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This study examined acoustic parameters, perceptual features, and speech intelligibility using a large, methodologically standardized cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 105 PD patients (55 females, 50 males; mean age\u2009\u2248\u200957 years) undergoing STN-DBS were evaluated. All received posterolateral electrode placement, bilateral stimulation, and a postoperative 30\u201335% reduction in levodopa. Acoustic measures fundamental frequency (F0), jitter, shimmer, harmonic-to-noise ratio (HNR), and maximum phonation time (MPT) were obtained one day preoperatively and at three months postoperatively. Perceptual ratings (GRBAS), Voice Handicap Index-10 (VHI-10), and speech intelligibility (percentage of correctly produced words) were assessed concurrently.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Motor symptoms improved in the medication-on state (19.4 \u2192 13.6). Acoustic analysis showed no significant postoperative change in F0, shimmer, HNR, or MPT; however, jitter improved significantly in both sexes. On the GRBAS scale, all parameters improved in females, whereas grade, roughness, and asthenia improved in males. VHI-10 scores improved overall (22.7 \u2192 21.8;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.031), driven primarily by females (27.5 \u2192 25.9;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004). Speech intelligibility increased in the full cohort (70.1% \u2192 71.7%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01) and reached significance in females but not males. Higher age and greater motor severity correlated with reduced intelligibility, while sex, PD subtype, and stimulation parameters showed no associations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>STN-DBS yields short-term motor improvement and produces parameter-specific speech effects. Utilizing a highly standardized \u201cpure\u201d cohort enhances interpretability and suggests that, under controlled conditions, STN-DBS can exert a beneficial influence on speech performance despite its multifactorial impact.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00405-026-10063-9","type":"journal-article","created":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T09:50:03Z","timestamp":1773654603000},"page":"3173-3182","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of subthalamic nucleus deep brain stimulation on voice and speech in Parkinson\u2019s disease"],"prefix":"10.1007","volume":"283","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0965-1390","authenticated-orcid":false,"given":"Ozan","family":"Tuysuz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1394-5188","authenticated-orcid":false,"given":"Ozan","family":"Hasimoglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1740-789X","authenticated-orcid":false,"given":"R\u0131dvan","family":"Basaran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1883-8755","authenticated-orcid":false,"given":"Ayca Altinkaya","family":"Uslu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9350-8046","authenticated-orcid":false,"given":"Selin Ustun","family":"Bezgin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahin","family":"Ogreden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1731-3233","authenticated-orcid":false,"given":"Ozgur","family":"Yigit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,15]]},"reference":[{"issue":"7","key":"10063_CR1","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1002\/mdc3.14065","volume":"11","author":"C Theyer","year":"2024","unstructured":"Theyer C, Beliveau V, Krismer F et al (2024) Long-Term medication profiles in parkinson\u2019s disease under subthalamic deep brain stimulation: a controlled study. 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