{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T22:23:56Z","timestamp":1787264636447,"version":"build-2736575974"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T00:00:00Z","timestamp":1787184000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T00:00:00Z","timestamp":1787184000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Arch Otorhinolaryngol"],"DOI":"10.1007\/s00405-026-10535-y","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T21:38:57Z","timestamp":1787261937000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Genetic contributions to familial M\u00e9ni\u00e8re\u2019s disease: a systematic review"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-6967-6152","authenticated-orcid":false,"given":"Cassandre","family":"Djian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Jonard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandrine","family":"Marlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,20]]},"reference":[{"issue":"Suppl 1","key":"10535_CR1","doi-asserted-by":"publisher","first-page":"S71","DOI":"10.1007\/s00415-015-7930-1","volume":"263","author":"R G\u00fcrkov","year":"2016","unstructured":"G\u00fcrkov R, Pyyk\u00f6 I, Zou J, Kentala E (2016) What is Meni\u00e8re\u2019s disease? A contemporary re-evaluation of endolymphatic hydrops. J Neurol 263(Suppl 1):S71-81. https:\/\/doi.org\/10.1007\/s00415-015-7930-1","journal-title":"J Neurol"},{"issue":"1","key":"10535_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3233\/VES-150549","volume":"25","author":"JA Lopez-Escamez","year":"2015","unstructured":"Lopez-Escamez JA, Carey J, Chung WH, Goebel JA, Magnusson M, Mandal\u00e0 M et al (2015) Diagnostic criteria for Meni\u00e8re\u2019s disease. J Vestib Res Equilib Orientat 25(1):1\u20137. https:\/\/doi.org\/10.3233\/VES-150549","journal-title":"J Vestib Res Equilib Orientat"},{"key":"10535_CR3","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2019.107872","volume":"397","author":"A Gallego-Martinez","year":"2020","unstructured":"Gallego-Martinez A, Lopez-Escamez JA (2020) Genetic architecture of Meniere\u2019s disease. Hear Res 397:107872","journal-title":"Hear Res"},{"issue":"1","key":"10535_CR4","doi-asserted-by":"publisher","first-page":"49","DOI":"10.21053\/ceo.2021.00920","volume":"15","author":"L Frejo","year":"2022","unstructured":"Frejo L, Lopez-Escamez JA (2022) Cytokines and Inflammation in Meniere disease. Clin Exp Otorhinolaryngol 15(1):49\u201359. https:\/\/doi.org\/10.21053\/ceo.2021.00920","journal-title":"Clin Exp Otorhinolaryngol"},{"issue":"12","key":"10535_CR5","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1016\/j.autrev.2012.02.020","volume":"11","author":"I Gazquez","year":"2012","unstructured":"Gazquez I, Requena T, Espinosa JM, Batuecas A, Lopez-Escamez JA (2012) Genetic and clinical heterogeneity in Meniere\u2019s disease. Autoimmun Rev 11(12):925\u2013926. https:\/\/doi.org\/10.1016\/j.autrev.2012.02.020","journal-title":"Autoimmun Rev"},{"issue":"4","key":"10535_CR6","doi-asserted-by":"publisher","first-page":"261","DOI":"10.3233\/VES-200786","volume":"31","author":"M Eliezer","year":"2021","unstructured":"Eliezer M, Atty\u00e9 A, Toupet M, Hautefort C (2021) Imaging of endolymphatic hydrops: a comprehensive update in primary and secondary hydropic ear disease. J Vestib Res Equilib Orientat 31(4):261\u2013268. https:\/\/doi.org\/10.3233\/VES-200786","journal-title":"J Vestib Res Equilib Orientat"},{"issue":"Suppl 1","key":"10535_CR7","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1007\/s00415-019-09399-6","volume":"266","author":"R Teggi","year":"2019","unstructured":"Teggi R, Carpini SD, Zagato L (2019) Endolymphatic hydrops and ionic transporters: genetic and biohumoral aspects. J Neurol 266(Suppl 1):47\u201351. https:\/\/doi.org\/10.1007\/s00415-019-09399-6","journal-title":"J Neurol"},{"issue":"3","key":"10535_CR8","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1007\/BF00181831","volume":"251","author":"L Naftalin","year":"1994","unstructured":"Naftalin L (1994) The possible roles of hormones and enzymes in the production of the acute attack in Meni\u00e8re\u2019s disease. Eur Arch Oto-Rhino-Laryngol Off J Eur Fed Oto-Rhino-Laryngol Soc EUFOS Affil Ger Soc Oto-Rhino-Laryngol - Head Neck Surg 251(3):173\u2013177. https:\/\/doi.org\/10.1007\/BF00181831","journal-title":"Eur Arch Oto-Rhino-Laryngol Off J Eur Fed Oto-Rhino-Laryngol Soc EUFOS Affil Ger Soc Oto-Rhino-Laryngol - Head Neck Surg"},{"issue":"3","key":"10535_CR9","doi-asserted-by":"publisher","first-page":"2901","DOI":"10.1007\/s11033-022-08149-8","volume":"50","author":"Q Dai","year":"2023","unstructured":"Dai Q, Long L, Zhao H, Wang R, Zheng H, Duan M (2023) Genetic advances in Meniere disease. Mol Biol Rep 50(3):2901\u20132908. https:\/\/doi.org\/10.1007\/s11033-022-08149-8","journal-title":"Mol Biol Rep"},{"issue":"6","key":"10535_CR10","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1111\/ahg.12327","volume":"83","author":"S Skarp","year":"2019","unstructured":"Skarp S, Kanervo L, Kotim\u00e4ki J, Sorri M, M\u00e4nnikk\u00f6 M, Hietikko E (2019) Whole-exome sequencing suggests multiallelic inheritance for childhood-onset M\u00e9ni\u00e8re\u2019s disease. Ann Hum Genet 83(6):389\u2013396. https:\/\/doi.org\/10.1111\/ahg.12327","journal-title":"Ann Hum Genet"},{"issue":"4","key":"10535_CR11","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1093\/hmg\/ddu524","volume":"24","author":"T Requena","year":"2015","unstructured":"Requena T, Cabrera S, Mart\u00edn-Sierra C, Price SD, Lysakowski A, Lopez-Escamez JA (2015) Identification of two novel mutations in FAM136A and DTNA genes in autosomal-dominant familial Meniere\u2019s disease. Hum Mol Genet 24(4):1119\u201326. https:\/\/doi.org\/10.1093\/hmg\/ddu524","journal-title":"Hum Mol Genet"},{"issue":"16","key":"10535_CR12","doi-asserted-by":"publisher","first-page":"3407","DOI":"10.1093\/hmg\/ddw183","volume":"25","author":"C Mart\u00edn-Sierra","year":"2016","unstructured":"Mart\u00edn-Sierra C, Requena T, Frejo L, Price SD, Gallego-Martinez A, Batuecas-Caletrio A et al (2016) A novel missense variant in PRKCB segregates low-frequency hearing loss in an autosomal dominant family with Meniere\u2019s disease. Hum Mol Genet 25(16):3407\u201315. https:\/\/doi.org\/10.1093\/hmg\/ddw183","journal-title":"Hum Mol Genet"},{"issue":"2","key":"10535_CR13","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1038\/ejhg.2016.154","volume":"25","author":"C Mart\u00edn-Sierra","year":"2017","unstructured":"Mart\u00edn-Sierra C, Gallego-Martinez A, Requena T, Frejo L, Batuecas-Caletr\u00edo A, Lopez-Escamez JA (2017) Variable expressivity and genetic heterogeneity involving DPT and SEMA3D genes in autosomal dominant familial Meniere\u2019s disease. Eur J Hum Genet EJHG 25(2):200\u2013207. https:\/\/doi.org\/10.1038\/ejhg.2016.154","journal-title":"Eur J Hum Genet EJHG"},{"issue":"6","key":"10535_CR14","doi-asserted-by":"publisher","first-page":"1598","DOI":"10.1097\/AUD.0000000000000878","volume":"41","author":"P Roman-Naranjo","year":"2020","unstructured":"Roman-Naranjo P, Gallego-Martinez A, Soto-Varela A, Aran I, Moleon MDC, Espinosa-Sanchez JM et al (2020) Burden of rare variants in the OTOG gene in familial Meniere\u2019s disease. Ear Hear 41(6):1598\u20131605. https:\/\/doi.org\/10.1097\/AUD.0000000000000878","journal-title":"Ear Hear"},{"issue":"5","key":"10535_CR15","doi-asserted-by":"publisher","first-page":"319","DOI":"10.34172\/aim.2020.21","volume":"23","author":"Z Mehrjoo","year":"2020","unstructured":"Mehrjoo Z, Kahrizi K, Mohseni M, Akbari M, Arzhangi S, Jalalvand K et al (2020) Limbic system associated membrane protein mutation in an Iranian family diagnosed with M\u00e9ni\u00e8re\u2019s disease. Arch Iran Med 23(5):319\u201325. https:\/\/doi.org\/10.34172\/aim.2020.21","journal-title":"Arch Iran Med"},{"key":"10535_CR16","doi-asserted-by":"publisher","first-page":"108329","DOI":"10.1016\/j.heares.2021.108329","volume":"409","author":"P Roman-Naranjo","year":"2021","unstructured":"Roman-Naranjo P, Moleon MDC, Aran I, Escalera-Balsera A, Soto-Varela A, B\u00e4chinger D et al (2021) Rare coding variants involving MYO7A and other genes encoding stereocilia link proteins in familial meniere disease. Hear Res 409:108329. https:\/\/doi.org\/10.1016\/j.heares.2021.108329","journal-title":"Hear Res"},{"issue":"6","key":"10535_CR17","doi-asserted-by":"publisher","first-page":"998","DOI":"10.3390\/genes13060998","volume":"13","author":"S Skarp","year":"2022","unstructured":"Skarp S, Korvala J, Kotim\u00e4ki J, Sorri M, M\u00e4nnikk\u00f6 M, Hietikko E (2022) New genetic variants in CYP2B6 and SLC6A support the role of oxidative stress in familial M\u00e9ni\u00e8re\u2019s disease. Genes 13(6):998. https:\/\/doi.org\/10.3390\/genes13060998","journal-title":"Genes"},{"key":"10535_CR18","doi-asserted-by":"crossref","unstructured":"Rom\u00e1n-Naranjo P, Parra-Perez AM, Escalera-Balsera A, Soto-Varela A, Gallego-Martinez A, Aran I et al (2022) Ultrarare missense and frameshift variants in the TECTA gene may involve tectorial membrane in familial Meniere disease [Internet]. [cit\u00e9 4 d\u00e9c 2025]. Disponible sur: http:\/\/medrxiv.org\/lookup\/doi\/10.1101\/2022.02.18.22270926","DOI":"10.1101\/2022.02.18.22270926"},{"key":"10535_CR19","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.heares.2019.01.003","volume":"376","author":"H Kremer","year":"2019","unstructured":"Kremer H (2019) Hereditary hearing loss; about the known and the unknown. Hear Res 376:58\u201368. https:\/\/doi.org\/10.1016\/j.heares.2019.01.003","journal-title":"Hear Res"},{"issue":"13","key":"10535_CR20","doi-asserted-by":"publisher","first-page":"1524","DOI":"10.1177\/1535370221999746","volume":"246","author":"E Wonkam-Tingang","year":"2021","unstructured":"Wonkam-Tingang E, Schrauwen I, Esoh KK, Bharadwaj T, Nouel-Saied LM, Acharya A et al (2021) A novel variant in DMXL2 gene is associated with autosomal dominant non-syndromic hearing impairment (DFNA71) in a Cameroonian family. Exp Biol Med Maywood NJ 246(13):1524\u20131532. https:\/\/doi.org\/10.1177\/1535370221999746","journal-title":"Exp Biol Med Maywood NJ"},{"issue":"1","key":"10535_CR21","doi-asserted-by":"publisher","first-page":"8326","DOI":"10.1038\/s41598-024-57415-1","volume":"14","author":"K Watanabe","year":"2024","unstructured":"Watanabe K, Nishio SY, Usami SI, Deafness Gene Study Consortium (2024) The prevalence and clinical features of MYO7A-related hearing loss including DFNA11, DFNB2 and USH1B. Sci Rep 14(1):8326. https:\/\/doi.org\/10.1038\/s41598-024-57415-1","journal-title":"Sci Rep"},{"issue":"2","key":"10535_CR22","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1038\/72793","volume":"24","author":"MC Simmler","year":"2000","unstructured":"Simmler MC, Cohen-Salmon M, El-Amraoui A, Guillaud L, Benichou JC, Petit C et al (2000) Targeted disruption of otog results in deafness and severe imbalance. Nat Genet 24(2):139\u2013143. https:\/\/doi.org\/10.1038\/72793","journal-title":"Nat Genet"},{"issue":"3","key":"10535_CR23","doi-asserted-by":"publisher","first-page":"2708","DOI":"10.1111\/ejn.16083","volume":"58","author":"V Babu","year":"2023","unstructured":"Babu V, Bahari R, Laban N, Kulaga J, Abdul Z, Zakkar B et al (2023) RotaRod and acoustic startle reflex performance of two potential mouse models for Meniere\u2019s disease. Eur J Neurosci 58(3):2708\u20132723. https:\/\/doi.org\/10.1111\/ejn.16083","journal-title":"Eur J Neurosci"},{"issue":"3","key":"10535_CR24","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1016\/j.devcel.2004.06.016","volume":"7","author":"W Wang","year":"2004","unstructured":"Wang W, Grimmer JF, Van De Water TR, Lufkin T (2004) Hmx2 and Hmx3 homeobox genes direct development of the murine inner ear and hypothalamus and can be functionally replaced by Drosophila Hmx. Dev Cell 7(3):439\u201353. https:\/\/doi.org\/10.1016\/j.devcel.2004.06.016","journal-title":"Dev Cell"},{"issue":"10","key":"10535_CR25","doi-asserted-by":"publisher","first-page":"2551","DOI":"10.1093\/hmg\/ddt646","volume":"23","author":"PK Legan","year":"2014","unstructured":"Legan PK, Goodyear RJ, Mor\u00edn M, Mencia A, Pollard H, Olavarrieta L et al (2014) Three deaf mice: mouse models for TECTA-based human hereditary deafness reveal domain-specific structural phenotypes in the tectorial membrane. Hum Mol Genet 23(10):2551\u201368. https:\/\/doi.org\/10.1093\/hmg\/ddt646","journal-title":"Hum Mol Genet"},{"issue":"1","key":"10535_CR26","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/s0896-6273(00)00102-1","volume":"28","author":"PK Legan","year":"2000","unstructured":"Legan PK, Lukashkina VA, Goodyear RJ, K\u00f6ssi M, Russell IJ, Richardson GP (2000) A targeted deletion in alpha-tectorin reveals that the tectorial membrane is required for the gain and timing of cochlear feedback. Neuron 28(1):273\u2013285. https:\/\/doi.org\/10.1016\/s0896-6273(00)00102-1","journal-title":"Neuron"},{"issue":"3","key":"10535_CR27","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1007\/s40136-014-0048-7","volume":"2","author":"CC Wick","year":"2014","unstructured":"Wick CC, Semaan MT, Zheng QY, Megerian CA (2014) A genetic murine model of endolymphatic hydrops: the phex mouse. Curr Otorhinolaryngol Rep 2(3):144\u2013151. https:\/\/doi.org\/10.1007\/s40136-014-0048-7","journal-title":"Curr Otorhinolaryngol Rep"},{"issue":"1\u20132","key":"10535_CR28","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.heares.2008.01.002","volume":"237","author":"CA Megerian","year":"2008","unstructured":"Megerian CA, Semaan MT, Aftab S, Kisley LB, Zheng QY, Pawlowski KS et al (2008) A mouse model with postnatal endolymphatic hydrops and hearing loss. Hear Res 237(1\u20132):90\u2013105. https:\/\/doi.org\/10.1016\/j.heares.2008.01.002","journal-title":"Hear Res"}],"container-title":["European Archives of Oto-Rhino-Laryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00405-026-10535-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00405-026-10535-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00405-026-10535-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T21:38:57Z","timestamp":1787261937000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00405-026-10535-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,20]]},"references-count":28,"alternative-id":["10535"],"URL":"https:\/\/doi.org\/10.1007\/s00405-026-10535-y","relation":{},"ISSN":["0937-4477","1434-4726"],"issn-type":[{"value":"0937-4477","type":"print"},{"value":"1434-4726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,20]]},"assertion":[{"value":"12 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 August 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"None.","order":1,"name":"Ethics","label":"Conflict of interests","group":{"name":"EthicsHeading","label":"Declarations"}}]}}