, Ishikawa T, Kaname T, Bannai M, Tokunaga K, Sonoda S, Komaki R, Ihara M, Saenko VA, Alipov GK, Sekine I, Komatsu K, Takahashi H, Nakashima M, Sosonkina N, Mapendano CK, Ghadami M, Nomura M, Liang DS, Miwa N, Kim DK, Garidkhuu A, Natsume N, Ohta T, Tomita H, Kaneko A, Kikuchi M, Russomando G, Hirayama K, Ishibashi M, Takahashi A, Saitou N, Murray JC, Saito S, Nakamura Y, Niikawa N (2006) A SNP in the ABCC11 gene is the determinant of human earwax type. Nat Genet 38(3):324\u2013330. https:\/\/pubmed.ncbi.nlm.nih.gov\/16444273\/","journal-title":"Nat Genet"}],"container-title":["European Archives of Oto-Rhino-Laryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00405-025-09933-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00405-025-09933-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00405-025-09933-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T12:43:49Z","timestamp":1775479429000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00405-025-09933-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,6]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["9933"],"URL":"https:\/\/doi.org\/10.1007\/s00405-025-09933-5","relation":{},"ISSN":["0937-4477","1434-4726"],"issn-type":[{"value":"0937-4477","type":"print"},{"value":"1434-4726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,6]]},"assertion":[{"value":"7 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 January 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no conflicts of interest to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}