{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T17:51:45Z","timestamp":1781632305507,"version":"3.54.5"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:00:00Z","timestamp":1768867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:00:00Z","timestamp":1768867200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Manipal Academy of Higher Education, Manipal"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Arch Otorhinolaryngol"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Inverted papilloma (IP) is a benign Schneiderian epithelial tumour with a well-recognized potential for recurrence and malignant transformation, most commonly to squamous cell carcinoma (SCC). Carcinoma arising in the nasopharynx after prior IP is exceedingly rare, and distinguishing malignant conversion from a metachronous nasopharyngeal carcinoma (NPC) poses a diagnostic challenge.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case report<\/jats:title>\n                    <jats:p>We report a rare, interesting case of a nasopharyngeal lesion with histopathological features of non-keratinizing SCC in a patient previously treated surgically for sinonasal IP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Differentiating malignant transformation of IP from a metachronous malignancy is complex. In this case, the short interval between diagnoses, anatomical separation, and absence of Schneiderian features favour interpretation as a metachronous NPC, highlighting the importance of continued surveillance and prompt evaluation of new symptoms in patients treated for IP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00405-025-09987-5","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T21:12:55Z","timestamp":1768943575000},"page":"2591-2595","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Metachronous nasopharyngeal carcinoma following\u00a0sinonasal inverted papilloma \u2013 a diagnostic enigma"],"prefix":"10.1007","volume":"283","author":[{"given":"Deviprasad","family":"Dosemane","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2006-8913","authenticated-orcid":false,"given":"Meera Niranjan","family":"Khadilkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nithya","family":"Chandy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Divya","family":"Subramanian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nayana","family":"Rao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"Iqbal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,20]]},"reference":[{"key":"9987_CR1","doi-asserted-by":"publisher","first-page":"2991","DOI":"10.1007\/s00405-017-4571-2","volume":"274","author":"M Re","year":"2017","unstructured":"Re M, Gioacchini FM, Bajraktari A et al (2017) Malignant transformation of sinonasal inverted papilloma and related genetic alterations: a systematic review. Eur Arch Otorhinolaryngol 274:2991\u20133000. https:\/\/doi.org\/10.1007\/s00405-017-4571-2","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"9987_CR2","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1097\/MOO.0000000000000781","volume":"30","author":"RH Kamel","year":"2022","unstructured":"Kamel RH, Khaled A, Abdelfattah AF, Awad AG (2022) Surgical treatment of sinonasal inverted papilloma. Curr Opin Otolaryngol Head Neck Surg 30:26\u201332. https:\/\/doi.org\/10.1097\/MOO.0000000000000781","journal-title":"Curr Opin Otolaryngol Head Neck Surg"},{"key":"9987_CR3","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.648895","author":"P Yang","year":"2021","unstructured":"Yang P, Meng G, Shu Q et al (2021) A short-term efficacy of Anlotinib in the treatment of refractory nasopharyngeal inverted papilloma: a case report. Front Oncol. https:\/\/doi.org\/10.3389\/fonc.2021.648895","journal-title":"Front Oncol"},{"key":"9987_CR4","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.anorl.2016.03.006","volume":"133","author":"Q Lisan","year":"2016","unstructured":"Lisan Q, Laccourreye O, Bonfils P (2016) Sinonasal inverted papilloma: from diagnosis to treatment. Eur Ann Otorhinolaryngol Head Neck Dis 133:337\u2013341. https:\/\/doi.org\/10.1016\/j.anorl.2016.03.006","journal-title":"Eur Ann Otorhinolaryngol Head Neck Dis"},{"key":"9987_CR5","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1007\/s00106-023-01406-7","volume":"72","author":"T Hildenbrand","year":"2024","unstructured":"Hildenbrand T, Weber RK (2024) Invertiertes papillom der Nase und Nasennebenh\u00f6hlen. HNO 72:257\u2013264. https:\/\/doi.org\/10.1007\/s00106-023-01406-7","journal-title":"HNO"},{"key":"9987_CR6","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1002\/lary.30128","volume":"133","author":"S Viitasalo","year":"2023","unstructured":"Viitasalo S, Ilmarinen T, Aaltonen L et al (2023) Sinonasal inverted papilloma \u2013 malignant transformation and non-sinonasal malignancies. Laryngoscope 133:506\u2013511. https:\/\/doi.org\/10.1002\/lary.30128","journal-title":"Laryngoscope"},{"key":"9987_CR7","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1007\/s10555-024-10176-9","volume":"43","author":"ZY Su","year":"2024","unstructured":"Su ZY, Siak PY, Lwin YY, Cheah S-C (2024) Epidemiology of nasopharyngeal carcinoma: current insights and future outlook. Cancer Metastasis Rev 43:919\u2013939. https:\/\/doi.org\/10.1007\/s10555-024-10176-9","journal-title":"Cancer Metastasis Rev"},{"key":"9987_CR8","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.wjorl.2016.11.004","volume":"3","author":"M Wang","year":"2017","unstructured":"Wang M, Noel JE (2017) Etiology of sinonasal inverted papilloma: a narrative review. World J Otorhinolaryngol Head Neck Surg 3:54\u201358. https:\/\/doi.org\/10.1016\/j.wjorl.2016.11.004","journal-title":"World J Otorhinolaryngol Head Neck Surg"},{"key":"9987_CR9","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.jcv.2016.04.001","volume":"79","author":"R-W Zhao","year":"2016","unstructured":"Zhao R-W, Guo Z-Q, Zhang R-X (2016) Human papillomavirus infection and the malignant transformation of sinonasal inverted papilloma: a meta -analysis. J Clin Virol 79:36\u201343. https:\/\/doi.org\/10.1016\/j.jcv.2016.04.001","journal-title":"J Clin Virol"},{"key":"9987_CR10","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/j.canrad.2010.01.012","volume":"14","author":"C-M Acevedo-Henao","year":"2010","unstructured":"Acevedo-Henao C-M, Talagas M, Marianowski R, Pradier O (2010) Recurrent inverted papilloma with intracranial and temporal fossa involvement: a case report and review of the literature. Cancer\/Radioth\u00e9rapie 14:202\u2013205. https:\/\/doi.org\/10.1016\/j.canrad.2010.01.012","journal-title":"Cancer\/Radioth\u00e9rapie"},{"key":"9987_CR11","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1017\/S0022215100049173","volume":"67","author":"A Radcliffe","year":"1953","unstructured":"Radcliffe A (1953) Transitional cell papilloma of the post-pharyngeal wall. J Laryngol Otol 67:682\u2013688. https:\/\/doi.org\/10.1017\/S0022215100049173","journal-title":"J Laryngol Otol"},{"key":"9987_CR12","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1177\/019459988008800623","volume":"88","author":"AP Wolff","year":"1980","unstructured":"Wolff AP, Ossoff RH, Clemis JD (1980) Four unusual neoplasms of the nasopharynx. Otolaryngol Head Neck Surg 88:753\u2013759. https:\/\/doi.org\/10.1177\/019459988008800623","journal-title":"Otolaryngol Head Neck Surg"},{"key":"9987_CR13","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1002\/hed.2890070309","volume":"7","author":"FC Astor","year":"1985","unstructured":"Astor FC, Donegan JO, Gluckman JL (1985) Unusual anatomic presentations of inverting papilloma. Head Neck Surg 7:243\u2013245. https:\/\/doi.org\/10.1002\/hed.2890070309","journal-title":"Head Neck Surg"},{"key":"9987_CR14","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1177\/014556130208100512","volume":"81","author":"W-K Low","year":"2002","unstructured":"Low W-K, Toh S-T, Lim C-M, Ramesh G (2002) Schneiderian papilloma of the nasopharynx. Ear Nose Throat J 81:336\u2013338. https:\/\/doi.org\/10.1177\/014556130208100512","journal-title":"Ear Nose Throat J"},{"key":"9987_CR15","doi-asserted-by":"publisher","first-page":"47","DOI":"10.12816\/0000518","volume":"35","author":"N Fageeh","year":"2013","unstructured":"Fageeh N, Al-Shraim M (2013) Inverted papilloma isolated in the nasopharynx. Bahrain Med Bull 35:47\u201349. https:\/\/doi.org\/10.12816\/0000518","journal-title":"Bahrain Med Bull"},{"key":"9987_CR16","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1016\/j.amjoto.2014.02.014","volume":"35","author":"M Kishikawa","year":"2014","unstructured":"Kishikawa M, Tsunoda A, Tanaka Y, Kishimoto S (2014) Large nasopharyngeal inverted papilloma presenting with rustling tinnitus. Am J Otolaryngol 35:402\u2013404. https:\/\/doi.org\/10.1016\/j.amjoto.2014.02.014","journal-title":"Am J Otolaryngol"},{"key":"9987_CR17","doi-asserted-by":"publisher","DOI":"10.15344\/2455-2356\/2015\/106","author":"M Ohki","year":"2015","unstructured":"Ohki M (2015) Nasopharyngeal inverted papilloma invading the parapharyngeal space accompanied by hearing loss. Int J Clin Case Stud. https:\/\/doi.org\/10.15344\/2455-2356\/2015\/106. 1:","journal-title":"Int J Clin Case Stud"},{"key":"9987_CR18","first-page":"1025","volume":"21","author":"PV Vlastarakos","year":"2016","unstructured":"Vlastarakos PV, Georgiadis T, Boutsi S, Konstantopoulos I (2016) Re-affirming the necessity of sending even minor surgical specimens for histopathology: a case of inverted papilloma of the adenoids. J BUON 21:1025\u20131026","journal-title":"J BUON"},{"key":"9987_CR19","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1007\/s12105-021-01335-3","volume":"15","author":"MW Saab-Chalhoub","year":"2021","unstructured":"Saab-Chalhoub MW, Guo X, Shi Q et al (2021) Low grade papillary sinonasal (Schneiderian) carcinoma: a series of five cases of a unique malignant neoplasm with comparison to inverted papilloma and conventional nonkeratinizing squamous cell carcinoma. Head Neck Pathol 15:1221\u20131234. https:\/\/doi.org\/10.1007\/s12105-021-01335-3","journal-title":"Head Neck Pathol"},{"key":"9987_CR20","doi-asserted-by":"publisher","DOI":"10.1177\/2050313X20922032","author":"S Flach","year":"2020","unstructured":"Flach S, Ferguson AS, White S et al (2020) Unique case of inverted papilloma of septum with nasopharyngeal carcinoma: is it a metachronous tumour? SAGE Open Med Case Rep. https:\/\/doi.org\/10.1177\/2050313X20922032","journal-title":"SAGE Open Med Case Rep"},{"key":"9987_CR21","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1177\/000348949910800413","volume":"108","author":"RL Sulica","year":"1999","unstructured":"Sulica RL, Debo RF, Wenig BM, Sessions RB (1999) Schneiderian papillomas of the pharynx. Ann Otol Rhinol Laryngol 108:392\u2013397. https:\/\/doi.org\/10.1177\/000348949910800413","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"9987_CR22","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1017\/S0022215113000042","volume":"127","author":"ZW Liu","year":"2013","unstructured":"Liu ZW, Walden A, Lee CA (2013) Sinonasal inverted papilloma involving the Temporal bone via the eustachian tube: case report. J Laryngol Otol 127:318\u2013320. https:\/\/doi.org\/10.1017\/S0022215113000042","journal-title":"J Laryngol Otol"},{"key":"9987_CR23","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.oraloncology.2019.01.024","volume":"90","author":"D Sharbel","year":"2019","unstructured":"Sharbel D, Chat V, Blumenthal D et al (2019) Cervical nodal metastasis after malignant conversion of sinonasal inverted papilloma: report of a rare case and literature review. Oral Oncol 90:45\u201347. https:\/\/doi.org\/10.1016\/j.oraloncology.2019.01.024","journal-title":"Oral Oncol"},{"key":"9987_CR24","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1002\/hed.21974","volume":"34","author":"AK El-Naggar","year":"2012","unstructured":"El-Naggar AK, Westra WH (2012) P16 expression as a surrogate marker for HPV\u2010related oropharyngeal carcinoma: a guide for interpretative relevance and consistency. Head Neck 34:459\u2013461. https:\/\/doi.org\/10.1002\/hed.21974","journal-title":"Head Neck"}],"container-title":["European Archives of Oto-Rhino-Laryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00405-025-09987-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00405-025-09987-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00405-025-09987-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T16:52:42Z","timestamp":1781628762000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00405-025-09987-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,20]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["9987"],"URL":"https:\/\/doi.org\/10.1007\/s00405-025-09987-5","relation":{},"ISSN":["0937-4477","1434-4726"],"issn-type":[{"value":"0937-4477","type":"print"},{"value":"1434-4726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,20]]},"assertion":[{"value":"16 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 December 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 January 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This report was documented in line with the principles of the Declaration of Helsinki. Approval was granted by Institutional Ethics Committee, Mangaluru \u2013 IEC KMC MLR 10\/2025\/664.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"<!--Emphasis Type='Bold' removed-->Ethics approval"}},{"value":"Consent to participate and publish was obtained from the patient.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"<!--Emphasis Type='Bold' removed-->Informed consent"}},{"value":"The authors have no relevant financial or non-financial interests to disclose.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"<!--Emphasis Type='Bold' removed-->Competing interests"}}]}}